KEGG   Homo sapiens (human): 5347
Entry
5347              CDS       T01001                                 
Symbol
PLK1, PLK, STPK13
Name
(RefSeq) polo like kinase 1
  KO
K06631  polo-like kinase 1 [EC:2.7.11.21]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04068  FoxO signaling pathway
hsa04110  Cell cycle
hsa04114  Oocyte meiosis
hsa04914  Progesterone-mediated oocyte maturation
Network
nt06512  Chromosome cohesion and segregation
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N01485  Cohesin dissociation in prophase
N01499  Modifying of condensin II subunits
N01562  Microtubule depolymerization at the minus ends
Drug target
Onvansertib (DG03017): D11458 D11459
Rigosertib (DG01416): D10154 D10155
Volasertib (DG01417): D10182 D10183
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    5347 (PLK1)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    5347 (PLK1)
   04114 Oocyte meiosis
    5347 (PLK1)
 09150 Organismal Systems
  09152 Endocrine system
   04914 Progesterone-mediated oocyte maturation
    5347 (PLK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    5347 (PLK1)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    5347 (PLK1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.21  polo kinase
     5347 (PLK1)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: Other
  PLK family [OT]
   5347 (PLK1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   SAC (spindle assembly checkpoint) factors
    Protein kinases
     5347 (PLK1)
  Centrosome formation proteins
   Kinases and associated factors
    5347 (PLK1)
  Sister chromatid separation proteins
   Polo kinases
    5347 (PLK1)
SSDB
Motif
Pfam: Pkinase POLO_box PK_Tyr_Ser-Thr Kinase-like Pkinase_fungal ABC1 APH
Other DBs
NCBI-GeneID: 5347
NCBI-ProteinID: NP_005021
OMIM: 602098
HGNC: 9077
Ensembl: ENSG00000166851
Pharos: P53350(Tchem)
UniProt: P53350
Structure
LinkDB
Position
16:23678889..23690367
AA seq 603 aa
MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLG
KGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFF
EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLG
NLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCI
MYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELL
NDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEE
PVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK
YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLK
YFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTK
LILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRL
KAS
NT seq 1812 nt   +upstreamnt  +downstreamnt
atgagtgctgcagtgactgcagggaagctggcacgggcaccggccgaccctgggaaagcc
ggggtccccggagttgcagctcccggagctccggcggcggctccaccggcgaaagagatc
ccggaggtcctagtggacccacgcagccggcggcgctatgtgcggggccgctttttgggc
aagggcggctttgccaagtgcttcgagatctcggacgcggacaccaaggaggtgttcgcg
ggcaagattgtgcctaagtctctgctgctcaagccgcaccagagggagaagatgtccatg
gaaatatccattcaccgcagcctcgcccaccagcacgtcgtaggattccacggctttttc
gaggacaacgacttcgtgttcgtggtgttggagctctgccgccggaggtctctcctggag
ctgcacaagaggaggaaagccctgactgagcctgaggcccgatactacctacggcaaatt
gtgcttggctgccagtacctgcaccgaaaccgagttattcatcgagacctcaagctgggc
aaccttttcctgaatgaagatctggaggtgaaaataggggattttggactggcaaccaaa
gtcgaatatgacggggagaggaagaagaccctgtgtgggactcctaattacatagctccc
gaggtgctgagcaagaaagggcacagtttcgaggtggatgtgtggtccattgggtgtatc
atgtataccttgttagtgggcaaaccaccttttgagacttcttgcctaaaagagacctac
ctccggatcaagaagaatgaatacagtattcccaagcacatcaaccccgtggccgcctcc
ctcatccagaagatgcttcagacagatcccactgcccgcccaaccattaacgagctgctt
aatgacgagttctttacttctggctatatccctgcccgtctccccatcacctgcctgacc
attccaccaaggttttcgattgctcccagcagcctggaccccagcaaccggaagcccctc
acagtcctcaataaaggcttggagaaccccctgcctgagcgtccccgggaaaaagaagaa
ccagtggttcgagagacaggtgaggtggtcgactgccacctcagtgacatgctgcagcag
ctgcacagtgtcaatgcctccaagccctcggagcgtgggctggtcaggcaagaggaggct
gaggatcctgcctgcatccccatcttctgggtcagcaagtgggtggactattcggacaag
tacggccttgggtatcagctctgtgataacagcgtgggggtgctcttcaatgactcaaca
