KEGG   PATHWAY: hahe00260
Entry
hahe00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Hahella sp. KA22
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
hahe00260  Glycine, serine and threonine metabolism
hahe00260

Module
hahe_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:hahe00260]
hahe_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:hahe00260]
hahe_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:hahe00260]
hahe_M00555  Betaine biosynthesis, choline => betaine [PATH:hahe00260]
hahe_M00621  Glycine cleavage system [PATH:hahe00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Hahella sp. KA22 [GN:hahe]
Gene
ENC22_07010  aspartate kinase [KO:K00928] [EC:2.7.2.4]
ENC22_11055  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
ENC22_21835  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
ENC22_27830  homoserine kinase [KO:K02204] [EC:2.7.1.39]
ENC22_18290  thrH; bifunctional phosphoserine phosphatase/homoserine phosphotransferase ThrH [KO:K02203] [EC:3.1.3.3 2.7.1.39]
ENC22_21830  threonine synthase [KO:K01733] [EC:4.2.3.1]
ENC22_03515  low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
ENC22_13100  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
ENC22_25640  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
ENC22_06385  alanine--glyoxylate aminotransferase family protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
ENC22_22960  D-2-hydroxyacid dehydrogenase [KO:K00018] [EC:1.1.1.29]
ENC22_29660  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
ENC22_24265  glycerate kinase [KO:K00865] [EC:2.7.1.165]
ENC22_15055  histidine phosphatase family protein [KO:K15634] [EC:5.4.2.11]
ENC22_23710  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
ENC22_22380  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
ENC22_10845  hypothetical protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
ENC22_07975  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
ENC22_06120  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
ENC22_20940  SDR family NAD(P)-dependent oxidoreductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
ENC22_22435  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
ENC22_22440  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
ENC22_13095  gcvP; glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
ENC22_13110  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
ENC22_03580  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
ENC22_00720  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
ENC22_09135  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
ENC22_28320  hypothetical protein [KO:K02437]
ENC22_13090  gcvH; glycine cleavage system protein GcvH [KO:K02437]
ENC22_25790  gcvH; glycine cleavage system protein GcvH [KO:K02437]
ENC22_25415  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
ENC22_03485  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
ENC22_03480  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
ENC22_13840  cysteine synthase family protein [KO:K01697] [EC:4.2.1.22]
ENC22_13105  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
ENC22_20005  PLP-dependent lyase/thiolase [KO:K01754] [EC:4.3.1.19]
ENC22_25330  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
ENC22_16310  pyridoxal-phosphate dependent enzyme [KO:K17989] [EC:4.3.1.17 4.3.1.19]
ENC22_01820  aspartate/glutamate racemase family protein [KO:K25316] [EC:5.1.1.10]
ENC22_11080  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
ENC22_30255  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
ENC22_11075  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
ENC22_30250  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
ENC22_23005  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
ENC22_23000  ectA; diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
ENC22_23010  L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
ENC22_23015  thpD; ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
hahe00010  Glycolysis / Gluconeogenesis
hahe00020  Citrate cycle (TCA cycle)
hahe00230  Purine metabolism
hahe00250  Alanine, aspartate and glutamate metabolism
hahe00270  Cysteine and methionine metabolism
hahe00290  Valine, leucine and isoleucine biosynthesis
hahe00300  Lysine biosynthesis
hahe00330  Arginine and proline metabolism
hahe00460  Cyanoamino acid metabolism
hahe00470  D-Amino acid metabolism
hahe00564  Glycerophospholipid metabolism
hahe00600  Sphingolipid metabolism
hahe00620  Pyruvate metabolism
hahe00630  Glyoxylate and dicarboxylate metabolism
hahe00640  Propanoate metabolism
hahe00680  Methane metabolism
hahe00860  Porphyrin metabolism
hahe00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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