KEGG   PATHWAY: dsi04150
Entry
dsi04150                    Pathway                                
Name
mTOR signaling pathway - Drosophila simulans
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
dsi04150  mTOR signaling pathway
dsi04150

Organism
Drosophila simulans [GN:dsi]
Gene
Dsimw501_GD10183  Dsim_GD10183; uncharacterized protein, isoform K [KO:K15728] [EC:3.1.3.4]
Dsimw501_GD10530  Dsim_GD10530; uncharacterized protein [KO:K14299]
Dsimw501_GD10659  Dsim_GD10659; uncharacterized protein, isoform C [KO:K00572]
Dsimw501_GD10848  Dsim_GD10848; uncharacterized protein [KO:K02149]
Dsimw501_GD11053  Dsim_GD11053; uncharacterized protein [KO:K20410]
Dsimw501_GD11125  Dsim_GD11125; uncharacterized protein [KO:K02149]
Dsimw501_GD11158  Dsim_GD11158; uncharacterized protein, isoform A [KO:K04513]
Dsimw501_GD11232  Dsim_GD11232; uncharacterized protein [KO:K19662] [EC:2.7.11.13]
Dsimw501_GD11233  Dsim_GD11233; uncharacterized protein, isoform A [KO:K02677] [EC:2.7.11.13]
Dsimw501_GD11385  Dsim_GD11385; uncharacterized protein [KO:K20398]
Dsimw501_GD12229  Dsim_GD12229; uncharacterized protein [KO:K20397]
Dsimw501_GD12297  Dsim_GD12297; uncharacterized protein [KO:K02375]
Dsimw501_GD12434  Dsim_GD12434; uncharacterized protein, isoform C [KO:K20401]
Dsimw501_GD12453  Dsim_GD12453; uncharacterized protein [KO:K08272]
Dsimw501_GD12638  Dsim_GD12638; uncharacterized protein [KO:K20406]
Dsimw501_GD12695  Dsim_GD12695; uncharacterized protein, isoform C [KO:K08269] [EC:2.7.11.1]
Dsimw501_GD12890  Dsim_GD12890; uncharacterized protein [KO:K04526]
Dsimw501_GD12891  Dsim_GD12891; uncharacterized protein [KO:K04526]
Dsimw501_GD12892  Dsim_GD12892; uncharacterized protein [KO:K04526]
Dsimw501_GD12928  Dsim_GD12928; uncharacterized protein, isoform D [KO:K03259]
Dsimw501_GD13118  Dsim_GD13118; uncharacterized protein [KO:K03259]
Dsimw501_GD13174  Dsim_GD13174; uncharacterized protein, isoform A [KO:K04688] [EC:2.7.11.1]
Dsimw501_GD13470  Dsim_GD13470; uncharacterized protein, isoform G [KO:K20404]
Dsimw501_GD13545  Dsim_GD13545; uncharacterized protein, isoform D [KO:K06276] [EC:2.7.11.1]
Dsimw501_GD14000  Dsim_GD14000; uncharacterized protein [KO:K09594]
Dsimw501_GD14038  Dsim_GD14038; uncharacterized protein, isoform A [KO:K03259]
Dsimw501_GD14067  Dsim_GD14067; uncharacterized protein [KO:K03259]
Dsimw501_GD14217  Dsim_GD14217; uncharacterized protein [KO:K04526]
Dsimw501_GD14218  Dsim_GD14218; uncharacterized protein [KO:K04526]
Dsimw501_GD14489  Dsim_GD14489; uncharacterized protein [KO:K02432]
Dsimw501_GD14516  Dsim_GD14516; uncharacterized protein, isoform B [KO:K13780]
Dsimw501_GD14854  Dsim_GD14854; uncharacterized protein [KO:K07207]
Dsimw501_GD15291  Dsim_GD15291; uncharacterized protein [KO:K16186]
Dsimw501_GD15629  Dsim_GD15629; uncharacterized protein [KO:K00444]
Dsimw501_GD15716  Dsim_GD15716; uncharacterized protein [KO:K20405]
Dsimw501_GD15910  Dsim_GD15910; uncharacterized protein [KO:K02151]
Dsimw501_GD16055  Dsim_GD16055; uncharacterized protein [KO:K08266]
Dsimw501_GD16145  Dsim_GD16145; uncharacterized protein [KO:K02991]
Dsimw501_GD16161  Dsim_GD16161; uncharacterized protein [KO:K02354]
Dsimw501_GD16213  Dsim_GD16213; uncharacterized protein [KO:K07204]
Dsimw501_GD16435  Dsim_GD16435; uncharacterized protein [KO:K03259]
Dsimw501_GD16528  Dsim_GD16528; uncharacterized protein [KO:K04690]
Dsimw501_GD16554  Dsim_GD16554; uncharacterized protein [KO:K07198] [EC:2.7.11.31]
Dsimw501_GD16607  Dsim_phl; phl [KO:K04365] [EC:2.7.11.1]
Dsimw501_GD16945  Dsim_Dsor1; Dsor1, isoform C [KO:K04368] [EC:2.7.12.2]
Dsimw501_GD17075  Dsim_GD17075; uncharacterized protein [KO:K02991]
Dsimw501_GD17550  Dsim_GD17550; uncharacterized protein [KO:K04373] [EC:2.7.11.1]
Dsimw501_GD17626  Dsim_GD17626; uncharacterized protein [KO:K20399]
Dsimw501_GD17676  Dsim_GD17676; uncharacterized protein, isoform C [KO:K20408]
Dsimw501_GD18002  Dsim_GD18002; uncharacterized protein, isoform A [KO:K03259]
Dsimw501_GD18094  Dsim_GD18094; uncharacterized protein [KO:K13780]
