KEGG   DISEASE: 前立腺癌
エントリ  
H00024                                                             
名称    
前立腺癌
  下位グループ
遺伝性前立腺癌 [DS:H02530]
概要    
Prostate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of key molecular alterations in prostate-cancer cells implicates carcinogen defenses (GSTP1), growth-factor-signaling pathways (NKX3.1, PTEN, and p27), and androgens (AR) as critical determinants of the phenotype of prostate-cancer cells. Glutathione S-transferases (GSTP1) are detoxifying enzymes. Cells of prostatic intraepithelial neoplasia, devoid of GSTP1, undergo genomic damage mediated by carcinogens. NKX3.1, PTEN, and p27 regulate the growth and survival of prostate cells in the normal prostate. Inadequate levels of PTEN and NKX3.1 lead to a reduction in p27 levels and to increased proliferation and decreased apoptosis. Androgen receptor (AR) is a transcription factor that is normally activated by its androgen ligand. During androgen withdrawal therapy, the AR signal transduction pathway also could be activated by amplification of the AR gene, by AR gene mutations, or by altered activity of AR coactivators. Through these mechanisms, tumor cells lead to the emergence of androgen-independent prostate cancer.
カテゴリ  
がん
階層分類  
ヒト疾患 [BR:jp08402]
 がん
  男性生殖器のがん
   H00024  前立腺癌
ICD-11 による疾患分類 [BR:jp08403]
 02 腫瘍
  悪性腫瘍, ただしリンパ, 造血, 中枢神経系または関連組織の原発腫瘍を除く
   悪性腫瘍, 原発性と確定または推定されるもの, 明示された部位のもの, ただしリンパ, 造血, 中枢神経系, 関連組織を除く
    男性生殖器の悪性腫瘍
     2C82  前立腺の悪性腫瘍
      H00024  前立腺癌
パスウェイ 
hsa05215  前立腺癌
関連パスウェイ
hsa05202  Transcriptional misregulation in cancer
hsa05206  MicroRNAs in cancer
hsa04110  Cell cycle
ネットワーク
nt06272  Prostate cancer
病因遺伝子 
AR (amplification, mutation) [HSA:367] [KO:K08557]
CDKN1B (allelic loss) [HSA:1027] [KO:K06624]
NKX3.1 (allelic loss) (decreased expression) [HSA:4824] [KO:K09348]
PTEN (allelic loss) [HSA:5728] [KO:K01110]
GSTP1 (hypermethylation) [HSA:2950] [KO:K23790]
TMPRSS2-ERG (translocation) [HSA:2078] [KO:K09435]
TMPRSS2-ETV1 (translocation) [HSA:2115] [KO:K09431]
TMPRSS2-ETV4 (translocation) [HSA:2118] [KO:K15592]
TMPRSS2-ETV5 (translocation) [HSA:2119] [KO:K15593]
SLC45A3-ETV1 (translocation) [HSA:2115] [KO:K09431]
SLC45A3-ELK4 (translocation) [HSA:2005] [KO:K04376]
DDX5-ETV4 (translocation) [HSA:2118] [KO:K15592]
MAD1L1 (somatic mutation) [HSA:8379] [KO:K06679]
KLF6 (somatic mutation) [HSA:1316] [KO:K09207]
MXI1 (somatic mutation) [HSA:4601] [KO:K09114]
ZFHX3 (somatic mutation) [HSA:463] [KO:K09378]
発癌物質  
Cadmium and cadmium compounds [CPD:C01413]
Chimney sweeping
治療薬   
デキサメタゾン [DR:D00292]
デキサメタゾンリン酸エステルナトリウム [DR:D00975]
ベタメタゾンリン酸エステルナトリウム [DR:D00972]
トリアムシノロンアセトニド [DR:D00983]
ヒドロコルチゾンコハク酸エステルナトリウム [DR:D00978]
トリアムシノロン [DR:D00385]
ベタメタゾン [DR:D00244]
プレドニゾロン [DR:D00472]
プレドニゾロンコハク酸エステルナトリウム [DR:D01239]
メチルプレドニゾロン [DR:D00407]
メチルプレドニゾロン酢酸エステル [DR:D00979]
エチニルエストラジオール [DR:D00554]
クロルマジノン酢酸エステル [DR:D01299]
リュープロレリン酢酸塩 [DR:D00989]
ゴセレリン酢酸塩 [DR:D00573]
デガレリクス酢酸塩 [DR:D09400]
イホスファミド [DR:D00343]
エストラムスチンリン酸エステルナトリウム水和物 [DR:D06397]
テガフール・ウラシル [DR:D02131]
ペプロマイシン硫酸塩 [DR:D02063]
ドセタキセル水和物 [DR:D02165]
ドセタキセル [DR:D07866]
カバジタキセルアセトン付加物 [DR:D10452]
シスプラチン [DR:D00275]
オラパリブ [DR:D09730] (BRCA遺伝子変異陽性)
フルタミド [DR:D00586]
ビカルタミド [DR:D00961]
エンザルタミド [DR:D10218]
アパルタミド [DR:D11040]
ダロルタミド [DR:D11045]
アビラテロン酢酸エステル [DR:D09701]
塩化ラジウム [DR:D10398]
テセルパツレブ [DR:D12116]
リンク   
ICD-11: 2C82
ICD-10: C61
OMIM: 176807
文献    
PMID:12878745 (gene, tumor type)
  著者
Nelson WG, De Marzo AM, Isaacs WB.
