KEGG   Homo sapiens (human): 10488
Entry
10488             CDS       T01001                                 
Symbol
CREB3, LUMAN, LZIP, sLZIP
Name
(RefSeq) cAMP responsive element binding protein 3
  KO
K09048  cyclic AMP-responsive element-binding protein 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04211  Longevity regulating pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04668  TNF signaling pathway
hsa04714  Thermogenesis
hsa04725  Cholinergic synapse
hsa04728  Dopaminergic synapse
hsa04911  Insulin secretion
hsa04915  Estrogen signaling pathway
hsa04916  Melanogenesis
hsa04918  Thyroid hormone synthesis
hsa04922  Glucagon signaling pathway
hsa04925  Aldosterone synthesis and secretion
hsa04926  Relaxin signaling pathway
hsa04927  Cortisol synthesis and secretion
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04931  Insulin resistance
hsa04934  Cushing syndrome
hsa04935  Growth hormone synthesis, secretion and action
hsa04962  Vasopressin-regulated water reabsorption
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05034  Alcoholism
hsa05161  Hepatitis B
hsa05163  Human cytomegalovirus infection
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05203  Viral carcinogenesis
hsa05207  Chemical carcinogenesis - receptor activation
hsa05215  Prostate cancer
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06167  Human cytomegalovirus (HCMV)
nt06180  Pathogenic Escherichia coli
nt06210  ERK signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06310  CRH-ACTH-cortisol signaling
nt06316  Renin-angiotensin-aldosterone signaling
nt06322  TRH-TSH-TH signaling
nt06324  GHRH-GH-IGF signaling
nt06360  Cushing syndrome
nt06461  Huntington disease
nt06465  Prion disease
nt06516  TNF signaling
  Element
N00297  ACTH-cortisol signaling pathway
N00298  CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00301  Angiotensin-aldosterone signaling pathway
N00302  Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
N00303  Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N00304  Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
N00305  Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
N00320  Mutation-activated PRKACA to ACTH-cortisol signaling pathway
N00321  Mutation-activated GNAS to ACTH-cortisol signaling pathway
N00322  Mutation-inactivated PRKAR1A to ACTH-cortisol signaling pathway
N00323  Mutation-inactivated PDE11A/PDE8B to ACTH-cortisol signaling pathway
N00324  CRHR-PKA-ACTH signaling pathway
N00325  Mutation-inactivated RASD1 to CRHR-PKA-ACTH signaling pathway
N00326  Mutation-activated GNAS to CRHR-PKA-ACTH signaling pathway
N00327  Mutation-inactivated PRKAR1A to CRHR-PKA-ACTH signaling pathway
N00410  DRD1-GNAS-AC-PKA signaling pathway
N00444  TNF-p38 signaling pathway
N00510  HTLV-1 Tax to CREB-mediated transcription
N00544  HBV HBx to CREB-mediated transcription
N00782  TSH-TG signaling pathway
N00910  GHRHR-PKA-GH signaling pathway
N00981  Mutation-caused aberrant Htt to CREB-mediated transcription
N01204  PRNP-PI3K-NOX2 signaling pathway
N01343  ACH-CHRN-RAS-ERK signaling pathway
N01351  E2-ER-RAS-ERK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    10488 (CREB3)
   04024 cAMP signaling pathway
    10488 (CREB3)
   04022 cGMP-PKG signaling pathway
    10488 (CREB3)
   04151 PI3K-Akt signaling pathway
    10488 (CREB3)
   04152 AMPK signaling pathway
    10488 (CREB3)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    10488 (CREB3)
   04922 Glucagon signaling pathway
    10488 (CREB3)
   04915 Estrogen signaling pathway
    10488 (CREB3)
   04926 Relaxin signaling pathway
    10488 (CREB3)
   04935 Growth hormone synthesis, secretion and action
    10488 (CREB3)
   04918 Thyroid hormone synthesis
    10488 (CREB3)
   04928 Parathyroid hormone synthesis, secretion and action
    10488 (CREB3)
   04916 Melanogenesis
    10488 (CREB3)
   04925 Aldosterone synthesis and secretion
    10488 (CREB3)
   04927 Cortisol synthesis and secretion
    10488 (CREB3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    10488 (CREB3)
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    10488 (CREB3)
  09156 Nervous system
   04725 Cholinergic synapse
    10488 (CREB3)
   04728 Dopaminergic synapse
    10488 (CREB3)
  09149 Aging
   04211 Longevity regulating pathway
    10488 (CREB3)
  09159 Environmental adaptation
   04714 Thermogenesis
    10488 (CREB3)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    10488 (CREB3)
   05203 Viral carcinogenesis
    10488 (CREB3)
  09162 Cancer: specific types
   05215 Prostate cancer
    10488 (CREB3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    10488 (CREB3)
   05161 Hepatitis B
    10488 (CREB3)
   05163 Human cytomegalovirus infection
    10488 (CREB3)
   05165 Human papillomavirus infection
    10488 (CREB3)
  09164 Neurodegenerative disease
   05016 Huntington disease
    10488 (CREB3)
   05020 Prion disease
    10488 (CREB3)
  09165 Substance dependence
   05030 Cocaine addiction
    10488 (CREB3)
   05031 Amphetamine addiction
    10488 (CREB3)
   05034 Alcoholism
    10488 (CREB3)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    10488 (CREB3)
   04934 Cushing syndrome
    10488 (CREB3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    10488 (CREB3)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   CREB
    10488 (CREB3)
SSDB
Motif
Pfam: bZIP_1 bZIP_2 bZIP_Maf
Other DBs
NCBI-GeneID: 10488
NCBI-ProteinID: NP_006359
OMIM: 606443
HGNC: 2347
Ensembl: ENSG00000107175
UniProt: O43889
LinkDB
Position
9:35732666..35736999
AA seq 371 aa
MELELDAGDQDLLAFLLEESGDLGTAPDEAVRAPLDWALPLSEVPSDWEVDDLLCSLLSP
PASLNILSSSNPCLVHHDHTYSLPRETVSMDLESESCRKEGTQMTPQHMEELAEQEIARL
VLTDEEKSLLEKEGLILPETLPLTKTEEQILKRVRRKIRNKRSAQESRRKKKVYVGGLES
RVLKYTAQNMELQNKVQLLEEQNLSLLDQLRKLQAMVIEISNKTSSSSTCILVLLVSFCL
LLVPAMYSSDTRGSLPAEHGVLSRQLRALPSEDPYQLELPALQSEVPKDSTHQWLDGSDC
VLQAPGNTSCLLHYMPQAPSAEPPLEWPFPDLFSEPLCRGPILPLQANLTRKGGWLPTGS
PSVILQDRYSG
NT seq 1116 nt   +upstreamnt  +downstreamnt
atggagctggaattggatgctggtgaccaagacctgctggccttcctgctagaggaaagt
ggagatttggggacggcacccgatgaggccgtgagggccccactggactgggcgctgccg
ctttctgaggtaccgagcgactgggaagtagatgatttgctgtgctccctgctgagtccc
ccagcgtcgttgaacattctcagctcctccaacccctgccttgtccaccatgaccacacc
tactccctcccacgggaaactgtctctatggatctagagagtgagagctgtagaaaagag
gggacccagatgactccacagcatatggaggagctggcagagcaggagattgctaggcta
gtactgacagatgaggagaagagtctattggagaaggaggggcttattctgcctgagaca
cttcctctcactaagacagaggaacaaattctgaaacgtgtgcggaggaagattcgaaat
aaaagatctgctcaagagagccgcaggaaaaagaaggtgtatgttgggggtttagagagc
agggtcttgaaatacacagcccagaatatggagcttcagaacaaagtacagcttctggag
gaacagaatttgtcccttctagatcaactgaggaaactccaggccatggtgattgagata
tcaaacaaaaccagcagcagcagcacctgcatcttggtcctactagtctccttctgcctc
ctccttgtacctgctatgtactcctctgacacaagggggagcctgccagctgagcatgga
gtgttgtcccgccagcttcgtgccctccccagtgaggacccttaccagctggagctgcct
gccctgcagtcagaagtgccgaaagacagcacacaccagtggttggacggctcagactgt
gtactccaggcccctggcaacacttcctgcctgctgcattacatgcctcaggctcccagt
gcagagcctcccctggagtggccattccctgacctcttctcagagcctctctgccgaggt
cccatcctccccctgcaggcaaatctcacaaggaagggaggatggcttcctactggtagc
ccctctgtcattttgcaggacagatactcaggctag

KEGG   Homo sapiens (human): 1385
Entry
1385              CDS       T01001                                 
Symbol
CREB1, CREB, CREB-1
Name
(RefSeq) cAMP responsive element binding protein 1
  KO
K05870  cyclic AMP-responsive element-binding protein 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04148  Efferocytosis
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04211  Longevity regulating pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04380  Osteoclast differentiation
hsa04612  Antigen processing and presentation
hsa04668  TNF signaling pathway
hsa04710  Circadian rhythm
hsa04713  Circadian entrainment
hsa04714  Thermogenesis
hsa04725  Cholinergic synapse
hsa04728  Dopaminergic synapse
hsa04911  Insulin secretion
hsa04915  Estrogen signaling pathway
hsa04916  Melanogenesis
hsa04918  Thyroid hormone synthesis
hsa04922  Glucagon signaling pathway
hsa04924  Renin secretion
hsa04925  Aldosterone synthesis and secretion
hsa04926  Relaxin signaling pathway
hsa04927  Cortisol synthesis and secretion
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04931  Insulin resistance
hsa04934  Cushing syndrome
hsa04935  Growth hormone synthesis, secretion and action
hsa04962  Vasopressin-regulated water reabsorption
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05034  Alcoholism
hsa05152  Tuberculosis
hsa05161  Hepatitis B
hsa05163  Human cytomegalovirus infection
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05203  Viral carcinogenesis
hsa05207  Chemical carcinogenesis - receptor activation
hsa05215  Prostate cancer
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06167  Human cytomegalovirus (HCMV)
nt06180  Pathogenic Escherichia coli
nt06210  ERK signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06310  CRH-ACTH-cortisol signaling
nt06316  Renin-angiotensin-aldosterone signaling
nt06322  TRH-TSH-TH signaling
nt06324  GHRH-GH-IGF signaling
nt06360  Cushing syndrome
nt06461  Huntington disease
nt06465  Prion disease
nt06516  TNF signaling
nt06535  Efferocytosis
  Element
N00297  ACTH-cortisol signaling pathway
N00298  CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00301  Angiotensin-aldosterone signaling pathway
N00302  Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
N00303  Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N00304  Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
