KEGG   PATHWAY: ko00240
Entry
ko00240                     Pathway                                
Name
Pyrimidine metabolism
Class
Metabolism; Nucleotide metabolism
Pathway map
ko00240  Pyrimidine metabolism
ko00240

Module
M00046  Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate [PATH:ko00240]
M00051  De novo pyrimidine biosynthesis, glutamine (+ PRPP) => UMP [PATH:ko00240]
M00052  Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTP [PATH:ko00240]
M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:ko00240]
M00938  Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP [PATH:ko00240]
M00939  Pyrimidine degradation, uracil => 3-hydroxypropanoate [PATH:ko00240]
M00968  Pentose bisphosphate pathway (nucleoside degradation), archaea, nucleoside/NMP => 3-PGA/glycerone phosphate [PATH:ko00240]
Drug
D00323  Flucytosine (JP18/USP/INN)
D00391  Trifluridine (JAN/USP/INN)
D00488  Pyrimethamine (JAN/USP/INN)
D02387  Cycloguanil pamoate (USAN)
D02487  Proguanil hydrochloride (JAN/USP)
D03034  Azelaic acid (USAN/INN)
D03771  Diaveridine (USAN/INN)
D08428  Proguanil (INN)
D12505  Olorofim (JAN/USAN/INN)
Other DBs
GO: 0006220 0006213
Orthology
K00207  DPYD; dihydropyrimidine dehydrogenase (NADP+) [EC:1.3.1.2]
K00226  pyrD; dihydroorotate dehydrogenase (fumarate) [EC:1.3.98.1]
K00254  DHODH, pyrD; dihydroorotate dehydrogenase [EC:1.3.5.2]
K00524  nrdJ; ribonucleotide reductase, class II [EC:1.17.4.2]
K00525  E1.17.4.1A, nrdA, nrdE; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
K00526  E1.17.4.1B, nrdB, nrdF; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
K00527  rtpR; ribonucleoside-triphosphate reductase (thioredoxin) [EC:1.17.4.2]
K00560  thyA, TYMS; thymidylate synthase [EC:2.1.1.45]
K00608  pyrBI; aspartate carbamoyltransferase [EC:2.1.3.2]
K00609  pyrB, PYR2; aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2]
K00610  pyrI; aspartate carbamoyltransferase regulatory subunit
K00756  pdp; pyrimidine-nucleoside phosphorylase [EC:2.4.2.2]
K00757  udp, UPP; uridine phosphorylase [EC:2.4.2.3]
K00758  deoA, TYMP; thymidine phosphorylase [EC:2.4.2.4]
K00761  upp, UPRT; uracil phosphoribosyltransferase [EC:2.4.2.9]
K00762  pyrE; orotate phosphoribosyltransferase [EC:2.4.2.10]
K00857  tdk, TK; thymidine kinase [EC:2.7.1.21]
K00876  udk, UCK; uridine kinase [EC:2.7.1.48]
K00893  DCK; deoxycitidine/deoxyadenosine/deoxyguanosine kinase [EC:2.7.1.74 2.7.1.76 2.7.1.113]
K00940  ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]
K00943  tmk, DTYMK; dTMP kinase [EC:2.7.4.9]
K00945  cmk; CMP/dCMP kinase [EC:2.7.4.25]
K01081  E3.1.3.5; 5'-nucleotidase [EC:3.1.3.5]
K01119  cpdB; 2',3'-cyclic-nucleotide 2'-phosphodiesterase / 3'-nucleotidase [EC:3.1.4.16 3.1.3.6]
K01240  URH1; uridine nucleosidase [EC:3.2.2.3]
K01250  rihA; pyrimidine-specific ribonucleoside hydrolase [EC:3.2.2.-]
K01431  UPB1, pydC; beta-ureidopropionase [EC:3.5.1.6]
K01464  DPYS, dht, hydA; dihydropyrimidinase [EC:3.5.2.2]
K01465  URA4, pyrC; dihydroorotase [EC:3.5.2.3]
K01485  codA; cytosine/creatinine deaminase [EC:3.5.4.1 3.5.4.21]
K01489  cdd, CDA; cytidine deaminase [EC:3.5.4.5]
K01493  comEB; dCMP deaminase [EC:3.5.4.12]
K01494  dcd; dCTP deaminase [EC:3.5.4.13]
K01510  ENTPD1_3_8, CD39; apyrase [EC:3.6.1.5]
K01511  ENTPD5_6; ectonucleoside triphosphate diphosphohydrolase 5/6 [EC:3.6.1.6]
