KEGG PATHWAY: bli00270

PATHWAY: bli00270

Entry

bli00270                    Pathway

Name

Cysteine and methionine metabolism - Bacillus licheniformis ATCC 14580

Description

Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].

Class

Metabolism; Amino acid metabolism

Pathway map

bli00270

Cysteine and methionine metabolism

Module

bli_M00017

Methionine biosynthesis, aspartate => homoserine => methionine [PATH:bli00270]

bli_M00021

Cysteine biosynthesis, serine => cysteine [PATH:bli00270]

bli_M00034

Methionine salvage pathway [PATH:bli00270]

bli_M00609

Cysteine biosynthesis, methionine => cysteine [PATH:bli00270]

Other DBs

GO:	0006534 0006555

Organism

Bacillus licheniformis ATCC 14580 [GN:bli]

Gene

BL03268

cysE; serine acetyltransferase [KO:K00640] [EC:2.3.1.30]

BL01516

cysEA; serine acetyltransferase [KO:K00640] [EC:2.3.1.30]

BL00857

cysK; cysteine synthetase A [KO:K01738] [EC:2.5.1.47]

BL00070

ytkP; cysteine synthase [KO:K01738] [EC:2.5.1.47]

BL02018

yrhB; cystathionine gamma-lyase YrhB [KO:K17217] [EC:4.4.1.1 4.4.1.2]

BL02659

yjcJ; putative Cystathionine beta-lyase [KO:K01760] [EC:4.4.1.13]

BL02532

patB; aminotransferase PatB [KO:K14155] [EC:4.4.1.13]

BL02019

yrhA; putative cysteine synthase YrhA [KO:K17216] [EC:2.5.1.134]

BL01781

ybgG; Homocysteine S-methyltransferase YbgG [KO:K00547] [EC:2.1.1.10]

BL01308

metH; putative 5-methyltetrahydrofolate--homocysteine methyltransferase MetH [KO:K00548] [EC:2.1.1.13]

BL01307

yitJ; Homocysteine S-methyltransferase [KO:K24042] [EC:2.1.1.13 1.5.1.54]

BL03738

metE; methionine synthase [KO:K00549] [EC:2.1.1.14]

BL02632

metK; S-adenosylmethionine synthetase [KO:K00789] [EC:2.5.1.6]

BL00389

speD; S-adenosylmethionine decarboxylase [KO:K01611] [EC:4.1.1.50]

BL03920

speE; spermidine synthase [KO:K00797] [EC:2.5.1.16]

BL02020

mtn; methylthioadenosine nucleosidase [KO:K01243] [EC:3.2.2.9]

BL03633

mtnK; methylthioribose kinase [KO:K00899] [EC:2.7.1.100]

BL02260

ylmD; conserved hypothetical protein YlmD [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]

BL01390

hypothetical protein [KO:K12960] [EC:3.5.4.31 3.5.4.28]

BL03632

mtnS; methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]

BL03541

mtnB; putative Methylthioribulose-1-phosphate dehydratase [KO:K08964 K08966] [EC:4.2.1.109 3.1.3.87]

BL03540

mtnW; 2,3-diketo-5-methylthiopentyl-1-phosphate enolase [KO:K08965] [EC:5.3.2.5]

BL00251

putative D-alpha-glycerophosphatase [KO:K08966] [EC:3.1.3.87]

BL03542

mtnZ; 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase [KO:K08967] [EC:1.13.11.53 1.13.11.54]

BL03539

mtnV; Aminotransferase, class I and II [KO:K08969] [EC:2.6.1.117]

BL00373

ytsP; conserved protein YtsP [KO:K08968] [EC:1.8.4.14]

BL02021

yrrT; probable S-adenosylmethionine-dependent methyltransferase YrrT [KO:K17462] [EC:2.1.1.-]

BL05306

luxS; autoinducer-2 production protein [KO:K07173] [EC:4.4.1.21]

BL00324

lysC; aspartokinase II alpha subunit and beta subunit [KO:K00928] [EC:2.7.2.4]

BL01851

yclM; Aspartate kinase YclM [KO:K00928] [EC:2.7.2.4]

BL01209

dapG; aspartokinase I (alpha and beta subunits) [KO:K00928] [EC:2.7.2.4]

BL01210

asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

BL02137

hom; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

BL01365

metA; homoserine O-succinyltransferase [KO:K00651] [EC:2.3.1.46 2.3.1.31]

BL02660

yjcI; Cys/Met metabolism pyridoxal-phosphate-dependent enzymes [KO:K01739] [EC:2.5.1.48]

BL00607

D-alanine aminotransferase [KO:K00826] [EC:2.6.1.42]

BL03930

ywaA; Branched-chain amino acid aminotransferase II [KO:K00826] [EC:2.6.1.42]

BL02746

aspB; aspartate aminotransferase [KO:K00812] [EC:2.6.1.1]