N00305  Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
N00320  Mutation-activated PRKACA to ACTH-cortisol signaling pathway
N00321  Mutation-activated GNAS to ACTH-cortisol signaling pathway
N00322  Mutation-inactivated PRKAR1A to ACTH-cortisol signaling pathway
N00323  Mutation-inactivated PDE11A/PDE8B to ACTH-cortisol signaling pathway
N00324  CRHR-PKA-ACTH signaling pathway
N00325  Mutation-inactivated RASD1 to CRHR-PKA-ACTH signaling pathway
N00326  Mutation-activated GNAS to CRHR-PKA-ACTH signaling pathway
N00327  Mutation-inactivated PRKAR1A to CRHR-PKA-ACTH signaling pathway
N00410  DRD1-GNAS-AC-PKA signaling pathway
N00444  TNF-p38 signaling pathway
N00544  HBV HBx to CREB-mediated transcription
N00782  TSH-TG signaling pathway
N00910  GHRHR-PKA-GH signaling pathway
N00981  Mutation-caused aberrant Htt to CREB-mediated transcription
N01204  PRNP-PI3K-NOX2 signaling pathway
N01343  ACH-CHRN-RAS-ERK signaling pathway
N01351  E2-ER-RAS-ERK signaling pathway
N01773  PTGS2-PGE2-TGFB1 pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    1385 (CREB1)
   04024 cAMP signaling pathway
    1385 (CREB1)
   04022 cGMP-PKG signaling pathway
    1385 (CREB1)
   04151 PI3K-Akt signaling pathway
    1385 (CREB1)
   04152 AMPK signaling pathway
    1385 (CREB1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    1385 (CREB1)
 09150 Organismal Systems
  09151 Immune system
   04612 Antigen processing and presentation
    1385 (CREB1)
  09152 Endocrine system
   04911 Insulin secretion
    1385 (CREB1)
   04922 Glucagon signaling pathway
    1385 (CREB1)
   04915 Estrogen signaling pathway
    1385 (CREB1)
   04926 Relaxin signaling pathway
    1385 (CREB1)
   04935 Growth hormone synthesis, secretion and action
    1385 (CREB1)
   04918 Thyroid hormone synthesis
    1385 (CREB1)
   04928 Parathyroid hormone synthesis, secretion and action
    1385 (CREB1)
   04916 Melanogenesis
    1385 (CREB1)
   04924 Renin secretion
    1385 (CREB1)
   04925 Aldosterone synthesis and secretion
    1385 (CREB1)
   04927 Cortisol synthesis and secretion
    1385 (CREB1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    1385 (CREB1)
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    1385 (CREB1)
  09156 Nervous system
   04725 Cholinergic synapse
    1385 (CREB1)
   04728 Dopaminergic synapse
    1385 (CREB1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    1385 (CREB1)
  09149 Aging
   04211 Longevity regulating pathway
    1385 (CREB1)
  09159 Environmental adaptation
   04710 Circadian rhythm
    1385 (CREB1)
   04713 Circadian entrainment
    1385 (CREB1)
   04714 Thermogenesis
    1385 (CREB1)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    1385 (CREB1)
   05203 Viral carcinogenesis
    1385 (CREB1)
  09162 Cancer: specific types
   05215 Prostate cancer
    1385 (CREB1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    1385 (CREB1)
   05161 Hepatitis B
    1385 (CREB1)
   05163 Human cytomegalovirus infection
    1385 (CREB1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    1385 (CREB1)
   05165 Human papillomavirus infection
    1385 (CREB1)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    1385 (CREB1)
  09164 Neurodegenerative disease
   05016 Huntington disease
    1385 (CREB1)
   05020 Prion disease
    1385 (CREB1)
  09165 Substance dependence
   05030 Cocaine addiction
    1385 (CREB1)
   05031 Amphetamine addiction
    1385 (CREB1)
   05034 Alcoholism
    1385 (CREB1)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    1385 (CREB1)
   04934 Cushing syndrome
    1385 (CREB1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    1385 (CREB1)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    1385 (CREB1)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   CREB
    1385 (CREB1)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Ubiquitas transcription factors
    1385 (CREB1)
SSDB
Motif
Pfam: pKID bZIP_1 bZIP_2 bZIP_Maf ASD2
Other DBs
NCBI-GeneID: 1385
NCBI-ProteinID: NP_004370
OMIM: 123810
HGNC: 2345
Ensembl: ENSG00000118260
UniProt: P16220 Q53X93
Structure
LinkDB
Position
2:207529962..207605988
AA seq 327 aa
MTMESGAENQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPN
GQTVQVHGVIQAAQPSVIQSPQVQTVQISTIAESEDSQESVDSVTDSQKRREILSRRPSY
RKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYIAITQGGAIQLA
NNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQVVVQAASGDVQTYQI
RTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENR
VAVLENQNKTLIEELKALKDLYCHKSD
NT seq 984 nt   +upstreamnt  +downstreamnt
atgaccatggaatctggagccgagaaccagcagagtggagatgcagctgtaacagaagct
gaaaaccaacaaatgacagttcaagcccagccacagattgccacattagcccaggtatct
atgccagcagctcatgcaacatcatctgctcccaccgtaactctagtacagctgcccaat
gggcagacagttcaagtccatggagtcattcaggcggcccagccatcagttattcagtct
ccacaagtccaaacagttcagatttcaactattgcagaaagtgaagattcacaggagtca
gtggatagtgtaactgattcccaaaagcgaagggaaattctttcaaggaggccttcctac
aggaaaattttgaatgacttatcttctgatgcaccaggagtgccaaggattgaagaagag
aagtctgaagaggagacttcagcacctgccatcaccactgtaacggtgccaactccaatt
taccaaactagcagtggacagtatattgccattacccagggaggagcaatacagctggct
aacaatggtaccgatggggtacagggcctgcaaacattaaccatgaccaatgcagcagcc
actcagccgggtactaccattctacagtatgcacagaccactgatggacagcagatctta
gtgcccagcaaccaagttgttgttcaagctgcctctggagacgtacaaacataccagatt
cgcacagcacccactagcactattgcccctggagttgttatggcatcctccccagcactt
cctacacagcctgctgaagaagcagcacgaaagagagaggtccgtctaatgaagaacagg
gaagcagctcgagagtgtcgtagaaagaagaaagaatatgtgaaatgtttagaaaacaga
gtggcagtgcttgaaaatcaaaacaagacattgattgaggagctaaaagcacttaaggac
ctttactgccacaaatcagattaa

KEGG   Homo sapiens (human): 1386
Entry
1386              CDS       T01001                                 
Symbol
ATF2, CRE-BP1, CREB-2, CREB2, HB16, TREB7
Name
(RefSeq) activating transcription factor 2
  KO
K04450  cyclic AMP-dependent transcription factor ATF-2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04211  Longevity regulating pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04668  TNF signaling pathway
hsa04714  Thermogenesis
hsa04728  Dopaminergic synapse
hsa04911  Insulin secretion
hsa04915  Estrogen signaling pathway
hsa04918  Thyroid hormone synthesis
hsa04922  Glucagon signaling pathway
hsa04925  Aldosterone synthesis and secretion
hsa04926  Relaxin signaling pathway
hsa04927  Cortisol synthesis and secretion
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04934  Cushing syndrome
hsa04935  Growth hormone synthesis, secretion and action
hsa05020  Prion disease
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05034  Alcoholism
hsa05161  Hepatitis B
hsa05163  Human cytomegalovirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05203  Viral carcinogenesis
hsa05207  Chemical carcinogenesis - receptor activation
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06167  Human cytomegalovirus (HCMV)
nt06180  Pathogenic Escherichia coli
nt06210  ERK signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06310  CRH-ACTH-cortisol signaling
nt06316  Renin-angiotensin-aldosterone signaling
nt06322  TRH-TSH-TH signaling
nt06324  GHRH-GH-IGF signaling
nt06360  Cushing syndrome
nt06461  Huntington disease
nt06465  Prion disease
nt06516  TNF signaling
  Element
N00297  ACTH-cortisol signaling pathway
N00298  CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00301  Angiotensin-aldosterone signaling pathway
N00302  Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
N00303  Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N00304  Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
N00305  Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
N00320  Mutation-activated PRKACA to ACTH-cortisol signaling pathway
N00321  Mutation-activated GNAS to ACTH-cortisol signaling pathway
N00322  Mutation-inactivated PRKAR1A to ACTH-cortisol signaling pathway
N00323  Mutation-inactivated PDE11A/PDE8B to ACTH-cortisol signaling pathway
N00324  CRHR-PKA-ACTH signaling pathway
N00325  Mutation-inactivated RASD1 to CRHR-PKA-ACTH signaling pathway
N00326  Mutation-activated GNAS to CRHR-PKA-ACTH signaling pathway
N00327  Mutation-inactivated PRKAR1A to CRHR-PKA-ACTH signaling pathway
N00410  DRD1-GNAS-AC-PKA signaling pathway
N00444  TNF-p38 signaling pathway
N00544  HBV HBx to CREB-mediated transcription
N00782  TSH-TG signaling pathway
N00910  GHRHR-PKA-GH signaling pathway
N00981  Mutation-caused aberrant Htt to CREB-mediated transcription
N01204  PRNP-PI3K-NOX2 signaling pathway
N01343  ACH-CHRN-RAS-ERK signaling pathway
N01351  E2-ER-RAS-ERK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    1386 (ATF2)
   04668 TNF signaling pathway
    1386 (ATF2)
   04022 cGMP-PKG signaling pathway
    1386 (ATF2)
   04151 PI3K-Akt signaling pathway
    1386 (ATF2)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    1386 (ATF2)
   04922 Glucagon signaling pathway
    1386 (ATF2)
   04915 Estrogen signaling pathway
    1386 (ATF2)
   04926 Relaxin signaling pathway
    1386 (ATF2)
   04935 Growth hormone synthesis, secretion and action
    1386 (ATF2)
   04918 Thyroid hormone synthesis
    1386 (ATF2)
   04928 Parathyroid hormone synthesis, secretion and action
    1386 (ATF2)
   04925 Aldosterone synthesis and secretion
    1386 (ATF2)
   04927 Cortisol synthesis and secretion
    1386 (ATF2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    1386 (ATF2)
  09156 Nervous system
   04728 Dopaminergic synapse
    1386 (ATF2)
  09149 Aging
   04211 Longevity regulating pathway
    1386 (ATF2)
  09159 Environmental adaptation
   04714 Thermogenesis
    1386 (ATF2)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    1386 (ATF2)
