KEGG   Homo sapiens (human): 2074
Entry
2074              CDS       T01001                                 
Symbol
ERCC6, ARMD5, CKN2, COFS, COFS1, CSB, CSB-PGBD3, POF11, RAD26, UVSS1
Name
(RefSeq) ERCC excision repair 6, chromatin remodeling factor
  KO
K10841  DNA excision repair protein ERCC-6
Organism
hsa  Homo sapiens (human)
Pathway
hsa03420  Nucleotide excision repair
Network
nt06502  Nucleotide excision repair
  Element
N01430  Transcription-coupled NER
Disease
H00076  Cockayne syndrome
H00403  Disorders of nucleotide excision repair
H00627  Premature ovarian failure
H00821  Age-related macular degeneration
H02131  UV-sensitive syndrome
H02570  Cerebro-oculo-facio-skeletal syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03420 Nucleotide excision repair
    2074 (ERCC6)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    2074 (ERCC6)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    2074 (ERCC6)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Chromatin remodeling factors
   B-WICH complex
    2074 (ERCC6)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   NER (nucleotide excision repair)
    TCR (transcription coupled repair) factors
     Other TCR factor
      2074 (ERCC6)
SSDB
Motif
Pfam: SNF2-rel_dom Helicase_C ResIII DEAD HDA2-3 Spt5-NGN
Other DBs
NCBI-GeneID: 2074
NCBI-ProteinID: NP_000115
OMIM: 609413
HGNC: 3438
Ensembl: ENSG00000225830
UniProt: Q03468 Q59FF6
Structure
LinkDB
Position
10:complement(49434881..49539538)
AA seq 1493 aa
MPNEGIPHSSQTQEQDCLQSQPVSNNEEMAIKQESGGDGEVEEYLSFRSVGDGLSTSAVG
CASAAPRRGPALLHIDRHQIQAVEPSAQALELQGLGVDVYDQDVLEQGVLQQVDNAIHEA
SRASQLVDVEKEYRSVLDDLTSCTTSLRQINKIIEQLSPQAATSRDINRKLDSVKRQKYN
KEQQLKKITAKQKHLQAILGGAEVKIELDHASLEEDAEPGPSSLGSMLMPVQETAWEELI
RTGQMTPFGTQIPQKQEKKPRKIMLNEASGFEKYLADQAKLSFERKKQGCNKRAARKAPA
PVTPPAPVQNKNKPNKKARVLSKKEERLKKHIKKLQKRALQFQGKVGLPKARRPWESDMR
PEAEGDSEGEESEYFPTEEEEEEEDDEVEGAEADLSGDGTDYELKPLPKGGKRQKKVPVQ
EIDDDFFPSSGEEAEAASVGEGGGGGRKVGRYRDDGDEDYYKQRLRRWNKLRLQDKEKRL
KLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRWLWELHCQQAGGILGDEMGLGKTI
QIIAFLAGLSYSKIRTRGSNYRFEGLGPTVIVCPTTVMHQWVKEFHTWWPPFRVAILHET
GSYTHKKEKLIRDVAHCHGILITSYSYIRLMQDDISRYDWHYVILDEGHKIRNPNAAVTL
ACKQFRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFSVPITMGGYSNAS
PVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLPDKNEQVLFCRLTDEQHKVYQNFV
DSKEVYRILNGEMQIFSGLIALRKICNHPDLFSGGPKNLKGLPDDELEEDQFGYWKRSGK
MIVVESLLKIWHKQGQRVLLFSQSRQMLDILEVFLRAQKYTYLKMDGTTTIASRQPLITR
YNEDTSIFVFLLTTRVGGLGVNLTGANRVVIYDPDWNPSTDTQARERAWRIGQKKQVTVY
RLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQRRFFKSNDLYELFTLTSPDASQSTETSA
IFAGTGSDVQTPKCHLKRRIQPAFGADHDVPKRKKFPASNISVNDATSSEEKSEAKGAEV
NAVTSNRSDPLKDDPHMSSNVTSNDRLGEETNAVSGPEELSVISGNGECSNSSGTGKTSM
PSGDESIDEKLGLSYKRERPSQAQTEAFWENKQMENNFYKHKSKTKHHSVAEEETLEKHL
RPKQKPKNSKHCRDAKFEGTRIPHLVKKRRYQKQDSENKSEAKEQSNDDYVLEKLFKKSV
GVHSVMKHDAIMDGASPDYVLVEAEANRVAQDALKALRLSRQRCLGAVSGVPTWTGHRGI
SGAPAGKKSRFGKKRNSNFSVQHPSSTSPTEKCQDGIMKKEGKDNVPEHFSGRAEDADSS
SGPLASSSLLAKMRARNHLILPERLESESGHLQEASALLPTTEHDDLLVEMRNFIAFQAH
TDGQASTREILQEFESKLSASQSCVFRELLRNLCTFHRTSGGEGIWKLKPEYC
NT seq 4482 nt   +upstreamnt  +downstreamnt
atgccaaatgagggaatcccccactcaagtcaaactcaggagcaagactgtttacagagt
caacctgtcagtaataatgaagaaatggcaatcaagcaagaaagtggtggtgatggggag
gtggaggagtacctctcctttcgttctgtgggtgacgggctgtccacctctgctgtgggg
