KEGG   PATHWAY: bmab00260
Entry
bmab00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Burkholderia mallei 2002734299
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bmab00260  Glycine, serine and threonine metabolism
bmab00260

Module
bmab_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bmab00260]
bmab_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bmab00260]
bmab_M00555  Betaine biosynthesis, choline => betaine [PATH:bmab00260]
bmab_M00621  Glycine cleavage system [PATH:bmab00260]
bmab_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:bmab00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Burkholderia mallei 2002734299 [GN:bmab]
Gene
BM45_1213  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BM45_1275  [KO:K00928] [EC:2.7.2.4]
BM45_1298  [KO:K00831] [EC:2.6.1.52]
BM45_1416  psdht; phenylserine dehydratase [KO:K01754] [EC:4.3.1.19]
BM45_1441  [KO:K00865] [EC:2.7.1.165]
BM45_1519  [KO:K00003] [EC:1.1.1.3]
BM45_1520  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
BM45_1584  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
BM45_1650  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BM45_2176  pssA; CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
BM45_2362  serC; phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
BM45_2518  [KO:K15634] [EC:5.4.2.11]
BM45_2788  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
BM45_2843  [KO:K00836] [EC:2.6.1.76]
BM45_2910  gcvT; glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
BM45_2911  gcvH; glycine cleavage system H protein [KO:K02437]
BM45_2912  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
BM45_2914  [KO:K01752] [EC:4.3.1.17]
BM45_3531  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
BM45_3535  [KO:K01754] [EC:4.3.1.19]
BM45_3623  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BM45_3624  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
BM45_3638  [KO:K00305] [EC:1.5.3.24 1.5.3.1]
BM45_3639  [KO:K00302] [EC:1.5.3.24 1.5.3.1]
BM45_4004  [KO:K00836] [EC:2.6.1.76]
BM45_4071  trpA; tryptophan synthase, alpha subunit [KO:K01695] [EC:4.2.1.20]
BM45_4073  trpB; tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]
BM45_4077  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BM45_4159  [KO:K01753] [EC:4.3.1.18]
BM45_4160  [KO:K01753] [EC:4.3.1.18]
BM45_4225  thrB; homoserine kinase [KO:K02204] [EC:2.7.1.39]
BM45_4430  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
BM45_4431  kbl; glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
BM45_4524  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BM45_466  [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BM45_4684  [KO:K01620] [EC:4.1.2.48]
BM45_4791  glyA2; serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
BM45_4794  [KO:K21833] [EC:1.5.7.3]
BM45_4795  [KO:K21834]
BM45_4796  [KO:K25960]
BM45_4797  [KO:K25961]
BM45_4798  [KO:K00479] [EC:1.14.13.251]
BM45_4799  [KO:K21832] [EC:1.14.13.251]
BM45_507  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
BM45_836  [KO:K16066] [EC:1.1.1.381 1.1.1.-]
BM45_837  [KO:K00600] [EC:2.1.2.1]
BM45_941  [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
C23135  (2S,3S)-2-Acetamido-3-hydroxy-4-aminobutyrate
C23136  4-Amino-L-allothreonine
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bmab00010  Glycolysis / Gluconeogenesis
bmab00020  Citrate cycle (TCA cycle)
bmab00230  Purine metabolism
bmab00250  Alanine, aspartate and glutamate metabolism
bmab00270  Cysteine and methionine metabolism
bmab00290  Valine, leucine and isoleucine biosynthesis
bmab00300  Lysine biosynthesis
bmab00330  Arginine and proline metabolism
bmab00460  Cyanoamino acid metabolism
bmab00470  D-Amino acid metabolism
bmab00564  Glycerophospholipid metabolism
bmab00600  Sphingolipid metabolism
bmab00620  Pyruvate metabolism
bmab00630  Glyoxylate and dicarboxylate metabolism
bmab00640  Propanoate metabolism
bmab00680  Methane metabolism
bmab00860  Porphyrin metabolism
bmab00920  Sulfur metabolism
KO pathway
ko00260   

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