KEGG   Homo sapiens (human): 1385
Entry
1385              CDS       T01001                                 
Symbol
CREB1, CREB, CREB-1
Name
(RefSeq) cAMP responsive element binding protein 1
  KO
K05870  cyclic AMP-responsive element-binding protein 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04148  Efferocytosis
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04211  Longevity regulating pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04380  Osteoclast differentiation
hsa04612  Antigen processing and presentation
hsa04668  TNF signaling pathway
hsa04710  Circadian rhythm
hsa04713  Circadian entrainment
hsa04714  Thermogenesis
hsa04725  Cholinergic synapse
hsa04728  Dopaminergic synapse
hsa04911  Insulin secretion
hsa04915  Estrogen signaling pathway
hsa04916  Melanogenesis
hsa04918  Thyroid hormone synthesis
hsa04922  Glucagon signaling pathway
hsa04924  Renin secretion
hsa04925  Aldosterone synthesis and secretion
hsa04926  Relaxin signaling pathway
hsa04927  Cortisol synthesis and secretion
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04931  Insulin resistance
hsa04934  Cushing syndrome
hsa04935  Growth hormone synthesis, secretion and action
hsa04962  Vasopressin-regulated water reabsorption
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05034  Alcoholism
hsa05152  Tuberculosis
hsa05161  Hepatitis B
hsa05163  Human cytomegalovirus infection
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05203  Viral carcinogenesis
hsa05207  Chemical carcinogenesis - receptor activation
hsa05215  Prostate cancer
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06167  Human cytomegalovirus (HCMV)
nt06180  Pathogenic Escherichia coli
nt06210  ERK signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06310  CRH-ACTH-cortisol signaling
nt06316  Renin-angiotensin-aldosterone signaling
nt06322  TRH-TSH-TH signaling
nt06324  GHRH-GH-IGF signaling
nt06360  Cushing syndrome
nt06461  Huntington disease
nt06465  Prion disease
nt06516  TNF signaling
nt06535  Efferocytosis
  Element
N00297  ACTH-cortisol signaling pathway
N00298  CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00301  Angiotensin-aldosterone signaling pathway
N00302  Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
N00303  Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N00304  Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
N00305  Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
N00320  Mutation-activated PRKACA to ACTH-cortisol signaling pathway
N00321  Mutation-activated GNAS to ACTH-cortisol signaling pathway
N00322  Mutation-inactivated PRKAR1A to ACTH-cortisol signaling pathway
N00323  Mutation-inactivated PDE11A/PDE8B to ACTH-cortisol signaling pathway
N00324  CRHR-PKA-ACTH signaling pathway
N00325  Mutation-inactivated RASD1 to CRHR-PKA-ACTH signaling pathway
N00326  Mutation-activated GNAS to CRHR-PKA-ACTH signaling pathway
N00327  Mutation-inactivated PRKAR1A to CRHR-PKA-ACTH signaling pathway
N00410  DRD1-GNAS-AC-PKA signaling pathway
N00444  TNF-p38 signaling pathway
N00544  HBV HBx to CREB-mediated transcription
N00782  TSH-TG signaling pathway
N00910  GHRHR-PKA-GH signaling pathway
N00981  Mutation-caused aberrant Htt to CREB-mediated transcription
N01204  PRNP-PI3K-NOX2 signaling pathway
N01343  ACH-CHRN-RAS-ERK signaling pathway
N01351  E2-ER-RAS-ERK signaling pathway
N01773  PTGS2-PGE2-TGFB1 pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    1385 (CREB1)
   04024 cAMP signaling pathway
