KEGG   Homo sapiens (human): 5515
Entry
5515              CDS       T01001                                 
Symbol
PPP2CA, HJS3, NEDLBA, PP2Ac, PP2CA, PP2Calpha, RP-C
Name
(RefSeq) protein phosphatase 2 catalytic subunit alpha
  KO
K04382  serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03015  mRNA surveillance pathway
hsa04071  Sphingolipid signaling pathway
hsa04110  Cell cycle
hsa04114  Oocyte meiosis
hsa04136  Autophagy - other
hsa04140  Autophagy - animal
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04350  TGF-beta signaling pathway
hsa04382  Cornified envelope formation
hsa04390  Hippo signaling pathway
hsa04530  Tight junction
hsa04660  T cell receptor signaling pathway
hsa04728  Dopaminergic synapse
hsa04730  Long-term depression
hsa05142  Chagas disease
hsa05160  Hepatitis C
hsa05165  Human papillomavirus infection
Network
nt06166  Human papillomavirus (HPV)
nt06512  Chromosome cohesion and segregation
nt06530  PI3K signaling
nt06537  TCR/BCR signaling
nt06545  Cornified envelope formation
  Element
N00355  PP2A-AKT signaling pathway
N00356  HPV E7 to PP2A-AKT signaling patyway
N01485  Cohesin dissociation in prophase
N01497  Condensin loading
N01579  CD80/CD86-CTLA4-PP2A signaling pathway
N01930  Processing of profilaggrin to filaggrin and binding to keratin filaments
Disease
H02632  Houge-Janssens syndrome
Drug target
Fostriecin sodium: D04262
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   03015 mRNA surveillance pathway
    5515 (PPP2CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    5515 (PPP2CA)
   04390 Hippo signaling pathway
    5515 (PPP2CA)
   04071 Sphingolipid signaling pathway
    5515 (PPP2CA)
   04151 PI3K-Akt signaling pathway
    5515 (PPP2CA)
   04152 AMPK signaling pathway
    5515 (PPP2CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    5515 (PPP2CA)
   04136 Autophagy - other
    5515 (PPP2CA)
  09143 Cell growth and death
   04110 Cell cycle
    5515 (PPP2CA)
   04114 Oocyte meiosis
    5515 (PPP2CA)
  09144 Cellular community - eukaryotes
   04530 Tight junction
    5515 (PPP2CA)
 09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    5515 (PPP2CA)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    5515 (PPP2CA)
  09156 Nervous system
   04728 Dopaminergic synapse
    5515 (PPP2CA)
   04730 Long-term depression
    5515 (PPP2CA)
  09158 Development and regeneration
   04382 Cornified envelope formation
    5515 (PPP2CA)
 09160 Human Diseases
  09172 Infectious disease: viral
   05160 Hepatitis C
    5515 (PPP2CA)
   05165 Human papillomavirus infection
    5515 (PPP2CA)
  09174 Infectious disease: parasitic
   05142 Chagas disease
    5515 (PPP2CA)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    5515 (PPP2CA)
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    5515 (PPP2CA)
   04131 Membrane trafficking [BR:hsa04131]
    5515 (PPP2CA)
   03036 Chromosome and associated proteins [BR:hsa03036]
    5515 (PPP2CA)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    5515 (PPP2CA)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     5515 (PPP2CA)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-2 (PP2A)
    Catalytic subunits
     5515 (PPP2CA)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   Surveillance factors
    Protein phosphatase 2A
     5515 (PPP2CA)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Other autophagy associated proteins
   Others
    5515 (PPP2CA)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   Other centromeric chromatin formation proteins
    PP2A (protein phosphatase 2A)
     5515 (PPP2CA)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   5515 (PPP2CA)
SSDB
Motif
Pfam: Metallophos STPPase_N zf-TAZ Glyco_hydro_65N YqzH
Other DBs
NCBI-GeneID: 5515
NCBI-ProteinID: NP_002706
OMIM: 176915
HGNC: 9299
Ensembl: ENSG00000113575
UniProt: P67775 B3KUN1
Structure
LinkDB
Position
5:complement(134194332..134226073)
AA seq 309 aa
MDEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHG
QFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHES
RQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHI
RALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRA
HQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHV
TRRTPDYFL
NT seq 930 nt   +upstreamnt  +downstreamnt
atggacgagaaggtgttcaccaaggagctggaccagtggatcgagcagctgaacgagtgc
aagcagctgtccgagtcccaggtcaagagcctctgcgagaaggctaaagaaatcctgaca
aaagaatccaacgtgcaagaggttcgatgtccagttactgtctgtggagatgtgcatggg
caatttcatgatctcatggaactgtttagaattggtggcaaatcaccagatacaaattac
ttgtttatgggagattatgttgacagaggatattattcagttgaaacagttacactgctt
gtagctcttaaggttcgttaccgtgaacgcatcaccattcttcgagggaatcatgagagc
agacagatcacacaagtttatggtttctatgatgaatgtttaagaaaatatggaaatgca
aatgtttggaaatattttacagatctttttgactatcttcctctcactgccttggtggat
gggcagatcttctgtctacatggtggtctctcgccatctatagatacactggatcatatc
agagcacttgatcgcctacaagaagttccccatgagggtccaatgtgtgacttgctgtgg
tcagatccagatgaccgtggtggttggggtatatctcctcgaggagctggttacaccttt
gggcaagatatttctgagacatttaatcatgccaatggcctcacgttggtgtctagagct
caccagctagtgatggagggatataactggtgccatgaccggaatgtagtaacgattttc
agtgctccaaactattgttatcgttgtggtaaccaagctgcaatcatggaacttgacgat
actctaaaatactctttcttgcagtttgacccagcacctcgtagaggcgagccacatgtt
actcgtcgtaccccagactacttcctgtaa

KEGG   Homo sapiens (human): 5516
Entry
5516              CDS       T01001                                 
Symbol
PPP2CB, PP2Abeta, PP2CB
Name
(RefSeq) protein phosphatase 2 catalytic subunit beta
  KO
K04382  serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03015  mRNA surveillance pathway
hsa04071  Sphingolipid signaling pathway
hsa04110  Cell cycle
hsa04114  Oocyte meiosis
hsa04136  Autophagy - other
hsa04140  Autophagy - animal
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04350  TGF-beta signaling pathway
hsa04382  Cornified envelope formation
hsa04390  Hippo signaling pathway
hsa04530  Tight junction
hsa04660  T cell receptor signaling pathway
hsa04728  Dopaminergic synapse
hsa04730  Long-term depression
hsa05142  Chagas disease
hsa05160  Hepatitis C
hsa05165  Human papillomavirus infection
Network
nt06166  Human papillomavirus (HPV)
nt06512  Chromosome cohesion and segregation
nt06530  PI3K signaling
nt06537  TCR/BCR signaling
nt06545  Cornified envelope formation
  Element
N00355  PP2A-AKT signaling pathway
N00356  HPV E7 to PP2A-AKT signaling patyway
N01485  Cohesin dissociation in prophase
N01497  Condensin loading
N01579  CD80/CD86-CTLA4-PP2A signaling pathway
N01930  Processing of profilaggrin to filaggrin and binding to keratin filaments
Drug target
Fostriecin sodium: D04262
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   03015 mRNA surveillance pathway
    5516 (PPP2CB)
 09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    5516 (PPP2CB)
   04390 Hippo signaling pathway
    5516 (PPP2CB)
   04071 Sphingolipid signaling pathway
    5516 (PPP2CB)
   04151 PI3K-Akt signaling pathway
    5516 (PPP2CB)
   04152 AMPK signaling pathway
    5516 (PPP2CB)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    5516 (PPP2CB)
   04136 Autophagy - other
    5516 (PPP2CB)
  09143 Cell growth and death
   04110 Cell cycle
    5516 (PPP2CB)
   04114 Oocyte meiosis
    5516 (PPP2CB)
  09144 Cellular community - eukaryotes
   04530 Tight junction
    5516 (PPP2CB)
 09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    5516 (PPP2CB)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    5516 (PPP2CB)
  09156 Nervous system
   04728 Dopaminergic synapse
    5516 (PPP2CB)
   04730 Long-term depression
    5516 (PPP2CB)
  09158 Development and regeneration
   04382 Cornified envelope formation
    5516 (PPP2CB)
 09160 Human Diseases
  09172 Infectious disease: viral
   05160 Hepatitis C
    5516 (PPP2CB)
   05165 Human papillomavirus infection
    5516 (PPP2CB)
  09174 Infectious disease: parasitic
   05142 Chagas disease
    5516 (PPP2CB)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    5516 (PPP2CB)
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    5516 (PPP2CB)