tgcgcatcagcagctccgaggagagggccagccctgctgcacatcgaccgacatcagatc
caggcagtagagcctagcgcccaggcccttgagctgcagggtttgggtgtggacgtctat
gaccaggacgtgctggaacagggagtgcttcagcaggtggacaatgccatccatgaggcc
agccgtgcctcccagctcgttgacgtggagaaggagtatcggtcggtcctggatgacctc
acgtcatgtacgacatccctaaggcaaatcaataaaattattgaacagcttagccctcaa
gctgccaccagcagagacatcaacaggaaactagattctgtaaaacgacagaagtataat
aaggaacaacagctaaaaaagatcactgcaaaacaaaagcatctccaggccatccttgga
ggagcagaggtgaaaattgaactagatcacgccagtctggaggaggatgcagagccgggg
ccatccagtcttggcagcatgctcatgcctgtccaggagactgcctgggaagagctcatc
cgcactggccagatgacaccttttggtacccagatccctcagaaacaggagaaaaagccc
agaaaaatcatgcttaatgaagcatcaggcttcgaaaagtatttggcagatcaagcaaaa
ctgtcttttgaaaggaagaagcaaggttgtaataaaagagcagctagaaaagctccagcc
ccagtcacgcctccagccccagtgcaaaataaaaacaaaccaaacaagaaagccagagtt
ctgtccaaaaaagaggagcgtttgaaaaagcacatcaagaaactccagaagagggctttg
cagttccaggggaaagtgggattgccaaaggcaaggagaccttgggagtcagacatgagg
ccagaggcagagggagactctgagggtgaagagtctgagtatttccccacagaggaggag
gaagaggaggaagatgacgaggtggagggggcagaggcggacctgtctggagatggtact
gactatgagctgaagcctctgcccaagggcgggaaacggcagaagaaagtgccagtgcag
gagattgatgatgactttttcccaagttctggggaagaagctgaagctgcttctgtagga
gaaggaggaggaggaggtcggaaagtgggaagataccgagatgatggagatgaagattat
tataagcagcggttaaggagatggaataaactgagactgcaggacaaagagaaacgtctg
aagctggaggacgattctgaggaaagtgatgctgaatttgacgaaggttttaaagtgcca
ggttttctgttcaaaaagctttttaagtaccagcagacaggtgttaggtggctgtgggaa
ttgcactgccagcaggcaggaggaattctgggagatgaaatgggattgggcaagaccatc
cagataattgccttcttggcaggtctgagctacagcaagatcaggactcgtggttcaaat
tacaggtttgaggggttgggtccaactgtaattgtctgtccaacaacagtgatgcatcag
tgggtgaaggaatttcacacgtggtggcctccgttcagagtggcaattctacatgaaacc
ggttcctatacccacaaaaaggagaaactaattcgagatgttgctcattgtcatggaatt
ttgatcacatcttactcctacattcgattgatgcaggatgacattagcaggtatgactgg
cactatgtgatcttggacgaaggacacaaaattcgaaatccaaatgctgctgtcaccctt
gcttgcaaacagtttcgcacccctcatcggatcattctgtctggctcaccgatgcaaaat
aacctccgagagctgtggtcgctctttgacttcatcttcccgggaaagttaggcacgttg
cctgtgtttatggagcagttctccgtccccatcaccatggggggatattcaaatgcttcc
ccagtacaggtcaaaactgcttacaagtgtgcatgtgtcttacgagataccataaatcca
tacctactgcggagaatgaagtcagatgtcaagatgagcctttctttgccagataaaaat
gaacaggtcttattttgccgtcttacagatgagcagcataaagtctaccaaaatttcgtt
gattccaaagaagtttacaggattctcaatggagagatgcagattttctccggacttata
gccctaagaaaaatttgcaaccaccctgatctcttttctggaggtcccaagaatctcaaa
ggtcttcctgatgatgaactagaagaagatcagtttgggtactggaaacgttctgggaaa
atgattgttgttgagtctttgttgaaaatatggcacaagcagggtcagcgagtattgctg
ttttctcagtcaaggcagatgctggacatacttgaagtattccttagagcccaaaagtat
acctatctcaagatggatggtaccactacaatagcttcaagacagccactgattacgaga
tacaatgaggacacatccatatttgtgtttcttctgaccacgcgggtgggcggcttaggt
gtcaacctgacgggggcaaacagagttgtcatctatgacccagactggaacccaagcacg
gacacgcaggcccgggagcgagcatggagaataggccagaagaagcaagtgactgtgtac
aggctcctgactgcgggcaccattgaagaaaagatctaccaccgacaaatcttcaagcag
tttttgacaaatagagtgctaaaagacccaaaacaaaggcggtttttcaaatccaatgat
ctctatgagctatttactctgactagtcctgatgcatcccagagcactgaaacaagtgca
atttttgcaggaactggatcagatgttcagacacccaaatgccatctaaaaagaaggatt
caaccagcctttggagcagaccatgatgttccaaaacgcaagaagttccctgcttctaac
atatctgtaaatgatgccacatcatctgaagagaaatctgaggctaaaggagctgaagta
aatgcagtaacttctaatcgaagtgatcctttgaaagatgaccctcacatgagtagtaat
gtaactagcaatgataggcttggagaagagacaaatgcagtatctggaccagaagagttg
tcagtgattagtggaaatggggaatgttcaaattcttcaggaacaggcaaaacttctatg
ccatctggtgatgaaagcattgatgaaaagttaggtctttcttacaaaagagaaagaccc
