KEGG   Homo sapiens (human): 3576
Entry
3576              CDS       T01001                                 
Symbol
CXCL8, GCP-1, GCP1, IL8, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1, SCYB8
Name
(RefSeq) C-X-C motif chemokine ligand 8
  KO
K10030  interleukin 8
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04061  Viral protein interaction with cytokine and cytokine receptor
hsa04062  Chemokine signaling pathway
hsa04064  NF-kappa B signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04218  Cellular senescence
hsa04620  Toll-like receptor signaling pathway
hsa04621  NOD-like receptor signaling pathway
hsa04622  RIG-I-like receptor signaling pathway
hsa04657  IL-17 signaling pathway
hsa04932  Non-alcoholic fatty liver disease
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04936  Alcoholic liver disease
hsa05120  Epithelial cell signaling in Helicobacter pylori infection
hsa05130  Pathogenic Escherichia coli infection
hsa05131  Shigellosis
hsa05132  Salmonella infection
hsa05133  Pertussis
hsa05134  Legionellosis
hsa05135  Yersinia infection
hsa05142  Chagas disease
hsa05144  Malaria
hsa05146  Amoebiasis
hsa05161  Hepatitis B
hsa05163  Human cytomegalovirus infection
hsa05164  Influenza A
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05171  Coronavirus disease - COVID-19
hsa05200  Pathways in cancer
hsa05202  Transcriptional misregulation in cancer
hsa05219  Bladder cancer
hsa05323  Rheumatoid arthritis
hsa05417  Lipid and atherosclerosis
Network
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06167  Human cytomegalovirus (HCMV)
nt06171  SARS coronavirus 2 (SARS-CoV-2)
nt06224  CXCR signaling (cancer)
nt06240  Transcription (cancer)
nt06263  Hepatocellular carcinoma
nt06533  Chemokine signaling
nt06542  HIF signaling
  Element
N00140  FUS-DDIT3 fusion to NFKB-mediated transcription
N00152  CXCR-GNB/G-ERK signaling pathway
N00153  CCR/CXCR-GNB/G-PI3K-RAC signaling pathway
N00154  CXCR-GNB/G-PI3K-AKT signaling pathway
N00544  HBV HBx to CREB-mediated transcription
N01307  SARS-CoV-2 S to AngII-AT1R-NOX2 signaling pathway
N01746  CCR/CXCR-GNB/G-PI3K signaling pathway
N01870  HIF-2A signaling pathway
N01873  VHL mutation to HIF-2 signaling pathway
Drug target
Adakitug: D12656
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    3576 (CXCL8)
   04072 Phospholipase D signaling pathway
    3576 (CXCL8)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    3576 (CXCL8)
   04061 Viral protein interaction with cytokine and cytokine receptor
    3576 (CXCL8)
 09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    3576 (CXCL8)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    3576 (CXCL8)
   04621 NOD-like receptor signaling pathway
    3576 (CXCL8)
   04622 RIG-I-like receptor signaling pathway
    3576 (CXCL8)
   04657 IL-17 signaling pathway
    3576 (CXCL8)
   04062 Chemokine signaling pathway
    3576 (CXCL8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3576 (CXCL8)
   05202 Transcriptional misregulation in cancer
    3576 (CXCL8)
  09162 Cancer: specific types
   05219 Bladder cancer
    3576 (CXCL8)
  09172 Infectious disease: viral
   05161 Hepatitis B
    3576 (CXCL8)
   05171 Coronavirus disease - COVID-19
    3576 (CXCL8)
   05164 Influenza A
    3576 (CXCL8)
   05163 Human cytomegalovirus infection
    3576 (CXCL8)
   05167 Kaposi sarcoma-associated herpesvirus infection
    3576 (CXCL8)
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    3576 (CXCL8)
   05130 Pathogenic Escherichia coli infection
    3576 (CXCL8)
   05132 Salmonella infection
    3576 (CXCL8)
   05131 Shigellosis
    3576 (CXCL8)
   05135 Yersinia infection
    3576 (CXCL8)
   05133 Pertussis
    3576 (CXCL8)
   05134 Legionellosis
    3576 (CXCL8)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    3576 (CXCL8)
   05144 Malaria
    3576 (CXCL8)
   05142 Chagas disease
    3576 (CXCL8)
  09163 Immune disease
   05323 Rheumatoid arthritis
    3576 (CXCL8)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    3576 (CXCL8)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    3576 (CXCL8)
   04932 Non-alcoholic fatty liver disease
    3576 (CXCL8)
   04933 AGE-RAGE signaling pathway in diabetic complications
