KEGG   PATHWAY: eck00260
Entry
eck00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Escherichia coli 55989 (EAEC)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
eck00260  Glycine, serine and threonine metabolism
eck00260

Module
eck_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:eck00260]
eck_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:eck00260]
eck_M00555  Betaine biosynthesis, choline => betaine [PATH:eck00260]
eck_M00621  Glycine cleavage system [PATH:eck00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Escherichia coli 55989 (EAEC) [GN:eck]
Gene
EC55989_0002  thrA; fused aspartokinase I; homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
EC55989_0003  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
EC55989_0004  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
EC55989_0109  lpd; lipoamide dehydrogenase, E3 component is part of three enzyme complexes [KO:K00382] [EC:1.8.1.4]
EC55989_0313  betA; choline dehydrogenase, a flavoprotein [KO:K00108] [EC:1.1.99.1]
EC55989_0314  betB; betaine aldehyde dehydrogenase, NAD-dependent [KO:K00130] [EC:1.2.1.8]
EC55989_0528  glxK; glycerate kinase II [KO:K00865] [EC:2.7.1.165]
EC55989_0734  gpmA; phosphoglyceromutase 1 [KO:K01834] [EC:5.4.2.11]
EC55989_0915  ltaE; L-allo-threonine aldolase, PLP-dependent [KO:K01620] [EC:4.1.2.48]
EC55989_0952  serC; 3-phosphoserine/phosphohydroxythreonine aminotransferase [KO:K00831] [EC:2.6.1.52]
EC55989_1146  ycdW; 2-ketoacid reductase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
EC55989_1418  trpA; tryptophan synthase, alpha subunit [KO:K01695] [EC:4.2.1.20]
EC55989_1419  trpB; tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]
EC55989_1522  tynA; tyramine oxidase, copper-requiring [KO:K00276] [EC:1.4.3.21]
EC55989_1680  ydfG; L-allo-threonine dehydrogenase, NAD(P)-binding [KO:K16066] [EC:1.1.1.381 1.1.1.-]
EC55989_1987  sdaA; L-serine deaminase I [KO:K01752] [EC:4.3.1.17]
EC55989_2659  dsdA; D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
EC55989_2837  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
EC55989_2875  pssA; phosphatidylserine synthase (CDP-diacylglycerol-serine O-phosphatidyltransferase) [KO:K00998] [EC:2.7.8.8]
EC55989_3076  sdaB; L-serine deaminase II [KO:K01752] [EC:4.3.1.17]
EC55989_3117  ygeA; putative racemase [KO:K25316]
EC55989_3190  gcvP; glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex [KO:K00281] [EC:1.4.4.2]
EC55989_3191  gcvH; glycine cleavage complex lipoylprotein [KO:K02437]
EC55989_3192  gcvT; aminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex [KO:K00605] [EC:2.1.2.10]
EC55989_3200  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
EC55989_3529  tdcG; L-serine dehydratase 3 [KO:K01752] [EC:4.3.1.17]
EC55989_3534  tdcB; catabolic threonine dehydratase, PLP-dependent [KO:K01754] [EC:4.3.1.19]
EC55989_3542  garK; glycerate kinase I [KO:K00865] [EC:2.7.1.165]
EC55989_3843  asd; aspartate-semialdehyde dehydrogenase, NAD(P)-binding [KO:K00133] [EC:1.2.1.11]
EC55989_4009  tiaE; 2-oxo-carboxylic acid reductase (glyoxalate reductase) (2-ketoaldonate reductase) [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
EC55989_4079  gpmI; phosphoglycero mutase III, cofactor-independent [KO:K15633] [EC:5.4.2.12]
EC55989_4083  tdh; threonine 3-dehydrogenase, NAD(P)-binding [KO:K00060] [EC:1.1.1.103]
EC55989_4084  kbl; glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
EC55989_4244  ilvA; threonine deaminase [KO:K01754] [EC:4.3.1.19]
EC55989_4422  metL; fused aspartokinase II; homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
EC55989_4512  lysC; aspartokinase III [KO:K00928] [EC:2.7.2.4]
EC55989_5050  serB; 3-phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
EC55989_5057  ytjC; phosphoglyceromutase 2, co-factor independent [KO:K15634] [EC:5.4.2.11]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
eck00010  Glycolysis / Gluconeogenesis
eck00020  Citrate cycle (TCA cycle)
eck00230  Purine metabolism
eck00250  Alanine, aspartate and glutamate metabolism
eck00270  Cysteine and methionine metabolism
eck00290  Valine, leucine and isoleucine biosynthesis
eck00300  Lysine biosynthesis
eck00330  Arginine and proline metabolism
eck00460  Cyanoamino acid metabolism
eck00470  D-Amino acid metabolism
eck00564  Glycerophospholipid metabolism
eck00600  Sphingolipid metabolism
eck00620  Pyruvate metabolism
eck00630  Glyoxylate and dicarboxylate metabolism
eck00640  Propanoate metabolism
eck00680  Methane metabolism
eck00860  Porphyrin metabolism
eck00920  Sulfur metabolism
KO pathway
ko00260   

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