agccaggctcaaacagaagctttttgggagaataaacaaatggaaaataatttttataag
cacaagtcaaaaacaaaacatcatagtgtggcagaagaagagaccctggagaaacatctg
agaccaaagcaaaagcctaagaactctaagcattgcagagacgccaagtttgaaggaact
cgaattccacacctggtgaagaaaaggcgttaccagaagcaagacagtgaaaacaagagt
gaggccaaggaacagagcaatgacgattatgttttggaaaagcttttcaaaaaatcagtt
ggcgtgcacagtgtcatgaagcacgatgccatcatggatggagccagcccagattatgta
ctggtggaggcagaagccaaccgagtggcccaggatgccctgaaagcactgaggctctct
cgtcagcggtgtctgggagcagtgtctggtgttcccacctggactggccacagggggatt
tctggtgcaccagcaggaaaaaagagtagatttggtaagaaaaggaattctaacttctct
gtgcagcatccttcatcaacatctccaacagagaagtgccaggatggcatcatgaaaaag
gagggaaaagataatgtccctgagcattttagtggaagagcagaagatgcagactcttca
tccgggcccctcgcttcctcctcactcttggctaaaatgagagctagaaaccacctgatt
ctgccagagcgtttagaaagtgaaagcgggcacctgcaggaagcttctgccctgctgccc
accacagaacacgatgaccttctggtggagatgagaaacttcatcgctttccaggcccac
actgatggccaggccagcaccagggagatactgcaggagtttgaatccaagttatctgca
tcacagtcttgtgtcttccgagaactattgagaaatctgtgcactttccatagaacttct
ggtggtgaaggaatttggaaactcaagccagaatactgctaa

KEGG   Homo sapiens (human): 1161
Entry
1161              CDS       T01001                                 
Symbol
ERCC8, CKN1, CSA, UVSS2
Name
(RefSeq) ERCC excision repair 8, CSA ubiquitin ligase complex subunit
  KO
K10570  DNA excision repair protein ERCC-8
Organism
hsa  Homo sapiens (human)
Pathway
hsa03420  Nucleotide excision repair
hsa04120  Ubiquitin mediated proteolysis
Network
nt06502  Nucleotide excision repair
  Element
N01430  Transcription-coupled NER
Disease
H00076  Cockayne syndrome
H00403  Disorders of nucleotide excision repair
H02131  UV-sensitive syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    1161 (ERCC8)
  09124 Replication and repair
   03420 Nucleotide excision repair
    1161 (ERCC8)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    1161 (ERCC8)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    1161 (ERCC8)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  Multi subunit type E3
   Cul4 complex
    Target recognizing subunit (DCAF)
     1161 (ERCC8)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   NER (nucleotide excision repair)
    TCR (transcription coupled repair) factors
     Cul4-CSA complex
      1161 (ERCC8)
SSDB
Motif
Pfam: WD40 WD40_Prp19 WD40_CDC20-Fz WD40_WDHD1_1st Beta-prop_EML_2 EIF3I Beta-prop_TEP1_2nd Beta-prop_WDR75_1st WD40_MABP1-WDR62_2nd Beta-prop_CAF1B_HIR1 Beta-prop_EIPR1 Beta-prop_RIG_2nd Beta-prop_WDR90_POC16_2nd WDR55 Beta-prop_EML WD_LRWD1 ANAPC4_WD40 Beta-prop_TEP1_C WD40_RFWD3 WDR90_beta-prop_4th WD40_MABP1-WDR62_1st Beta-prop_IFT122_1st Beta-prop_WDR19_1st Beta-prop_IFT140_1st NBCH_WD40 Beta-prop_RIG_1st Beta-prop_Nup120_160 Beta-prop_WDR35_TULP_N Beta-prop_WDR11_1st Beta-prop_HPS5 Beta-prop_NUP159_NUP214
Other DBs
NCBI-GeneID: 1161
NCBI-ProteinID: NP_000073
OMIM: 609412
HGNC: 3439
Ensembl: ENSG00000049167
UniProt: Q13216
Structure
LinkDB
Position
5:complement(60866454..60945070)
AA seq 396 aa
MLGFLSARQTGLEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYML
SGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSF
DKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSH
ILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESA
NTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVS
CGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILA
WVPSLYEPVPDDDETTTKSQLNPAFEDAWSSSDEEG
