KEGG   PATHWAY: hsa04980
Entry
hsa04980                    Pathway                                
Name
Cobalamin transport and metabolism - Homo sapiens (human)
Class
Organismal Systems; Digestive system
Pathway map
hsa04980  Cobalamin transport and metabolism
hsa04980

Network
nt06538  Cobalamin transport and metabolism
  Element
N01807  Transfer of cobalamin to the portal blood
N01808  Intracellular processing of cobalamin (reduction)
N01809  Mutation-caused epigenetic silencing of MMACHC
N01810  Regulation of MMACHC expression
N01811  Mitochondrial adenocylation of cobalamin and loading onto MMUT
N01812  Cobalamin loading and activation of MTR
Organism
Homo sapiens (human) [GN:hsa]
Gene
166785  MMAA; metabolism of cobalamin associated A [KO:K07588] [EC:3.6.5.-]
25974  MMACHC; metabolism of cobalamin associated C [KO:K14618] [EC:1.16.1.6 2.5.1.151]
2694  CBLIF; cobalamin binding intrinsic factor [KO:K14615]
27249  MMADHC; metabolism of cobalamin associated D [KO:K26006]
3054  HCFC1; host cell factor C1 [KO:K14966]
326625  MMAB; metabolism of cobalamin associated B [KO:K00798] [EC:2.5.1.17]
4548  MTR; 5-methyltetrahydrofolate-homocysteine methyltransferase [KO:K00548] [EC:2.1.1.13]
4552  MTRR; 5-methyltetrahydrofolate-homocysteine methyltransferase reductase [KO:K00597] [EC:1.16.1.8]
4594  MMUT; methylmalonyl-CoA mutase [KO:K01847] [EC:5.4.99.2]
5052  PRDX1; peroxiredoxin 1 [KO:K13279] [EC:1.11.1.24]
51293  CD320; CD320 molecule [KO:K06734]
55788  LMBRD1; LMBR1 domain containing 1 [KO:K14617]
57215  THAP11; THAP domain containing 11 [KO:K23211]
5826  ABCD4; ATP binding cassette subfamily D member 4 [KO:K05678] [EC:7.6.2.8]
6947  TCN1; transcobalamin 1 [KO:K25741]
6948  TCN2; transcobalamin 2 [KO:K14619]
7629  ZNF76; zinc finger protein 76 [KO:K20828]
7702  ZNF143; zinc finger protein 143 [KO:K20828]
Compound
C00073  L-Methionine
C00091  Succinyl-CoA
C00101  Tetrahydrofolate
C00155  L-Homocysteine
C00194  Cobamide coenzyme
C00440  5-Methyltetrahydrofolate
C00541  Cob(II)alamin
C01213  (R)-Methylmalonyl-CoA
C02823  Cyanocobalamin
C06409  [Methionine synthase]-cob(II)alamin
C06410  [Methionine synthase]-methylcob(III)alamin
C06453  Methylcobalamin
C08230  Hydroxocobalamin
C22880  [Methionine synthase]-cob(I)alamin
Reference
PMID:35337617
  Authors
Nijland M, Martinez Felices JM, Slotboom DJ, Thangaratnarajah C
  Title
Membrane transport of cobalamin.
  Journal
Vitam Horm 119:121-148 (2022)
DOI:10.1016/bs.vh.2022.01.008
Reference
PMID:35337623
  Authors
Hannibal L, Jacobsen DW
  Title
Intracellular processing of vitamin B(12) by MMACHC (CblC).
  Journal
Vitam Horm 119:275-298 (2022)
DOI:10.1016/bs.vh.2022.02.001
Reference
PMID:35337626
  Authors
Watkins D, Rosenblatt DS
  Title
Inherited defects of cobalamin metabolism.
  Journal
Vitam Horm 119:355-376 (2022)
DOI:10.1016/bs.vh.2022.01.010
Reference
PMID:36422244
  Authors
Kosa M, Galla Z, Lenart I, Barath A, Grecso N, Racz G, Bereczki C, Monostori P
  Title
Vitamin B12 (Cobalamin): Its Fate from Ingestion to Metabolism with Particular Emphasis on Diagnostic Approaches of Acquired Neonatal/Infantile Deficiency  Detected by Newborn Screening.
  Journal
Metabolites 12:metabo12111104 (2022)
DOI:10.3390/metabo12111104
Reference
PMID:20301503
  Authors
Sloan JL, Carrillo N, Adams D, Venditti CP
  Title
Disorders of Intracellular Cobalamin Metabolism.
  Journal
GeneReviews(1993)
Reference
PMID:23539619
  Authors
Gherasim C, Lofgren M, Banerjee R
  Title
Navigating the B(12) road: assimilation, delivery, and disorders of cobalamin.
  Journal
J Biol Chem 288:13186-93 (2013)
DOI:10.1074/jbc.R113.458810
Related
pathway
hsa00270  Cysteine and methionine metabolism
hsa00280  Valine, leucine and isoleucine degradation
hsa00670  One carbon pool by folate
hsa04144  Endocytosis
hsa04977  Vitamin digestion and absorption
KO pathway
ko04980   

DBGET integrated database retrieval system