    1385 (CREB1)
   04022 cGMP-PKG signaling pathway
    1385 (CREB1)
   04151 PI3K-Akt signaling pathway
    1385 (CREB1)
   04152 AMPK signaling pathway
    1385 (CREB1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    1385 (CREB1)
 09150 Organismal Systems
  09151 Immune system
   04612 Antigen processing and presentation
    1385 (CREB1)
  09152 Endocrine system
   04911 Insulin secretion
    1385 (CREB1)
   04922 Glucagon signaling pathway
    1385 (CREB1)
   04915 Estrogen signaling pathway
    1385 (CREB1)
   04926 Relaxin signaling pathway
    1385 (CREB1)
   04935 Growth hormone synthesis, secretion and action
    1385 (CREB1)
   04918 Thyroid hormone synthesis
    1385 (CREB1)
   04928 Parathyroid hormone synthesis, secretion and action
    1385 (CREB1)
   04916 Melanogenesis
    1385 (CREB1)
   04924 Renin secretion
    1385 (CREB1)
   04925 Aldosterone synthesis and secretion
    1385 (CREB1)
   04927 Cortisol synthesis and secretion
    1385 (CREB1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    1385 (CREB1)
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    1385 (CREB1)
  09156 Nervous system
   04725 Cholinergic synapse
    1385 (CREB1)
   04728 Dopaminergic synapse
    1385 (CREB1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    1385 (CREB1)
  09149 Aging
   04211 Longevity regulating pathway
    1385 (CREB1)
  09159 Environmental adaptation
   04710 Circadian rhythm
    1385 (CREB1)
   04713 Circadian entrainment
    1385 (CREB1)
   04714 Thermogenesis
    1385 (CREB1)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    1385 (CREB1)
   05203 Viral carcinogenesis
    1385 (CREB1)
  09162 Cancer: specific types
   05215 Prostate cancer
    1385 (CREB1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    1385 (CREB1)
   05161 Hepatitis B
    1385 (CREB1)
   05163 Human cytomegalovirus infection
    1385 (CREB1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    1385 (CREB1)
   05165 Human papillomavirus infection
    1385 (CREB1)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    1385 (CREB1)
  09164 Neurodegenerative disease
   05016 Huntington disease
    1385 (CREB1)
   05020 Prion disease
    1385 (CREB1)
  09165 Substance dependence
   05030 Cocaine addiction
    1385 (CREB1)
   05031 Amphetamine addiction
    1385 (CREB1)
   05034 Alcoholism
    1385 (CREB1)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    1385 (CREB1)
   04934 Cushing syndrome
    1385 (CREB1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    1385 (CREB1)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    1385 (CREB1)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   CREB
    1385 (CREB1)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Ubiquitas transcription factors
    1385 (CREB1)
SSDB
Motif
Pfam: pKID bZIP_1 bZIP_2 bZIP_Maf ASD2
Other DBs
NCBI-GeneID: 1385
NCBI-ProteinID: NP_004370
OMIM: 123810
HGNC: 2345
Ensembl: ENSG00000118260
UniProt: P16220 Q53X93
Structure
LinkDB
Position
2:207529962..207605988
AA seq 327 aa
MTMESGAENQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPN
GQTVQVHGVIQAAQPSVIQSPQVQTVQISTIAESEDSQESVDSVTDSQKRREILSRRPSY
RKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYIAITQGGAIQLA
NNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQVVVQAASGDVQTYQI
RTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENR
VAVLENQNKTLIEELKALKDLYCHKSD
NT seq 984 nt   +upstreamnt  +downstreamnt
atgaccatggaatctggagccgagaaccagcagagtggagatgcagctgtaacagaagct