NT seq 1191 nt   +upstreamnt  +downstreamnt
atgctggggtttttgtccgcacgccaaacgggtttggaggaccctcttcgccttcggaga
gcagagtcaacacggagagttttgggactggaattaaataaagacagagatgttgaaaga
atccacggcggtggaattaacacccttgacattgaacctgttgaagggagatacatgtta
tcaggtggttcagatggtgtgattgtactttatgaccttgagaactccagcagacaatct
tattacacatgtaaagcagtgtgttccattggcagagatcatcctgatgttcacagatac
agtgtggagactgtacagtggtatcctcatgacactggcatgttcacatcaagctcattt
gataaaactctgaaagtatgggatacaaatacattacaaactgcagatgtatttaatttt
gaggaaacagtttatagtcatcatatgtctccagtctccaccaagcactgtttggtagca
gttggtactagaggacccaaagtacaactttgtgacttgaagtctggatcctgttctcac
attctacagggtcacagacaagaaatattagcagtttcctggtctccacgttatgactat
atcttggcaacagcaagtgctgacagtagagtaaaattatgggatgtgagaagagcatca
ggatgtttgattactcttgatcaacataatgggaaaaagtcacaagctgttgaatcagca
aacactgctcataatgggaaagttaatggcttatgttttacaagtgatggacttcacctc
ctcactgttggtacagataatcgaatgaggctctggaatagttccaatggagaaaacaca
cttgtgaactatggaaaagtttgtaataacagtaaaaaaggattgaaattcactgtctcc
tgtggctgcagttcagaatttgtttttgtaccatatggtagcaccattgctgtttataca
gtttactcaggagaacagataactatgcttaagggacattataaaactgttgactgctgt
gtatttcagtcaaatttccaggaactttatagtggtagcagagactgcaacattctggct
tgggttccatccttatatgaaccagttcctgatgatgatgagactacaacaaaatcacaa
ttaaatccggcctttgaagatgcctggagcagcagtgatgaagaaggatga

KEGG   Homo sapiens (human): 9978
Entry
9978              CDS       T01001                                 
Symbol
RBX1, BA554C12.1, RNF75, ROC1
Name
(RefSeq) ring-box 1
  KO
K03868  E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03420  Nucleotide excision repair
hsa04066  HIF-1 signaling pathway
hsa04110  Cell cycle
hsa04114  Oocyte meiosis
hsa04120  Ubiquitin mediated proteolysis
hsa04141  Protein processing in endoplasmic reticulum
hsa04310  Wnt signaling pathway
hsa04350  TGF-beta signaling pathway
hsa04710  Circadian rhythm
hsa05131  Shigellosis
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
hsa05211  Renal cell carcinoma
Network
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06182  Shigella
nt06225  HIF-1 signaling (cancer)
nt06230  Cell cycle (cancer)
nt06261  Gastric cancer
nt06264  Renal cell carcinoma
nt06267  Small cell lung cancer
nt06272  Prostate cancer
nt06502  Nucleotide excision repair
nt06509  DNA replication
nt06516  TNF signaling
nt06541  Cytoskeleton in neurons
nt06542  HIF signaling
  Element
N00080  Loss of VHL to HIF-1 signaling pathway
N00081  Mutation-inactivated VHL to HIF-1 signaling pathway
N00091  p27-Cell cycle G1/S
N00092  Amplified MYC to p27-cell cycle G1/S
N00942  Shigella OspG to TNF-NFKB signaling pathway
N01425  Global genome NER
N01430  Transcription-coupled NER
N01473  DNA replication termination
N01855  Neurofilament regulation, ubiqutination by Gigaxonin
N01872  Proteasomal degradation of HIF by VHL complex
N01873  VHL mutation to HIF-2 signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    9978 (RBX1)
   04120 Ubiquitin mediated proteolysis
    9978 (RBX1)
  09124 Replication and repair
   03420 Nucleotide excision repair
    9978 (RBX1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    9978 (RBX1)
   04350 TGF-beta signaling pathway
    9978 (RBX1)
   04066 HIF-1 signaling pathway
    9978 (RBX1)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    9978 (RBX1)
   04114 Oocyte meiosis
    9978 (RBX1)
 09150 Organismal Systems
  09159 Environmental adaptation
   04710 Circadian rhythm