    3576 (CXCL8)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    3576 (CXCL8)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    3576 (CXCL8)
Cytokines and neuropeptides [BR:hsa04052]
 Cytokines
  Chemokines
   3576 (CXCL8)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Chemokines
   3576 (CXCL8)
SSDB
Motif
Pfam: IL8 CXCL16
Other DBs
NCBI-GeneID: 3576
NCBI-ProteinID: NP_000575
OMIM: 146930
HGNC: 6025
Ensembl: ENSG00000169429
UniProt: P10145
Structure
LinkDB
Position
4:73740569..73743716
AA seq 99 aa
MTSKLAVALLAAFLISAALCEGAVLPRSAKELRCQCIKTYSKPFHPKFIKELRVIESGPH
CANTEIIVKLSDGRELCLDPKENWVQRVVEKFLKRAENS
NT seq 300 nt   +upstreamnt  +downstreamnt
atgacttccaagctggccgtggctctcttggcagccttcctgatttctgcagctctgtgt
gaaggtgcagttttgccaaggagtgctaaagaacttagatgtcagtgcataaagacatac
tccaaacctttccaccccaaatttatcaaagaactgagagtgattgagagtggaccacac
tgcgccaacacagaaattattgtaaagctttctgatggaagagagctctgtctggacccc
aaggaaaactgggtgcagagggttgtggagaagtttttgaagagggctgagaattcataa

KEGG   Homo sapiens (human): 5111
Entry
5111              CDS       T01001                                 
Symbol
PCNA, ATLD2
Name
(RefSeq) proliferating cell nuclear antigen
  KO
K04802  proliferating cell nuclear antigen
Organism
hsa  Homo sapiens (human)
Pathway
hsa03030  DNA replication
hsa03410  Base excision repair
hsa03420  Nucleotide excision repair
hsa03430  Mismatch repair
hsa04110  Cell cycle
hsa04530  Tight junction
hsa05161  Hepatitis B
Network
nt06162  Hepatitis B virus (HBV)
nt06263  Hepatocellular carcinoma
nt06502  Nucleotide excision repair
nt06503  Mismatch repair
nt06504  Base excision repair
nt06506  Double-strand break repair
nt06509  DNA replication
  Element
N00544  HBV HBx to CREB-mediated transcription
N01431  Core NER reaction
N01432  Mismatch repair
N01436  Long patch BER
N01452  Homologous recombination
N01471  Origin unwinding and elongation
N01472  Okazaki fragment maturation
Disease
H02014  Ataxia-telangiectasia-like syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    5111 (PCNA)
   03410 Base excision repair
    5111 (PCNA)
   03420 Nucleotide excision repair
    5111 (PCNA)
   03430 Mismatch repair
    5111 (PCNA)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    5111 (PCNA)
  09144 Cellular community - eukaryotes
   04530 Tight junction
    5111 (PCNA)
 09160 Human Diseases
  09172 Infectious disease: viral
   05161 Hepatitis B
    5111 (PCNA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    5111 (PCNA)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    5111 (PCNA)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Elongation Factors
   Other elongation factors
    5111 (PCNA)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Long Patch-BER factors
     5111 (PCNA)
   MMR (mismatch excision repair)
    Other MMR factors
     5111 (PCNA)
  TLS (translesion DNA synthesis) factors
   Other TLS factors
    5111 (PCNA)
SSDB
Motif
Pfam: PCNA_C PCNA_N Rad1 Rad9 Hus1 AMA-1 FmdE
Other DBs
NCBI-GeneID: 5111
NCBI-ProteinID: NP_002583
OMIM: 176740
HGNC: 8729
Ensembl: ENSG00000132646
UniProt: P12004
Structure
LinkDB
Position
20:complement(5114953..5126622)
AA seq 261 aa
MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSMDSSHVSLVQLTLRSEGFDTY
RCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMD
LDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVISCAKDGVKFSASGELGNGNI
KLSQTSNVDKEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSSTVTLSMSADVPLVVEYK
IADMGHLKYYLAPKIEDEEGS
NT seq 786 nt   +upstreamnt  +downstreamnt
atgttcgaggcgcgcctggtccagggctccatcctcaagaaggtgttggaggcactcaag
gacctcatcaacgaggcctgctgggatattagctccagcggtgtaaacctgcagagcatg
gactcgtcccacgtctctttggtgcagctcaccctgcggtctgagggcttcgacacctac
cgctgcgaccgcaacctggccatgggcgtgaacctcaccagtatgtccaaaatactaaaa
tgcgccggcaatgaagatatcattacactaagggccgaagataacgcggataccttggcg
ctagtatttgaagcaccaaaccaggagaaagtttcagactatgaaatgaagttgatggat
ttagatgttgaacaacttggaattccagaacaggagtacagctgtgtagtaaagatgcct
tctggtgaatttgcacgtatatgccgagatctcagccatattggagatgctgttgtaatt
tcctgtgcaaaagacggagtgaaattttctgcaagtggagaacttggaaatggaaacatt
aaattgtcacagacaagtaatgtcgataaagaggaggaagctgttaccatagagatgaat
gaaccagttcaactaacttttgcactgaggtacctgaacttctttacaaaagccactcca
ctctcttcaacggtgacactcagtatgtctgcagatgtaccccttgttgtagagtataaa
attgcggatatgggacacttaaaatactacttggctcccaagatcgaggatgaagaagga
tcttag

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