KEGG   PATHWAY: ecoh00330
Entry
ecoh00330                   Pathway                                
Name
Arginine and proline metabolism - Escherichia coli O145:H28 RM13516 (EHEC)
Class
Metabolism; Amino acid metabolism
Pathway map
ecoh00330  Arginine and proline metabolism
ecoh00330

Module
ecoh_M00015  Proline biosynthesis, glutamate => proline [PATH:ecoh00330]
ecoh_M00133  Polyamine biosynthesis, arginine => agmatine => putrescine => spermidine [PATH:ecoh00330]
ecoh_M00136  GABA biosynthesis, prokaryotes, putrescine => GABA [PATH:ecoh00330]
ecoh_M00879  Arginine succinyltransferase pathway, arginine => glutamate [PATH:ecoh00330]
ecoh_M00970  Proline degradation, proline => glutamate [PATH:ecoh00330]
Other DBs
GO: 0006525 0006560
Organism
Escherichia coli O145:H28 RM13516 (EHEC) [GN:ecoh]
Gene
ECRM13516_0125  speD; S-adenosylmethionine decarboxylase proenzyme, prokaryotic class 1A [KO:K01611] [EC:4.1.1.50]
ECRM13516_0126  speE; Spermidine synthase [KO:K00797] [EC:2.5.1.16]
ECRM13516_0251  proB; Glutamate 5-kinase / RNA-binding C-terminal domain PUA [KO:K00931] [EC:2.7.2.11]
ECRM13516_0252  proA; Gamma-glutamyl phosphate reductase [KO:K00147] [EC:1.2.1.41]
ECRM13516_0315  codA; Cytosine deaminase [KO:K01485] [EC:3.5.4.1 3.5.4.21]
ECRM13516_0364  proC; Pyrroline-5-carboxylate reductase [KO:K00286] [EC:1.5.1.2]
ECRM13516_0968  aspC; Aspartate aminotransferase [KO:K00813] [EC:2.6.1.1]
ECRM13516_1120  putA; Transcriptional repressor of PutA and PutP / Proline dehydrogenase (Proline oxidase) / Delta-1-pyrroline-5-carboxylate dehydrogenase [KO:K13821] [EC:1.5.5.2 1.2.1.88]
ECRM13516_1688  [KO:K09470] [EC:6.3.1.11]
ECRM13516_1689  puuD; Gamma-glutamyl-GABA hydrolase [KO:K09473] [EC:3.5.1.94]
ECRM13516_1691  aldH; Gamma-glutamyl-aminobutyraldehyde dehydrogenase [KO:K09472] [EC:1.2.1.99]
ECRM13516_1692  orfL; Gamma-glutamyl-putrescine oxidase [KO:K09471] [EC:1.4.3.-]
ECRM13516_1802  [KO:K00137] [EC:1.2.1.19]
ECRM13516_1977  speG; Spermidine N1-acetyltransferase [KO:K00657] [EC:2.3.1.57]
ECRM13516_2146  ydjS; Succinylglutamate desuccinylase [KO:K05526] [EC:3.5.1.96]
ECRM13516_2147  [KO:K01484] [EC:3.5.3.23]
ECRM13516_2148  astD; Succinylglutamic semialdehyde dehydrogenase [KO:K06447] [EC:1.2.1.71]
ECRM13516_2149  [KO:K00673] [EC:2.3.1.109]
ECRM13516_2150  argD; Succinylornithine transaminase [KO:K00840] [EC:2.6.1.81]
ECRM13516_3665  speB; Agmatinase [KO:K01480] [EC:3.5.3.11]
ECRM13516_3667  speA; Biosynthetic arginine decarboxylase [KO:K01585] [EC:4.1.1.19]
ECRM13516_3697  speC; Ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
ECRM13516_3836  ygjG; Putrescine aminotransferase [KO:K09251] [EC:2.6.1.82]
ECRM13516_5000  adiA; Arginine decarboxylase, catabolic [KO:K01584] [EC:4.1.1.19]
Compound
C00012  Peptide
C00019  S-Adenosyl-L-methionine
C00022  Pyruvate
C00025  L-Glutamate
C00048  Glyoxylate
C00062  L-Arginine
C00077  L-Ornithine
C00086  Urea
C00134  Putrescine
C00148  L-Proline
C00179  Agmatine
C00213  Sarcosine
C00223  p-Coumaroyl-CoA
C00300  Creatine
C00315  Spermidine
C00334  4-Aminobutanoate