    9978 (RBX1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    9978 (RBX1)
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    9978 (RBX1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    9978 (RBX1)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    9978 (RBX1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    9978 (RBX1)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    9978 (RBX1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.32  cullin-RING-type E3 NEDD8 transferase
     9978 (RBX1)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  UBL E3 ligases
   9978 (RBX1)
  Multi subunit type E3
   SCF complex
    Ring finger protein
     9978 (RBX1)
   Cul2 complex
     9978 (RBX1)
   Cul3 complex
     9978 (RBX1)
   Cul4 complex
     9978 (RBX1)
   Cul7 complex
     9978 (RBX1)
   Cul8 complex
     9978 (RBX1)
   Cul9 complex
     9978 (RBX1)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   NER (nucleotide excision repair)
    GGR (global genome repair) factors
     Cul4-DDB2 complex
      9978 (RBX1)
    TCR (transcription coupled repair) factors
     Cul4-CSA complex
      9978 (RBX1)
SSDB
Motif
Pfam: zf-rbx1 zf-ANAPC11 zf-RING_2 zf-C3HC4 zf-C3HC4_2 zf-RING_11 zf-RING_16
Other DBs
NCBI-GeneID: 9978
NCBI-ProteinID: NP_055063
OMIM: 603814
HGNC: 9928
Ensembl: ENSG00000100387
UniProt: P62877
Structure
LinkDB
Position
22:40951378..40973309
AA seq 108 aa
MAAAMDVDTPSGTNSGAGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQ
ASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH
NT seq 327 nt   +upstreamnt  +downstreamnt
atggcggcagcgatggatgtggataccccgagcggcaccaacagcggcgcgggcaagaag
cgctttgaagtgaaaaagtggaatgcagtagccctctgggcctgggatattgtggttgat
aactgtgccatctgcaggaaccacattatggatctttgcatagaatgtcaagctaaccag
gcgtccgctacttcagaagagtgtactgtcgcatggggagtctgtaaccatgcttttcac
ttccactgcatctctcgctggctcaaaacacgacaggtgtgtccattggacaacagagag
tgggaattccaaaagtatgggcactag

KEGG   Homo sapiens (human): 8451
Entry
8451              CDS       T01001                                 
Symbol
CUL4A
Name
(RefSeq) cullin 4A
  KO
K10609  cullin 4
Organism
hsa  Homo sapiens (human)
Pathway
hsa03420  Nucleotide excision repair
hsa04120  Ubiquitin mediated proteolysis
hsa05170  Human immunodeficiency virus 1 infection
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06502  Nucleotide excision repair
  Element
N00456  HIV Vpr to CDC25-cell cycle G2M
N01425  Global genome NER
N01430  Transcription-coupled NER
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    8451 (CUL4A)
  09124 Replication and repair
   03420 Nucleotide excision repair
    8451 (CUL4A)
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    8451 (CUL4A)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    8451 (CUL4A)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    8451 (CUL4A)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    8451 (CUL4A)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  Multi subunit type E3
   Cul4 complex
    Cullin
     8451 (CUL4A)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   NER (nucleotide excision repair)
    GGR (global genome repair) factors
     Cul4-DDB2 complex
      8451 (CUL4A)
    TCR (transcription coupled repair) factors
     Cul4-CSA complex
      8451 (CUL4A)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   8451 (CUL4A)
