KEGG   PATHWAY: bsr00260
Entry
bsr00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Bacillus subtilis subsp. subtilis RO-NN-1
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bsr00260  Glycine, serine and threonine metabolism
bsr00260

Module
bsr_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bsr00260]
bsr_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bsr00260]
bsr_M00555  Betaine biosynthesis, choline => betaine [PATH:bsr00260]
bsr_M00621  Glycine cleavage system [PATH:bsr00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Bacillus subtilis subsp. subtilis RO-NN-1 [GN:bsr]
Gene
I33_2901  aspartate kinase, monofunctional class [KO:K00928] [EC:2.7.2.4]
I33_0434  yclM; putative aspartokinase III [KO:K00928] [EC:2.7.2.4]
I33_1863  aspartate kinase, monofunctional class [KO:K00928] [EC:2.7.2.4]
I33_1862  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
I33_3325  hom; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
I33_3323  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
I33_3324  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
I33_3833  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
I33_3587  glyoxylate reductase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
I33_4169  glycerate kinase 2 [KO:K00865] [EC:2.7.1.165]
I33_3508  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
I33_2079  putative D-isomer specific 2-hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
I33_2372  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
I33_1133  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
I33_2949  YsaA [KO:K25528] [EC:3.1.3.3]
I33_1886  8-amino-7-oxononanoate synthase [KO:K00639] [EC:2.3.1.29]
I33_1885  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
I33_2136  amine oxidase, flavin-containing [KO:K00274] [EC:1.4.3.4]
I33_2536  glycine cleavage system P-protein [KO:K00282] [EC:1.4.4.2]
I33_2535  glycine cleavage system P-protein [KO:K00283] [EC:1.4.4.2]
I33_2537  gcvT; glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
I33_2484  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
I33_0908  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
I33_1641  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
I33_3388  gcvH; glycine cleavage system H protein [KO:K02437]
I33_0266  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
I33_3189  alcohol dehydrogenase [KO:K11440] [EC:1.1.1.1]
I33_3190  betB; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
I33_2767  yrhB; putative cystathionine gamma-synthase [KO:K17217] [EC:4.4.1.1 4.4.1.2]
I33_1771  sdaAB; L-serine dehydratase, iron-sulfur-dependent, beta subunit [KO:K01752] [EC:4.3.1.17]
I33_1772  sdaAA; L-serine dehydratase, iron-sulfur-dependent, alpha subunit [KO:K01752] [EC:4.3.1.17]
I33_2235  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
I33_2452  dsdA; D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
I33_3562  putative amino acid racemase [KO:K25316] [EC:5.1.1.10]
I33_2323  trpA; tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
I33_2324  trpB; tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bsr00010  Glycolysis / Gluconeogenesis
bsr00020  Citrate cycle (TCA cycle)
bsr00230  Purine metabolism
bsr00250  Alanine, aspartate and glutamate metabolism
bsr00270  Cysteine and methionine metabolism
bsr00290  Valine, leucine and isoleucine biosynthesis
bsr00300  Lysine biosynthesis
bsr00330  Arginine and proline metabolism
bsr00460  Cyanoamino acid metabolism
bsr00470  D-Amino acid metabolism
bsr00564  Glycerophospholipid metabolism
bsr00600  Sphingolipid metabolism
bsr00620  Pyruvate metabolism
bsr00630  Glyoxylate and dicarboxylate metabolism
bsr00640  Propanoate metabolism
bsr00680  Methane metabolism
bsr00860  Porphyrin metabolism
bsr00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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