KEGG   PATHWAY: hag00260
Entry
hag00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Halomonas sp. GFAJ-1
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
hag00260  Glycine, serine and threonine metabolism
hag00260

Module
hag_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:hag00260]
hag_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:hag00260]
hag_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:hag00260]
hag_M00555  Betaine biosynthesis, choline => betaine [PATH:hag00260]
hag_M00621  Glycine cleavage system [PATH:hag00260]
hag_M00919  Ectoine degradation, ectoine => aspartate [PATH:hag00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Halomonas sp. GFAJ-1 [GN:hag]
Gene
BB497_00270  aspartate kinase [KO:K00928] [EC:2.7.2.4]
BB497_13675  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BB497_01335  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
BB497_06380  homoserine kinase [KO:K02204] [EC:2.7.1.39]
BB497_01330  threonine synthase [KO:K01733] [EC:4.2.3.1]
BB497_07420  threonine aldolase [KO:K01620] [EC:4.1.2.48]
BB497_15600  threonine aldolase [KO:K01620] [EC:4.1.2.48]
BB497_15275  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BB497_12360  glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
BB497_00070  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
BB497_06435  glycerate kinase [KO:K00865] [EC:2.7.1.165]
BB497_05475  hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
BB497_04695  phosphoglucomutase [KO:K15634] [EC:5.4.2.11]
BB497_03705  phosphoglycerate mutase (2,3-diphosphoglycerate-independent) [KO:K15633] [EC:5.4.2.12]
BB497_04795  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BB497_12040  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
BB497_10225  phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
BB497_12160  glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
BB497_12175  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
BB497_05110  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BB497_08485  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BB497_12165  glycine cleavage system protein H [KO:K02437]
BB497_02045  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
BB497_11475  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
BB497_11480  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BB497_06100  aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BB497_16185  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
BB497_03755  PLP-dependent threonine dehydratase [KO:K01754] [EC:4.3.1.19]
BB497_08245  aspartate/glutamate racemase [KO:K25316] [EC:5.1.1.10]
BB497_10075  alanine racemase [KO:K25317] [EC:5.1.1.10]
BB497_15825  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
BB497_13650  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
BB497_15830  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
BB497_13655  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
BB497_12485  diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
BB497_12480  diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
BB497_12490  L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
BB497_06365  ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
BB497_00065  ectoine hydrolase DoeA [KO:K15783] [EC:3.5.4.44]
BB497_00060  N-alpha-acetyl diaminobutyric acid deacetylase DoeB [KO:K15784] [EC:3.5.1.125]
BB497_00045  hypothetical protein [KO:K15785] [EC:2.6.1.76]
BB497_00050  NAD-dependent succinate-semialdehyde dehydrogenase [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
hag00010  Glycolysis / Gluconeogenesis
hag00020  Citrate cycle (TCA cycle)
hag00230  Purine metabolism
hag00250  Alanine, aspartate and glutamate metabolism
hag00270  Cysteine and methionine metabolism
hag00290  Valine, leucine and isoleucine biosynthesis
hag00300  Lysine biosynthesis
hag00330  Arginine and proline metabolism
hag00460  Cyanoamino acid metabolism
hag00470  D-Amino acid metabolism
hag00564  Glycerophospholipid metabolism
hag00620  Pyruvate metabolism
hag00630  Glyoxylate and dicarboxylate metabolism
hag00640  Propanoate metabolism
hag00680  Methane metabolism
hag00860  Porphyrin metabolism
hag00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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