SSDB
Motif
Pfam: Cullin Cullin_Nedd8 SecA_SW
Other DBs
NCBI-GeneID: 8451
NCBI-ProteinID: NP_001008895
OMIM: 603137
HGNC: 2554
Ensembl: ENSG00000139842
UniProt: Q13619
Structure
LinkDB
Position
13:113208193..113267108
AA seq 759 aa
MADEAPRKGSFSALVGRTNGLTKPAALAAAPAKPGGAGGSKKLVIKNFRDRPRLPDNYTQ
DTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILP
FREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRT
HIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETN
CLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLT
AILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKD
MVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAG
NKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLK
HECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPME
VHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLL
MFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEF
KHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELY
NQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA
NT seq 2280 nt   +upstreamnt  +downstreamnt
atggcggacgaggccccgcggaagggcagcttctcggcgctcgtgggccgcaccaacggc
ctcaccaagcccgcggccctggccgccgcgcccgccaagccggggggcgcgggcggctcc
aagaagctggtcatcaagaacttccgagacagacctcggctgcccgacaactacacgcag
gacacgtggcggaagctgcacgaggcggtgcgggccgtgcagagcagcacctccatcagg
tacaacctcgaggagctctaccaggctgtggaaaatctctgttctcacaaagtctcccca
atgctctacaagcaactgcgtcaggcctgtgaagaccacgtccaggcacagatccttccg
tttagagaagactcactagatagtgttttatttttaaagaagattaacacgtgctggcag
gaccactgcagacaaatgatcatgatcagaagcatcttcctgttcttggaccgcacctat
gtgctgcagaactccacgctgccctccatctgggatatgggattagaactgtttagaacc
catattattagtgataaaatggttcagagtaaaaccattgatggaatcctactgctgatc
gagcgcgagaggagcggcgaggccgtggaccggagcctgttgcggagcctcctgggcatg
ctgtctgacctgcaggtgtataaagattcatttgaactgaaatttttggaagagactaat
tgcttatatgctgccgaaggccaaaggttaatgcaggaaagagaggttccagaatatctt
aaccatgtaagtaaacgcttagaggaagagggagacagagtaatcacttacttggaccac
agcacacagaaaccactgattgcttgtgtggagaaacagctattaggagaacatttaaca
gcaattctgcagaaagggctcgaccacttactggatgagaacagagtgccggacctcgca
cagatgtaccagctgttcagccgggtgaggggcgggcagcaggcgctgctgcagcactgg
agcgagtacatcaagacttttggaacagcgatcgtaatcaatcctgagaaagacaaagac
atggtccaagacctgttggacttcaaggacaaggtggaccacgtgatcgaggtctgcttc
cagaagaatgagcggttcgtcaacctgatgaaggagtcctttgagacgttcatcaacaag
agacccaacaagcctgcagaactgatcgcaaagcatgtggattcaaagttaagagcaggc
aacaaagaagccacagacgaggagctggagcggacgttggacaagatcatgatcctgttc
aggtttatccacggtaaagatgtctttgaagcattttataaaaaagatttggcaaaaaga
ctccttgttgggaaaagtgcctcagtcgatgctgaaaagtctatgttgtcaaagctcaag
catgagtgcggtgcagccttcaccagcaagctggaaggcatgttcaaggacatggagctt
tcgaaggacatcatggttcatttcaagcagcatatgcagaatcagagtgactcaggccct
atagacctcacagtgaacatactcacaatgggctactggccaacatacacgcccatggaa
gtgcacttaaccccagaaatgattaaacttcaggaagtatttaaggcattttatcttgga
aagcacagtggtcgaaaacttcagtggcaaactactttgggacatgctgttttaaaagcg
gagtttaaagaagggaagaaggaattccaggtgtccctcttccagacactggtgctcctc
atgttcaacgagggagatggcttcagctttgaggagataaaaatggccacggggatagag
gatagtgaattgcgcagaacgctgcagtccctggcctgtggcaaagcacgtgtgctgatt
aaaagtcccaaaggaaaggaagtggaagatggagacaagttcatttttaatggagagttc
aagcacaagttgtttagaataaagatcaatcaaattcagatgaaggaaactgttgaggaa
caggttagcaccactgagagagtgtttcaggatagacaatatcagattgatgctgctatc
gtcagaataatgaagatgagaaagactcttggtcataatcttctagtttctgaattatat
aatcagctgaaatttccagtaaagcctggagatttgaaaaagagaattgaatctctgata