C00406  Feruloyl-CoA
C00431  5-Aminopentanoate
C00436  N-Carbamoylputrescine
C00441  L-Aspartate 4-semialdehyde
C00533  Nitric oxide
C00555  4-Aminobutyraldehyde
C00581  Guanidinoacetate
C00750  Spermine
C00763  D-Proline
C00791  Creatinine
C00884  Homocarnosine
C00986  1,3-Diaminopropane
C01035  4-Guanidinobutanoate
C01043  N-Carbamoylsarcosine
C01110  5-Amino-2-oxopentanoic acid
C01137  S-Adenosylmethioninamine
C01157  Hydroxyproline
C01165  L-Glutamate 5-semialdehyde
C01250  N-Acetyl-L-glutamate 5-semialdehyde
C01682  Nopaline
C02305  Phosphocreatine
C02565  N-Methylhydantoin
C02647  4-Guanidinobutanal
C02714  N-Acetylputrescine
C02946  4-Acetamidobutanoate
C03078  4-Guanidinobutanamide
C03166  Phosphoguanidinoacetate
C03287  L-Glutamyl 5-phosphate
C03296  N2-Succinyl-L-arginine
C03375  Norspermidine
C03415  N2-Succinyl-L-ornithine
C03564  1-Pyrroline-2-carboxylate
C03771  5-Guanidino-2-oxopentanoate
C03912  (S)-1-Pyrroline-5-carboxylate
C04137  Octopine
C04281  L-1-Pyrroline-3-hydroxy-5-carboxylate
C05147  trans-3-Hydroxy-L-proline
C05931  N-Succinyl-L-glutamate
C05932  N-Succinyl-L-glutamate 5-semialdehyde
C05933  N(omega)-Hydroxyarginine
C05936  N4-Acetylaminobutanal
C05938  L-4-Hydroxyglutamate semialdehyde
C05945  L-Arginine phosphate
C05946  (4R)-4-Hydroxy-2-oxoglutarate
C05947  L-erythro-4-Hydroxyglutamate
C10497  Feruloylputrescine
C15699  gamma-L-Glutamylputrescine
C15700  gamma-Glutamyl-gamma-aminobutyraldehyde
C15767  4-(L-gamma-Glutamylamino)butanoate
C18172  Carboxyspermidine
C18174  Carboxynorspermidine
C18326  p-Coumaroylputrescine
C19706  cis-3-Hydroxy-L-proline
C20560  N1-(3-Aminopropyl)agmatine
C22886  N1-[(S)-3-amino-3-carboxypropyl]agmatine
Reference
PMID:5288244
  Authors
Haake P, Allen GW.
  Title
Studies on phosphorylation by phosphoroguanidinates. The mechanism of action of creatine: ATP transphosphorylase (creatine kinase).
  Journal
Proc Natl Acad Sci U S A 68:2691-3 (1971)
DOI:10.1073/pnas.68.11.2691
Reference
PMID:16499623
  Authors
Kurihara S, Oda S, Kumagai H, Suzuki H.
  Title
Gamma-glutamyl-gamma-aminobutyrate hydrolase in the putrescine utilization pathway of Escherichia coli K-12.
  Journal
FEMS Microbiol Lett 256:318-23 (2006)
DOI:10.1111/j.1574-6968.2006.00137.x
Reference
PMID:15590624
  Authors
Kurihara S, Oda S, Kato K, Kim HG, Koyanagi T, Kumagai H, Suzuki H.
  Title
A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12.
  Journal
J Biol Chem 280:4602-8 (2005)
DOI:10.1074/jbc.M411114200
Related
pathway
ecoh00020  Citrate cycle (TCA cycle)
ecoh00220  Arginine biosynthesis
ecoh00250  Alanine, aspartate and glutamate metabolism
ecoh00260  Glycine, serine and threonine metabolism
ecoh00270  Cysteine and methionine metabolism
ecoh00310  Lysine degradation
ecoh00410  beta-Alanine metabolism
ecoh00470  D-Amino acid metabolism
ecoh00480  Glutathione metabolism
ecoh00630  Glyoxylate and dicarboxylate metabolism
ecoh00650  Butanoate metabolism
ecoh00770  Pantothenate and CoA biosynthesis
KO pathway
ko00330   

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