BL01805

Thiosulfate sulfurtransferase [KO:K01011] [EC:2.8.1.1 2.8.1.2]

BL01703

ldh; L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]

BL00397

mdh; malate dehydrogenase [KO:K00024] [EC:1.1.1.37]

BL02309

sdaAB; L-serine dehydratase (beta chain) [KO:K01752] [EC:4.3.1.17]

BL02310

sdaAA; L-serine dehydratase (alpha chain) [KO:K01752] [EC:4.3.1.17]

BL00647

serA; phosphoglycerate dehydrogenase SerA [KO:K00058] [EC:1.1.1.95 1.1.1.399]

BL05093

serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

Compound

C00019

S-Adenosyl-L-methionine

C00021

S-Adenosyl-L-homocysteine

C00022

Pyruvate

C00041

L-Alanine

C00049

L-Aspartate

C00051

Glutathione

C00059

Sulfate

C00065

L-Serine

C00073

L-Methionine

C00094

Sulfite

C00097

L-Cysteine

C00109

2-Oxobutanoate

C00155

L-Homocysteine

C00170

5'-Methylthioadenosine

C00197

3-Phospho-D-glycerate

C00263

L-Homoserine

C00283

Hydrogen sulfide

C00409

Methanethiol

C00441

L-Aspartate 4-semialdehyde

C00491

L-Cystine

C00506

L-Cysteate

C00606

3-Sulfino-L-alanine

C00793

D-Cysteine

C00957

Mercaptopyruvate

C00979

O-Acetyl-L-serine

C01005

O-Phospho-L-serine

C01077

O-Acetyl-L-homoserine

C01118

O-Succinyl-L-homoserine

C01137

S-Adenosylmethioninamine

C01180

4-Methylthio-2-oxobutanoic acid

C01234

1-Aminocyclopropane-1-carboxylate

C01817

L-Homocystine

C01962

Thiocysteine

C02218

Dehydroalanine

C02291

L-Cystathionine

C02356

(S)-2-Aminobutanoate

C02989

L-Methionine S-oxide

C03082

4-Phospho-L-aspartate

C03089

5-Methylthio-D-ribose

C03145

N-Formylmethionine

C03232

3-Phosphonooxypyruvate

C03431

S-Inosyl-L-homocysteine

C03539

S-Ribosyl-L-homocysteine

C04188

S-Methyl-5-thio-D-ribose 1-phosphate

C04582

S-Methyl-5-thio-D-ribulose 1-phosphate

C05324

Nicotianamine

C05524

Aminoacyl-L-methionine

C05526

S-Glutathionyl-L-cysteine

C05527

3-Sulfinylpyruvate

C05528

3-Sulfopyruvate

C05823

3-Mercaptolactate

C05824

S-Sulfo-L-cysteine

C06547

Ethylene

C08276

3-(Methylthio)propanoate

C09306

Sulfur dioxide

C11437

1-Deoxy-D-xylulose 5-phosphate

C11481

HSO3-

C11499

(S)-3-Sulfolactate

C11537

(2R)-3-Sulfolactate

C15606

1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one

C15650

2,3-Diketo-5-methylthiopentyl-1-phosphate

C15651

2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate

C18049

N-Acyl-L-homoserine lactone

C19787

5'-S-Methyl-5'-thioinosine

C21015

gamma-L-Glutamyl-L-2-aminobutyrate

C21016

Ophthalmate

C22359

S-Methyl-1-thio-D-xylulose 5-phosphate

Reference

PMID:15102328

Authors

Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A

Title

Bacterial variations on the methionine salvage pathway.

Journal

BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9

Reference

PMID:14551435

Authors

Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.

Title

A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.

Journal

Science 302:286-90 (2003)
DOI:10.1126/science.1086997

Reference

PMID:12022921

Authors

Sekowska A, Danchin A.

Title

The methionine salvage pathway in Bacillus subtilis.

Journal

BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8

Reference

PMID:12670965

Authors

Berger BJ, English S, Chan G, Knodel MH.

Title

Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.

Journal

J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003

Reference

PMID:17169919

Authors

Goyer A, Collakova E, Shachar-Hill Y, Hanson AD

Title

Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.

Journal

Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055

Reference

PMID:17030798

Authors

Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S

Title

Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.

Journal

Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103

Reference

PMID:18625006

Authors

Pirkov I, Norbeck J, Gustafsson L, Albers E

Title

A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.

Journal

FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x

Reference

PMID:18391471

Authors

Ashida H, Saito Y, Kojima C, Yokota A

Title

Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.

Journal

Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651

Reference

PMID:10613873

Authors

Kitabatake M, So MW, Tumbula DL, Soll D

Title

Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?

Journal

J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000

Reference

PMID:12644499

Authors

Mino K, Ishikawa K

Title

Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.

Journal

J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003

Reference

PMID:18520135

Authors

Tanabe S

Title

Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.

Journal

Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:19270684

Authors