KEGG   PATHWAY: eame00260
Entry
eame00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Ewingella americana
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
eame00260  Glycine, serine and threonine metabolism
eame00260

Module
eame_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:eame00260]
eame_M00555  Betaine biosynthesis, choline => betaine [PATH:eame00260]
eame_M00621  Glycine cleavage system [PATH:eame00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Ewingella americana [GN:eame]
Gene
GXP68_01755  lysC; lysine-sensitive aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
GXP68_17760  thrA; bifunctional aspartate kinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
GXP68_20600  bifunctional aspartate kinase/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
GXP68_00845  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
GXP68_17755  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
GXP68_17750  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
GXP68_13870  ltaE; low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
GXP68_15640  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
GXP68_09500  ghrA; glyoxylate/hydroxypyruvate reductase GhrA [KO:K12972] [EC:1.1.1.79 1.1.1.81]
GXP68_00080  ghrB; glyoxylate/hydroxypyruvate reductase GhrB [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
GXP68_17100  glycerate kinase [KO:K00865] [EC:2.7.1.165]
GXP68_14770  gpmA; 2,3-diphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
GXP68_17790  gpmB; 2,3-diphosphoglycerate-dependent phosphoglycerate mutase GpmB [KO:K15634] [EC:5.4.2.11]
GXP68_20755  gpmM; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
GXP68_02920  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
GXP68_17835  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
GXP68_10390  ydfG; bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG [KO:K16066] [EC:1.1.1.381 1.1.1.-]
GXP68_20775  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
GXP68_02975  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
GXP68_02965  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
GXP68_17315  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
GXP68_02970  gcvH; glycine cleavage system protein GcvH [KO:K02437]
GXP68_03770  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
GXP68_14120  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
GXP68_14125  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
GXP68_17995  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
GXP68_07985  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
GXP68_20430  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
GXP68_17095  amino acid deaminase [KO:K01753] [EC:4.3.1.18]
GXP68_06195  aspartate/glutamate racemase family protein [KO:K25316] [EC:5.1.1.10]
GXP68_08870  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
GXP68_08875  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
GXP68_08285  diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
GXP68_08290  aspartate aminotransferase family protein [KO:K13745] [EC:4.1.1.86]
GXP68_09670  aspartate aminotransferase family protein [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
eame00010  Glycolysis / Gluconeogenesis
eame00020  Citrate cycle (TCA cycle)
eame00230  Purine metabolism
eame00250  Alanine, aspartate and glutamate metabolism
eame00270  Cysteine and methionine metabolism
eame00290  Valine, leucine and isoleucine biosynthesis
eame00300  Lysine biosynthesis
eame00330  Arginine and proline metabolism
eame00460  Cyanoamino acid metabolism
eame00470  D-Amino acid metabolism
eame00564  Glycerophospholipid metabolism
eame00600  Sphingolipid metabolism
eame00620  Pyruvate metabolism
eame00630  Glyoxylate and dicarboxylate metabolism
eame00640  Propanoate metabolism
eame00680  Methane metabolism
eame00860  Porphyrin metabolism
eame00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system