   05203 Viral carcinogenesis
    1386 (ATF2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    1386 (ATF2)
   05161 Hepatitis B
    1386 (ATF2)
   05163 Human cytomegalovirus infection
    1386 (ATF2)
  09164 Neurodegenerative disease
   05020 Prion disease
    1386 (ATF2)
  09165 Substance dependence
   05030 Cocaine addiction
    1386 (ATF2)
   05031 Amphetamine addiction
    1386 (ATF2)
   05034 Alcoholism
    1386 (ATF2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    1386 (ATF2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    1386 (ATF2)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   AP-1(-like) components, CRE-BP/ATF
    1386 (ATF2)
SSDB
Motif
Pfam: bZIP_1 bZIP_2 bZIP_Maf zf-C2H2 Herpes_UL16
Other DBs
NCBI-GeneID: 1386
NCBI-ProteinID: NP_001243019
OMIM: 123811
HGNC: 784
Ensembl: ENSG00000115966
UniProt: P15336
Structure
LinkDB
Position
2:complement(175072259..175168203)
AA seq 505 aa
MKFKLHVNSARQYKDLWNMSDDKPFLCTAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARN
DSVIVADQTPTPTRFLKNCEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIR
SKIEEPSVVETTHQDSPLPHPESTTSDEKEVPLAQTAQPTSAIVRPASLQVPNVLLTSSD
SSVIIQQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITSSNV
HVPAAVPLVRPVTMVPSVPGIPGPSSPQPVQSEAKMRLKAALTQQHPPVTNGDTVKGHGS
GLVRTQSEESRPQSLQQPATSTTETPASPAHTTPQTQSTSGRRRRAANEDPDEKRRKFLE
RNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQLLLAHKDCPV
TAMQKKSGYHTADKDDSSEDISVPSSPHTEAIQHSSVSTSNGVSSTSKAEAVATSVLTQM
ADQSTEPALSQIVMAPSSQSQPSGS
NT seq 1518 nt   +upstreamnt  +downstreamnt
atgaaattcaagttacatgtgaattctgccaggcaatacaaggacctgtggaatatgagt
gatgacaaaccctttctatgtactgcgcctggatgtggccagcgttttaccaacgaggat
catttggctgtccataaacataaacatgagatgacactgaaatttggtccagcacgtaat
gacagtgtcattgtggctgatcagaccccaacaccaacaagattcttgaaaaactgtgaa
gaagtgggtttgtttaatgagttggcgagtccatttgagaatgaattcaagaaagcttca
gaagatgacattaaaaaaatgcctctagatttatcccctcttgcaacacctatcataaga
agcaaaattgaggagccttctgttgtagaaacaactcaccaggatagtcctttacctcac
ccagagtctactaccagtgatgagaaggaagtaccattggcacaaactgcacagcccaca
tcagctattgttcgtccagcatcattacaggttcccaatgtgctgcttacaagttctgac
tcaagtgtaattattcagcaggcagtaccttcaccaacctcaagtactgtaatcacccag
gcaccatcctctaacaggccaattgtccctgtaccaggcccatttcctcttctgttacat
cttcctaatggacaaaccatgcctgttgctattcctgcatcaattacaagttctaatgtg
catgttccagctgcagtcccactcgttcgaccagtcaccatggtgcctagtgttccagga
atcccaggtccttcctctccccaaccagtacagtcagaagcaaaaatgagattaaaagct
gctttgacccagcaacatcctccagttaccaatggtgatactgtcaaaggtcatggtagc
ggattggttaggactcagtcagaggaatctcgaccgcagtcattacaacagccagccaca
tccactacagaaactccggcttctccagctcacacaactccacagacccaaagtacaagt
ggtcgtcggagaagagcagctaacgaagatcctgatgaaaaaaggagaaagtttttagag
cgaaatagagcagcagcttcaagatgccgacaaaaaaggaaagtctgggttcagtcttta
gagaagaaagctgaagacttgagttcattaaatggtcagctgcagagtgaagtcaccctg
ctgagaaatgaagtggcacagctgaaacagcttcttctggctcataaagattgccctgta
accgccatgcagaagaaatctggctatcatactgctgataaagatgatagttcagaagac
atttcagtgccgagtagtccacatacagaagctatacagcatagttcggtcagcacatcc
aatggagtcagttcaacctccaaggcagaagctgtagccacttcagtcctcacccagatg
gcggaccagagtacagagcctgctctttcacagatcgttatggctccttcctcccagtca
cagccctcaggaagttga

KEGG   Homo sapiens (human): 1388
Entry
1388              CDS       T01001                                 
Symbol
ATF6B, ATF6beta, CREB-RP, CREBL1, G13
Name
(RefSeq) activating transcription factor 6 beta
  KO
K09049  cyclic AMP-dependent transcription factor ATF-6 beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04141  Protein processing in endoplasmic reticulum
hsa04151  PI3K-Akt signaling pathway
hsa04211  Longevity regulating pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04668  TNF signaling pathway
hsa04728  Dopaminergic synapse
hsa04911  Insulin secretion
hsa04915  Estrogen signaling pathway
hsa04918  Thyroid hormone synthesis
hsa04925  Aldosterone synthesis and secretion
hsa04926  Relaxin signaling pathway
hsa04927  Cortisol synthesis and secretion
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04934  Cushing syndrome
hsa04935  Growth hormone synthesis, secretion and action
hsa05020  Prion disease
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05034  Alcoholism
hsa05161  Hepatitis B
hsa05163  Human cytomegalovirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05203  Viral carcinogenesis
hsa05207  Chemical carcinogenesis - receptor activation
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06167  Human cytomegalovirus (HCMV)
nt06180  Pathogenic Escherichia coli
nt06210  ERK signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06310  CRH-ACTH-cortisol signaling
nt06316  Renin-angiotensin-aldosterone signaling
nt06322  TRH-TSH-TH signaling
nt06324  GHRH-GH-IGF signaling
nt06360  Cushing syndrome
nt06461  Huntington disease
nt06465  Prion disease
nt06516  TNF signaling
  Element
N00297  ACTH-cortisol signaling pathway
N00298  CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00301  Angiotensin-aldosterone signaling pathway
N00302  Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
N00303  Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N00304  Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
N00305  Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
N00320  Mutation-activated PRKACA to ACTH-cortisol signaling pathway
N00321  Mutation-activated GNAS to ACTH-cortisol signaling pathway
N00322  Mutation-inactivated PRKAR1A to ACTH-cortisol signaling pathway
N00323  Mutation-inactivated PDE11A/PDE8B to ACTH-cortisol signaling pathway
N00324  CRHR-PKA-ACTH signaling pathway
N00325  Mutation-inactivated RASD1 to CRHR-PKA-ACTH signaling pathway
N00326  Mutation-activated GNAS to CRHR-PKA-ACTH signaling pathway
N00327  Mutation-inactivated PRKAR1A to CRHR-PKA-ACTH signaling pathway
N00410  DRD1-GNAS-AC-PKA signaling pathway
N00444  TNF-p38 signaling pathway
N00544  HBV HBx to CREB-mediated transcription
N00782  TSH-TG signaling pathway
N00910  GHRHR-PKA-GH signaling pathway
N00981  Mutation-caused aberrant Htt to CREB-mediated transcription
N01204  PRNP-PI3K-NOX2 signaling pathway
N01343  ACH-CHRN-RAS-ERK signaling pathway
N01351  E2-ER-RAS-ERK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    1388 (ATF6B)
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    1388 (ATF6B)
   04022 cGMP-PKG signaling pathway
    1388 (ATF6B)
   04151 PI3K-Akt signaling pathway
    1388 (ATF6B)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    1388 (ATF6B)
   04915 Estrogen signaling pathway
    1388 (ATF6B)
   04926 Relaxin signaling pathway
    1388 (ATF6B)
   04935 Growth hormone synthesis, secretion and action
    1388 (ATF6B)
   04918 Thyroid hormone synthesis
    1388 (ATF6B)
   04928 Parathyroid hormone synthesis, secretion and action
    1388 (ATF6B)
   04925 Aldosterone synthesis and secretion
    1388 (ATF6B)
   04927 Cortisol synthesis and secretion
    1388 (ATF6B)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    1388 (ATF6B)
  09156 Nervous system
   04728 Dopaminergic synapse
    1388 (ATF6B)
  09149 Aging
   04211 Longevity regulating pathway
    1388 (ATF6B)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    1388 (ATF6B)
   05203 Viral carcinogenesis
    1388 (ATF6B)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    1388 (ATF6B)
   05161 Hepatitis B
    1388 (ATF6B)
   05163 Human cytomegalovirus infection
    1388 (ATF6B)
  09164 Neurodegenerative disease
   05020 Prion disease
    1388 (ATF6B)
  09165 Substance dependence
   05030 Cocaine addiction
    1388 (ATF6B)
   05031 Amphetamine addiction
    1388 (ATF6B)
   05034 Alcoholism
    1388 (ATF6B)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    1388 (ATF6B)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    1388 (ATF6B)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   CREB
    1388 (ATF6B)
SSDB
Motif
Pfam: bZIP_1 bZIP_2 bZIP_Maf DUF4407 GIT_CC ZapB YabA Docking
Other DBs
NCBI-GeneID: 1388
NCBI-ProteinID: NP_004372
OMIM: 600984
HGNC: 2349
Ensembl: ENSG00000213676
UniProt: Q99941 Q6AZW6
LinkDB
Position
6:complement(32115264..32128246)
AA seq 703 aa
MAELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDG
SSLDVGMDVSPSEPPWELLPIFPDLQVKSEPSSPCSSSSLSSESSRLSTEPSSEALGVGE
VLHVKTESLAPPLCLLGDDPTSSFETVQINVIPTSDDSSDVQTKIEPVSPCSSVNSEASL
LSADSSSQAFIGEEVLEVKTESLSPSGCLLWDVPAPSLGAVQISMGPSLDGSSGKALPTR
KPPLQPKPVVLTTVPMPSRAVPPSTTVLLQSLVQPPPVSPVVLIQGAIRVQPEGPAPSLP
RPERKSIVPAPMPGNSCPPEVDAKLLKRQQRMIKNRESACQSRRKKKEYLQGLEARLQAV
LADNQQLRRENAALRRRLEALLAENSELKLGSGNRKVVCIMVFLLFIAFNFGPVSISEPP
SAPISPRMNKGEPQPRRHLLGFSEQEPVQGVEPLQGSSQGPKEPQPSPTDQPSFSNLTAF
PGGAKELLLRDLDQLFLSSDCRHFNRTESLRLADELSGWVQRHQRGRRKIPQRAQERQKS
QPRKKSPPVKAVPIQPPGPPERDSVGQLQLYRHPDRSQPAFLDAIDRREDTFYVVSFRRD
HLLLPAISHNKTSRPKMSLVMPAMAPNETLSGRGAPGDYEEMMQIECEVMDTRVIHIKTS
TVPPSLRKQPSPTPGNATGGPLPVSAASQAHQASHQPLYLNHP
NT seq 2112 nt   +upstreamnt  +downstreamnt
atggcggagctgatgctgctcagcgagattgctgacccgacgcgtttcttcaccgacaac
ctgcttagcccggaggactggggtctgcagaacagcaccttgtattctggcctagatgaa
gtggccgaggagcagacgcagctcttccgttgcccggagcaggatgtcccgtttgacggc
agctccctggacgtggggatggatgtcagcccctctgagcccccatgggaactcctgccg
atcttcccagatcttcaggtgaagtctgagccatcttccccctgctcttcctcctccctc
agctccgagtcatcgcgtctctccacagagccatccagcgaggctcttggggtaggggag
gtgctccatgtgaagacagagtccttggcacccccactgtgtctcctgggagatgaccca
acatcctcatttgaaaccgtccagatcaacgttatccccacctctgatgattcctcagat
gtccagaccaagatagaacctgtctctccatgttcttccgtcaactctgaggcctccctg
ctctcagccgactcctccagccaggcttttataggagaggaggtcctggaagtgaagaca
gagtccctgtccccttcaggatgcctcctgtgggatgtcccagccccctcacttggagct
gtccagatcagcatgggcccatcccttgatggctcctcaggcaaagccctgcccacccgg
aagccgccactgcagcccaaacctgtagtgctaaccactgtcccaatgccatccagagct
