KEGG   Homo sapiens (human): 3558
Entry
3558              CDS       T01001                                 
Symbol
IL2, IL-2, TCGF, lymphokine
Name
(RefSeq) interleukin 2
  KO
K05429  interleukin 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04061  Viral protein interaction with cytokine and cytokine receptor
hsa04151  PI3K-Akt signaling pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04658  Th1 and Th2 cell differentiation
hsa04659  Th17 cell differentiation
hsa04660  T cell receptor signaling pathway
hsa04672  Intestinal immune network for IgA production
hsa04940  Type I diabetes mellitus
hsa05135  Yersinia infection
hsa05142  Chagas disease
hsa05162  Measles
hsa05166  Human T-cell leukemia virus 1 infection
hsa05171  Coronavirus disease - COVID-19
hsa05200  Pathways in cancer
hsa05320  Autoimmune thyroid disease
hsa05321  Inflammatory bowel disease
hsa05330  Allograft rejection
hsa05332  Graft-versus-host disease
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06219  JAK-STAT signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06266  Non-small cell lung cancer
nt06276  Chronic myeloid leukemia
nt06518  JAK-STAT signaling
  Element
N00053  Cytokine-Jak-STAT signaling pathway
N00491  HTLV-1 p12 to Jak-STAT signaling pathway
N01554  IL2 family to Jak-STAT signaling pathway
Disease
H00084  Graft-versus-host disease
H00408  Type 1 diabetes mellitus
Drug target
Eciskafusp alfa: D12791
Imneskibart: D12850
Pegenzileukin: D12625
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    3558 (IL2)
   04151 PI3K-Akt signaling pathway
    3558 (IL2)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    3558 (IL2)
   04061 Viral protein interaction with cytokine and cytokine receptor
    3558 (IL2)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    3558 (IL2)
   04660 T cell receptor signaling pathway
    3558 (IL2)
   04658 Th1 and Th2 cell differentiation
    3558 (IL2)
   04659 Th17 cell differentiation
    3558 (IL2)
   04672 Intestinal immune network for IgA production
    3558 (IL2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3558 (IL2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    3558 (IL2)
   05171 Coronavirus disease - COVID-19
    3558 (IL2)
   05162 Measles
    3558 (IL2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    3558 (IL2)
  09174 Infectious disease: parasitic
   05142 Chagas disease
    3558 (IL2)
  09163 Immune disease
   05320 Autoimmune thyroid disease
    3558 (IL2)
   05321 Inflammatory bowel disease
    3558 (IL2)
   05330 Allograft rejection
    3558 (IL2)
   05332 Graft-versus-host disease
    3558 (IL2)
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    3558 (IL2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    3558 (IL2)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    3558 (IL2)
Cytokines and neuropeptides [BR:hsa04052]
 Cytokines
  Interleukins
   3558 (IL2)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Cytokines
   3558 (IL2)
SSDB
Motif
Pfam: IL2 Plasmid_RAQPRD
Other DBs
NCBI-GeneID: 3558
NCBI-ProteinID: NP_000577
OMIM: 147680
HGNC: 6001
Ensembl: ENSG00000109471
UniProt: P60568 Q0GK43
Structure
LinkDB
Position
4:complement(122451470..122456725)
AA seq 153 aa
MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRML
TFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSE
TTFMCEYADETATIVEFLNRWITFCQSIISTLT
NT seq 462 nt   +upstreamnt  +downstreamnt
