KEGG   PATHWAY: ecok00630
Entry
ecok00630                   Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Escherichia coli K-12 MDS42
Class
Metabolism; Carbohydrate metabolism
Pathway map
ecok00630  Glyoxylate and dicarboxylate metabolism
ecok00630

Module
ecok_M00012  Glyoxylate cycle [PATH:ecok00630]
ecok_M00621  Glycine cleavage system [PATH:ecok00630]
Other DBs
GO: 0046487 0043648
Organism
Escherichia coli K-12 MDS42 [GN:ecok]
Gene
ECMDS42_0107  lpd; lipoamide dehydrogenase, E3 component is part of three enzyme complexes [KO:K00382] [EC:1.8.1.4]
ECMDS42_0109  acnB; bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase [KO:K01682] [EC:4.2.1.3 4.2.1.99]
ECMDS42_0255  prpC; 2-methylcitrate synthase [KO:K01659] [EC:2.3.3.5]
ECMDS42_0400  gcl; glyoxylate carboligase [KO:K01608] [EC:4.1.1.47]
ECMDS42_0401  hyi; hydroxypyruvate isomerase [KO:K01816] [EC:5.3.1.22]
ECMDS42_0402  glxR; tartronate semialdehyde reductase, NADH-dependent [KO:K00042] [EC:1.1.1.60]
ECMDS42_0407  glxK; glycerate kinase II [KO:K00865] [EC:2.7.1.165]
ECMDS42_0570  gltA; citrate synthase [KO:K01647] [EC:2.3.3.1]
ECMDS42_0868  ycdW; 2-ketoacid reductase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
ECMDS42_1026  purU; formyltetrahydrofolate hydrolase [KO:K01433] [EC:3.5.1.10]
ECMDS42_1074  acnA; aconitate hydratase 1 [KO:K27802]
ECMDS42_1129  aldA; aldehyde dehydrogenase A, NAD-linked [KO:K07248] [EC:1.2.1.22 1.2.1.21]
ECMDS42_1407  katE; hydroperoxidase HPII(III) [KO:K03781] [EC:1.11.1.6]
ECMDS42_1474  yeaU; predicted dehydrogenase [KO:K07246] [EC:1.1.1.93 4.1.1.73 1.1.1.83]
ECMDS42_1527  eda; multifunctional 2-keto-3-deoxygluconate 6-phosphate aldolase and 2-keto-4-hydroxyglutarate aldolase/oxaloacetate decarboxylase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
ECMDS42_1792  atoB; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
ECMDS42_1930  oxc; predicted oxalyl-CoA decarboxylase [KO:K01577] [EC:4.1.1.8]
ECMDS42_1931  frc; formyl-CoA transferase, NAD(P)-binding [KO:K07749] [EC:2.8.3.16]
ECMDS42_2095  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
ECMDS42_2304  fucO; L-1,2-propanediol oxidoreductase [KO:K00048] [EC:1.1.1.77]
ECMDS42_2352  yqeF; predicted acyltransferase [KO:K00626] [EC:2.3.1.9]
ECMDS42_2402  gcvP; glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex [KO:K00281] [EC:1.4.4.2]
ECMDS42_2403  gcvH; glycine cleavage complex lipoylprotein [KO:K02437]
ECMDS42_2404  gcvT; aminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex [KO:K00605] [EC:2.1.2.10]
ECMDS42_2417  yliK; methylmalonyl-CoA mutase [KO:K01847] [EC:5.4.99.2]
ECMDS42_2530  ttdA; L-tartrate dehydratase, alpha subunit [KO:K03779] [EC:4.2.1.32]
ECMDS42_2531  ttdB; L-tartrate dehydratase, beta subunit [KO:K03780] [EC:4.2.1.32]
ECMDS42_2591  garK; glycerate kinase I [KO:K00865] [EC:2.7.1.165]
ECMDS42_2592  garR; tartronate semialdehyde reductase [KO:K00042] [EC:1.1.1.60]
ECMDS42_2700  mdh; malate dehydrogenase, NAD(P)-binding [KO:K00024] [EC:1.1.1.37]
ECMDS42_2831  gph; phosphoglycolate phosphatase [KO:K01091] [EC:3.1.3.18]
ECMDS42_2990  tiaE; 2-keto-D-gluconate reductase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
ECMDS42_3309  glnA; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
ECMDS42_3331  fdoI; formate dehydrogenase-O, cytochrome b556 subunit [KO:K00127]
ECMDS42_3332  fdoH; formate dehydrogenase-O, Fe-S subunit [KO:K00124]
ECMDS42_3333  fdoG; formate dehydrogenase-O, large subunit [KO:K00123] [EC:1.17.1.9]
ECMDS42_3452  aceB; malate synthase A [KO:K01638] [EC:2.3.3.9]
ECMDS42_3453  aceA; isocitrate lyase [KO:K01637] [EC:4.1.3.1 4.1.3.30]
ECMDS42_3508  acs; bifunctional acetyl-CoA synthetase [KO:K01895] [EC:6.2.1.1]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00049  L-Aspartate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C05840  Iminoaspartate
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C19838  D-erythro-3-Hydroxyaspartate
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
ecok00010  Glycolysis / Gluconeogenesis
ecok00020  Citrate cycle (TCA cycle)
ecok00030  Pentose phosphate pathway
ecok00053  Ascorbate and aldarate metabolism
ecok00071  Fatty acid degradation
ecok00230  Purine metabolism
ecok00250  Alanine, aspartate and glutamate metabolism
ecok00260  Glycine, serine and threonine metabolism
ecok00270  Cysteine and methionine metabolism
ecok00620  Pyruvate metabolism
ecok00710  Carbon fixation by Calvin cycle
ecok00750  Vitamin B6 metabolism
ecok00910  Nitrogen metabolism
KO pathway
ko00630   

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