gacagagactatatggagagagacaaagacaatccgaatcagtaccactacgtggcctga

KEGG   Homo sapiens (human): 1642
Entry
1642              CDS       T01001                                 
Symbol
DDB1, DDBA, UV-DDB1, WHIKERS, XAP1, XPCE, XPE, XPE-BF
Name
(RefSeq) damage specific DNA binding protein 1
  KO
K10610  DNA damage-binding protein 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa03420  Nucleotide excision repair
hsa04120  Ubiquitin mediated proteolysis
hsa05161  Hepatitis B
hsa05170  Human immunodeficiency virus 1 infection
hsa05203  Viral carcinogenesis
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06502  Nucleotide excision repair
  Element
N00456  HIV Vpr to CDC25-cell cycle G2M
N01425  Global genome NER
N01430  Transcription-coupled NER
Disease
H00403  Disorders of nucleotide excision repair
H02560  White-Kernohan syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    1642 (DDB1)
  09124 Replication and repair
   03420 Nucleotide excision repair
    1642 (DDB1)
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    1642 (DDB1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    1642 (DDB1)
   05161 Hepatitis B
    1642 (DDB1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    1642 (DDB1)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    1642 (DDB1)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  Multi subunit type E3
   Cul4 complex
    Adoptor protein
     1642 (DDB1)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   NER (nucleotide excision repair)
    GGR (global genome repair) factors
     Cul4-DDB2 complex
      1642 (DDB1)
    TCR (transcription coupled repair) factors
     Cul4-CSA complex
      1642 (DDB1)
SSDB
Motif
Pfam: Beta-prop_RSE1_2nd CPSF_A Beta-prop_RSE1_1st Beta-prop_RIG_2nd Beta_propel
Other DBs
NCBI-GeneID: 1642
NCBI-ProteinID: NP_001914
OMIM: 600045
HGNC: 2717
Ensembl: ENSG00000167986
UniProt: Q16531
Structure
LinkDB
Position
11:complement(61299451..61333105)
AA seq 1140 aa
MSYNYVVTAQKPTAVNGCVTGHFTSAEDLNLLIAKNTRLEIYVVTAEGLRPVKEVGMYGK
IAVMELFRPKGESKDLLFILTAKYNACILEYKQSGESIDIITRAHGNVQDRIGRPSETGI
IGIIDPECRMIGLRLYDGLFKVIPLDRDNKELKAFNIRLEELHVIDVKFLYGCQAPTICF
VYQDPQGRHVKTYEVSLREKEFNKGPWKQENVEAEASMVIAVPEPFGGAIIIGQESITYH
NGDKYLAIAPPIIKQSTIVCHNRVDPNGSRYLLGDMEGRLFMLLLEKEEQMDGTVTLKDL
RVELLGETSIAECLTYLDNGVVFVGSRLGDSQLVKLNVDSNEQGSYVVAMETFTNLGPIV
DMCVVDLERQGQGQLVTCSGAFKEGSLRIIRNGIGIHEHASIDLPGIKGLWPLRSDPNRE
TDDTLVLSFVGQTRVLMLNGEEVEETELMGFVDDQQTFFCGNVAHQQLIQITSASVRLVS
QEPKALVSEWKEPQAKNISVASCNSSQVVVAVGRALYYLQIHPQELRQISHTEMEHEVAC
LDITPLGDSNGLSPLCAIGLWTDISARILKLPSFELLHKEMLGGEIIPRSILMTTFESSH
YLLCALGDGALFYFGLNIETGLLSDRKKVTLGTQPTVLRTFRSLSTTNVFACSDRPTVIY
SSNHKLVFSNVNLKEVNYMCPLNSDGYPDSLALANNSTLTIGTIDEIQKLHIRTVPLYES
PRKICYQEVSQCFGVLSSRIEVQDTSGGTTALRPSASTQALSSSVSSSKLFSSSTAPHET
SFGEEVEVHNLLIIDQHTFEVLHAHQFLQNEYALSLVSCKLGKDPNTYFIVGTAMVYPEE
AEPKQGRIVVFQYSDGKLQTVAEKEVKGAVYSMVEFNGKLLASINSTVRLYEWTTEKELR
TECNHYNNIMALYLKTKGDFILVGDLMRSVLLLAYKPMEGNFEEIARDFNPNWMSAVEIL
DDDNFLGAENAFNLFVCQKDSAATTDEERQHLQEVGLFHLGEFVNVFCHGSLVMQNLGET
STPTQGSVLFGTVNGMIGLVTSLSESWYNLLLDMQNRLNKVIKSVGKIEHSFWRSFHTER
KTEPATGFIDGDLIESFLDISRPKMQEVVANLQYDDGSGMKREATADDLIKVVEELTRIH
NT seq 3423 nt   +upstreamnt  +downstreamnt
atgtcgtacaactacgtggtaacggcccagaagcccaccgccgtgaacggctgcgtgacc
ggacactttacttcggccgaagacttaaacctgttgattgccaaaaacacgagattagag
atctatgtggtcaccgccgaggggcttcggcccgtcaaagaggtgggcatgtatgggaag
