KEGG   PATHWAY: bpso00260
Entry
bpso00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Burkholderia pseudomallei A79A
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bpso00260  Glycine, serine and threonine metabolism
bpso00260

Module
bpso_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bpso00260]
bpso_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bpso00260]
bpso_M00555  Betaine biosynthesis, choline => betaine [PATH:bpso00260]
bpso_M00621  Glycine cleavage system [PATH:bpso00260]
bpso_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:bpso00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Burkholderia pseudomallei A79A [GN:bpso]
Gene
X996_1927  aspartate kinase domain protein [KO:K00928] [EC:2.7.2.4]
X996_5844  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
X996_2183  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
X996_5761  thrB; homoserine kinase [KO:K02204] [EC:2.7.1.39]
X996_2184  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
X996_4887  ltaE; low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
X996_2429  ltaA; L-allo-threonine aldolase [KO:K01620] [EC:4.1.2.48]
X996_1401  beta-eliminating lyase family protein [KO:K00600] [EC:2.1.2.1]
X996_3726  glyA2; serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
X996_370  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K12972] [EC:1.1.1.79 1.1.1.81]
X996_2285  ghrB; glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
X996_1702  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
X996_2103  glycerate kinase family protein [KO:K00865] [EC:2.7.1.165]
X996_5006  glycerate kinase family protein [KO:K00865] [EC:2.7.1.165]
X996_235  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
X996_1253  histidine phosphatase super family protein [KO:K15634] [EC:5.4.2.11]
X996_549  putative d-3-phosphoglycerate dehydrogenase oxidoreductase protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
X996_2961  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
X996_1637  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
X996_1948  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
X996_2250  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
X996_1400  ydfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [KO:K16066] [EC:1.1.1.381 1.1.1.-]
X996_5137  kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
X996_5136  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
X996_748  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
X996_750  gcvT; glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
X996_2631  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
X996_5231  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
X996_1868  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
X996_749  gcvH; glycine cleavage system H protein [KO:K02437]
X996_3017  pssA; CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
X996_3712  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
X996_3713  betB; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
X996_3733  ring hydroxylating alpha subunit family protein [KO:K00479] [EC:1.14.13.251]
X996_3734  2Fe-2S iron-sulfur cluster binding domain protein [KO:K21832] [EC:1.14.13.251]
X996_3729  flavin oxidoreductase / NADH oxidase family protein [KO:K21833] [EC:1.5.7.3]
X996_3730  4Fe-4S dicluster domain protein [KO:K21834]
X996_3731  electron transfer flavodomain protein [KO:K25960]
X996_3732  electron transfer flavodomain protein [KO:K25961]
X996_3697  sarcosine oxidase, alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]
X996_3695  sarcosine oxidase, beta subunit [KO:K00303] [EC:1.5.3.24 1.5.3.1]
X996_3698  sarcosine oxidase, gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
X996_3696  soxD; subunit delta of sarcosine oxidase [KO:K00304] [EC:1.5.3.24 1.5.3.1]
X996_746  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
X996_3694  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
X996_67  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
X996_2074  psdht; phenylserine dehydratase [KO:K01754] [EC:4.3.1.19]
X996_4485  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
X996_72  putative D-serine deaminase (D-serine dehydratase) protein [KO:K01753] [EC:4.3.1.18]
X996_5395  dsdA; D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
X996_5850  trpA; tryptophan synthase, alpha subunit [KO:K01695] [EC:4.2.1.20]
X996_5848  trpB; tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]
X996_201  2,4-diaminobutyrate 4-transaminase family protein [KO:K00836] [EC:2.6.1.76]
X996_6001  2,4-diaminobutyrate 4-transaminase family protein [KO:K00836] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bpso00010  Glycolysis / Gluconeogenesis
bpso00020  Citrate cycle (TCA cycle)
bpso00230  Purine metabolism
bpso00250  Alanine, aspartate and glutamate metabolism
bpso00270  Cysteine and methionine metabolism
bpso00290  Valine, leucine and isoleucine biosynthesis
bpso00300  Lysine biosynthesis
bpso00330  Arginine and proline metabolism
bpso00460  Cyanoamino acid metabolism
bpso00470  D-Amino acid metabolism
bpso00564  Glycerophospholipid metabolism
bpso00600  Sphingolipid metabolism
bpso00620  Pyruvate metabolism
bpso00630  Glyoxylate and dicarboxylate metabolism
bpso00640  Propanoate metabolism
bpso00680  Methane metabolism
bpso00860  Porphyrin metabolism
bpso00920  Sulfur metabolism
KO pathway
ko00260   
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