KEGG   ORTHOLOGY: K04359
Entry
K04359                      KO                                     
Symbol
PDGFA
Name
platelet-derived growth factor subunit A
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map04010  MAPK signaling pathway
map04014  Ras signaling pathway
map04015  Rap1 signaling pathway
map04020  Calcium signaling pathway
map04072  Phospholipase D signaling pathway
map04151  PI3K-Akt signaling pathway
map04510  Focal adhesion
map04540  Gap junction
map04630  JAK-STAT signaling pathway
map04810  Regulation of actin cytoskeleton
map05200  Pathways in cancer
map05202  Transcriptional misregulation in cancer
map05206  MicroRNAs in cancer
map05214  Glioma
map05215  Prostate cancer
map05218  Melanoma
map05231  Choline metabolism in cancer
map05418  Fluid shear stress and atherosclerosis
Disease
H00015  Malignant pleural mesothelioma
H00042  Glioma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04014 Ras signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04015 Rap1 signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04630 JAK-STAT signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04020 Calcium signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04072 Phospholipase D signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04151 PI3K-Akt signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04359  PDGFA; platelet-derived growth factor subunit A
   04540 Gap junction
    K04359  PDGFA; platelet-derived growth factor subunit A
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04359  PDGFA; platelet-derived growth factor subunit A
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
   05202 Transcriptional misregulation in cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
   05206 MicroRNAs in cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
   05231 Choline metabolism in cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
  09162 Cancer: specific types
   05214 Glioma
    K04359  PDGFA; platelet-derived growth factor subunit A
   05218 Melanoma
    K04359  PDGFA; platelet-derived growth factor subunit A
   05215 Prostate cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K04359  PDGFA; platelet-derived growth factor subunit A
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04359  PDGFA; platelet-derived growth factor subunit A
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K04359  PDGFA; platelet-derived growth factor subunit A
   00536 Glycosaminoglycan binding proteins
    K04359  PDGFA; platelet-derived growth factor subunit A
Cytokines and growth factors [BR:ko04052]
 Growth factors
  Growth factors (RTK binding)
   K04359  PDGFA; platelet-derived growth factor subunit A
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Heparin
  Growth factors/receptors
   K04359  PDGFA; platelet-derived growth factor subunit A
Other DBs
GO: 0005161
Genes