attgcggtcatggagcttttcaggcccaagggggagagcaaggacctgctgtttatcttg
acagcgaagtacaatgcctgcatcctggagtataaacagagtggcgagagcattgacatc
attacgcgagcccatggcaatgtccaggaccgcattggccgcccctcagagaccggcatt
attggcatcattgaccctgagtgccggatgattggcctgcgtctctatgatggccttttc
aaggttattccactagatcgcgataataaagaactcaaggccttcaacatccgcctggag
gagctgcatgtcattgatgtcaagttcctatatggttgccaagcacctactatttgcttt
gtctaccaggaccctcaggggcggcacgtaaaaacctatgaggtgtctctccgagaaaag
gaattcaataagggcccttggaaacaggaaaatgtcgaagctgaagcttccatggtgatc
gcagtcccagagccctttgggggggccatcatcattggacaggagtcaatcacctatcac
aatggtgacaaatacctggctattgcccctcctatcatcaagcaaagcacgattgtgtgc
cacaatcgagtggaccctaatggctcaagatacctgctgggagacatggaaggccggctc
ttcatgctgcttttggagaaggaggaacagatggatggcaccgtcactctcaaggatctc
cgtgtagaactccttggagagacctctattgctgagtgcttgacataccttgataatggt
gttgtgtttgtcgggtctcgcctgggtgactcccagcttgtgaagctcaacgttgacagt
aatgaacaaggctcctatgtagtggccatggaaacctttaccaacttaggacccattgtc
gatatgtgcgtggtggacctggagaggcaggggcaggggcagctggtcacttgctctggg
gctttcaaggaaggttctttgcggatcatccggaatggaattggaatccacgagcatgcc
agcattgacttaccaggcatcaaaggattatggccactgcggtctgaccctaatcgtgag
actgatgacactttggtgctctcttttgtgggccagacaagagttctcatgttaaatgga
gaggaggtagaagaaaccgaactgatgggtttcgtggatgatcagcagactttcttctgt
ggcaacgtggctcatcagcagcttatccagatcacttcagcatcggtgaggttggtctct
caagaacccaaagctctggtcagtgaatggaaggagcctcaggccaagaacatcagtgtg
gcctcctgcaatagcagccaggtggtggtggctgtaggcagggccctctactatctgcag
atccatcctcaggagctccggcagatcagccacacagagatggaacatgaagtggcttgc
ttggacatcaccccattaggagacagcaatggactgtcccctctttgtgccattggcctc
tggacggacatctcggctcgtatcttgaagttgccctcttttgaactactgcacaaggag
atgctgggtggagagatcattcctcgctccatcctgatgaccacctttgagagtagccat
tacctcctttgtgccttgggagatggagcgcttttctactttgggctcaacattgagaca
ggtctgttgagcgaccgtaagaaggtgactttgggcacccagcccaccgtattgaggact
tttcgttctctttctaccaccaacgtctttgcttgttctgaccgccccactgtcatctat
agcagcaaccacaaattggtcttctcaaatgtcaacctcaaggaagtgaactacatgtgt
cccctcaattcagatggctatcctgacagcctggcgctggccaacaatagcaccctcacc
attggcaccatcgatgagatccagaagctgcacattcgcacagttcccctctatgagtct
ccaaggaagatctgctaccaggaagtgtcccagtgtttcggggtcctctccagccgcatt
gaagtccaagacacgagtgggggcacgacagccttgaggcccagcgctagcacccaggct
ctgtccagcagtgtaagctccagcaagctgttctccagcagcactgctcctcatgagacc
tcctttggagaagaggtggaggtgcacaacctacttatcattgaccaacacacctttgaa
gtgcttcatgcccaccagtttctgcagaatgaatatgccctcagtctggtttcctgcaag
ctgggcaaagaccccaacacttacttcattgtgggcacagcaatggtgtatcctgaagag
gcagagcccaagcagggtcgcattgtggtctttcagtattcggatggaaaactacagact
gtggctgaaaaggaagtgaaaggggccgtgtactctatggtggaatttaacgggaagctg
ttagccagcatcaatagcacggtgcggctctatgagtggacaacagagaaggagctgcgc
actgagtgcaaccactacaacaacatcatggccctctacctgaagaccaagggcgacttc
atcctggtgggcgaccttatgcgctcagtgctgctgcttgcctacaagcccatggaagga
aactttgaagagattgctcgagactttaatcccaactggatgagtgctgtggaaatcttg
gatgatgacaattttctgggggctgaaaatgcctttaacttgtttgtgtgtcaaaaggat
agcgctgccaccactgacgaggagcggcagcacctccaggaggttggtcttttccacctg
ggcgagtttgtcaatgtcttttgccacggctctctggtaatgcagaatctgggtgagact
tccacccccacacaaggctcggtgctcttcggcacggtcaacggcatgatagggctggtg
acctcactgtcagagagctggtacaacctcctgctggacatgcagaatcgactcaataaa
gtcatcaaaagtgtggggaagatcgagcactccttctggagatcctttcacaccgagcgg
aagacagaaccagccacaggtttcatcgacggtgacttgattgagagtttcctggatatt
agccgccccaagatgcaggaggtggtggcaaacctacagtatgacgatggcagcggtatg
aagcgagaggccactgcagacgacctcatcaaggttgtggaggagctaactcggatccat
tag

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