atgtacaggatgcaactcctgtcttgcattgcactaagtcttgcacttgtcacaaacagt
gcacctacttcaagttctacaaagaaaacacagctacaactggagcatttactgctggat
ttacagatgattttgaatggaattaataattacaagaatcccaaactcaccaggatgctc
acatttaagttttacatgcccaagaaggccacagaactgaaacatcttcagtgtctagaa
gaagaactcaaacctctggaggaagtgctaaatttagctcaaagcaaaaactttcactta
agacccagggacttaatcagcaatatcaacgtaatagttctggaactaaagggatctgaa
acaacattcatgtgtgaatatgctgatgagacagcaaccattgtagaatttctgaacaga
tggattaccttttgtcaaagcatcatctcaacactgacttga

KEGG   Homo sapiens (human): 3565
Entry
3565              CDS       T01001                                 
Symbol
IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4
Name
(RefSeq) interleukin 4
  KO
K05430  interleukin 4
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04151  PI3K-Akt signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04640  Hematopoietic cell lineage
hsa04657  IL-17 signaling pathway
hsa04658  Th1 and Th2 cell differentiation
hsa04659  Th17 cell differentiation
hsa04660  T cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04672  Intestinal immune network for IgA production
hsa05140  Leishmaniasis
hsa05200  Pathways in cancer
hsa05310  Asthma
hsa05320  Autoimmune thyroid disease
hsa05321  Inflammatory bowel disease
hsa05330  Allograft rejection
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06219  JAK-STAT signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06266  Non-small cell lung cancer
nt06276  Chronic myeloid leukemia
nt06518  JAK-STAT signaling
  Element
N00053  Cytokine-Jak-STAT signaling pathway
N01554  IL2 family to Jak-STAT signaling pathway
Disease
H00079  Asthma
Drug target
Binetrakin: D03117
Pascolizumab: D05377
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    3565 (IL4)
   04151 PI3K-Akt signaling pathway
    3565 (IL4)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    3565 (IL4)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    3565 (IL4)
   04660 T cell receptor signaling pathway
    3565 (IL4)
   04658 Th1 and Th2 cell differentiation
    3565 (IL4)
   04659 Th17 cell differentiation
    3565 (IL4)
   04657 IL-17 signaling pathway
    3565 (IL4)
   04664 Fc epsilon RI signaling pathway
    3565 (IL4)
   04672 Intestinal immune network for IgA production
    3565 (IL4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3565 (IL4)
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    3565 (IL4)
  09163 Immune disease
   05310 Asthma
    3565 (IL4)
   05320 Autoimmune thyroid disease
    3565 (IL4)
   05321 Inflammatory bowel disease
    3565 (IL4)
   05330 Allograft rejection
    3565 (IL4)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    3565 (IL4)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    3565 (IL4)
Cytokines and neuropeptides [BR:hsa04052]
 Cytokines
  Interleukins
   3565 (IL4)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Cytokines
   3565 (IL4)
SSDB
Motif
Pfam: IL4 Mannosyl_trans3
Other DBs
NCBI-GeneID: 3565
NCBI-ProteinID: NP_000580
OMIM: 147780
HGNC: 6014
Ensembl: ENSG00000113520
UniProt: P05112 D4HNR6
Structure
LinkDB
Position
5:132673989..132682678
AA seq 153 aa
MGLTSQLLPPLFFLLACAGNFVHGHKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAAS
KNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGL
NSCPVKEANQSTLENFLERLKTIMREKYSKCSS
NT seq 462 nt   +upstreamnt  +downstreamnt
atgggtctcacctcccaactgcttccccctctgttcttcctgctagcatgtgccggcaac
tttgtccacggacacaagtgcgatatcaccttacaggagatcatcaaaactttgaacagc