Dsimw501_GD18325  Dsim_GD18325; uncharacterized protein, isoform A [KO:K03259]
Dsimw501_GD18919  Dsim_GD18919; uncharacterized protein, isoform A [KO:K07298] [EC:2.7.11.1]
Dsimw501_GD19074  Dsim_GD19074; uncharacterized protein, isoform A [KO:K04456] [EC:2.7.11.1]
Dsimw501_GD19444  Dsim_GD19444; uncharacterized protein, isoform A [KO:K06519]
Dsimw501_GD19685  Dsim_GD19685; uncharacterized protein [KO:K03875]
Dsimw501_GD19794  Dsim_GD19794; uncharacterized protein [KO:K07208]
Dsimw501_GD19797  Dsim_GD19797; uncharacterized protein [KO:K02150]
Dsimw501_GD19837  Dsim_GD19837; uncharacterized protein [KO:K02151]
Dsimw501_GD19971  Dsim_GD19971; uncharacterized protein [KO:K05087] [EC:2.7.10.1]
Dsimw501_GD20048  Dsim_GD20048; uncharacterized protein [KO:K00922] [EC:2.7.1.153]
Dsimw501_GD20107  Dsim_GD20107; uncharacterized protein [KO:K02152]
Dsimw501_GD20310  Dsim_ird5; ird5 [KO:K07209] [EC:2.7.11.10]
Dsimw501_GD20509  Dsim_GD20509; uncharacterized protein [KO:K00714]
Dsimw501_GD20555  Dsim_GD20555; uncharacterized protein [KO:K02147]
Dsimw501_GD20763  Dsim_GD20763; uncharacterized protein [KO:K20403]
Dsimw501_GD20791  Dsim_Ras85D; Ras85D [KO:K07827]
Dsimw501_GD20832  Dsim_GD20832; uncharacterized protein [KO:K16185]
Dsimw501_GD21013  Dsim_GD21013; uncharacterized protein [KO:K14004]
Dsimw501_GD21066  Dsim_GD21066; uncharacterized protein [KO:K07206]
Dsimw501_GD21071  Dsim_GD21071; uncharacterized protein [KO:K20396]
Dsimw501_GD21574  Dsim_GD21574; uncharacterized protein [KO:K03083] [EC:2.7.11.26]
Dsimw501_GD21903  Dsim_GD21903; uncharacterized protein, isoform D [KO:K02144]
Dsimw501_GD22093  Dsim_Vha68-1; Vha68-1, isoform B [KO:K02145] [EC:7.1.2.2]
Dsimw501_GD22136  Dsim_GD22136; uncharacterized protein, isoform A [KO:K13780]
Dsimw501_GD22287  Dsim_GD22287; uncharacterized protein, isoform C [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
Dsimw501_GD22290  Dsim_GD22290; uncharacterized protein, isoform B [KO:K16172]
Dsimw501_GD23016  Dsim_GD23016; uncharacterized protein, isoform A [KO:K02649]
Dsimw501_GD23137  Dsim_GD23137; uncharacterized protein [KO:K20407]
Dsimw501_GD23460  Dsim_wg; wingless [KO:K00445]
Dsimw501_GD23462  Dsim_GD23462; uncharacterized protein [KO:K01357]
Dsimw501_GD23761  Dsim_GD23761; uncharacterized protein [KO:K20409]
Dsimw501_GD23860  Dsim_GD23860; uncharacterized protein [KO:K02145] [EC:7.1.2.2]
Dsimw501_GD23861  Dsim_GD23861; uncharacterized protein [KO:K02145] [EC:7.1.2.2]
Dsimw501_GD23862  Dsim_GD23862; uncharacterized protein [KO:K07203] [EC:2.7.11.1]
Dsimw501_GD23927  Dsim_Sos; Sos [KO:K03099]
Dsimw501_GD24107  Dsim_GD24107; uncharacterized protein, isoform O [KO:K10421]
Dsimw501_GD24112  Dsim_GD24112; uncharacterized protein, isoform A [KO:K04370]
Dsimw501_GD24462  Dsim_GD24462; uncharacterized protein [KO:K08267]
Dsimw501_GD24627  Dsim_GD24627; uncharacterized protein [KO:K16344]
Dsimw501_GD24735  Dsim_GD24735; uncharacterized protein, isoform C [KO:K03083] [EC:2.7.11.26]
Dsimw501_GD25545  Dsim_GD25545; uncharacterized protein, isoform A [KO:K02148]
Dsimw501_GD25605  Dsim_GD25605; uncharacterized protein [KO:K02151]
Dsimw501_GD25755  Dsim_drk; drk, isoform B [KO:K04364]
Dsimw501_GD25759  Dsim_GD25759; uncharacterized protein [KO:K03068]
Dsimw501_GD27626  Dsim_GD27626; uncharacterized protein [KO:K02149]
Dsimw501_GD28051  Dsim_GD28051; uncharacterized protein, isoform A [KO:K08271]
Dsimw501_GD28130  Dsim_GD28130; uncharacterized protein [KO:K05459]
Dsimw501_GD28502  Dsim_GD28502; uncharacterized protein [KO:K04371] [EC:2.7.11.24]
Dsimw501_GD28595  Dsim_GD28595; uncharacterized protein [KO:K03209]
Dsimw501_GD28772  Dsim_GD28772; uncharacterized protein, isoform C [KO:K08271]
Dsimw501_GD29351  Dsim_GD29351; uncharacterized protein [KO:K02353]
Dsimw501_GD29430  Dsim_GD29430; uncharacterized protein [KO:K03258]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
dsi00561  Glycerolipid metabolism
dsi04140  Autophagy - animal
KO pathway
ko04150   

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