KEGG   PATHWAY: eco00240
Entry
eco00240                    Pathway                                
Name
Pyrimidine metabolism - Escherichia coli K-12 MG1655
Class
Metabolism; Nucleotide metabolism
Pathway map
eco00240  Pyrimidine metabolism
eco00240

Module
eco_M00051  De novo pyrimidine biosynthesis, glutamine (+ PRPP) => UMP [PATH:eco00240]
eco_M00052  Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTP [PATH:eco00240]
eco_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:eco00240]
eco_M00938  Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP [PATH:eco00240]
eco_M00939  Pyrimidine degradation, uracil => 3-hydroxypropanoate [PATH:eco00240]
Other DBs
GO: 0006220 0006213
Organism
Escherichia coli K-12 MG1655 [GN:eco]
Gene
b0030  rihC; ribonucleoside hydrolase RihC [KO:K12700] [EC:3.2.2.-]
b0032  carA; carbamoyl phosphate synthetase subunit alpha [KO:K01956] [EC:6.3.5.5]
b0033  carB; carbamoyl phosphate synthetase subunit beta [KO:K01955] [EC:6.3.5.5]
b0171  pyrH; UMP kinase [KO:K09903] [EC:2.7.4.22]
b0337  codA; cytosine/isoguanine deaminase [KO:K01485] [EC:3.5.4.1 3.5.4.21]
b0391  ppnP; nucleoside phosphorylase PpnP [KO:K09913] [EC:2.4.2.1 2.4.2.2]
b0480  ushA; 5'-nucleotidase/UDP-sugar hydrolase [KO:K11751] [EC:3.1.3.5 3.6.1.45]
b0651  rihA; pyrimidine-specific ribonucleoside hydrolase RihA [KO:K01250] [EC:3.2.2.-]
b0675  umpH; UMP phosphatase [KO:K02566] [EC:3.1.3.5]
b0910  cmk; cytidylate kinase [KO:K00945] [EC:2.7.4.25]
b0945  pyrD; dihydroorotate dehydrogenase, type 2 [KO:K00254] [EC:1.3.5.2]
b1007  rutF; FMN reductase RutF [KO:K09024] [EC:1.5.1.-]
b1008  rutE; putative malonic semialdehyde reductase [KO:K09019] [EC:1.1.1.-]
b1009  rutD; putative aminoacrylate hydrolase RutD [KO:K09023] [EC:3.5.1.-]
b1010  rutC; putative aminoacrylate peracid reductase RutC [KO:K09021]
b1011  rutB; peroxyureidoacrylate/ureidoacrylate amidohydrolase [KO:K09020] [EC:3.5.1.110]
b1012  rutA; pyrimidine monooxygenase RutA [KO:K09018] [EC:1.14.99.46]
b1062  pyrC; dihydroorotase [KO:K01465] [EC:3.5.2.3]
b1098  tmk; hypothetical protein [KO:K00943] [EC:2.7.4.9]
b1238  tdk; thymidine/deoxyuridine kinase [KO:K00857] [EC:2.7.1.21]
b1281  pyrF; orotidine-5'-phosphate decarboxylase [KO:K01591] [EC:4.1.1.23]
b1539  ydfG; 3-hydroxy acid dehydrogenase YdfG [KO:K16066] [EC:1.1.1.381 1.1.1.-]
b1759  nudG; 5-hydroxy-CTP diphosphatase [KO:K08320] [EC:3.6.1.65]
b2065  dcd; dCTP deaminase [KO:K01494] [EC:3.5.4.13]
b2066  udk; uridine/cytidine kinase [KO:K00876] [EC:2.7.1.48]
b2143  cdd; cytidine/deoxycytidine deaminase [KO:K01489] [EC:3.5.4.5]
b2146  preT; NAD-dependent dihydropyrimidine dehydrogenase subunit PreT [KO:K17722] [EC:1.3.1.1]
b2147  preA; NAD-dependent dihydropyrimidine dehydrogenase subunit PreA [KO:K17723] [EC:1.3.1.1]
b2162  rihB; pyrimidine-specific ribonucleoside hydrolase RihB [KO:K10213] [EC:3.2.2.8]
b2165  psuG; pseudouridine-5'-phosphate glycosidase [KO:K16329] [EC:4.2.1.70]
b2166  psuK; putative pseudouridine kinase [KO:K16328] [EC:2.7.1.83]
b2234  nrdA; ribonucleoside-diphosphate reductase 1 subunit alpha [KO:K00525] [EC:1.17.4.1]
b2235  nrdB; ribonucleoside-diphosphate reductase 1 subunit beta [KO:K00526] [EC:1.17.4.1]
b2291  yfbR; dCMP phosphohydrolase [KO:K08722] [EC:3.1.3.89]
b2361  yfdR; CPS-53 (KpLE1) prophage; 5'-deoxynucleotidase [KO:K06952] [EC:3.1.3.89]
b2498  upp; uracil phosphoribosyltransferase [KO:K00761] [EC:2.4.2.9]