gtgcctcccagcaccacagtccttctgcagtccctcgtccagccacccccagtgtcccca
gttgtcctcatccagggtgctattcgagtccagcctgaagggccggctccctctctacca
cggcctgagaggaagagcatcgttcccgctcctatgcctggaaactcctgcccgcctgaa
gtggatgcaaagctgctgaagcggcagcagcgaatgatcaagaaccgggagtcagcctgc
cagtcccggagaaagaagaaagagtatctgcagggactggaggctcggctgcaagcagta
ctggctgacaaccagcagctccgccgagagaatgctgccctccggcggcggctggaggcc
ctgctggctgaaaacagcgagctcaagttagggtctggaaacaggaaggtggtctgcatc
atggtcttccttctcttcattgccttcaactttggacctgtcagcatcagtgagcctcct
tcagctcccatctctcctcggatgaacaagggggagcctcaaccccggagacacttgctg
gggttctcagagcaagagccagttcagggagttgaacctctccaggggtcctcccagggc
cctaaggagccccagcccagccccacagaccagcccagtttcagcaacctgacagccttc
cctgggggcgccaaggagctactactaagagacctagaccagctcttcctctcctctgat
tgccggcacttcaaccgcactgagtccctgaggcttgctgacgagttgagtggctgggtc
cagcgccaccagagaggccggaggaagatccctcagagggcccaggagagacagaagtct
cagccacggaagaagtcacctccagttaaggcagtccccatccaaccccctggaccccca
gaaagggattctgtgggccagctgcaactatatcgccacccagaccgttcgcagccagca
ttcttggatgcaattgaccgacgggaagacacattttatgttgtctctttccgaagggac
cacctgctgctcccagccatcagccacaacaagacctcccggcccaagatgtccctggtg
atgcctgccatggcccccaatgagaccctgtcaggccgtggggccccgggggactatgag
gagatgatgcagatcgagtgtgaggtcatggacaccagggtgattcacatcaagacctcc
acagtgcccccctcgctccgaaaacagccatccccaaccccaggcaatgccacaggtggc
cccttgccagtctctgcagccagccaggcccaccaggcctcccaccagcccctctacctc
aatcatccctga

KEGG   Homo sapiens (human): 148327
Entry
148327            CDS       T01001                                 
Symbol
CREB3L4, AIBZIP, ATCE1, CREB3, CREB4, JAL, hJAL
Name
(RefSeq) cAMP responsive element binding protein 3 like 4
  KO
K09048  cyclic AMP-responsive element-binding protein 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04211  Longevity regulating pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04668  TNF signaling pathway
hsa04714  Thermogenesis
hsa04725  Cholinergic synapse
hsa04728  Dopaminergic synapse
hsa04911  Insulin secretion
hsa04915  Estrogen signaling pathway
hsa04916  Melanogenesis
hsa04918  Thyroid hormone synthesis
hsa04922  Glucagon signaling pathway
hsa04925  Aldosterone synthesis and secretion
hsa04926  Relaxin signaling pathway
hsa04927  Cortisol synthesis and secretion
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04931  Insulin resistance
hsa04934  Cushing syndrome
hsa04935  Growth hormone synthesis, secretion and action
hsa04962  Vasopressin-regulated water reabsorption
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05034  Alcoholism
hsa05161  Hepatitis B
hsa05163  Human cytomegalovirus infection
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05203  Viral carcinogenesis
hsa05207  Chemical carcinogenesis - receptor activation
hsa05215  Prostate cancer
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06167  Human cytomegalovirus (HCMV)
nt06180  Pathogenic Escherichia coli
nt06210  ERK signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06310  CRH-ACTH-cortisol signaling
nt06316  Renin-angiotensin-aldosterone signaling
nt06322  TRH-TSH-TH signaling
nt06324  GHRH-GH-IGF signaling
nt06360  Cushing syndrome
nt06461  Huntington disease
nt06465  Prion disease
nt06516  TNF signaling
  Element
N00297  ACTH-cortisol signaling pathway
N00298  CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00301  Angiotensin-aldosterone signaling pathway
N00302  Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
N00303  Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N00304  Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
N00305  Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
N00320  Mutation-activated PRKACA to ACTH-cortisol signaling pathway
N00321  Mutation-activated GNAS to ACTH-cortisol signaling pathway
N00322  Mutation-inactivated PRKAR1A to ACTH-cortisol signaling pathway
N00323  Mutation-inactivated PDE11A/PDE8B to ACTH-cortisol signaling pathway
N00324  CRHR-PKA-ACTH signaling pathway
N00325  Mutation-inactivated RASD1 to CRHR-PKA-ACTH signaling pathway
N00326  Mutation-activated GNAS to CRHR-PKA-ACTH signaling pathway
N00327  Mutation-inactivated PRKAR1A to CRHR-PKA-ACTH signaling pathway
N00410  DRD1-GNAS-AC-PKA signaling pathway
N00444  TNF-p38 signaling pathway
N00544  HBV HBx to CREB-mediated transcription
N00782  TSH-TG signaling pathway
N00910  GHRHR-PKA-GH signaling pathway
N00981  Mutation-caused aberrant Htt to CREB-mediated transcription
N01204  PRNP-PI3K-NOX2 signaling pathway
N01343  ACH-CHRN-RAS-ERK signaling pathway
N01351  E2-ER-RAS-ERK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    148327 (CREB3L4)
   04024 cAMP signaling pathway
    148327 (CREB3L4)
   04022 cGMP-PKG signaling pathway
    148327 (CREB3L4)
   04151 PI3K-Akt signaling pathway
    148327 (CREB3L4)
   04152 AMPK signaling pathway
    148327 (CREB3L4)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    148327 (CREB3L4)
   04922 Glucagon signaling pathway
    148327 (CREB3L4)
   04915 Estrogen signaling pathway
    148327 (CREB3L4)
   04926 Relaxin signaling pathway
    148327 (CREB3L4)
   04935 Growth hormone synthesis, secretion and action
    148327 (CREB3L4)
   04918 Thyroid hormone synthesis
    148327 (CREB3L4)
   04928 Parathyroid hormone synthesis, secretion and action
    148327 (CREB3L4)
   04916 Melanogenesis
    148327 (CREB3L4)
   04925 Aldosterone synthesis and secretion
    148327 (CREB3L4)
   04927 Cortisol synthesis and secretion
    148327 (CREB3L4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    148327 (CREB3L4)
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    148327 (CREB3L4)
  09156 Nervous system
   04725 Cholinergic synapse
    148327 (CREB3L4)
   04728 Dopaminergic synapse
    148327 (CREB3L4)
  09149 Aging
   04211 Longevity regulating pathway
    148327 (CREB3L4)
  09159 Environmental adaptation
   04714 Thermogenesis
    148327 (CREB3L4)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    148327 (CREB3L4)
   05203 Viral carcinogenesis
    148327 (CREB3L4)
  09162 Cancer: specific types
   05215 Prostate cancer
    148327 (CREB3L4)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    148327 (CREB3L4)
   05161 Hepatitis B
    148327 (CREB3L4)
   05163 Human cytomegalovirus infection
    148327 (CREB3L4)
   05165 Human papillomavirus infection
    148327 (CREB3L4)
  09164 Neurodegenerative disease
   05016 Huntington disease
    148327 (CREB3L4)
   05020 Prion disease
    148327 (CREB3L4)
  09165 Substance dependence
   05030 Cocaine addiction
    148327 (CREB3L4)
   05031 Amphetamine addiction
    148327 (CREB3L4)
   05034 Alcoholism
    148327 (CREB3L4)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    148327 (CREB3L4)
   04934 Cushing syndrome
    148327 (CREB3L4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    148327 (CREB3L4)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   CREB
    148327 (CREB3L4)
SSDB
Motif
Pfam: bZIP_1 bZIP_2 bZIP_Maf ZapB OppC_N DUF4407 HAUS-augmin3 ATG16 KASH_CCD APG6_N DUF1664
Other DBs
NCBI-GeneID: 148327
NCBI-ProteinID: NP_001242907
OMIM: 607138
HGNC: 18854
Ensembl: ENSG00000143578
UniProt: Q8TEY5
LinkDB
Position
1:153967487..153974359
AA seq 395 aa
MDLGIPDLLDAWLEPPEDIFSTGSVLELGLHCPPPEVPVTRLQEQGLQGWKSGGDRGCGL
QESEPEDFLKLFIDPNEVYCSEASPGSDSGISEDPCHPDSPPAPRATSSPMLYEVVYEAG
ALERMQGETGPNVGLISIQLDQWSPAFMVPDSCMVSELPFDAHAHILPRAGTVAPVPCTT
LLPCQTLFLTDEEKRLLGQEGVSLPSHLPLTKAEERVLKKVRRKIRNKQSAQDSRRRKKE
YIDGLESRVAACSAQNQELQKKVQELERHNISLVAQLRQLQTLIAQTSNKAAQTSTCVLI
LLFSLALIILPSFSPFQSRPEAGSEDYQPHGVTSRNILTHKDVTENLETQVVESRLREPP
GAKDANGSTRTLLEKMGGKPRPSGRIRSVLHADEM
NT seq 1188 nt   +upstreamnt  +downstreamnt
atggatctcggaatccctgacctgctggacgcgtggctggagcccccagaggatatcttc
tcgacaggatccgtcctggagctgggactccactgcccccctccagaggttccggtaact
aggctacaggaacagggactgcaaggctggaagtccggtggggaccgtggctgtggcctt
caagagagtgagcctgaagatttcttgaagcttttcattgatcccaatgaggtgtactgc
tcagaagcatctcctggcagtgacagtggcatctctgaggacccctgccatccagacagt
ccccctgcccccagggcaaccagttctcctatgctctatgaggttgtctatgaggcaggg
gccctggagaggatgcagggggaaactgggccaaatgtaggccttatctccatccagcta
gatcagtggagcccagcatttatggtgcctgattcctgcatggtcagtgagctgcccttt
gatgctcatgcccacatcctgcccagagcaggcaccgtagccccagtgccctgtacaacc
ctgctgccctgtcaaaccctgttcctgaccgatgaggagaagcgtctgctggggcaggaa
ggggtttccctgccctctcacctgcccctcaccaaggcagaggagagggtcctcaagaag
gtcaggaggaaaatccgtaacaagcagtcagctcaggacagtcggcggcggaagaaggag
tacattgatgggctggagagcagggtggcagcctgttctgcacagaaccaagaattacag
aaaaaagtccaggagctggagaggcacaacatctccttggtagctcagctccgccagctg
cagacgctaattgctcaaacttccaacaaagctgcccagaccagcacttgtgttttgatt
cttcttttttccctggctctcatcatcctgcccagcttcagtccattccagagtcgacca
gaagctgggtctgaggattaccagcctcacggagtgacttccagaaatatcctgacccac
aaggacgtaacagaaaatctggagacccaagtggtagagtccagactgagggagccacct
ggagccaaggatgcaaatggctcaacaaggacactgcttgagaagatgggagggaagcca
agacccagtgggcgcatccggtccgtgctgcatgcagatgagatgtga

KEGG   Homo sapiens (human): 468
Entry
468               CDS       T01001                                 
Symbol
ATF4, CREB-2, CREB2, TAXREB67, TXREB
Name
(RefSeq) activating transcription factor 4
  KO
K04374  cyclic AMP-dependent transcription factor ATF-4
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04137  Mitophagy - animal
hsa04141  Protein processing in endoplasmic reticulum
hsa04151  PI3K-Akt signaling pathway
hsa04210  Apoptosis
hsa04211  Longevity regulating pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04668  TNF signaling pathway
hsa04720  Long-term potentiation
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04728  Dopaminergic synapse
hsa04911  Insulin secretion
hsa04912  GnRH signaling pathway
hsa04915  Estrogen signaling pathway
