KEGG   PATHWAY: eal00260
Entry
eal00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Escherichia albertii
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
eal00260  Glycine, serine and threonine metabolism
eal00260

Module
eal_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:eal00260]
eal_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:eal00260]
eal_M00621  Glycine cleavage system [PATH:eal00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Escherichia albertii [GN:eal]
Gene
EAKF1_ch1887  lysC; aspartate kinase III [KO:K00928] [EC:2.7.2.4]
EAKF1_ch1421c  thrA; aspartokinase/homoserine dehydrogenase [KO:K12524] [EC:2.7.2.4 1.1.1.3]
EAKF1_ch1973c  metL; bifunctional aspartate kinase II/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
EAKF1_ch2526  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
EAKF1_ch1420c  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
EAKF1_ch1419c  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
EAKF1_ch0603  ltaE; L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
EAKF1_ch3453  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
EAKF1_ch0394c  D-isomer specific 2-hydroxyacid dehydrogenase family protein [KO:K12972] [EC:1.1.1.79 1.1.1.81]
EAKF1_ch2388c  tkrA; 2-ketogluconate reductase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
EAKF1_ch2813  glycerate kinase [KO:K00865] [EC:2.7.1.165]
EAKF1_ch0720  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
EAKF1_ch1430c  phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
EAKF1_ch2329c  gpmI; phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
EAKF1_ch3082  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
EAKF1_ch0549c  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
EAKF1_ch1437c  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
EAKF1_ch4499c  3-hydroxy acid dehydrogenase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
EAKF1_ch2324  kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
EAKF1_ch2325  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
EAKF1_ch3093  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
EAKF1_ch3091  gcvT; glycine cleavage system aminomethyltransferase T [KO:K00605] [EC:2.1.2.10]
EAKF1_ch1840c  dihydrolipoamide dehydrogenase of 2-oxoglutaratedehydrogenase [KO:K00382] [EC:1.8.1.4]
EAKF1_ch1306c  lpdA; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
EAKF1_ch3092  gcvH; glycine cleavage system protein H [KO:K02437]
EAKF1_ch3407c  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
EAKF1_ch4237c  sdaA; L-serine ammonia-lyase 1 [KO:K01752] [EC:4.3.1.17]
EAKF1_ch3217c  sdaB; L-serine ammonia-lyase 2 [KO:K01752] [EC:4.3.1.17]
EAKF1_ch2821  tdcG; L-serine ammonia-lyase TdcG [KO:K01752] [EC:4.3.1.17]
EAKF1_ch2816  tdcB; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
EAKF1_ch2169c  ilvA; threonine dehydratase biosynthetic [KO:K01754] [EC:4.3.1.19]
EAKF1_ch3623c  dsdA; D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
EAKF1_ch3176  putative racemase [KO:K25316] [EC:5.1.1.10]
EAKF1_ch0174  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
EAKF1_ch0173  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
eal00010  Glycolysis / Gluconeogenesis
eal00020  Citrate cycle (TCA cycle)
eal00230  Purine metabolism
eal00250  Alanine, aspartate and glutamate metabolism
eal00270  Cysteine and methionine metabolism
eal00290  Valine, leucine and isoleucine biosynthesis
eal00300  Lysine biosynthesis
eal00330  Arginine and proline metabolism
eal00460  Cyanoamino acid metabolism
eal00470  D-Amino acid metabolism
eal00564  Glycerophospholipid metabolism
eal00620  Pyruvate metabolism
eal00630  Glyoxylate and dicarboxylate metabolism
eal00640  Propanoate metabolism
eal00680  Methane metabolism
eal00860  Porphyrin metabolism
eal00920  Sulfur metabolism
KO pathway
ko00260   
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