KEGG   PATHWAY: hsa00670
Entry
hsa00670                    Pathway                                
Name
One carbon pool by folate - Homo sapiens (human)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
hsa00670  One carbon pool by folate
hsa00670

Module
hsa_M00035  Methionine degradation [PATH:hsa00670]
hsa_M00141  C1-unit interconversion, eukaryotes [PATH:hsa00670]
hsa_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:hsa00670]
hsa_M00555  Betaine biosynthesis, choline => betaine [PATH:hsa00670]
hsa_M00621  Glycine cleavage system [PATH:hsa00670]
hsa_M00974  Betaine metabolism, animals, betaine => glycine [PATH:hsa00670]
Network
nt06030  Methionine metabolism
nt06038  Folate metabolism
  Element
N01629  Remethylation, THF to 5-MTHF
N01630  Remethylation, Hcy to Met
N01725  Tetrahydrofolate biosynthesis
N01726  Folate cycle
N01867  Demethylation of dimethylglycine
N01868  Demethylation of sarcosine
N01869  THF conversion, THF to 5,10-MTHF
Drug
D00142  Methotrexate (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01064  Raltitrexed (JAN/USAN/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D02115  Methotrexate sodium
D03828  Pemetrexed disodium (USAN)
D03942  Edatrexate (USAN/INN)
D04197  Floxuridine (USP/INN)
D04766  Lometrexol sodium (USAN)
D04964  Metesind glucuronate (USAN)
D05500  Piritrexim isethionate (USAN)
D05589  Pralatrexate (JAN/USAN/INN)
D05999  Talotrexin ammonium (USAN)
D06238  Trimetrexate (USAN/INN)
D06239  Trimetrexate glucuronate (USAN)
D06503  Pemetrexed sodium hydrate (JAN)
D07472  Pemetrexed (INN)
D07974  Fluorouracil sodium salt
D10596  Pemetrexed sodium hemipentahydrate (JAN)
D10803  Plevitrexed (INN)
D11352  Pemetrexed tromethamine (USAN)
D11447  Arfolitixorin (USAN/INN)
D12388  Fosifloxuridine nafalbenamide
D12528  Arfolitixorin sulfate (JAN)
D13147  Pemetrexed dipotassium heptahydrate
Other DBs
GO: 0035999
Organism
Homo sapiens (human) [GN:hsa]
Gene
100528021  ST20-MTHFS; ST20-MTHFS readthrough [KO:K01934] [EC:6.3.3.2]
102724560  CBS; cystathionine beta-synthase like [KO:K01697] [EC:4.2.1.22]
10588  MTHFS; methenyltetrahydrofolate synthetase [KO:K01934] [EC:6.3.3.2]
10768  AHCYL1; adenosylhomocysteinase like 1 [KO:K01251] [EC:3.13.2.1]
10797  MTHFD2; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase [KO:K13403] [EC:1.5.1.15 3.5.4.9]
10840  ALDH1L1; aldehyde dehydrogenase 1 family member L1 [KO:K00289] [EC:1.5.1.6]
10841  FTCD; formimidoyltransferase cyclodeaminase [KO:K13990] [EC:2.1.2.5 4.3.1.4]
124908081  [KO:K02437]
1491  CTH; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
160428  ALDH1L2; aldehyde dehydrogenase 1 family member L2 [KO:K00289] [EC:1.5.1.6]
1719  DHFR; dihydrofolate reductase [KO:K00287] [EC:1.5.1.3]
1738  DLD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
1757  SARDH; sarcosine dehydrogenase [KO:K00314] [EC:1.5.8.3]
191  AHCY; adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]
200895  DHFR2; dihydrofolate reductase 2 [KO:K00287] [EC:1.5.1.3]
23382  AHCYL2; adenosylhomocysteinase like 2 [KO:K01251] [EC:3.13.2.1]
23743  BHMT2; betaine--homocysteine S-methyltransferase 2 [KO:K00547] [EC:2.1.1.10]
25902  MTHFD1L; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like [KO:K13402] [EC:6.3.4.3]
2618  GART; phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
2653  GCSH; glycine cleavage system protein H [KO:K02437]
27232  GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
2731  GLDC; glycine decarboxylase [KO:K00281] [EC:1.4.4.2]
27430  MAT2B; methionine adenosyltransferase 2 non-catalytic beta subunit [KO:K00789] [EC:2.5.1.6]
275  AMT; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
29958  DMGDH; dimethylglycine dehydrogenase [KO:K00315] [EC:1.5.8.4]
4143  MAT1A; methionine adenosyltransferase 1A [KO:K00789] [EC:2.5.1.6]
4144  MAT2A; methionine adenosyltransferase 2A [KO:K00789] [EC:2.5.1.6]
441024  MTHFD2L; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like [KO:K13403] [EC:1.5.1.15 3.5.4.9]
4522  MTHFD1; methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 [KO:K00288] [EC:1.5.1.5 3.5.4.9 6.3.4.3]
4524  MTHFR; methylenetetrahydrofolate reductase [KO:K25004]
4548  MTR; 5-methyltetrahydrofolate-homocysteine methyltransferase [KO:K00548] [EC:2.1.1.13]
471  ATIC; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
501  ALDH7A1; aldehyde dehydrogenase 7 family member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
55349  CHDH; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
635  BHMT; betaine--homocysteine S-methyltransferase [KO:K00544] [EC:2.1.1.5]
6470  SHMT1; serine hydroxymethyltransferase 1 [KO:K00600] [EC:2.1.2.1]
6472  SHMT2; serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
7298  TYMS; thymidylate synthetase [KO:K00560] [EC:2.1.1.45]
875  CBS; cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
Compound
C00002  ATP
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00037  Glycine
C00065  L-Serine
C00073  L-Methionine
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00155  L-Homocysteine
C00212  Adenosine
C00213  Sarcosine
C00234  10-Formyltetrahydrofolate
C00364  dTMP
C00365  dUMP
C00415  Dihydrofolate
C00440  5-Methyltetrahydrofolate
C00445  5,10-Methenyltetrahydrofolate
C00504  Folate
C00576  Betaine aldehyde
C00664  5-Formiminotetrahydrofolate
C00719  Betaine
C01026  N,N-Dimethylglycine
C02291  L-Cystathionine
C03479  Folinic acid
Related
pathway
hsa00260  Glycine, serine and threonine metabolism
hsa00270  Cysteine and methionine metabolism
hsa00790  Folate biosynthesis
KO pathway
ko00670   

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