hsa04918  Thyroid hormone synthesis
hsa04922  Glucagon signaling pathway
hsa04925  Aldosterone synthesis and secretion
hsa04926  Relaxin signaling pathway
hsa04927  Cortisol synthesis and secretion
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04932  Non-alcoholic fatty liver disease
hsa04934  Cushing syndrome
hsa04935  Growth hormone synthesis, secretion and action
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05034  Alcoholism
hsa05161  Hepatitis B
hsa05163  Human cytomegalovirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05203  Viral carcinogenesis
hsa05207  Chemical carcinogenesis - receptor activation
hsa05215  Prostate cancer
hsa05417  Lipid and atherosclerosis
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06167  Human cytomegalovirus (HCMV)
nt06180  Pathogenic Escherichia coli
nt06210  ERK signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06310  CRH-ACTH-cortisol signaling
nt06316  Renin-angiotensin-aldosterone signaling
nt06322  TRH-TSH-TH signaling
nt06324  GHRH-GH-IGF signaling
nt06360  Cushing syndrome
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
nt06466  Pathways of neurodegeneration
nt06516  TNF signaling
nt06534  Unfolded protein response
  Element
N00297  ACTH-cortisol signaling pathway
N00298  CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00301  Angiotensin-aldosterone signaling pathway
N00302  Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
N00303  Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N00304  Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
N00305  Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
N00320  Mutation-activated PRKACA to ACTH-cortisol signaling pathway
N00321  Mutation-activated GNAS to ACTH-cortisol signaling pathway
N00322  Mutation-inactivated PRKAR1A to ACTH-cortisol signaling pathway
N00323  Mutation-inactivated PDE11A/PDE8B to ACTH-cortisol signaling pathway
N00324  CRHR-PKA-ACTH signaling pathway
N00325  Mutation-inactivated RASD1 to CRHR-PKA-ACTH signaling pathway
N00326  Mutation-activated GNAS to CRHR-PKA-ACTH signaling pathway
N00327  Mutation-inactivated PRKAR1A to CRHR-PKA-ACTH signaling pathway
N00410  DRD1-GNAS-AC-PKA signaling pathway
N00444  TNF-p38 signaling pathway
N00544  HBV HBx to CREB-mediated transcription
N00782  TSH-TG signaling pathway
N00910  GHRHR-PKA-GH signaling pathway
N00981  Mutation-caused aberrant Htt to CREB-mediated transcription
N01009  PERK-ATF4 signaling pathway
N01010  Mutation-caused aberrant PSEN1 to PERK-ATF4 signaling pathway
N01035  Mutation-caused aberrant SNCA to PERK-ATF4 signaling pathway
N01149  Mutation-caused aberrant SOD1 to PERK-ATF4 signaling pathway
N01198  Scrapie conformation PrPSc to PERK-ATF4 signaling pathway
N01204  PRNP-PI3K-NOX2 signaling pathway
N01343  ACH-CHRN-RAS-ERK signaling pathway
N01351  E2-ER-RAS-ERK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    468 (ATF4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    468 (ATF4)
   04668 TNF signaling pathway
    468 (ATF4)
   04022 cGMP-PKG signaling pathway
    468 (ATF4)
   04151 PI3K-Akt signaling pathway
    468 (ATF4)
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    468 (ATF4)
  09143 Cell growth and death
   04210 Apoptosis
    468 (ATF4)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    468 (ATF4)
   04922 Glucagon signaling pathway
    468 (ATF4)
   04912 GnRH signaling pathway
    468 (ATF4)
   04915 Estrogen signaling pathway
    468 (ATF4)
   04926 Relaxin signaling pathway
    468 (ATF4)
   04935 Growth hormone synthesis, secretion and action
    468 (ATF4)
   04918 Thyroid hormone synthesis
    468 (ATF4)
   04928 Parathyroid hormone synthesis, secretion and action
    468 (ATF4)
   04925 Aldosterone synthesis and secretion
    468 (ATF4)
   04927 Cortisol synthesis and secretion
    468 (ATF4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    468 (ATF4)
  09156 Nervous system
   04725 Cholinergic synapse
    468 (ATF4)
   04728 Dopaminergic synapse
    468 (ATF4)
   04720 Long-term potentiation
    468 (ATF4)
   04722 Neurotrophin signaling pathway
    468 (ATF4)
  09149 Aging
   04211 Longevity regulating pathway
    468 (ATF4)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    468 (ATF4)
   05203 Viral carcinogenesis
    468 (ATF4)
  09162 Cancer: specific types
   05215 Prostate cancer
    468 (ATF4)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    468 (ATF4)
   05161 Hepatitis B
    468 (ATF4)
   05163 Human cytomegalovirus infection
    468 (ATF4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    468 (ATF4)
   05012 Parkinson disease
    468 (ATF4)
   05014 Amyotrophic lateral sclerosis
    468 (ATF4)
   05020 Prion disease
    468 (ATF4)
   05022 Pathways of neurodegeneration - multiple diseases
    468 (ATF4)
  09165 Substance dependence
   05030 Cocaine addiction
    468 (ATF4)
   05031 Amphetamine addiction
    468 (ATF4)
   05034 Alcoholism
    468 (ATF4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    468 (ATF4)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    468 (ATF4)
   04934 Cushing syndrome
    468 (ATF4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    468 (ATF4)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   AP-1(-like) components, CRE-BP/ATF
    468 (ATF4)
SSDB
Motif
Pfam: bZIP_1 bZIP_2 DUF3450 DUF4407 Nop53 AAA_13 Laminin_II bZIP_Maf
Other DBs
NCBI-GeneID: 468
NCBI-ProteinID: NP_001666
OMIM: 604064
HGNC: 786
Ensembl: ENSG00000128272
UniProt: P18848
Structure
LinkDB
Position
22:39520559..39522686
AA seq 351 aa
MTEMSFLSSEVLVGDLMSPFDQSGLGAEESLGLLDDYLEVAKHFKPHGFSSDKAKAGSSE
WLAVDGLVSPSNNSKEDAFSGTDWMLEKMDLKEFDLDALLGIDDLETMPDDLLTTLDDTC
DLFAPLVQETNKQPPQTVNPIGHLPESLTKPDQVAPFTFLQPLPLSPGVLSSTPDHSFSL
ELGSEVDITEGDRKPDYTAYVAMIPQCIKEEDTPSDNDSGICMSPESYLGSPQHSPSTRG
SPNRSLPSPGVLCGSARPKPYDPPGEKMVAAKVKGEKLDKKLKKMEQNKTAATRYRQKKR
AEQEALTGECKELEKKNEALKERADSLAKEIQYLKDLIEEVRKARGKKRVP
NT seq 1056 nt   +upstreamnt  +downstreamnt
atgaccgaaatgagcttcctgagcagcgaggtgttggtgggggacttgatgtcccccttc
gaccagtcgggtttgggggctgaagaaagcctaggtctcttagatgattacctggaggtg
gccaagcacttcaaacctcatgggttctccagcgacaaggctaaggcgggctcctccgaa
tggctggctgtggatgggttggtcagtccctccaacaacagcaaggaggatgccttctcc
gggacagattggatgttggagaaaatggatttgaaggagttcgacttggatgccctgttg
ggtatagatgacctggaaaccatgccagatgaccttctgaccacgttggatgacacttgt
gatctctttgcccccctagtccaggagactaataagcagcccccccagacggtgaaccca
attggccatctcccagaaagtttaacaaaacccgaccaggttgcccccttcaccttctta
caacctcttcccctttccccaggggtcctgtcctccactccagatcattcctttagttta
gagctgggcagtgaagtggatatcactgaaggagataggaagccagactacactgcttac
gttgccatgatccctcagtgcataaaggaggaagacaccccttcagataatgatagtggc
atctgtatgagcccagagtcctatctggggtctcctcagcacagcccctctaccaggggc
tctccaaataggagcctcccatctccaggtgttctctgtgggtctgcccgtcccaaacct
tacgatcctcctggagagaagatggtagcagcaaaagtaaagggtgagaaactggataag
aagctgaaaaaaatggagcaaaacaagacagcagccactaggtaccgccagaagaagagg
gcggagcaggaggctcttactggtgagtgcaaagagctggaaaagaagaacgaggctcta
aaagagagggcggattccctggccaaggagatccagtacctgaaagatttgatagaagag
gtccgcaaggcaagggggaagaaaagggtcccctag

KEGG   Homo sapiens (human): 64764
Entry
64764             CDS       T01001                                 
Symbol
CREB3L2, BBF2H7
Name
(RefSeq) cAMP responsive element binding protein 3 like 2
  KO
K09048  cyclic AMP-responsive element-binding protein 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04211  Longevity regulating pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04668  TNF signaling pathway
hsa04714  Thermogenesis
hsa04725  Cholinergic synapse
hsa04728  Dopaminergic synapse
hsa04911  Insulin secretion
hsa04915  Estrogen signaling pathway
hsa04916  Melanogenesis
hsa04918  Thyroid hormone synthesis
hsa04922  Glucagon signaling pathway
hsa04925  Aldosterone synthesis and secretion
hsa04926  Relaxin signaling pathway
hsa04927  Cortisol synthesis and secretion
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04931  Insulin resistance
hsa04934  Cushing syndrome
hsa04935  Growth hormone synthesis, secretion and action
hsa04962  Vasopressin-regulated water reabsorption
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05034  Alcoholism
hsa05161  Hepatitis B
hsa05163  Human cytomegalovirus infection
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05203  Viral carcinogenesis
hsa05207  Chemical carcinogenesis - receptor activation
hsa05215  Prostate cancer
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06167  Human cytomegalovirus (HCMV)
nt06180  Pathogenic Escherichia coli
nt06210  ERK signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06310  CRH-ACTH-cortisol signaling
nt06316  Renin-angiotensin-aldosterone signaling
nt06322  TRH-TSH-TH signaling
nt06324  GHRH-GH-IGF signaling
nt06360  Cushing syndrome
nt06461  Huntington disease
nt06465  Prion disease
nt06516  TNF signaling
  Element
N00297  ACTH-cortisol signaling pathway
N00298  CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00301  Angiotensin-aldosterone signaling pathway
N00302  Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
N00303  Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N00304  Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
N00305  Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
N00320  Mutation-activated PRKACA to ACTH-cortisol signaling pathway
N00321  Mutation-activated GNAS to ACTH-cortisol signaling pathway
N00322  Mutation-inactivated PRKAR1A to ACTH-cortisol signaling pathway
N00323  Mutation-inactivated PDE11A/PDE8B to ACTH-cortisol signaling pathway
N00324  CRHR-PKA-ACTH signaling pathway