  タイトル
Prostate cancer.
  雑誌
N Engl J Med 349:366-81 (2003)
DOI:10.1056/NEJMra021562
文献    
PMID:17384581 (gene, tumor type)
  著者
De Marzo AM, Platz EA, Sutcliffe S, Xu J, Gronberg H, Drake CG, Nakai Y, Isaacs WB, Nelson WG.
  タイトル
Inflammation in prostate carcinogenesis.
  雑誌
Nat Rev Cancer 7:256-69 (2007)
DOI:10.1038/nrc2090
文献    
PMID:11018010 (tumor type)
  著者
Abate-Shen C, Shen MM.
  タイトル
Molecular genetics of prostate cancer.
  雑誌
Genes Dev 14:2410-34 (2000)
DOI:10.1101/gad.819500
文献    
  著者
Porkka KP, Visakorpi T.
  タイトル
Molecular mechanisms of prostate cancer.
  雑誌
Eur Urol 45:683-91 (2004)
DOI:10.1016/j.eururo.2004.01.012
文献    
  著者
Brenner JC, Chinnaiyan AM
  タイトル
Translocations in epithelial cancers.
  雑誌
Biochim Biophys Acta 1796:201-15 (2009)
DOI:10.1016/j.bbcan.2009.04.005
文献    
PMID:15660110 (carcinogen)
  著者
Luch A.
  タイトル
Nature and nurture - lessons from chemical carcinogenesis.
  雑誌
Nat Rev Cancer 5:113-25 (2005)
DOI:10.1038/nrc1546
文献    
PMID:9498904 (carcinogen)
  著者
Boffetta P, Jourenkova N, Gustavsson P.
  タイトル
Cancer risk from occupational and environmental exposure to polycyclic aromatic hydrocarbons.
  雑誌
Cancer Causes Control 8:444-72 (1997)
DOI:10.1023/a:1018465507029
文献    
  著者
Tsukasaki K, Miller CW, Greenspun E, Eshaghian S, Kawabata H, Fujimoto T, Tomonaga M, Sawyers C, Said JW, Koeffler HP
  タイトル
Mutations in the mitotic check point gene, MAD1L1, in human cancers.
  雑誌
Oncogene 20:3301-5 (2001)
DOI:10.1038/sj.onc.1204421
文献    
  著者
Narla G, Heath KE, Reeves HL, Li D, Giono LE, Kimmelman AC, Glucksman MJ, Narla J, Eng FJ, Chan AM, Ferrari AC, Martignetti JA, Friedman SL
  タイトル
KLF6, a candidate tumor suppressor gene mutated in prostate cancer.
  雑誌
Science 294:2563-6 (2001)
DOI:10.1126/science.1066326
文献    
PMID:7773287
  著者
Eagle LR, Yin X, Brothman AR, Williams BJ, Atkin NB, Prochownik EV
  タイトル
Mutation of the MXI1 gene in prostate cancer.
  雑誌
Nat Genet 9:249-55 (1995)
DOI:10.1038/ng0395-249
文献    
  著者
Sun X, Frierson HF, Chen C, Li C, Ran Q, Otto KB, Cantarel BL, Vessella RL, Gao AC, Petros J, Miura Y, Simons JW, Dong JT
  タイトル
Frequent somatic mutations of the transcription factor ATBF1 in human prostate cancer.
  雑誌
Nat Genet 37:407-12 (2005)
DOI:10.1038/ng1528
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