KEGG   PATHWAY: fvr00260
Entry
fvr00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Fusarium verticillioides
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
fvr00260  Glycine, serine and threonine metabolism
fvr00260

Module
fvr_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:fvr00260]
fvr_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:fvr00260]
fvr_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:fvr00260]
fvr_M00621  Glycine cleavage system [PATH:fvr00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Fusarium verticillioides [GN:fvr]
Gene
FVEG_07836  aspartate kinase [KO:K00928] [EC:2.7.2.4]
FVEG_12521  aspartate kinase [KO:K00928] [EC:2.7.2.4]
FVEG_02169  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
FVEG_03824  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
FVEG_03006  homoserine kinase [KO:K00872] [EC:2.7.1.39]
FVEG_05954  threonine synthase [KO:K01733] [EC:4.2.3.1]
FVEG_10108  threonine aldolase [KO:K01620] [EC:4.1.2.48]
FVEG_04256  threonine aldolase [KO:K01620] [EC:4.1.2.48]
FVEG_06864  threonine aldolase [KO:K01620] [EC:4.1.2.48]
FVEG_04963  serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
FVEG_02339  serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
FVEG_02585  serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
FVEG_11573  alanine-glyoxylate transaminase/(R)-3-amino-2-methylpropionate-pyruvate transaminase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
FVEG_03437  glycerate kinase [KO:K00865] [EC:2.7.1.165]
FVEG_05781  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
FVEG_04687  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
FVEG_03753  hypothetical protein [KO:K15918] [EC:2.7.1.31]
FVEG_04198  hypothetical protein [KO:K15918] [EC:2.7.1.31]
FVEG_04031  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
FVEG_07790  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
FVEG_04880  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
FVEG_02203  hypothetical protein [KO:K01079] [EC:3.1.3.3]
FVEG_08806  oxidoreductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
FVEG_10451  oxidoreductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
FVEG_05314  5-aminolevulinate synthase, mitochondrial [KO:K00643] [EC:2.3.1.37]
FVEG_00169  monoamine oxidase [KO:K00274] [EC:1.4.3.4]
FVEG_01667  monoamine oxidase [KO:K00274] [EC:1.4.3.4]
FVEG_08362  hypothetical protein [KO:K00274] [EC:1.4.3.4]
FVEG_11008  hypothetical protein [KO:K00274] [EC:1.4.3.4]
FVEG_06242  hypothetical protein [KO:K00274] [EC:1.4.3.4]
FVEG_04368  hypothetical protein [KO:K00276] [EC:1.4.3.21]
FVEG_09371  primary-amine oxidase [KO:K00276] [EC:1.4.3.21]
FVEG_12223  primary-amine oxidase [KO:K00276] [EC:1.4.3.21]
FVEG_10879  primary-amine oxidase [KO:K00276] [EC:1.4.3.21]
FVEG_13749  primary-amine oxidase [KO:K00276] [EC:1.4.3.21]
FVEG_08565  primary-amine oxidase [KO:K00276] [EC:1.4.3.21]
FVEG_11971  primary-amine oxidase [KO:K00276] [EC:1.4.3.21]
FVEG_15472  copper amine oxidase 1 [KO:K00276] [EC:1.4.3.21]
FVEG_11764  hypothetical protein [KO:K00276] [EC:1.4.3.21]
FVEG_02337  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
FVEG_01276  glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
FVEG_05079  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
FVEG_02338  glycine cleavage system H protein [KO:K02437]
FVEG_06633  glycine cleavage system H protein [KO:K02437]
FVEG_09824  D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
FVEG_06262  D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
FVEG_03267  hypothetical protein [KO:K00273] [EC:1.4.3.3]
FVEG_09912  hypothetical protein [KO:K00273] [EC:1.4.3.3]
FVEG_11222  hypothetical protein [KO:K00273] [EC:1.4.3.3]
FVEG_05046  phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
FVEG_04300  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
FVEG_10784  hypothetical protein [KO:K00309] [EC:1.5.3.10]
FVEG_13875  hypothetical protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
FVEG_05609  hypothetical protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
FVEG_06803  hypothetical protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
FVEG_13073  hypothetical protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
FVEG_02095  hypothetical protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
FVEG_02131  hypothetical protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
FVEG_08398  hypothetical protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
FVEG_10805  hypothetical protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
FVEG_12954  hypothetical protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
FVEG_10722  hypothetical protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
FVEG_12057  proline dehydrogenase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
FVEG_05602  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
FVEG_01304  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
FVEG_00354  threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
FVEG_02842  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
FVEG_10537  hypothetical protein [KO:K01754] [EC:4.3.1.19]
FVEG_08001  hypothetical protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
FVEG_09063  hypothetical protein [KO:K20498] [EC:4.3.1.18]
FVEG_13203  hypothetical protein [KO:K20498] [EC:4.3.1.18]
FVEG_11404  tryptophan synthase [KO:K01694] [EC:4.2.1.20]
FVEG_13904  tryptophan synthase, beta subunit [KO:K06001] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
fvr00010  Glycolysis / Gluconeogenesis
fvr00020  Citrate cycle (TCA cycle)
fvr00230  Purine metabolism
fvr00250  Alanine, aspartate and glutamate metabolism
fvr00270  Cysteine and methionine metabolism
fvr00290  Valine, leucine and isoleucine biosynthesis
fvr00300  Lysine biosynthesis
fvr00330  Arginine and proline metabolism
fvr00460  Cyanoamino acid metabolism
fvr00470  D-Amino acid metabolism
fvr00564  Glycerophospholipid metabolism
fvr00600  Sphingolipid metabolism
fvr00620  Pyruvate metabolism
fvr00630  Glyoxylate and dicarboxylate metabolism
fvr00640  Propanoate metabolism
fvr00680  Methane metabolism
fvr00860  Porphyrin metabolism
fvr00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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