N00325  Mutation-inactivated RASD1 to CRHR-PKA-ACTH signaling pathway
N00326  Mutation-activated GNAS to CRHR-PKA-ACTH signaling pathway
N00327  Mutation-inactivated PRKAR1A to CRHR-PKA-ACTH signaling pathway
N00410  DRD1-GNAS-AC-PKA signaling pathway
N00444  TNF-p38 signaling pathway
N00544  HBV HBx to CREB-mediated transcription
N00782  TSH-TG signaling pathway
N00910  GHRHR-PKA-GH signaling pathway
N00981  Mutation-caused aberrant Htt to CREB-mediated transcription
N01204  PRNP-PI3K-NOX2 signaling pathway
N01343  ACH-CHRN-RAS-ERK signaling pathway
N01351  E2-ER-RAS-ERK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    64764 (CREB3L2)
   04024 cAMP signaling pathway
    64764 (CREB3L2)
   04022 cGMP-PKG signaling pathway
    64764 (CREB3L2)
   04151 PI3K-Akt signaling pathway
    64764 (CREB3L2)
   04152 AMPK signaling pathway
    64764 (CREB3L2)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    64764 (CREB3L2)
   04922 Glucagon signaling pathway
    64764 (CREB3L2)
   04915 Estrogen signaling pathway
    64764 (CREB3L2)
   04926 Relaxin signaling pathway
    64764 (CREB3L2)
   04935 Growth hormone synthesis, secretion and action
    64764 (CREB3L2)
   04918 Thyroid hormone synthesis
    64764 (CREB3L2)
   04928 Parathyroid hormone synthesis, secretion and action
    64764 (CREB3L2)
   04916 Melanogenesis
    64764 (CREB3L2)
   04925 Aldosterone synthesis and secretion
    64764 (CREB3L2)
   04927 Cortisol synthesis and secretion
    64764 (CREB3L2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    64764 (CREB3L2)
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    64764 (CREB3L2)
  09156 Nervous system
   04725 Cholinergic synapse
    64764 (CREB3L2)
   04728 Dopaminergic synapse
    64764 (CREB3L2)
  09149 Aging
   04211 Longevity regulating pathway
    64764 (CREB3L2)
  09159 Environmental adaptation
   04714 Thermogenesis
    64764 (CREB3L2)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    64764 (CREB3L2)
   05203 Viral carcinogenesis
    64764 (CREB3L2)
  09162 Cancer: specific types
   05215 Prostate cancer
    64764 (CREB3L2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    64764 (CREB3L2)
   05161 Hepatitis B
    64764 (CREB3L2)
   05163 Human cytomegalovirus infection
    64764 (CREB3L2)
   05165 Human papillomavirus infection
    64764 (CREB3L2)
  09164 Neurodegenerative disease
   05016 Huntington disease
    64764 (CREB3L2)
   05020 Prion disease
    64764 (CREB3L2)
  09165 Substance dependence
   05030 Cocaine addiction
    64764 (CREB3L2)
   05031 Amphetamine addiction
    64764 (CREB3L2)
   05034 Alcoholism
    64764 (CREB3L2)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    64764 (CREB3L2)
   04934 Cushing syndrome
    64764 (CREB3L2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    64764 (CREB3L2)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   CREB
    64764 (CREB3L2)
SSDB
Motif
Pfam: bZIP_1 bZIP_2 bZIP_Maf HAUS-augmin3 DUF2207_C JMY DUF4404
Other DBs
NCBI-GeneID: 64764
NCBI-ProteinID: NP_919047
OMIM: 608834
HGNC: 23720
Ensembl: ENSG00000182158
UniProt: Q70SY1 Q68D60
LinkDB
Position
7:complement(137874979..138002086)
AA seq 520 aa
MEVLESGEQGVLQWDRKLSELSEPGDGEALMYHTHFSELLDEFSQNVLGQLLNDPFLSEK
SVSMEVEPSPTSPAPLIQAEHSYSLCEEPRAQSPFTHITTSDSFNDDEVESEKWYLSTDF
PSTSIKTEPVTDEPPPGLVPSVTLTITAISTPLEKEEPPLEMNTGVDSSCQTIIPKIKLE
PHEVDQFLNFSPKEAPVDHLHLPPTPPSSHGSDSEGSLSPNPRLHPFSLPQTHSPSRAAP
RAPSALSSSPLLTAPHKLQGSGPLVLTEEEKRTLIAEGYPIPTKLPLSKSEEKALKKIRR
KIKNKISAQESRRKKKEYMDSLEKKVESCSTENLELRKKVEVLENTNRTLLQQLQKLQTL
VMGKVSRTCKLAGTQTGTCLMVVVLCFAVAFGSFFQGYGPYPSATKMALPSQHSLQEPYT
ASVVRSRNLLIYEEHSPPEESSSPGSAGELGGWDRGSSLLRVSGLESRPDVDLPHFIISN
ETSLEKSVLLELQQHLVSAKLEGNETLKVVELDRRVNTTF
NT seq 1563 nt   +upstreamnt  +downstreamnt
atggaggtgctggagagcggggagcagggcgtgctgcagtgggaccgcaagctgagcgag
ctgtcagagcccggggacggcgaggccctcatgtaccacacgcacttctcagaacttctg
gatgagttttcccagaacgtcttgggtcagctcctgaatgatcctttcctctcagagaag
agtgtgtcaatggaggtggaaccttccccgacgtccccggcgcctctcatccaggctgag
cacagctactccctgtgcgaggagcctcgggcccagtcgcccttcacccacattaccacc
agtgacagcttcaatgacgatgaggtggaaagtgagaaatggtacctgtctacagacttc
ccttcaacatccatcaagacagagccagttacagacgaaccacccccaggactcgttccg
tctgtcactctgaccatcacagccatctccaccccgttggaaaaggaggaacctcctctg
gaaatgaacactggggttgattcctcgtgccagaccattattcctaaaattaagctggag
cctcatgaagtggatcagtttctaaacttctctcctaaagaagccccagtggaccacctg
catttgccgcccacccctccgagcagtcacggcagtgactcagagggcagcctgagtccc
aacccacgcctgcaccccttcagcctgcctcagacccacagcccctccagagctgcaccc
cgggccccctccgccctctccagctcccctctcctcacggctcctcataaactgcaggga
tcaggccctctggtcctgacagaggaggagaagaggaccctgatcgctgagggctatccc
atccccaccaaattgcccctgtcaaaatcagaggagaaggccctgaagaaaattcggagg
aagatcaagaataagatttctgctcaggaaagtaggagaaagaagaaagaatacatggac
agcctggagaaaaaagtggagtcttgttcaactgagaacttggagcttcggaagaaggta
gaggttctagagaacactaataggactctccttcagcaactccagaagcttcagactttg
gtgatgggcaaggtttctcgaacctgcaagttagctggcacgcagactggcacctgcctc
atggttgtggtgctgtgctttgccgttgcattcggcagcttctttcaaggctacgggccc
tatccttctgccaccaagatggctctgcccagccagcattccctgcaggagccctacaca
gcctccgtggtgagatccagaaacctgctgatctacgaggaacattctcccccagaggag
tcatccagcccgggctcggctggggagctggggggctgggatagaggttcctccctgctc
agggtgtcagggctggagtccaggccggatgtggatcttccccatttcattatctcgaat
gagaccagcctggagaagtcagtgcttttggagctgcagcagcacctggtcagcgccaaa
ctggaggggaatgaaacactaaaagttgtagaactcgacagaagagtgaacaccactttc
taa

KEGG   Homo sapiens (human): 84699
Entry
84699             CDS       T01001                                 
Symbol
CREB3L3, CREB-H, CREBH, HYST1481, HYTG2
Name
(RefSeq) cAMP responsive element binding protein 3 like 3
  KO
K09048  cyclic AMP-responsive element-binding protein 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04211  Longevity regulating pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04668  TNF signaling pathway
hsa04714  Thermogenesis
hsa04725  Cholinergic synapse
hsa04728  Dopaminergic synapse
hsa04911  Insulin secretion
hsa04915  Estrogen signaling pathway
hsa04916  Melanogenesis
hsa04918  Thyroid hormone synthesis
hsa04922  Glucagon signaling pathway
hsa04925  Aldosterone synthesis and secretion
hsa04926  Relaxin signaling pathway
hsa04927  Cortisol synthesis and secretion
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04931  Insulin resistance
hsa04934  Cushing syndrome
hsa04935  Growth hormone synthesis, secretion and action
hsa04962  Vasopressin-regulated water reabsorption
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05034  Alcoholism
hsa05161  Hepatitis B
hsa05163  Human cytomegalovirus infection
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05203  Viral carcinogenesis
hsa05207  Chemical carcinogenesis - receptor activation
hsa05215  Prostate cancer
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06167  Human cytomegalovirus (HCMV)
nt06180  Pathogenic Escherichia coli
nt06210  ERK signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06310  CRH-ACTH-cortisol signaling
nt06316  Renin-angiotensin-aldosterone signaling
nt06322  TRH-TSH-TH signaling
nt06324  GHRH-GH-IGF signaling
nt06360  Cushing syndrome
nt06461  Huntington disease
nt06465  Prion disease
nt06516  TNF signaling
  Element
N00297  ACTH-cortisol signaling pathway
N00298  CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00301  Angiotensin-aldosterone signaling pathway
N00302  Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
N00303  Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N00304  Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
N00305  Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
N00320  Mutation-activated PRKACA to ACTH-cortisol signaling pathway
N00321  Mutation-activated GNAS to ACTH-cortisol signaling pathway
N00322  Mutation-inactivated PRKAR1A to ACTH-cortisol signaling pathway
N00323  Mutation-inactivated PDE11A/PDE8B to ACTH-cortisol signaling pathway
N00324  CRHR-PKA-ACTH signaling pathway
N00325  Mutation-inactivated RASD1 to CRHR-PKA-ACTH signaling pathway
N00326  Mutation-activated GNAS to CRHR-PKA-ACTH signaling pathway
N00327  Mutation-inactivated PRKAR1A to CRHR-PKA-ACTH signaling pathway
N00410  DRD1-GNAS-AC-PKA signaling pathway
N00444  TNF-p38 signaling pathway
N00544  HBV HBx to CREB-mediated transcription
N00782  TSH-TG signaling pathway
N00910  GHRHR-PKA-GH signaling pathway
N00981  Mutation-caused aberrant Htt to CREB-mediated transcription
N01204  PRNP-PI3K-NOX2 signaling pathway
N01343  ACH-CHRN-RAS-ERK signaling pathway
N01351  E2-ER-RAS-ERK signaling pathway
Disease
H01637  Hypertriglyceridemia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    84699 (CREB3L3)
   04024 cAMP signaling pathway
    84699 (CREB3L3)
   04022 cGMP-PKG signaling pathway
    84699 (CREB3L3)
   04151 PI3K-Akt signaling pathway
    84699 (CREB3L3)
   04152 AMPK signaling pathway
    84699 (CREB3L3)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    84699 (CREB3L3)
   04922 Glucagon signaling pathway
    84699 (CREB3L3)
   04915 Estrogen signaling pathway
    84699 (CREB3L3)
   04926 Relaxin signaling pathway
    84699 (CREB3L3)
   04935 Growth hormone synthesis, secretion and action
    84699 (CREB3L3)
   04918 Thyroid hormone synthesis
    84699 (CREB3L3)
   04928 Parathyroid hormone synthesis, secretion and action
    84699 (CREB3L3)
   04916 Melanogenesis
    84699 (CREB3L3)
   04925 Aldosterone synthesis and secretion
    84699 (CREB3L3)
   04927 Cortisol synthesis and secretion
    84699 (CREB3L3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    84699 (CREB3L3)
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    84699 (CREB3L3)
  09156 Nervous system
