KEGG   PATHWAY: cgi00260
Entry
cgi00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Cryptococcus gattii
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
cgi00260  Glycine, serine and threonine metabolism
cgi00260

Module
cgi_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:cgi00260]
cgi_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:cgi00260]
cgi_M00621  Glycine cleavage system [PATH:cgi00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Cryptococcus gattii [GN:cgi]
Gene
CGB_H3050C  aspartate kinase [KO:K00928] [EC:2.7.2.4]
CGB_B3040C  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
CGB_I2690W  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
CGB_H5320C  homoserine kinase [KO:K00872] [EC:2.7.1.39]
CGB_B6540C  threonine synthase [KO:K01733] [EC:4.2.3.1]
CGB_C6780W  threonine aldolase [KO:K01620] [EC:4.1.2.48]
CGB_D9390C  glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
CGB_D1540C  alanine-glyoxylate transaminase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
CGB_C4210C  glyoxylate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
CGB_D7620W  hypothetical protein [KO:K15634] [EC:5.4.2.11]
CGB_K4230W  phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
CGB_H0610C  hypothetical protein [KO:K15918] [EC:2.7.1.31]
CGB_A8620C  D-3-phosphoglycerate dehydrogenase 2 [KO:K00058] [EC:1.1.1.95 1.1.1.399]
CGB_L0380W  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
CGB_B6450C  NADP(+)-dependent 3-hydroxy acid dehydrogenase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
CGB_C8020W  oxidoreductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
CGB_A1710W  5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
CGB_D1100W  hypothetical protein [KO:K00274] [EC:1.4.3.4]
CGB_G5250W  copper amine oxidase [KO:K00276] [EC:1.4.3.21]
CGB_D2000W  peroxisomal copper amine oxidase (Methylamine oxidase) [KO:K00276] [EC:1.4.3.21]
CGB_C1580W  glycine dehydrogenase mitochondrial precursor [KO:K00281] [EC:1.4.4.2]
CGB_C6460C  aminomethyltransferase, mitochondrial precursor [KO:K00605] [EC:2.1.2.10]
CGB_I0650W  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
CGB_N0380W  glycine dehydrogenase (decarboxylating) [KO:K02437]
CGB_G6310W  hypothetical protein [KO:K00273] [EC:1.4.3.3]
CGB_E0280W  D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
CGB_F4300W  hypothetical protein [KO:K00273] [EC:1.4.3.3]
CGB_C0100W  CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
CGB_A8240C  succinate-semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
CGB_C8500C  peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
CGB_D2010C  hypothetical protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
CGB_D0120C  hypothetical protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
CGB_A6640W  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
CGB_N2470C  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
CGB_K2580C  threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
CGB_K4320W  L-serine ammonia-lyase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
CGB_E3180C  serine family amino acid catabolism-related protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
CGB_H0760W  hypothetical protein [KO:K20498] [EC:4.3.1.18]
CGB_A7080C  tryptophan synthase [KO:K01694] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
cgi00010  Glycolysis / Gluconeogenesis
cgi00020  Citrate cycle (TCA cycle)
cgi00230  Purine metabolism
cgi00250  Alanine, aspartate and glutamate metabolism
cgi00270  Cysteine and methionine metabolism
cgi00290  Valine, leucine and isoleucine biosynthesis
cgi00300  Lysine biosynthesis
cgi00330  Arginine and proline metabolism
cgi00460  Cyanoamino acid metabolism
cgi00470  D-Amino acid metabolism
cgi00564  Glycerophospholipid metabolism
cgi00600  Sphingolipid metabolism
cgi00620  Pyruvate metabolism
cgi00630  Glyoxylate and dicarboxylate metabolism
cgi00640  Propanoate metabolism
cgi00680  Methane metabolism
cgi00860  Porphyrin metabolism
cgi00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system