K01513  ENPP1_3, CD203; ectonucleotide pyrophosphatase/phosphodiesterase family member 1/3 [EC:3.1.4.1 3.6.1.9]
K01518  NUDT2; bis(5'-nucleosidyl)-tetraphosphatase [EC:3.6.1.17]
K01520  dut; dUTP diphosphatase [EC:3.6.1.23]
K01591  pyrF; orotidine-5'-phosphate decarboxylase [EC:4.1.1.23]
K01937  pyrG, CTPS; CTP synthase [EC:6.3.4.2]
K01954  K01954; carbamoyl-phosphate synthase [EC:6.3.5.5]
K01955  carB, CPA2; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5]
K01956  carA, CPA1; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5]
K02566  nagD; 5'-nucleotidase [EC:3.1.3.5]
K02823  pyrDII; dihydroorotate dehydrogenase electron transfer subunit
K02825  pyrR; pyrimidine operon attenuation protein / uracil phosphoribosyltransferase [EC:2.4.2.9]
K03365  FCY1; cytosine/creatinine deaminase [EC:3.5.4.1 3.5.4.21]
K03465  thyX, thy1; thymidylate synthase (FAD) [EC:2.1.1.148]
K03787  surE; 5'/3'-nucleotidase [EC:3.1.3.5 3.1.3.6]
K04765  mazG; nucleoside triphosphate diphosphatase [EC:3.6.1.9]
K05961  dnk; deoxynucleoside kinase [EC:2.7.1.145]
K06016  pydC; beta-ureidopropionase / N-carbamoyl-L-amino-acid hydrolase [EC:3.5.1.6 3.5.1.87]
K06287  yhdE; nucleoside triphosphate pyrophosphatase [EC:3.6.1.-]
K06952  yfdR; 5'-nucleotidase [EC:3.1.3.89]
K06966  ppnN; pyrimidine/purine-5'-nucleotide nucleosidase [EC:3.2.2.10 3.2.2.-]
K07023  YGK1, HDDC2; 5'-deoxynucleotidase [EC:3.1.3.89]
K07043  upp; UTP pyrophosphatase [EC:3.6.1.-]
K08320  nudG; (d)CTP diphosphatase [EC:3.6.1.65]
K08693  yfkN; 2',3'-cyclic-nucleotide 2'-phosphodiesterase / 3'-nucleotidase / 5'-nucleotidase [EC:3.1.4.16 3.1.3.6 3.1.3.5]
K08722  yfbR; 5'-deoxynucleotidase [EC:3.1.3.89]
K08723  yjjG; pyrimidine 5'-nucleotidase [EC:3.1.3.-]
K09018  rutA; pyrimidine oxygenase [EC:1.14.99.46]
K09019  rutE; 3-hydroxypropanoate dehydrogenase [EC:1.1.1.-]
K09020  rutB; ureidoacrylate peracid hydrolase [EC:3.5.1.110]
K09021  rutC; aminoacrylate peracid reductase
K09023  rutD; aminoacrylate hydrolase [EC:3.5.1.-]
K09024  rutF; flavin reductase [EC:1.5.1.-]
K09769  ymdB; 2',3'-cyclic-nucleotide 2'-phosphodiesterase [EC:3.1.4.16]
K09887  dcd; dCTP deaminase (dUMP-forming) [EC:3.5.4.30]
K09903  pyrH; uridylate kinase [EC:2.7.4.22]
K09913  ppnP; purine/pyrimidine-nucleoside phosphorylase [EC:2.4.2.1 2.4.2.2]
K10213  rihB; ribosylpyrimidine nucleosidase [EC:3.2.2.8]
K10807  RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
K10808  RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase [EC:6.3.5.5 2.1.3.2 3.5.2.3]
K11541  URA2; carbamoyl-phosphate synthase / aspartate carbamoyltransferase [EC:6.3.5.5 2.1.3.2]
K11751  ushA; 5'-nucleotidase / UDP-sugar diphosphatase [EC:3.1.3.5 3.6.1.45]
K12304  CANT1; soluble calcium-activated nucleotidase 1 [EC:3.6.1.6]
K12305  ENTPD4, LALP70; ectonucleoside triphosphate diphosphohydrolase 4 [EC:3.6.1.6]
K12700  rihC; non-specific riboncleoside hydrolase [EC:3.2.2.-]
K13421  UMPS; uridine monophosphate synthetase [EC:2.4.2.10 4.1.1.23]
K13799  panC-cmk; pantoate ligase / CMP/dCMP kinase [EC:6.3.2.1 2.7.4.25]
K13800  CMPK1, UMPK; UMP-CMP kinase [EC:2.7.4.14]
K13809  CMPK2; UMP-CMP kinase 2, mitochondrial [EC:2.7.4.14]
K13998  DHFR-TS; dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]
K14641  APY; apyrase [EC:3.6.1.5]
K14642  YND1; golgi apyrase [EC:3.6.1.5]
K15519  dck; deoxyadenosine/deoxycytidine kinase [EC:2.7.1.76 2.7.1.74]
K16066  ydfG; 3-hydroxy acid dehydrogenase / malonic semialdehyde reductase [EC:1.1.1.381 1.1.1.-]
