KEGG    Network variation - Regulation of kinetochore-microtubule interactions
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ENTRYnt06515
NameRegulation of kinetochore-microtubule interactions
CategoryPathway view; Cellular process
Pathwayhsa04110 Cell cycle
DiseaseH01288 Mosaic variegated aneuploidy syndrome
H00268 Lissencephaly
H00269 Primary microcephaly
H01881 Complex cortical dysplasia with other brain malformations
Display drug-target relation   disease type
N01525    CENPA=CENPC=CENP-LN+CENP-HIKM+..=CENP-TWSX
    SSMGA       CENPT*
 
N01526    CPC=CENPC=MIS12C+KNL1C+CENP-..CPC+CENPC+MIS12C+K..=CENP-TWSX=NDC80C
    MCPH4     KNL1*
 
N01532        MIS12=CEP57=(MAD1+MAD2)
    MVA2       CEP57*
    PC         MAD1*
 
N01529    AURKBNDC80=MPS1KNL1=(BUB1+BUB3+BUBR1)=(MAD1+MAD2)KNL1+MCC
    MCPH30/CRC         BUB1*
    MVA1/CRC         BUBR1*
 
N01533              TRIP13+MAD2L1BPMCCANAPC
    MVA3           TRIP13*
 
N01536    NDC80C=(SKA1+SKA2+SKA3)=PP1(MPS1,AURKB)
    NSLH2     PPP1CB*
 
N01531    (AURKA,AURKB)PP1CENPE+(SKAP+Astrin..=NDC80C
    CRC AURKA*
    MCPH13     CENPE*
    ROCHIS     SKAP*
 
N01534    BUB1+CENPF=RZZ=(NDE1+NDEL1+LIS1),..=Dynein
    STROMS CENPF*
    LIS4/MHAC     NDE1*
    LIS1     LIS1*
    HMN7B/Perry     DCTN1*
    CMT2O/SMALED1/MRD13       DYNC1H1*
    SRTD3       DYNC2H1*
    NEDMIBA       DYNC1I2*
    SRTD15       DYNC2LI1*
 
N01535    (CENPF,BUBR1)=CENPE=microtubule
    LIS3     TUBA1A*
    KTCN     TUBA3D*
    ALS22     TUBA4A*
    MACTHC2     TUBA8*
    CDCBM6/CSCSC1     TUBB*
    MACTHC1     TUBB1*
    CDCBM5     TUBB2A*
    CDCBM7     TUBB2B*
    CDCBM1/CFEOM3A     TUBB3*
    HLD6/DYT4     TUBB4A*
    LCAEOD     TUBB4B*
    FPVEPD     TUBB6*
    OOMD2     TUBB8*
 
N01544    CDK5RAP2=gamma-TuRC+TPX2=ch-TOG=microtubule
    MCPH3 CDK5RAP2*
N01549      gamma-TuRC=Augumin=TPX2+microtubule
    CDCBM4   TUBG1*
    PAMDDFS   TUBGCP2*
    MCCRP3   TUBGCP4*
    MCCRP1   TUBGCP6*
 
N01547    AURKA(TACC3+ch-TOG)(TACC3+ch-TOG)=microtubuleclathrin=(TACC3+ch-TOG)=microtubule
N01548            CLTC+PIK3C2A=TACC3
    MRD56         CLTC*
    OCSKD         PIC3C2A*
 
N01553      (CLIP1,CLIP2)+(CLA..=EB1=microtubule
 
N01561    (AURKA,AURKB)(MCAK+KIF18B)=EB1,EB3=microtubule
 
N01562    PLK1KIF2A=DDA3=microtubule
N01563    (AURKA,AURKB)KIF2A
    CDCBM3   KIF2A*

Disease nameDisease category
SSMGAH02607Short stature and microcephaly with genital anomaliesCongenital malformation
MCPH4H00269Primary microcephalyCongenital malformation
MVA2H01288Mosaic variegated aneuploidy syndromeChromosomal abnormality
PCH00024Prostate cancerCancer
MCPH30/CRCH00269Primary microcephalyCongenital malformation
H00020Colorectal cancerCancer
MVA1/CRCH01288Mosaic variegated aneuploidy syndromeChromosomal abnormality
H00020Colorectal cancerCancer
MVA3H01288Mosaic variegated aneuploidy syndromeChromosomal abnormality
NSLH2H02191Noonan-like syndrome with loose anagen hairCongenital malformation
CRCH00020Colorectal cancerCancer
MCPH13H00269Primary microcephalyCongenital malformation
ROCHISH02585Roifman-Chitayat syndromeImmune system disease
STROMSH01814Stromme syndromeCongenital malformation
LIS4/MHACH00268LissencephalyCongenital malformation
H01870MicrohydranencephalyCongenital malformation
LIS1H00268LissencephalyCongenital malformation
HMN7B/PerryH00856Distal hereditary motor neuropathiesNervous system disease
H00879Perry syndromeNeurodegenerative disease
CMT2O/SMALED1/MRD13H00264Charcot-Marie-Tooth diseaseNeurodegenerative disease
H00455Spinal muscular atrophyNeurodegenerative disease
H00773Autosomal dominant intellectual developmental disorderMental and behavioural disorder
SRTD3H02157Short-rib thoracic dysplasiaCongenital malformation
NEDMIBAH02461Neurodevelopmental disorder with microcephalyCongenital malformation
SRTD15H02157Short-rib thoracic dysplasiaCongenital malformation
LIS3H00268LissencephalyCongenital malformation
KTCNH00789KeratoconusNervous system disease
ALS22H00058Amyotrophic lateral sclerosis (ALS)Neurodegenerative disease
MACTHC2H01740MacrothrombocytopeniaHematologic disease
CDCBM6/CSCSC1H01881Complex cortical dysplasia with other brain malformationsCongenital malformation
H01579Congenital symmetric circumferential skin creasesCongenital malformation
MACTHC1H01740MacrothrombocytopeniaHematologic disease
CDCBM5H01881Complex cortical dysplasia with other brain malformationsCongenital malformation
CDCBM7H01881Complex cortical dysplasia with other brain malformationsCongenital malformation
CDCBM1/CFEOM3AH01881Complex cortical dysplasia with other brain malformationsCongenital malformation
H00838Congenital fibrosis of the extraocular musclesNervous system disease
HLD6/DYT4H00679Hypomyelinating leukodystrophyInherited metabolic disorder
H00831Primary dystoniaNervous system disease
LCAEODH00837Leber congenital amaurosisNervous system disease
FPVEPDH02594Congenital facial palsy with ptosis and velopharyngeal dysfunctionNervous system disease
OOMD2H01897Oocyte/zygote/embryo maturation arrestReproductive system disease
MCPH3H00269Primary microcephalyCongenital malformation
CDCBM4H01881Complex cortical dysplasia with other brain malformationsCongenital malformation
PAMDDFSH02606Pachygyria, microcephaly, developmental delay, and dysmorphic facies, with or without seizuresCongenital malformation
MCCRP3H01880Autosomal recessive microcephaly and chorioretinopathyCongenital malformation
MCCRP1H01880Autosomal recessive microcephaly and chorioretinopathyCongenital malformation
MRD56H00773Autosomal dominant intellectual developmental disorderMental and behavioural disorder
OCSKDH02595Oculoskeletodental syndromeCongenital malformation
CDCBM3H01881Complex cortical dysplasia with other brain malformationsCongenital malformation