HSA: 5154(PDGFA)
PTR: 740202(PDGFA)
PPS: 100991389(PDGFA)
GGO: 101132059(PDGFA)
PON: 100440212(PDGFA)
NLE: 100583683(PDGFA)
MCC: 707725(PDGFA)
MCF: 102126620(PDGFA)
CSAB: 103246906(PDGFA)
CATY: 105571784(PDGFA)
PANU: 100998521(PDGFA)
TGE: 112620011(PDGFA)
RRO: 104664975(PDGFA)
RBB: 108542315(PDGFA)
TFN: 117072614(PDGFA)
PTEH: 111523727(PDGFA)
CJC: 100412906(PDGFA)
SBQ: 101034511(PDGFA)
CSYR: 103255351(PDGFA)
MMUR: 105868355(PDGFA)
OGA: 100944643(PDGFA)
MMU: 18590(Pdgfa)
MCAL: 110294651(Pdgfa)
MPAH: 110312881(Pdgfa)
RNO: 25266(Pdgfa)
MCOC: 116068639(Pdgfa)
MUN: 110550699(Pdgfa)
CGE: 100771503(Pdgfa)
PLEU: 114682214(Pdgfa)
NGI: 103748699(Pdgfa)
HGL: 101725739(Pdgfa)
CCAN: 109684500(Pdgfa)
DORD: 105990925(Pdgfa)
DSP: 122113621(Pdgfa)
NCAR: 124970285
OCU: 100352388(PDGFA)
TUP: 102499235(PDGFA)
CFA: 491597(PDGFA)
VVP: 112929281(PDGFA)
VLG: 121487555(PDGFA)
AML: 100473486(PDGFA)
UMR: 103670054(PDGFA)
UAR: 123802515(PDGFA)
ELK: 111145884
LLV: 125090848
MPUF: 101684232(PDGFA)
ORO: 101386160(PDGFA)
ZCA: 113933137(PDGFA)
MLX: 117999262(PDGFA)
FCA: 101087287(PDGFA)
PYU: 121017467(PDGFA)
PBG: 122471191(PDGFA)
PPAD: 109251089(PDGFA)
AJU: 106966514(PDGFA)
HHV: 120227991(PDGFA)
BTA: 505908(PDGFA)
BOM: 102271219(PDGFA)
BIU: 109578611(PDGFA)
BBUB: 102394875(PDGFA)
CHX: 102174268(PDGFA)
OAS: 114110564(PDGFA)
ODA: 120882986(PDGFA)
CCAD: 122433132(PDGFA)
SSC: 100519764(PDGFA)
CFR: 102520052(PDGFA)
CBAI: 105077813(PDGFA)
CDK: 105102061(PDGFA)
VPC: 102532201(PDGFA)
BACU: 103005337(PDGFA)
LVE: 103089216(PDGFA)
OOR: 101287211(PDGFA)
DLE: 111169371(PDGFA)
PCAD: 102989848(PDGFA)
PSIU: 116740378(PDGFA)
ECB: 100055086(PDGFA)
EPZ: 103555992(PDGFA)
EAI: 106834748(PDGFA)
MYB: 102253551(PDGFA)
MYD: 102762551(PDGFA)
MMYO: 118658213(PDGFA)
MLF: 102422469(PDGFA)
MNA: 107543141(PDGFA)
PKL: 118715966(PDGFA)
HAI: 109380137(PDGFA)
DRO: 112319719(PDGFA)
SHON: 118995064(PDGFA)
AJM: 119043762(PDGFA)
PDIC: 114510403(PDGFA)
PHAS: 123810721(PDGFA)
MMF: 118615652(PDGFA)
RFQ: 117016876(PDGFA)
PALE: 102893670(PDGFA)
PGIG: 120615920(PDGFA)
PVP: 105294593(PDGFA)
RAY: 107497394(PDGFA)
TOD: 119241452(PDGFA)
SARA: 101545086(PDGFA)
TMU: 101344666
DNM: 101420455(PDGFA)
MDO: 100020951(PDGFA)
GAS: 123234190(PDGFA)
SHR: 100924985(PDGFA) 116422035
PCW: 110201572(PDGFA)
OAA: 100081033(PDGFA)
GGA: 374196(PDGFA)
PCOC: 116237353(PDGFA)
MGP: 100545955(PDGFA)
CJO: 107320713(PDGFA)
NMEL: 110405632(PDGFA)
APLA: 101803502(PDGFA)
ACYG: 106033384(PDGFA)
AFUL: 116495257(PDGFA)
TGU: 100222155(PDGFA)
LSR: 110475507(PDGFA)
SCAN: 103817870(PDGFA)
PMOA: 120513085(PDGFA)
OTC: 121334533(PDGFA)
PRUF: 121350738(PDGFA)
GFR: 102032936(PDGFA)
FAB: 101810376(PDGFA)
PHI: 102099148(PDGFA)
PMAJ: 107211209(PDGFA)
CCAE: 111936274(PDGFA)
CCW: 104685042(PDGFA)
ETL: 114054750(PDGFA)
ZAB: 102075181(PDGFA)
FPG: 101922505(PDGFA)
FCH: 102059520(PDGFA)
CLV: 102085857(PDGFA)
EGZ: 104128975(PDGFA)
NNI: 104015206(PDGFA)