K16328  psuK; pseudouridine kinase [EC:2.7.1.83]
K16329  psuG; pseudouridylate synthase [EC:4.2.1.70]
K16330  K16330; pseudouridylate synthase / pseudouridine kinase [EC:4.2.1.70 2.7.1.83]
K16904  DCTPP1; dCTP diphosphatase [EC:3.6.1.12]
K17722  preT; dihydropyrimidine dehydrogenase (NAD+) subunit PreT [EC:1.3.1.1]
K17723  preA; dihydropyrimidine dehydrogenase (NAD+) subunit PreA [EC:1.3.1.1]
K17828  pyrDI; dihydroorotate dehydrogenase (NAD+) catalytic subunit [EC:1.3.1.14]
K18533  AK9; adenylate/nucleoside-diphosphate kinase [EC:2.7.4.3 2.7.4.6]
K18931  deoA; AMP phosphorylase [EC:2.4.2.57]
K19794  bar; barbiturase [EC:3.5.2.1]
K19795  E3.5.1.95; ureidomalonase [EC:3.5.1.95]
K19796  gp42; Straboviridae dCMP hydroxymethylase [EC:2.1.2.8]
K19797  gp1; Straboviridae T-even-induced deoxynucleotide kinase [EC:2.7.4.12]
K19970  NT5E, CD73; 5'-nucleotidase [EC:3.1.3.5]
K21057  E2.7.1.213; cytidine kinase [EC:2.7.1.213]
K21636  nrdD; ribonucleoside-triphosphate reductase (formate) [EC:1.1.98.6]
K22026  K22026; nucleoside kinase [EC:2.7.1.73 2.7.1.213 2.7.1.-]
K24242  NT5C3; 7-methylguanosine nucleotidase
K24670  K24670; 2',3'-cyclic-nucleotide 2'-phosphodiesterase / phosphoenolpyruvate phosphatase
K25434  pynA; pyrimidine 5'-nucleotidase
K25435  ASMTL; putative bifunctional nucleoside triphosphate pyrophosphatase / methyltransferase
K25589  inuH; inosine/uridine nucleosidase
K26955  NUDT25, NUDX25; bis(5'-nucleosidyl)-tetraphosphatase
K27603  pycC; uridylate cyclase
K27604  pycC; cytidylate cyclase
Compound
C00015  UDP
C00039  DNA
C00046  RNA
C00055  CMP
C00063  CTP
C00064  L-Glutamine
C00075  UTP
C00086  Urea
C00099  beta-Alanine
C00105  UMP
C00106  Uracil
C00112  CDP
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00169  Carbamoyl phosphate
C00178  Thymine
C00214  Thymidine
C00222  3-Oxopropanoate
C00239  dCMP
C00295  Orotate
C00299  Uridine
C00337  (S)-Dihydroorotate
C00363  dTDP
C00364  dTMP
C00365  dUMP
C00380  Cytosine
C00383  Malonate
C00429  5,6-Dihydrouracil
C00438  N-Carbamoyl-L-aspartate
C00458  dCTP
C00459  dTTP
C00460  dUTP
C00475  Cytidine
C00526  Deoxyuridine
C00672  2-Deoxy-D-ribose 1-phosphate
C00705  dCDP
C00813  Barbiturate
C00881  Deoxycytidine
C00941  3',5'-Cyclic CMP
C01013  3-Hydroxypropanoate
C01103  Orotidine 5'-phosphate
C01168  Pseudouridine 5'-phosphate
C01205  (R)-3-Amino-2-methylpropanoate
C01346  dUDP
C01368  3'-UMP
C01563  Carbamate
C02067  Pseudouridine
C02170  Methylmalonate
C02354  2',3'-Cyclic CMP
C02355  2',3'-Cyclic UMP
C02376  5-Methylcytosine
C02642  3-Ureidopropionate
C03997  5-Hydroxymethyldeoxycytidylate
C05281  5-Methylbarbiturate
C05822  3'-CMP
C06198  P1,P4-Bis(5'-uridyl) tetraphosphate
C11038  2'-Deoxy-5-hydroxymethylcytidine-5'-diphosphate
C11039  2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate
C15607  3-Oxo-3-ureidopropanoate
C20231  (Z)-3-Ureidoacrylate peracid
C20249  (Z)-3-Peroxyaminoacrylate
C20253  Aminoacrylate
C20254  Ureidoacrylate
C20846  3-Oxo-3-ureidoisobutyrate
C21028  (R)-5,6-Dihydrothymine
C21029  (R)-3-Ureidoisobutyrate
C22509  3',5'-Cyclic UMP
Related
pathway
ko00030  Pentose phosphate pathway
ko00220  Arginine biosynthesis
ko00250  Alanine, aspartate and glutamate metabolism
ko00280  Valine, leucine and isoleucine degradation
ko00410  beta-Alanine metabolism

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