KEGG   PATHWAY: bli00260
Entry
bli00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Bacillus licheniformis ATCC 14580
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bli00260  Glycine, serine and threonine metabolism
bli00260

Module
bli_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bli00260]
bli_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bli00260]
bli_M00555  Betaine biosynthesis, choline => betaine [PATH:bli00260]
bli_M00621  Glycine cleavage system [PATH:bli00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Bacillus licheniformis ATCC 14580 [GN:bli]
Gene
BL00324  lysC; aspartokinase II alpha subunit and beta subunit [KO:K00928] [EC:2.7.2.4]
BL01851  yclM; Aspartate kinase YclM [KO:K00928] [EC:2.7.2.4]
BL01209  dapG; aspartokinase I (alpha and beta subunits) [KO:K00928] [EC:2.7.2.4]
BL01210  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BL02137  hom; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
BL02135  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
BL02065  thrCA; threonine synthase [KO:K01733] [EC:4.2.3.1]
BL02136  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
BL03991  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BL03603  yvcT; probable 2-ketogluconate reductase YvcT [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
BL02363  glxK; Glycerate kinase GlxK [KO:K00865] [EC:2.7.1.165]
BL03467  pgm; phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
BL00647  serA; phosphoglycerate dehydrogenase SerA [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BL05093  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
BL00360  ysaA; putative metallopeptidase YsaA [KO:K25528] [EC:3.1.3.3]
BL03659  kbl; 2-amino-3-ketobutyrate CoA ligase (glycine acetyl transferase) [KO:K00639] [EC:2.3.1.29]
BL03658  tdh; threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
BL01561  gcvPA; glycine decarboxylase (subunit 1) (glycine cleavage system protein P) [KO:K00282] [EC:1.4.4.2]
BL01560  gcvPB; glycine decarboxylase (subunit 2) (glycine cleavage system protein P) [KO:K00283] [EC:1.4.4.2]
BL01562  gcvT; aminomethyltransferase (glycine cleavage system protein T) [KO:K00605] [EC:2.1.2.10]
BL03015  acoL; acetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase) [KO:K00382] [EC:1.8.1.4]
BL01619  pdhD; dihydrolipoamide dehydrogenase E3 subunit of both pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes [KO:K00382] [EC:1.8.1.4]
BL01503  bfmBC; branched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase) [KO:K00382] [EC:1.8.1.4]
BL02176  gcvH; glycine cleavage system protein H [KO:K02437]
BL02540  pssA; phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
BL02563  gbsB; alcohol dehydrogenase [KO:K11440] [EC:1.1.1.1]
BL02564  gbsA; glycine betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BL02018  yrhB; cystathionine gamma-lyase YrhB [KO:K17217] [EC:4.4.1.1 4.4.1.2]
BL02309  sdaAB; L-serine dehydratase (beta chain) [KO:K01752] [EC:4.3.1.17]
BL02310  sdaAA; L-serine dehydratase (alpha chain) [KO:K01752] [EC:4.3.1.17]
BL03302  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
BL02770  trpA; tryptophan synthase (alpha subunit) [KO:K01695] [EC:4.2.1.20]
BL02771  trpB; tryptophan synthase (beta subunit) [KO:K01696] [EC:4.2.1.20]
BL01336  4-aminobutyrate aminotransferase [KO:K00836] [EC:2.6.1.76]
BL01335  putative L-2,4-diaminobutyrate decarboxylase [KO:K13745] [EC:4.1.1.86]
BL02887  putative aminoacid decarboxylase [KO:K13745] [EC:4.1.1.86]
BL01735  Putative L-2,4-diaminobutyrate decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bli00010  Glycolysis / Gluconeogenesis
bli00020  Citrate cycle (TCA cycle)
bli00230  Purine metabolism
bli00250  Alanine, aspartate and glutamate metabolism
bli00270  Cysteine and methionine metabolism
bli00290  Valine, leucine and isoleucine biosynthesis
bli00300  Lysine biosynthesis
bli00330  Arginine and proline metabolism
bli00460  Cyanoamino acid metabolism
bli00470  D-Amino acid metabolism
bli00564  Glycerophospholipid metabolism
bli00600  Sphingolipid metabolism
bli00620  Pyruvate metabolism
bli00630  Glyoxylate and dicarboxylate metabolism
bli00640  Propanoate metabolism
bli00680  Methane metabolism
bli00860  Porphyrin metabolism
bli00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system