cgcctcatcctctacaatgatggtgacagcctgcagtacatagagcgtgacggcactgag
tcctacctcaccgtgagttcccatcccaactccttgatgaagaagatcaccctccttaaa
tatttccgcaattacatgagcgagcacttgctgaaggcaggtgccaacatcacgccgcgc
gaaggtgatgagctcgcccggctgccctacctacggacctggttccgcacccgcagcgcc
atcatcctgcacctcagcaacggcagcgtgcagatcaacttcttccaggatcacaccaag
ctcatcttgtgcccactgatggcagccgtgacctacatcgacgagaagcgggacttccgc
acataccgcctgagtctcctggaggagtacggctgctgcaaggagctggccagccggctc
cgctacgcccgcactatggtggacaagctgctgagctcacgctcggccagcaaccgtctc
aaggcctcctaa

KEGG   Homo sapiens (human): 9212
Entry
9212              CDS       T01001                                 
Symbol
AURKB, AIK2, AIM-1, AIM1, ARK-2, ARK2, AurB, IPL1, PPP1R48, STK-1, STK12, STK5, aurkb-sv1, aurkb-sv2
Name
(RefSeq) aurora kinase B
  KO
K11479  aurora kinase B [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03083  Polycomb repressive complex
hsa04110  Cell cycle
Network
nt06512  Chromosome cohesion and segregation
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N01485  Cohesin dissociation in prophase
N01499  Modifying of condensin II subunits
N01500  Modifying of condensin I subunits
N01526  Organization of the outer kinetochore
N01529  Recruitment and formation of the MCC
N01531  CENPE interaction with NDC80 complex
N01536  Dephosphorylation of kinetochore
N01561  Microtubule depolymerization
N01563  Inhibition of Kif2A
Drug target
Ilorasertib: D10423
Tinengotinib: D12545
Tozasertib (DG01365): D08279 D08344
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09126 Chromosome
   03083 Polycomb repressive complex
    9212 (AURKB)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    9212 (AURKB)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    9212 (AURKB)
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    9212 (AURKB)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    9212 (AURKB)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     9212 (AURKB)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: AGC group
  AUR family [OT]
   9212 (AURKB)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     9212 (AURKB)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   Kinetochore proteins
    CPC (chromosomal passenger complex)
     9212 (AURKB)
   SAC (spindle assembly checkpoint) factors
    Protein kinases
     9212 (AURKB)
  Sister chromatid separation proteins
   Aurora kinases
    9212 (AURKB)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kinase-like ABC1
Other DBs
NCBI-GeneID: 9212
NCBI-ProteinID: NP_001300879
OMIM: 604970
HGNC: 11390
Ensembl: ENSG00000178999
Pharos: Q96GD4(Tchem)
UniProt: Q96GD4
Structure
LinkDB
Position
17:complement(8204731..8210575)
AA seq 344 aa
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
NT seq 1035 nt   +upstreamnt  +downstreamnt
atggcccagaaggagaactcctacccctggccctacggccgacagacggctccatctggc
ctgagcaccctgccccagcgagtcctccggaaagagcctgtcaccccatctgcacttgtc
ctcatgagccgctccaatgtccagcccacagctgcccctggccagaaggtgatggagaat
agcagtgggacacccgacatcttaacgcggcacttcacaattgatgactttgagattggg
cgtcctctgggcaaaggcaagtttggaaacgtgtacttggctcgggagaagaaaagccat
ttcatcgtggcgctcaaggtcctcttcaagtcccagatagagaaggagggcgtggagcat
cagctgcgcagagagatcgaaatccaggcccacctgcaccatcccaacatcctgcgtctc
tacaactatttttatgaccggaggaggatctacttgattctagagtatgccccccgcggg
gagctctacaaggagctgcagaagagctgcacatttgacgagcagcgaacagccacgatc
atggaggagttggcagatgctctaatgtactgccatgggaagaaggtgattcacagagac
ataaagccagaaaatctgctcttagggctcaagggagagctgaagattgctgacttcggc
tggtctgtgcatgcgccctccctgaggaggaagacaatgtgtggcaccctggactacctg
cccccagagatgattgaggggcgcatgcacaatgagaaggtggatctgtggtgcattgga
gtgctttgctatgagctgctggtggggaacccaccctttgagagtgcatcacacaacgag
acctatcgccgcatcgtcaaggtggacctaaagttccccgcttccgtgcccatgggagcc
caggacctcatctccaaactgctcaggcataacccctcggaacggctgcccctggcccag
gtctcagcccacccttgggtccgggccaactctcggagggtgctgcctccctctgccctt
caatctgtcgcctga

KEGG   Homo sapiens (human): 983
Entry
983               CDS       T01001                                 