   04725 Cholinergic synapse
    84699 (CREB3L3)
   04728 Dopaminergic synapse
    84699 (CREB3L3)
  09149 Aging
   04211 Longevity regulating pathway
    84699 (CREB3L3)
  09159 Environmental adaptation
   04714 Thermogenesis
    84699 (CREB3L3)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    84699 (CREB3L3)
   05203 Viral carcinogenesis
    84699 (CREB3L3)
  09162 Cancer: specific types
   05215 Prostate cancer
    84699 (CREB3L3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    84699 (CREB3L3)
   05161 Hepatitis B
    84699 (CREB3L3)
   05163 Human cytomegalovirus infection
    84699 (CREB3L3)
   05165 Human papillomavirus infection
    84699 (CREB3L3)
  09164 Neurodegenerative disease
   05016 Huntington disease
    84699 (CREB3L3)
   05020 Prion disease
    84699 (CREB3L3)
  09165 Substance dependence
   05030 Cocaine addiction
    84699 (CREB3L3)
   05031 Amphetamine addiction
    84699 (CREB3L3)
   05034 Alcoholism
    84699 (CREB3L3)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    84699 (CREB3L3)
   04934 Cushing syndrome
    84699 (CREB3L3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    84699 (CREB3L3)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   CREB
    84699 (CREB3L3)
SSDB
Motif
Pfam: bZIP_1 bZIP_2 bZIP_Maf KASH_CCD Mit_KHE1 OppC_N pEK499_p136 ZapB DUF1664
Other DBs
NCBI-GeneID: 84699
NCBI-ProteinID: NP_115996
OMIM: 611998
HGNC: 18855
Ensembl: ENSG00000060566
UniProt: Q68CJ9
LinkDB
Position
19:4153631..4173054
AA seq 461 aa
MNTDLAAGKMASAACSMDPIDSFELLDLLFDRQDGILRHVELGEGWGHVKDQQVLPNPDS
DDFLSSILGSGDSLPSSPLWSPEGSDSGISEDLPSDPQDTPPRSGPATSPAGCHPAQPGK
GPCLSYHPGNSCSTTTPGPVIQVPEASVTIDLEMWSPGGRICAEKPADPVDLSPRCNLTV
KDLLLSGSSGDLQQHHLGASYLLRPGAGHCQELVLTEDEKKLLAKEGITLPTQLPLTKYE
ERVLKKIRRKIRNKQSAQESRKKKKEYIDGLETRMSACTAQNQELQRKVLHLEKQNLSLL
EQLKKLQAIVVQSTSKSAQTGTCVAVLLLSFALIILPSISPFGPNKTESPGDFAPVRVFS
RTLHNDAASRVAADAVPGSEAPGPRPEADTTREESPGSPGADWGFQDTANLTNSTEELDN
ATLVLRNATEGLGQVALLDWVAPGPSTGSGRAGLEAAGDEL
NT seq 1386 nt   +upstreamnt  +downstreamnt
atgaatacggatttagctgctggaaagatggcttctgctgcctgctccatggaccccatc
gacagctttgagctcctggatctcctgtttgaccggcaggacggcatcctgagacacgtg
gagctgggcgagggctggggtcacgtcaaggaccagcaggtcctgccaaaccccgactct
gacgacttcctcagctccatcctgggctctggagactcactgcccagctccccactctgg
tcccccgaaggcagtgatagtggcatctccgaagacctcccctccgacccccaggacacc
cctccacgcagcggaccagccacctcccccgccggctgccatcctgcccagcctggcaag
gggccctgcctctcctatcatcctggcaactcttgctccaccacaaccccagggccagtg
atccaagtacctgaagcctctgtgaccatagacctggaaatgtggagcccaggaggaagg
atctgtgctgagaagccggctgatccggtggacctgtccccacgatgcaatctcaccgtg
aaagacctcctcctttcgggcagcagtggggacctgcaacagcatcacctgggggcctcc
tacctcctgcgacctggggctgggcactgtcaggagctggtgctcaccgaggatgagaag
aagctgctggctaaagaaggcatcaccctgcccactcagctgcccctcactaagtacgag
gagcgagtgctgaaaaaaatccgccggaaaatccggaacaagcagtcggcgcaagaaagc
aggaagaagaagaaggaatatatcgatggcctggagactcggatgtcagcttgcactgct
cagaatcaggagttacagaggaaagtcttgcatctcgagaagcaaaacctgtccctcttg
gagcaactgaagaaactccaggccattgtggtgcagtccaccagcaagtcagcccagaca
ggcacctgtgtcgcagtcctgttgctgtcctttgccctcatcatcctcccctccatcagc
ccttttggccccaacaaaaccgagagccctggggactttgcgcctgtacgagtgttctcc
agaactttgcacaacgatgctgcctcccgcgtggctgctgatgctgtgccaggctccgag
gccccaggaccccgacccgaggctgacacaacccgagaagagtctccaggaagccccggg
gcagactggggcttccaggacaccgcgaacctgaccaattcgacggaggagctggacaac
gccaccctggtcctgaggaatgcaacagaggggctgggccaggtcgccctgctggactgg
gtggcgcctgggccgagcactggctcaggacgtgcagggctggaggcggcgggagacgag
ctgtga

KEGG   Homo sapiens (human): 90993
Entry
90993             CDS       T01001                                 
Symbol
CREB3L1, C16DELp11.2, DEL16p11.2, OASIS, OI16
Name
(RefSeq) cAMP responsive element binding protein 3 like 1
  KO
K09048  cyclic AMP-responsive element-binding protein 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04211  Longevity regulating pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04668  TNF signaling pathway
hsa04714  Thermogenesis
hsa04725  Cholinergic synapse
hsa04728  Dopaminergic synapse
hsa04911  Insulin secretion
hsa04915  Estrogen signaling pathway
hsa04916  Melanogenesis
hsa04918  Thyroid hormone synthesis
hsa04922  Glucagon signaling pathway
hsa04925  Aldosterone synthesis and secretion
hsa04926  Relaxin signaling pathway
hsa04927  Cortisol synthesis and secretion
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04931  Insulin resistance
hsa04934  Cushing syndrome
hsa04935  Growth hormone synthesis, secretion and action
hsa04962  Vasopressin-regulated water reabsorption
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05034  Alcoholism
hsa05161  Hepatitis B
hsa05163  Human cytomegalovirus infection
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05203  Viral carcinogenesis
hsa05207  Chemical carcinogenesis - receptor activation
hsa05215  Prostate cancer
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06167  Human cytomegalovirus (HCMV)
nt06180  Pathogenic Escherichia coli
nt06210  ERK signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06310  CRH-ACTH-cortisol signaling
nt06316  Renin-angiotensin-aldosterone signaling
nt06322  TRH-TSH-TH signaling
nt06324  GHRH-GH-IGF signaling
nt06360  Cushing syndrome
nt06461  Huntington disease
nt06465  Prion disease
nt06516  TNF signaling
  Element
N00297  ACTH-cortisol signaling pathway
N00298  CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00301  Angiotensin-aldosterone signaling pathway
N00302  Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
N00303  Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N00304  Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
N00305  Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
N00320  Mutation-activated PRKACA to ACTH-cortisol signaling pathway
N00321  Mutation-activated GNAS to ACTH-cortisol signaling pathway
N00322  Mutation-inactivated PRKAR1A to ACTH-cortisol signaling pathway
N00323  Mutation-inactivated PDE11A/PDE8B to ACTH-cortisol signaling pathway
N00324  CRHR-PKA-ACTH signaling pathway
N00325  Mutation-inactivated RASD1 to CRHR-PKA-ACTH signaling pathway
N00326  Mutation-activated GNAS to CRHR-PKA-ACTH signaling pathway
N00327  Mutation-inactivated PRKAR1A to CRHR-PKA-ACTH signaling pathway
N00410  DRD1-GNAS-AC-PKA signaling pathway
N00444  TNF-p38 signaling pathway
N00544  HBV HBx to CREB-mediated transcription
N00782  TSH-TG signaling pathway
N00910  GHRHR-PKA-GH signaling pathway
N00981  Mutation-caused aberrant Htt to CREB-mediated transcription
N01204  PRNP-PI3K-NOX2 signaling pathway
N01343  ACH-CHRN-RAS-ERK signaling pathway
N01351  E2-ER-RAS-ERK signaling pathway
Disease
H00506  Osteogenesis imperfecta
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    90993 (CREB3L1)
   04024 cAMP signaling pathway
    90993 (CREB3L1)
   04022 cGMP-PKG signaling pathway
    90993 (CREB3L1)
   04151 PI3K-Akt signaling pathway
    90993 (CREB3L1)
   04152 AMPK signaling pathway
    90993 (CREB3L1)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    90993 (CREB3L1)
   04922 Glucagon signaling pathway
    90993 (CREB3L1)
   04915 Estrogen signaling pathway
    90993 (CREB3L1)
   04926 Relaxin signaling pathway
    90993 (CREB3L1)
   04935 Growth hormone synthesis, secretion and action
    90993 (CREB3L1)
   04918 Thyroid hormone synthesis
    90993 (CREB3L1)
   04928 Parathyroid hormone synthesis, secretion and action
    90993 (CREB3L1)
   04916 Melanogenesis
    90993 (CREB3L1)
   04925 Aldosterone synthesis and secretion
    90993 (CREB3L1)
   04927 Cortisol synthesis and secretion
    90993 (CREB3L1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    90993 (CREB3L1)
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    90993 (CREB3L1)
  09156 Nervous system
   04725 Cholinergic synapse
    90993 (CREB3L1)
   04728 Dopaminergic synapse
    90993 (CREB3L1)
  09149 Aging
   04211 Longevity regulating pathway
    90993 (CREB3L1)
  09159 Environmental adaptation
   04714 Thermogenesis
    90993 (CREB3L1)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    90993 (CREB3L1)
   05203 Viral carcinogenesis
    90993 (CREB3L1)
  09162 Cancer: specific types
   05215 Prostate cancer
    90993 (CREB3L1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    90993 (CREB3L1)
   05161 Hepatitis B
    90993 (CREB3L1)
   05163 Human cytomegalovirus infection
    90993 (CREB3L1)
   05165 Human papillomavirus infection
    90993 (CREB3L1)
  09164 Neurodegenerative disease
   05016 Huntington disease
    90993 (CREB3L1)
   05020 Prion disease
    90993 (CREB3L1)
  09165 Substance dependence
   05030 Cocaine addiction
    90993 (CREB3L1)
   05031 Amphetamine addiction
    90993 (CREB3L1)
   05034 Alcoholism
    90993 (CREB3L1)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    90993 (CREB3L1)
   04934 Cushing syndrome
    90993 (CREB3L1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    90993 (CREB3L1)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   CREB
    90993 (CREB3L1)
SSDB
Motif
Pfam: bZIP_1 bZIP_2 bZIP_Maf LMBR1 Spc29 HAUS-augmin3 UQCC2_CBP6 TPR_MLP1_2 Prominin RNase_Y_N SKA2 DUF4404 APG6_N EcsC
Other DBs
NCBI-GeneID: 90993
NCBI-ProteinID: NP_443086
OMIM: 616215
HGNC: 18856
Ensembl: ENSG00000157613
UniProt: Q96BA8 B2RA75
LinkDB
Position
11:46277662..46321409
AA seq 519 aa
MDAVLEPFPADRLFPGSSFLDLGDLNESDFLNNAHFPEHLDHFTENMEDFSNDLFSSFFD
DPVLDEKSPLLDMELDSPTPGIQAEHSYSLSGDSAPQSPLVPIKMEDTTQDAEHGAWALG
HKLCSIMVKQEQSPELPVDPLAAPSAMAAAAAMATTPLLGLSPLSRLPIPHQAPGEMTQL
PVIKAEPLEVNQFLKVTPEDLVQMPPTPPSSHGSDSDGSQSPRSLPPSSPVRPMARSSTA
ISTSPLLTAPHKLQGTSGPLLLTEEEKRTLIAEGYPIPTKLPLTKAEEKALKRVRRKIKN