ctcacagagcagaagactctgtgcaccgagttgaccgtaacagacatctttgctgcctcc
aagaacacaactgagaaggaaaccttctgcagggctgcgactgtgctccggcagttctac
agccaccatgagaaggacactcgctgcctgggtgcgactgcacagcagttccacaggcac
aagcagctgatccgattcctgaaacggctcgacaggaacctctggggcctggcgggcttg
aattcctgtcctgtgaaggaagccaaccagagtacgttggaaaacttcttggaaaggcta
aagacgatcatgagagagaaatattcaaagtgttcgagctga

KEGG   Homo sapiens (human): 3574
Entry
3574              CDS       T01001                                 
Symbol
IL7, IL-7
Name
(RefSeq) interleukin 7
  KO
K05431  interleukin 7
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04151  PI3K-Akt signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04640  Hematopoietic cell lineage
hsa05200  Pathways in cancer
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06219  JAK-STAT signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06266  Non-small cell lung cancer
nt06276  Chronic myeloid leukemia
nt06518  JAK-STAT signaling
  Element
N00053  Cytokine-Jak-STAT signaling pathway
N01554  IL2 family to Jak-STAT signaling pathway
Disease
H00842  Epidermodysplasia verruciformis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    3574 (IL7)
   04151 PI3K-Akt signaling pathway
    3574 (IL7)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    3574 (IL7)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    3574 (IL7)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3574 (IL7)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    3574 (IL7)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    3574 (IL7)
Cytokines and neuropeptides [BR:hsa04052]
 Cytokines
  Interleukins
   3574 (IL7)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Cytokines
   3574 (IL7)
SSDB
Motif
Pfam: IL7
Other DBs
NCBI-GeneID: 3574
NCBI-ProteinID: NP_000871
OMIM: 146660
HGNC: 6023
Ensembl: ENSG00000104432
UniProt: P13232 A8K673
Structure
LinkDB
Position
8:complement(78675044..78805463)
AA seq 177 aa
MFHVSFRYIFGLPPLILVLLPVASSDCDIEGKDGKQYESVLMVSIDQLLDSMKEIGSNCL
NNEFNFFKRHICDANKEGMFLFRAARKLRQFLKMNSTGDFDLHLLKVSEGTTILLNCTGQ
VKGRKPAALGEAQPTKSLEENKSLKEQKKLNDLCFLKRLLQEIKTCWNKILMGTKEH
NT seq 534 nt   +upstreamnt  +downstreamnt
atgttccatgtttcttttaggtatatctttggacttcctcccctgatccttgttctgttg
ccagtagcatcatctgattgtgatattgaaggtaaagatggcaaacaatatgagagtgtt
ctaatggtcagcatcgatcaattattggacagcatgaaagaaattggtagcaattgcctg
aataatgaatttaacttttttaaaagacatatctgtgatgctaataaggaaggtatgttt
ttattccgtgctgctcgcaagttgaggcaatttcttaaaatgaatagcactggtgatttt
gatctccacttattaaaagtttcagaaggcacaacaatactgttgaactgcactggccag
gttaaaggaagaaaaccagctgccctgggtgaagcccaaccaacaaagagtttggaagaa
aataaatctttaaaggaacagaaaaaactgaatgacttgtgtttcctaaagagactatta
caagagataaaaacttgttggaataaaattttgatgggcactaaagaacactga

KEGG   Homo sapiens (human): 3578
Entry
3578              CDS       T01001                                 
Symbol
IL9, HP40, IL-9, P40
Name
(RefSeq) interleukin 9
  KO
K05432  interleukin 9
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  JAK-STAT signaling pathway
hsa05310  Asthma
Network
nt06518  JAK-STAT signaling
  Element
N01554  IL2 family to Jak-STAT signaling pathway
Drug target
Enokizumab: D09897
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    3578 (IL9)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    3578 (IL9)
 09160 Human Diseases
  09163 Immune disease
   05310 Asthma
    3578 (IL9)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    3578 (IL9)
Cytokines and neuropeptides [BR:hsa04052]
 Cytokines
  Interleukins
