KEGG   DISEASE: 神経膠腫
エントリ  
H00042                                                             

名称    
神経膠腫
  上位グループ
固形腫瘍 [DS:H02421]
概要    
Gliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (astrocytomas), oligodendrocytes (oligodendrogliomas), mixtures of various glial cells (for example,oligoastrocytomas) and ependymal cells (ependymomas). The most malignant form of infiltrating astrocytoma - glioblastoma multiforme (GBM) - is one of the most aggressive human cancers. GBM may develop de novo (primary glioblastoma) or by progression from low-grade or anaplastic astrocytoma (secondary glioblastoma). Primary glioblastomas develop in older patients and typically show genetic alterations (EGFR amplification, p16/INK4a deletion, and PTEN mutations) at frequencies of 24-34%. Secondary glioblastomas develop in younger patients and frequently show overexpression of PDGF and CDK4 as well as p53 mutations (65%) and loss of Rb playing major roles in such transformations. Loss of PTEN has been implicated in both pathways, although it is much more common in the pathogenesis of primary GBM.
カテゴリ  
がん
階層分類  
ヒト疾患 [BR:jp08402]
 がん
  眼、脳および中枢神経系のがん
   H00042  神経膠腫
ICD-11 による疾患分類 [BR:jp08403]
 02 Neoplasms
  Neoplasms of brain or central nervous system
   2A00  Primary neoplasms of brain
    H00042  神経膠腫
パスウェイ 
hsa05214  神経膠腫
関連パスウェイ
hsa05200  Pathways in cancer
hsa05206  MicroRNAs in cancer
ネットワーク
nt06273  Glioma
  エレメント
N00006  Amplified EGFR to RAS-ERK signaling pathway
N00016  PDGF-overexpression to RAS-ERK signaling pathway
N00018  Amplified PDGFR to RAS-ERK signaling pathway
N00027  Amplified EGFR to PLCG-CAMK signaling pathway
N00029  Amplified PDGFR to PLCG-CAMK signaling pathway
N00035  Amplified EGFR to PI3K signaling pathway
N00040  Amplified PDGFR to PI3K signaling pathway
N00041  EGFR-overexpression to RAS-ERK signaling pathway
N00042  EGFR-overexpression to PI3K signaling pathway
N00051  Deleted PTEN to PI3K signaling pathway
N00052  Mutation-inactivated PTEN to PI3K signaling pathway
N00067  Deleted p14(ARF) to p21-cell cycle G1/S
N00068  Amplified MDM2 to p21-cell cycle G1/S
N00071  Deleted p16(INK4a) to p16-cell cycle G1/S
N00072  Amplified CDK4 to cell cycle G1/S
N00074  Loss of RB1 to cell cycle G1/S
N00115  Mutation-inactivated TP53 to transcription
N00513  Mutation-activated EGFR to RAS-ERK signaling pathway
N00514  Mutation-activated EGFR to PI3K signaling pathway
病因遺伝子 
EGFR (amplification, mutation, overexpression) [HSA:1956] [KO:K04361]
MDM2 (amplification, overexpression) [HSA:4193] [KO:K06643]
PTEN (mutation) [HSA:5728] [KO:K01110]
p16/INK4A (deletion) [HSA:1029] [KO:K06621]
PDGF-A (overexpression) [HSA:5154] [KO:K04359]
PDGF-B (overexpression) [HSA:5155] [KO:K17386]
PDGFR-alpha (overexpression, amplification) [HSA:5156] [KO:K04363]
PDGFR-beta (overexpression, amplification) [HSA:5159] [KO:K05089]
CDK4 (amplification) [HSA:1019] [KO:K02089]
p53 (mutation) [HSA:7157] [KO:K04451]
RB1 (loss) [HSA:5925] [KO:K06618]
発癌物質  
X- and gamma-radiation
治療薬   
カルムスチン [DR:D00254]
テモゾロミド [DR:D06067]
ブレオマイシン塩酸塩 [DR:D03229]
ビンクリスチン硫酸塩 [DR:D02197]
プロカルバジン塩酸塩 [DR:D00478]
ベバシズマブ [DR:D06409]
アミノレブリン酸塩酸塩 [DR:D02908]
コメント  
ICD-O: 9401/3, Tumor type: Anaplastic astrocytoma
ICD-O: 9440/3, Tumor type: Glioblastoma
リンク   
ICD-11: 2A00.0
ICD-10: C71
MeSH: D005910
文献    
PMID:15639402 (gene, tumor type)
  著者
Soni D, King JA, Kaye AH, Hovens CM.
  タイトル
Genetics of glioblastoma multiforme: mitogenic signaling and cell cycle pathways converge.
  雑誌
J Clin Neurosci 12:1-5 (2005)
DOI:10.1016/j.jocn.2004.04.001
文献    
  著者
Holland EC.
  タイトル
Gliomagenesis: genetic alterations and mouse models.
  雑誌
Nat Rev Genet 2:120-9 (2001)
DOI:10.1038/35052535
文献    
  著者
Gan HK, Cvrljevic AN, Johns TG
  タイトル
The epidermal growth factor receptor variant III (EGFRvIII): where wild things are altered.
  雑誌
FEBS J 280:5350-70 (2013)
DOI:10.1111/febs.12393
文献    
  著者
Zhu Y, Parada LF.
  タイトル
The molecular and genetic basis of neurological tumours.
  雑誌
Nat Rev Cancer 2:616-26 (2002)
DOI:10.1038/nrc866
文献    
PMID:11604478 (carcinogen)
  著者
Bondy ML, Wang LE, El-Zein R, de Andrade M, Selvan MS, Bruner JM, Levin VA, Alfred Yung WK, Adatto P, Wei Q.
  タイトル
Gamma-radiation sensitivity and risk of glioma.
  雑誌
J Natl Cancer Inst 93:1553-7 (2001)
DOI:10.1093/jnci/93.20.1553
文献    
PMID:2790826 (carcinogen)
  著者
Preston-Martin S, Mack W, Henderson BE.
  タイトル
Risk factors for gliomas and meningiomas in males in Los Angeles County.
  雑誌
Cancer Res 49:6137-43 (1989)
文献    
PMID:12826827 (marker)
  著者
Hill C, Hunter SB, Brat DJ.
  タイトル
Genetic markers in glioblastoma: prognostic significance and future therapeutic implications.
  雑誌
Adv Anat Pathol 10:212-7 (2003)
DOI:10.1097/00125480-200307000-00004
LinkDB    

» English version

DBGET integrated database retrieval system