KISAQESRRKKKEYVECLEKKVETFTSENNELWKKVETLENANRTLLQQLQKLQTLVTNK
ISRPYKMAATQTGTCLMVAALCFVLVLGSLVPCLPEFSSGSQTVKEDPLAADGVYTASQM
PSRSLLFYDDGAGLWEDGRSTLLPMEPPDGWEINPGGPAEQRPRDHLQHDHLDSTHETTK
YLSEAWPKDGGNGTSPDFSHSKEWFHDRDLGPNTTIKLS
NT seq 1560 nt   +upstreamnt  +downstreamnt
atggacgccgtcttggaacccttcccggccgacaggctgttccccggatccagcttcctg
gacttgggggatctgaacgagtcggacttcctcaacaatgcgcactttcctgagcacctg
gaccactttacggagaacatggaggacttctccaatgacctgttcagcagcttctttgat
gaccctgtgctggatgagaagagccctctattggacatggaactggactcccctacgcca
ggcatccaggcggagcacagctactccctgagcggcgactcagcgccccagagccccctt
gtgcccatcaagatggaggacaccacccaagatgcagagcatggagcatgggcgctggga
cacaaactgtgctccatcatggtgaagcaggagcagagcccggagctgcccgtggaccct
ctggctgccccctcggccatggctgccgcggccgccatggccaccaccccgctgctgggc
ctcagccccttgtccaggctgcccatcccccaccaggccccgggagagatgactcagctg
ccagtgatcaaagcagagcctctggaggtgaaccagttcctcaaagtgacaccggaggac
ctggtgcagatgcctccgacgccccccagcagccatggcagtgacagcgacggctcccag
agtccccgctctctgcccccctccagccctgtcaggcccatggcgcgctcctccacggcc
atctccacctccccactcctcactgcccctcacaaattacaggggacatcagggccactg
ctcctgacagaggaggagaagcggaccctgattgctgagggctaccccatccccacaaaa
ctccccctcaccaaagccgaggagaaggccttgaagagagtccggaggaaaatcaagaac
aagatctcagcccaggagagccgtcgtaagaagaaggagtatgtggagtgtctagaaaag
aaggtggagacatttacatctgagaacaatgaactgtggaagaaggtggagaccctggag
aatgccaacaggaccctgctccagcagctgcagaaactccagactctggtcaccaacaag
atctccagaccttacaagatggccgccacccagactgggacctgcctcatggtggcagcc
ttgtgctttgttctggtgctgggctccctcgtgccctgccttcccgagttctcctccggc
tcccagactgtgaaggaagaccccctggccgcagacggcgtctacacggccagccagatg
ccctcccgaagcctcctattctacgatgacggggcaggcttatgggaagatggccgcagc
accctgctgcccatggagcccccagatggctgggaaatcaaccccggggggccggcagag
cagcggccccgggaccacctgcagcatgatcacctggacagcacccacgagaccaccaag
tacctgagtgaggcctggcctaaagacggtggaaacggcaccagccccgacttctcccac
tccaaggagtggttccacgacagggatctgggccccaacaccaccatcaaactctcctag

KEGG   Homo sapiens (human): 9586
Entry
9586              CDS       T01001                                 
Symbol
CREB5, CRE-BPA, CREB-5, CREBPA
Name
(RefSeq) cAMP responsive element binding protein 5
  KO
K09047  cyclic AMP-responsive element-binding protein 5
Organism
hsa  Homo sapiens (human)
Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04211  Longevity regulating pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04668  TNF signaling pathway
hsa04714  Thermogenesis
hsa04725  Cholinergic synapse
hsa04728  Dopaminergic synapse
hsa04911  Insulin secretion
hsa04915  Estrogen signaling pathway
hsa04918  Thyroid hormone synthesis
hsa04922  Glucagon signaling pathway
hsa04925  Aldosterone synthesis and secretion
hsa04926  Relaxin signaling pathway
hsa04927  Cortisol synthesis and secretion
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04931  Insulin resistance
hsa04934  Cushing syndrome
hsa04935  Growth hormone synthesis, secretion and action
hsa04962  Vasopressin-regulated water reabsorption
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05034  Alcoholism
hsa05161  Hepatitis B
hsa05163  Human cytomegalovirus infection
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05203  Viral carcinogenesis
hsa05207  Chemical carcinogenesis - receptor activation
hsa05215  Prostate cancer
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06167  Human cytomegalovirus (HCMV)
nt06180  Pathogenic Escherichia coli
nt06210  ERK signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06310  CRH-ACTH-cortisol signaling
nt06316  Renin-angiotensin-aldosterone signaling
nt06322  TRH-TSH-TH signaling
nt06324  GHRH-GH-IGF signaling
nt06360  Cushing syndrome
nt06461  Huntington disease
nt06465  Prion disease
nt06516  TNF signaling
  Element
N00297  ACTH-cortisol signaling pathway
N00298  CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00301  Angiotensin-aldosterone signaling pathway
N00302  Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
N00303  Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N00304  Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
N00305  Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
N00320  Mutation-activated PRKACA to ACTH-cortisol signaling pathway
N00321  Mutation-activated GNAS to ACTH-cortisol signaling pathway
N00322  Mutation-inactivated PRKAR1A to ACTH-cortisol signaling pathway
N00323  Mutation-inactivated PDE11A/PDE8B to ACTH-cortisol signaling pathway
N00324  CRHR-PKA-ACTH signaling pathway
N00325  Mutation-inactivated RASD1 to CRHR-PKA-ACTH signaling pathway
N00326  Mutation-activated GNAS to CRHR-PKA-ACTH signaling pathway
N00327  Mutation-inactivated PRKAR1A to CRHR-PKA-ACTH signaling pathway
N00410  DRD1-GNAS-AC-PKA signaling pathway
N00444  TNF-p38 signaling pathway
N00544  HBV HBx to CREB-mediated transcription
N00782  TSH-TG signaling pathway
N00910  GHRHR-PKA-GH signaling pathway
N00981  Mutation-caused aberrant Htt to CREB-mediated transcription
N01204  PRNP-PI3K-NOX2 signaling pathway
N01343  ACH-CHRN-RAS-ERK signaling pathway
N01351  E2-ER-RAS-ERK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    9586 (CREB5)
   04024 cAMP signaling pathway
    9586 (CREB5)
   04022 cGMP-PKG signaling pathway
    9586 (CREB5)
   04151 PI3K-Akt signaling pathway
    9586 (CREB5)
   04152 AMPK signaling pathway
    9586 (CREB5)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    9586 (CREB5)
   04922 Glucagon signaling pathway
    9586 (CREB5)
   04915 Estrogen signaling pathway
    9586 (CREB5)
   04926 Relaxin signaling pathway
    9586 (CREB5)
   04935 Growth hormone synthesis, secretion and action
    9586 (CREB5)
   04918 Thyroid hormone synthesis
    9586 (CREB5)
   04928 Parathyroid hormone synthesis, secretion and action
    9586 (CREB5)
   04925 Aldosterone synthesis and secretion
    9586 (CREB5)
   04927 Cortisol synthesis and secretion
    9586 (CREB5)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    9586 (CREB5)
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    9586 (CREB5)
  09156 Nervous system
   04725 Cholinergic synapse
    9586 (CREB5)
   04728 Dopaminergic synapse
    9586 (CREB5)
  09149 Aging
   04211 Longevity regulating pathway
    9586 (CREB5)
  09159 Environmental adaptation
   04714 Thermogenesis
    9586 (CREB5)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    9586 (CREB5)
   05203 Viral carcinogenesis
    9586 (CREB5)
  09162 Cancer: specific types
   05215 Prostate cancer
    9586 (CREB5)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    9586 (CREB5)
   05161 Hepatitis B
    9586 (CREB5)
   05163 Human cytomegalovirus infection
    9586 (CREB5)
   05165 Human papillomavirus infection
    9586 (CREB5)
  09164 Neurodegenerative disease
   05016 Huntington disease
    9586 (CREB5)
   05020 Prion disease
    9586 (CREB5)
  09165 Substance dependence
   05030 Cocaine addiction
    9586 (CREB5)
   05031 Amphetamine addiction
    9586 (CREB5)
   05034 Alcoholism
    9586 (CREB5)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    9586 (CREB5)
   04934 Cushing syndrome
    9586 (CREB5)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    9586 (CREB5)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   AP-1(-like) components, CRE-BP/ATF
    9586 (CREB5)
SSDB
Motif
Pfam: bZIP_1 bZIP_2 bZIP_Maf TolA_bind_tri ZapB NDUFB11 DUF3874 DUF6262
Other DBs
NCBI-GeneID: 9586
NCBI-ProteinID: NP_878901
OMIM: 618262
HGNC: 16844
Ensembl: ENSG00000146592
UniProt: Q02930
LinkDB
Position
7:28299321..28825894
AA seq 508 aa
MIYEESKMNLEQERPFVCSAPGCSQRFPTEDHLMIHRHKHEMTLKFPSIKTDNMLSDQTP
TPTRFLKNCEEVGLFSELDCSLEHEFRKAQEEESSKRNISMHNAVGGAMTGPGTHQLSSA
RLPNHDTNVVIQQAMPSPQSSSVITQAPSTNRQIGPVPGSLSSLLHLHNRQRQPMPASMP
GTLPNPTMPGSSAVLMPMERQMSVNSSIMGMQGPNLSNPCASPQVQPMHSEAKMRLKAAL
THHPAAMSNGNMNTMGHMMEMMGSRQDQTPHHHMHSHPHQHQTLPPHHPYPHQHQHPAHH
PHPQPHHQQNHPHHHSHSHLHAHPAHHQTSPHPPLHTGNQAQVSPATQQMQPTQTIQPPQ
PTGGRRRRVVDEDPDERRRKFLERNRAAATRCRQKRKVWVMSLEKKAEELTQTNMQLQNE
VSMLKNEVAQLKQLLLTHKDCPITAMQKESQGYLSPESSPPASPVPACSQQQVIQHNTIT
TSSSVSEVVGSSTLSQLTTHRTDLNPIL
NT seq 1527 nt   +upstreamnt  +downstreamnt
atgatttatgaggaatccaagatgaatttggagcaggagaggccgtttgtctgcagtgcc
ccaggctgctcccagcgcttcccaacagaggaccatctgatgattcataggcacaaacat
gaaatgactttgaagtttccttcaataaaaacagacaatatgttatcagatcaaactccg
accccaacgagattcctgaagaactgcgaggaggtgggcctcttcagcgagctggactgc
tccctggagcacgagttcaggaaggctcaggaagaggagagcagcaagcggaatatctcg
atgcataatgcagttggtggggccatgacggggcccggaactcaccagcttagcagcgct
cggctgcccaaccatgacaccaacgttgtgattcagcaagccatgccgtcgcctcagtcc
agctctgtcatcactcaggcaccttccaccaaccgccagatcgggcctgtcccaggctct
ctatcttctctgctacatctccacaacagacagagacagcccatgccagcctccatgcct
gggaccctgcccaaccctacaatgccaggatcttccgccgtcttgatgccaatggagcga
caaatgtcagtgaactccagcatcatggggatgcaaggtccaaatctcagcaacccctgt
gcttctccccaggtccagccaatgcattcagaagccaaaatgaggttgaaggctgcattg
actcaccaccctgctgccatgtcaaatgggaacatgaacaccatgggacacatgatggag
atgatgggctcccggcaggaccagacgccacaccatcacatgcactcgcacccgcatcag
caccagacactgccaccccatcacccttacccacaccagcaccagcacccagcacaccat
cctcaccctcaaccccatcaccagcagaaccatccacatcaccactcccattcccacctt
catgcacacccagcacatcaccagacctcgccacatccgcccctgcacaccggcaaccaa
gcacaggtttcaccagcaacacaacagatgcagccaacccagacaatacagccaccccag
cccacaggggggcgccggcgaagggtggtagacgaggatccggacgagaggcggcggaaa
tttctggaacggaaccgggcagctgccacccgctgcagacagaagaggaaggtctgggtg
atgtcattggaaaagaaagcagaagaactcacccagacaaacatgcagcttcagaatgaa
gtgtctatgttgaaaaatgaggtggcccagctgaaacagttgttgttaacacataaagac
tgcccaataacagccatgcagaaagaatcacaaggatatctaagtccagagagtagccct
cctgctagtcctgtcccagcttgctcccagcaacaagtcatccagcataataccatcact
acttcctcatcggtcagcgaggtggtaggaagctccaccctcagccagctcaccactcac
agaacagacctgaatccgattctttaa

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