   3578 (IL9)
SSDB
Other DBs
NCBI-GeneID: 3578
NCBI-ProteinID: NP_000581
OMIM: 146931
HGNC: 6029
Ensembl: ENSG00000145839
UniProt: P15248
Structure
LinkDB
Position
5:complement(135892246..135895841)
AA seq 144 aa
MLLAMVLTSALLLCSVAGQGCPTLAGILDINFLINKMQEDPASKCHCSANVTSCLCLGIP
SDNCTRPCFSERLSQMTNTTMQTRYPLIFSRVKKSVEVLKNNKCPYFSCEQPCNQTTAGN
ALTFLKSLLEIFQKEKMRGMRGKI
NT seq 435 nt   +upstreamnt  +downstreamnt
atgcttctggccatggtccttacctctgccctgctcctgtgctccgtggcaggccagggg
tgtccaaccttggcggggatcctggacatcaacttcctcatcaacaagatgcaggaagat
ccagcttccaagtgccactgcagtgctaatgtgaccagttgtctctgtttgggcattccc
tctgacaactgcaccagaccatgcttcagtgagagactgtctcagatgaccaataccacc
atgcaaacaagatacccactgattttcagtcgggtgaaaaaatcagttgaagtactaaag
aacaacaagtgtccatatttttcctgtgaacagccatgcaaccaaaccacggcaggcaac
gcgctgacatttctgaagagtcttctggaaattttccagaaagaaaagatgagagggatg
agaggcaagatatga

KEGG   Homo sapiens (human): 3600
Entry
3600              CDS       T01001                                 
Symbol
IL15, IL-15
Name
(RefSeq) interleukin 15
  KO
K05433  interleukin 15
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  JAK-STAT signaling pathway
hsa04668  TNF signaling pathway
hsa04672  Intestinal immune network for IgA production
hsa05166  Human T-cell leukemia virus 1 infection
hsa05200  Pathways in cancer
hsa05323  Rheumatoid arthritis
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06219  JAK-STAT signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06266  Non-small cell lung cancer
nt06276  Chronic myeloid leukemia
nt06518  JAK-STAT signaling
  Element
N00053  Cytokine-Jak-STAT signaling pathway
N01554  IL2 family to Jak-STAT signaling pathway
Drug target
Ordesekimab: D12306
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    3600 (IL15)
   04668 TNF signaling pathway
    3600 (IL15)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    3600 (IL15)
 09150 Organismal Systems
  09151 Immune system
   04672 Intestinal immune network for IgA production
    3600 (IL15)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3600 (IL15)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    3600 (IL15)
  09163 Immune disease
   05323 Rheumatoid arthritis
    3600 (IL15)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    3600 (IL15)
Cytokines and neuropeptides [BR:hsa04052]
 Cytokines
  Interleukins
   3600 (IL15)
SSDB
Motif
Pfam: IL15
Other DBs
NCBI-GeneID: 3600
NCBI-ProteinID: NP_000576
OMIM: 600554
HGNC: 5977
Ensembl: ENSG00000164136
UniProt: P40933
Structure
LinkDB
Position
4:141636583..141733987
AA seq 162 aa
MRISKPHLRSISIQCYLCLLLNSHFLTEAGIHVFILGCFSAGLPKTEANWVNVISDLKKI
EDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANN
SLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTS
NT seq 489 nt   +upstreamnt  +downstreamnt
atgagaatttcgaaaccacatttgagaagtatttccatccagtgctacttgtgtttactt
ctaaacagtcattttctaactgaagctggcattcatgtcttcattttgggctgtttcagt
gcagggcttcctaaaacagaagccaactgggtgaatgtaataagtgatttgaaaaaaatt
gaagatcttattcaatctatgcatattgatgctactttatatacggaaagtgatgttcac
cccagttgcaaagtaacagcaatgaagtgctttctcttggagttacaagttatttcactt
gagtccggagatgcaagtattcatgatacagtagaaaatctgatcatcctagcaaacaac
agtttgtcttctaatgggaatgtaacagaatctggatgcaaagaatgtgaggaactggag
gaaaaaaatattaaagaatttttgcagagttttgtacatattgtccaaatgttcatcaac
acttcttga

KEGG   Homo sapiens (human): 59067
Entry
59067             CDS       T01001                                 
Symbol
IL21, CVID11, IL-21, Za11
Name
(RefSeq) interleukin 21
  KO