gaaaaccaacaaatgacagttcaagcccagccacagattgccacattagcccaggtatct
atgccagcagctcatgcaacatcatctgctcccaccgtaactctagtacagctgcccaat
gggcagacagttcaagtccatggagtcattcaggcggcccagccatcagttattcagtct
ccacaagtccaaacagttcagatttcaactattgcagaaagtgaagattcacaggagtca
gtggatagtgtaactgattcccaaaagcgaagggaaattctttcaaggaggccttcctac
aggaaaattttgaatgacttatcttctgatgcaccaggagtgccaaggattgaagaagag
aagtctgaagaggagacttcagcacctgccatcaccactgtaacggtgccaactccaatt
taccaaactagcagtggacagtatattgccattacccagggaggagcaatacagctggct
aacaatggtaccgatggggtacagggcctgcaaacattaaccatgaccaatgcagcagcc
actcagccgggtactaccattctacagtatgcacagaccactgatggacagcagatctta
gtgcccagcaaccaagttgttgttcaagctgcctctggagacgtacaaacataccagatt
cgcacagcacccactagcactattgcccctggagttgttatggcatcctccccagcactt
cctacacagcctgctgaagaagcagcacgaaagagagaggtccgtctaatgaagaacagg
gaagcagctcgagagtgtcgtagaaagaagaaagaatatgtgaaatgtttagaaaacaga
gtggcagtgcttgaaaatcaaaacaagacattgattgaggagctaaaagcacttaaggac
ctttactgccacaaatcagattaa

KEGG   Homo sapiens (human): 1788
Entry
1788              CDS       T01001                                 
Symbol
DNMT3A, DNMT3A2, HESJAS, M.HsaIIIA, TBRS
Name
(RefSeq) DNA methyltransferase 3 alpha
  KO
K17398  DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00270  Cysteine and methionine metabolism
hsa01100  Metabolic pathways
hsa04148  Efferocytosis
hsa05206  MicroRNAs in cancer
Module
hsa_M00035  Methionine degradation
Network
nt06030  Methionine metabolism
nt06535  Efferocytosis
  Element
N01607  Methionine degradation
N01773  PTGS2-PGE2-TGFB1 pathway
N01774  ERK-DUSP4 negative feedback pathway
Disease
H00003  Acute myeloid leukemia
H01892  Peripheral T cell lymphoma
H02294  Tatton-Brown-Rahman syndrome
H02410  Myelodysplastic/myeloproliferative neoplasms
H02411  Chronic myelomonocytic leukemia
H02668  Heyn-Sproul-Jackson syndrome
Drug target
Azacitidine: D03021<JP/US>
Decitabine: D03665<US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    1788 (DNMT3A)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    1788 (DNMT3A)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    1788 (DNMT3A)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    1788 (DNMT3A)
   03032 DNA replication proteins [BR:hsa03032]
    1788 (DNMT3A)
   03036 Chromosome and associated proteins [BR:hsa03036]
    1788 (DNMT3A)
Enzymes [BR:hsa01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.37  DNA (cytosine-5-)-methyltransferase
     1788 (DNMT3A)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   Cys4 GATA-factors
    1788 (DNMT3A)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Termination Factors
   DNA methylation enzymes
    1788 (DNMT3A)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Heterochromatin formation proteins
   Other heterochromatin formation proteins
    1788 (DNMT3A)
SSDB
Motif
Pfam: DNM3A_N ADD_DNMT3 DNMT3_ADD_GATA1-like DNA_methylase PWWP
Other DBs
NCBI-GeneID: 1788
NCBI-ProteinID: NP_072046
OMIM: 602769
HGNC: 2978
Ensembl: ENSG00000119772
UniProt: Q9Y6K1
Structure
LinkDB
Position
2:complement(25227874..25342590)
AA seq 912 aa
MPAMPSSGPGDTSSSAAEREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPV
ESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGEG
AAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIESMKMEGSRGRLRGGLGWESSL
RQRPMPRLTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIAGMNAVEENQGPGESQKVE
EASPPAVQQPTDPASPTVATTPEPVGSDAGDKNATKAGDDEPEYEDGRGFGIGELVWGKL
RGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYN
KQPMYRKAIYEVLQVASSRAGKLFPVCHDSDESDTAKAVEVQNKPMIEWALGGFQPSGPK
GLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKPRKSTAEKPKVKEIIDERTRERLV
YEVRQKCRNIEDICISCGSLNVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTIC
CGGREVLMCGNNNCCRCFCVECVDLLVGPGAAQAAIKEDPWNCYMCGHKGTYGLLRRRED
WPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRY
IASEVCEDSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPAR
KGLYEGTGRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMI
DAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNSI
KQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRH
LFAPLKEYFACV
NT seq 2739 nt   +upstreamnt  +downstreamnt
atgcccgccatgccctccagcggccccggggacaccagcagctctgctgcggagcgggag
gaggaccgaaaggacggagaggagcaggaggagccgcgtggcaaggaggagcgccaagag
cccagcaccacggcacggaaggtggggcggcctgggaggaagcgcaagcaccccccggtg
gaaagcggtgacacgccaaaggaccctgcggtgatctccaagtccccatccatggcccag
gactcaggcgcctcagagctattacccaatggggacttggagaagcggagtgagccccag
ccagaggaggggagccctgctggggggcagaagggcggggccccagcagagggagagggt
gcagctgagaccctgcctgaagcctcaagagcagtggaaaatggctgctgcacccccaag
gagggccgaggagcccctgcagaagcgggcaaagaacagaaggagaccaacatcgaatcc
atgaaaatggagggctcccggggccggctgcggggtggcttgggctgggagtccagcctc
cgtcagcggcccatgccgaggctcaccttccaggcgggggacccctactacatcagcaag
cgcaagcgggacgagtggctggcacgctggaaaagggaggctgagaagaaagccaaggtc
attgcaggaatgaatgctgtggaagaaaaccaggggcccggggagtctcagaaggtggag
gaggccagccctcctgctgtgcagcagcccactgaccccgcatcccccactgtggctacc
acgcctgagcccgtggggtccgatgctggggacaagaatgccaccaaagcaggcgatgac
gagccagagtacgaggacggccggggctttggcattggggagctggtgtgggggaaactg
cggggcttctcctggtggccaggccgcattgtgtcttggtggatgacgggccggagccga
gcagctgaaggcacccgctgggtcatgtggttcggagacggcaaattctcagtggtgtgt
gttgagaagctgatgccgctgagctcgttttgcagtgcgttccaccaggccacgtacaac
aagcagcccatgtaccgcaaagccatctacgaggtcctgcaggtggccagcagccgcgcg
gggaagctgttcccggtgtgccacgacagcgatgagagtgacactgccaaggccgtggag
gtgcagaacaagcccatgattgaatgggccctggggggcttccagccttctggccctaag
ggcctggagccaccagaagaagagaagaatccctacaaagaagtgtacacggacatgtgg
gtggaacctgaggcagctgcctacgcaccacctccaccagccaaaaagccccggaagagc
acagcggagaagcccaaggtcaaggagattattgatgagcgcacaagagagcggctggtg
tacgaggtgcggcagaagtgccggaacattgaggacatctgcatctcctgtgggagcctc
aatgttaccctggaacaccccctcttcgttggaggaatgtgccaaaactgcaagaactgc
tttctggagtgtgcgtaccagtacgacgacgacggctaccagtcctactgcaccatctgc
tgtgggggccgtgaggtgctcatgtgcggaaacaacaactgctgcaggtgcttttgcgtg
gagtgtgtggacctcttggtggggccgggggctgcccaggcagccattaaggaagacccc
tggaactgctacatgtgcgggcacaagggtacctacgggctgctgcggcggcgagaggac
tggccctcccggctccagatgttcttcgctaataaccacgaccaggaatttgaccctcca
aaggtttacccacctgtcccagctgagaagaggaagcccatccgggtgctgtctctcttt
gatggaatcgctacagggctcctggtgctgaaggacttgggcattcaggtggaccgctac
attgcctcggaggtgtgtgaggactccatcacggtgggcatggtgcggcaccaggggaag
atcatgtacgtcggggacgtccgcagcgtcacacagaagcatatccaggagtggggccca
ttcgatctggtgattgggggcagtccctgcaatgacctctccatcgtcaaccctgctcgc
aagggcctctacgagggcactggccggctcttctttgagttctaccgcctcctgcatgat
gcgcggcccaaggagggagatgatcgccccttcttctggctctttgagaatgtggtggcc
atgggcgttagtgacaagagggacatctcgcgatttctcgagtccaaccctgtgatgatt
gatgccaaagaagtgtcagctgcacacagggcccgctacttctggggtaaccttcccggt
atgaacaggccgttggcatccactgtgaatgataagctggagctgcaggagtgtctggag
catggcaggatagccaagttcagcaaagtgaggaccattactacgaggtcaaactccata
aagcagggcaaagaccagcattttcctgtcttcatgaatgagaaagaggacatcttatgg
tgcactgaaatggaaagggtatttggtttcccagtccactatactgacgtctccaacatg
agccgcttggcgaggcagagactgctgggccggtcatggagcgtgccagtcatccgccac
ctcttcgctccgctgaaggagtattttgcgtgtgtgtaa

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