b2518  ndk; nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
b2675  nrdE; ribonucleoside-diphosphate reductase 2 subunit alpha [KO:K00525] [EC:1.17.4.1]
b2676  nrdF; ribonucleoside-diphosphate reductase 2 subunit beta [KO:K00526] [EC:1.17.4.1]
b2744  umpG; broad specificity 5'(3')-nucleotidase and polyphosphatase [KO:K03787] [EC:3.1.3.5 3.1.3.6]
b2780  pyrG; CTP synthetase [KO:K01937] [EC:6.3.4.2]
b2781  mazG; nucleoside triphosphate pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
b2795  ppnN; nucleotide 5'-monophosphate nucleosidase [KO:K06966] [EC:3.2.2.10 3.2.2.-]
b2827  thyA; thymidylate synthase [KO:K00560] [EC:2.1.1.45]
b2873  hyuA; phenylhydantoinase [KO:K01464] [EC:3.5.2.2]
b3085  ygjP; putative metal-dependent hydrolase [KO:K07043] [EC:3.6.1.-]
b3248  yhdE; nucleoside triphosphate pyrophosphatase YhdE [KO:K06287] [EC:3.6.1.-]
b3640  dut; dUTP diphosphatase [KO:K01520] [EC:3.6.1.23]
b3642  pyrE; orotate phosphoribosyltransferase [KO:K00762] [EC:2.4.2.10]
b3831  udp; uridine phosphorylase [KO:K00757] [EC:2.4.2.3]
b4213  cpdB; 2'3' cyclic nucleotide phosphodiesterase/3' nucleotidase [KO:K01119] [EC:3.1.4.16 3.1.3.6]
b4238  nrdD; anaerobic ribonucleoside-triphosphate reductase [KO:K21636] [EC:1.1.98.6]
b4244  pyrI; aspartate carbamoyltransferase, PyrI subunit [KO:K00610]
b4245  pyrB; aspartate carbamoyltransferase catalytic subunit [KO:K00609] [EC:2.1.3.2]
b4374  yjjG; pyrimidine 5'-nucleotidase YjjG [KO:K08723] [EC:3.1.3.-]
b4382  deoA; thymidine phosphorylase [KO:K00758] [EC:2.4.2.4]
Compound
C00015  UDP
C00039  DNA
C00046  RNA
C00055  CMP
C00063  CTP
C00064  L-Glutamine
C00075  UTP
C00086  Urea
C00099  beta-Alanine
C00105  UMP
C00106  Uracil
C00112  CDP
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00169  Carbamoyl phosphate
C00178  Thymine
C00214  Thymidine
C00222  3-Oxopropanoate
C00239  dCMP
C00295  Orotate
C00299  Uridine
C00337  (S)-Dihydroorotate
C00363  dTDP
C00364  dTMP
C00365  dUMP
C00380  Cytosine
C00383  Malonate
C00429  5,6-Dihydrouracil
C00438  N-Carbamoyl-L-aspartate
C00458  dCTP
C00459  dTTP
C00460  dUTP
C00475  Cytidine
C00526  Deoxyuridine
C00672  2-Deoxy-D-ribose 1-phosphate
C00705  dCDP
C00813  Barbiturate
C00881  Deoxycytidine
C00941  3',5'-Cyclic CMP
C01013  3-Hydroxypropanoate
C01103  Orotidine 5'-phosphate
C01168  Pseudouridine 5'-phosphate
C01205  (R)-3-Amino-2-methylpropanoate
C01346  dUDP
C01368  3'-UMP
C01563  Carbamate
C02067  Pseudouridine
C02170  Methylmalonate
C02354  2',3'-Cyclic CMP
C02355  2',3'-Cyclic UMP
C02376  5-Methylcytosine
C02642  3-Ureidopropionate
C03997  5-Hydroxymethyldeoxycytidylate
C05281  5-Methylbarbiturate
C05822  3'-CMP
C06198  P1,P4-Bis(5'-uridyl) tetraphosphate
C11038  2'-Deoxy-5-hydroxymethylcytidine-5'-diphosphate
C11039  2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate
C15607  3-Oxo-3-ureidopropanoate
C20231  (Z)-3-Ureidoacrylate peracid
C20249  (Z)-3-Peroxyaminoacrylate
C20253  Aminoacrylate
C20254  Ureidoacrylate
C20846  3-Oxo-3-ureidoisobutyrate
C21028  (R)-5,6-Dihydrothymine
C21029  (R)-3-Ureidoisobutyrate
C22509  3',5'-Cyclic UMP
Related
pathway
eco00030  Pentose phosphate pathway
eco00220  Arginine biosynthesis
eco00250  Alanine, aspartate and glutamate metabolism
eco00280  Valine, leucine and isoleucine degradation
eco00410  beta-Alanine metabolism
KO pathway
ko00240   

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