K05434  interleukin 21
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  JAK-STAT signaling pathway
hsa04659  Th17 cell differentiation
hsa05321  Inflammatory bowel disease
Network
nt06518  JAK-STAT signaling
  Element
N01554  IL2 family to Jak-STAT signaling pathway
Disease
H00088  Common variable immunodeficiency
H00408  Type 1 diabetes mellitus
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    59067 (IL21)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    59067 (IL21)
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    59067 (IL21)
 09160 Human Diseases
  09163 Immune disease
   05321 Inflammatory bowel disease
    59067 (IL21)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    59067 (IL21)
Cytokines and neuropeptides [BR:hsa04052]
 Cytokines
  Interleukins
   59067 (IL21)
SSDB
Motif
Pfam: IL15 RPA_interact_C
Other DBs
NCBI-GeneID: 59067
NCBI-ProteinID: NP_068575
OMIM: 605384
HGNC: 6005
Ensembl: ENSG00000138684
UniProt: Q9HBE4 A0A224B028
Structure
LinkDB
Position
4:complement(122610108..122621066)
AA seq 162 aa
MRSSPGNMERIVICLMVIFLGTLVHKSSSQGQDRHMIRMRQLIDIVDQLKNYVNDLVPEF
LPAPEDVETNCEWSAFSCFQKAQLKSANTGNNERIINVSIKKLKRKPPSTNAGRRQKHRL
TCPSCDSYEKKPPKEFLERFKSLLQKMIHQHLSSRTHGSEDS
NT seq 489 nt   +upstreamnt  +downstreamnt
atgagatccagtcctggcaacatggagaggattgtcatctgtctgatggtcatcttcttg
gggacactggtccacaaatcaagctcccaaggtcaagatcgccacatgattagaatgcgt
caacttatagatattgttgatcagctgaaaaattatgtgaatgacttggtccctgaattt
ctgccagctccagaagatgtagagacaaactgtgagtggtcagctttttcctgctttcag
aaggcccaactaaagtcagcaaatacaggaaacaatgaaaggataatcaatgtatcaatt
aaaaagctgaagaggaaaccaccttccacaaatgcagggagaagacagaaacacagacta
acatgcccttcatgtgattcttatgagaaaaaaccacccaaagaattcctagaaagattc
aaatcacttctccaaaagatgattcatcagcatctgtcctctagaacacacggaagtgaa
gattcctga

KEGG   Homo sapiens (human): 85480
Entry
85480             CDS       T01001                                 
Symbol
TSLP
Name
(RefSeq) thymic stromal lymphopoietin
  KO
K05436  thymic stromal lymphopoietin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  JAK-STAT signaling pathway
Network
nt06518  JAK-STAT signaling
  Element
N01554  IL2 family to Jak-STAT signaling pathway
Drug target
Tezepelumab: D11771<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    85480 (TSLP)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    85480 (TSLP)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    85480 (TSLP)
Cytokines and neuropeptides [BR:hsa04052]
 Cytokines
  CSF and other factors
   85480 (TSLP)
SSDB
Motif
Pfam: TSLP Tlr3_TMD
Other DBs
NCBI-GeneID: 85480
NCBI-ProteinID: NP_149024
OMIM: 607003
HGNC: 30743
Ensembl: ENSG00000145777
UniProt: Q969D9
Structure
LinkDB
Position
5:111070062..111078026
AA seq 159 aa
MFPFALLYVLSVSFRKIFILQLVGLVLTYDFTNCDFEKIKAAYLSTISKDLITYMSGTKS
TEFNNTVSCSNRPHCLTEIQSLTFNPTAGCASLAKEMFAMKTKAALAIWCPGYSETQINA
TQAMKKRRKRKVTTNKCLEQVSQLQGLWRRFNRPLLKQQ
NT seq 480 nt   +upstreamnt  +downstreamnt
atgttcccttttgccttactatatgttctgtcagtttctttcaggaaaatcttcatctta
caacttgtagggctggtgttaacttacgacttcactaactgtgactttgagaagattaaa
gcagcctatctcagtactatttctaaagacctgattacatatatgagtgggaccaaaagt
accgagttcaacaacaccgtctcttgtagcaatcggccacattgccttactgaaatccag
agcctaaccttcaatcccaccgccggctgcgcgtcgctcgccaaagaaatgttcgccatg
aaaactaaggctgccttagctatctggtgcccaggctattcggaaactcagataaatgct
actcaggcaatgaagaagaggagaaaaaggaaagtcacaaccaataaatgtctggaacaa
gtgtcacaattacaaggattgtggcgtcgcttcaatcgacctttactgaaacaacagtaa

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