ACUN: 113485656(PDGFA)
TALA: 104356513(PDGFA)
PADL: 103913559(PDGFA)
ACHC: 115335808(PDGFA)
AROW: 112974232(PDGFA)
NPD: 112959759(PDGFA)
DNE: 112992914(PDGFA)
ASN: 102386051(PDGFA)
AMJ: 102568490(PDGFA)
CPOO: 109314821(PDGFA)
GGN: 109294307(PDGFA)
PSS: 102453111(PDGFA)
CMY: 102936738(PDGFA)
CPIC: 101940087(PDGFA)
TST: 117883612(PDGFA)
CABI: 116819340(PDGFA)
MRV: 120373866(PDGFA)
ACS: 100560004(pdgfa)
PVT: 110090337(PDGFA)
SUND: 121914929(PDGFA)
PBI: 103066198(PDGFA)
PMUR: 107291891(PDGFA)
PGUT: 117673284(PDGFA)
VKO: 123025095(PDGFA)
PMUA: 114584301(PDGFA)
ZVI: 118092483(PDGFA)
GJA: 107115509(PDGFA)
XLA: 108701573(pdgfa.L) 397765(pdgfa.S)
XTR: 100038202(pdgfa)
NPR: 108800714(PDGFA)
RTEM: 120943462(PDGFA)
BBUF: 121008336(PDGFA)
BGAR: 122938815(PDGFA)
DRE: 103909601 378480(pdgfaa) 767790(pdgfab) 796490(pdgfbb)
PPRM: 120473118(pdgfab) 120489992(pdgfbb) 120495257
IPU: 108259440 108260470(pdgfbb)
SMEO: 124380081(pdgfaa) 124396930(pdgfbb)
TFD: 113638132(pdgfbb) 113657065
EEE: 113576794(pdgfa) 113581484
TRU: 101063539 101077475(pdgfa)
LCO: 104925707(pdgfa) 104938193
NCC: 104945697(pdgfa)
ELY: 117255028 117268594(pdgfab)
PLEP: 121942499 121957233(pdgfab)
SLUC: 116042707 116059555(pdgfab)
ECRA: 117957643(pdgfab) 117961247
PFLV: 114564713 114570050(pdgfa)
GAT: 120828147(pdgfab)
PPUG: 119220851(pdgfab)
MSAM: 119889692(pdgfab) 119898647
CUD: 121503987(pdgfab) 121508825
ONL: 100690958 100702821(pdgfa)
OAU: 116312442 116321448(pdgfab)
OLA: 101156252(pdgfa) 101171139
OML: 112137135 112147005(pdgfab)
XMA: 102226782(pdgfa) 102233791
XCO: 114145269 114160156(pdgfa)
XHE: 116720596 116735865(pdgfa)
PRET: 103469195(pdgfa) 103476211
PFOR: 103141010(pdgfa) 103154828
PLAI: 106936519 106942707(pdgfa)
PMEI: 106904598 106915785(pdgfa)
GAF: 122822550(pdgfab) 122830142
CVG: 107090056 107095213(pdgfa)
CTUL: 119773197(pdgfab) 119796294
NFU: 107373888 107376493(pdgfa)
KMR: 108237947 108247650(pdgfab)
ALIM: 106518714(pdgfa) 106522509
NWH: 119420987(pdgfab) 119422948
AOCE: 111562600(pdgfa) 111588207
POV: 109638650(pdgfa) 109639258
SSEN: 122770440 122785574(pdgfab)
HHIP: 117761949 117766492(pdgfab)
LCF: 108886167(pdgfa) 108887178
SDU: 111216525 111227111(pdgfa)
SLAL: 111667551(pdgfa) 111673426
XGL: 120788420(pdgfab) 120800741
BPEC: 110169079(pdgfa)
MALB: 109952877 109972908(pdgfa)
ONE: 115125364(pdgfa)
SFM: 108930223(pdgfa)
AANG: 118219868
LOC: 102685958(pdgfa)
LCM: 102352946(PDGFA)
RTP: 109916423(pdgfa) 109936774
BBEL: 109470751
SCLV: 120335980
BMOR: 101735793
OFU: 114357755
RMP: 119174722
 » show all
Reference
PMID:3422746
  Authors
Bonthron DT, Morton CC, Orkin SH, Collins T
  Title
Platelet-derived growth factor A chain: gene structure, chromosomal location, and basis for alternative mRNA splicing.
  Journal
Proc Natl Acad Sci U S A 85:1492-6 (1988)
DOI:10.1073/pnas.85.5.1492
  Sequence
[hsa:5154]
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