Symbol
CDK1, CDC2, CDC28A, P34CDC2
Name
(RefSeq) cyclin dependent kinase 1
  KO
K02087  cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04110  Cell cycle
hsa04114  Oocyte meiosis
hsa04115  p53 signaling pathway
hsa04218  Cellular senescence
hsa04540  Gap junction
hsa04914  Progesterone-mediated oocyte maturation
hsa05170  Human immunodeficiency virus 1 infection
hsa05203  Viral carcinogenesis
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06230  Cell cycle (cancer)
nt06512  Chromosome cohesion and segregation
  Element
N00455  CDC25-Cell cycle G2/M
N00456  HIV Vpr to CDC25-cell cycle G2M
N00457  HIV Vpr to cell cycle G2M
N00459  WEE1-Cell cycle G2/M
N00460  HIV Vpr to WEE1-cell cycle G2M
N00499  ATR-p21-Cell cycle G2/M
N01485  Cohesin dissociation in prophase
N01499  Modifying of condensin II subunits
N01500  Modifying of condensin I subunits
Drug target
Alvocidib (DG02041): D02880 D09868
Dinaciclib: D09604
Zotiraciclib (DG03058): D11599 D11600
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    983 (CDK1)
   04114 Oocyte meiosis
    983 (CDK1)
   04115 p53 signaling pathway
    983 (CDK1)
   04218 Cellular senescence
    983 (CDK1)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    983 (CDK1)
 09150 Organismal Systems
  09152 Endocrine system
   04914 Progesterone-mediated oocyte maturation
    983 (CDK1)
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    983 (CDK1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    983 (CDK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    983 (CDK1)
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    983 (CDK1)
   03036 Chromosome and associated proteins [BR:hsa03036]
    983 (CDK1)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    983 (CDK1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     983 (CDK1)
    2.7.11.23  [RNA-polymerase]-subunit kinase
     983 (CDK1)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CMGC group
  CDK family
   983 (CDK1)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Termination Factors
   Prevention of re-replication factors
    983 (CDK1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Kinases and associated factors
    983 (CDK1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   983 (CDK1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Haspin_kinase Kinase-like APH Seadorna_VP7 Choline_kinase Kdo
Other DBs
NCBI-GeneID: 983
NCBI-ProteinID: NP_001307847
OMIM: 116940
HGNC: 1722
Ensembl: ENSG00000170312
Pharos: P06493(Tchem)
UniProt: P06493
Structure
LinkDB
Position
10:60778331..60794852
AA seq 297 aa
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH
PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH
SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR
YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT
FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
NT seq 894 nt   +upstreamnt  +downstreamnt
atggaagattataccaaaatagagaaaattggagaaggtacctatggagttgtgtataag
ggtagacacaaaactacaggtcaagtggtagccatgaaaaaaatcagactagaaagtgaa
gaggaaggggttcctagtactgcaattcgggaaatttctctattaaaggaacttcgtcat
ccaaatatagtcagtcttcaggatgtgcttatgcaggattccaggttatatctcatcttt
gagtttctttccatggatctgaagaaatacttggattctatccctcctggtcagtacatg
gattcttcacttgttaagagttatttataccaaatcctacaggggattgtgttttgtcac
tctagaagagttcttcacagagacttaaaacctcaaaatctcttgattgatgacaaagga
acaattaaactggctgattttggccttgccagagcttttggaatacctatcagagtatat
acacatgaggtagtaacactctggtacagatctccagaagtattgctggggtcagctcgt
tactcaactccagttgacatttggagtataggcaccatatttgctgaactagcaactaag
aaaccacttttccatggggattcagaaattgatcaactcttcaggattttcagagctttg
ggcactcccaataatgaagtgtggccagaagtggaatctttacaggactataagaataca
tttcccaaatggaaaccaggaagcctagcatcccatgtcaaaaacttggatgaaaatggc
ttggatttgctctcgaaaatgttaatctatgatccagccaaacgaatttctggcaaaatg
gcactgaatcatccatattttaatgatttggacaatcagattaagaagatgtag

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