   04131 Membrane trafficking [BR:hsa04131]
    5516 (PPP2CB)
   03036 Chromosome and associated proteins [BR:hsa03036]
    5516 (PPP2CB)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    5516 (PPP2CB)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     5516 (PPP2CB)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-2 (PP2A)
    Catalytic subunits
     5516 (PPP2CB)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   Surveillance factors
    Protein phosphatase 2A
     5516 (PPP2CB)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Other autophagy associated proteins
   Others
    5516 (PPP2CB)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   Other centromeric chromatin formation proteins
    PP2A (protein phosphatase 2A)
     5516 (PPP2CB)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   5516 (PPP2CB)
SSDB
Motif
Pfam: Metallophos STPPase_N zf-TAZ Glyco_hydro_65N
Other DBs
NCBI-GeneID: 5516
NCBI-ProteinID: NP_001009552
OMIM: 176916
HGNC: 9300
Ensembl: ENSG00000104695
UniProt: P62714 A0A140VJS0
LinkDB
Position
8:complement(30785616..30812818)
AA seq 309 aa
MDDKAFTKELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHG
QFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHES
RQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHI
RALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRA
HQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHV
TRRTPDYFL
NT seq 930 nt   +upstreamnt  +downstreamnt
atggacgacaaggcgttcaccaaggagctggaccagtgggtcgagcagctgaacgagtgt
aagcagctgaacgagaaccaagtgcggacgctgtgcgagaaggcaaaggaaattttaaca
aaagaatcaaatgtgcaagaggttcgttgccctgttactgtctgtggagatgtgcatggt
caatttcatgatcttatggaactctttagaattggtggaaaatcaccggatacaaactac
ttattcatgggtgactatgtagacagaggatattattcagtggagactgtgactcttctt
gtagcattaaaggtgcgttatccagaacgcattacaatattgagaggaaatcacgaaagc
cgacaaattacccaagtatatggcttttatgatgaatgtctgcgaaagtatgggaatgcc
aacgtttggaaatattttacagatctctttgattatcttccacttacagctttagtagat
ggacagatattctgcctccatggtggcctctctccatccatagacacactggatcatata
agagccctggatcgtttacaggaagttccacatgagggcccaatgtgtgatctgttatgg
tcagatccagatgatcgtggtggatggggtatttcaccacgtggtgctggctacacattt
ggacaagacatttctgaaacctttaaccatgccaatggtctcacactggtttctcgtgcc
caccagcttgtaatggagggatacaattggtgtcatgatcggaatgtggttaccattttc
agtgcacccaattactgttatcgttgtgggaaccaggctgctatcatggaattagatgac
actttaaaatattccttccttcaatttgacccagcgcctcgtcgtggtgagcctcatgtt
acacggcgcaccccagactacttcctataa

KEGG   Homo sapiens (human): 5045
Entry
5045              CDS       T01001                                 
Symbol
FURIN, FUR, PACE, PCSK3, SPC1
Name
(RefSeq) furin, paired basic amino acid cleaving enzyme
  KO
K01349  furin [EC:3.4.21.75]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03250  Viral life cycle - HIV-1
hsa04382  Cornified envelope formation
Network
nt06544  Neuroactive ligand signaling
nt06545  Cornified envelope formation
  Element
N01916  Preprohormone cleavage, POMC
N01917  Preprohormone cleavage, PDYN
N01930  Processing of profilaggrin to filaggrin and binding to keratin filaments
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03250 Viral life cycle - HIV-1
    5045 (FURIN)
 09150 Organismal Systems
  09158 Development and regeneration
   04382 Cornified envelope formation
    5045 (FURIN)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5045 (FURIN)
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:hsa03110]
    5045 (FURIN)
   04131 Membrane trafficking [BR:hsa04131]
    5045 (FURIN)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.75  furin
     5045 (FURIN)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S8: subtilisin family
   5045 (FURIN)
Chaperones and folding catalysts [BR:hsa03110]
 Intramolecular chaperones
  Subtilisin family
   5045 (FURIN)
Membrane trafficking [BR:hsa04131]
 Endosome - Golgi transport
  Others
   Others
    5045 (FURIN)
SSDB
Motif
Pfam: Peptidase_S8 S8_pro-domain P_proprotein Furin-like_2 VSP DUF357
Other DBs
NCBI-GeneID: 5045
NCBI-ProteinID: NP_001276752
OMIM: 136950
HGNC: 8568
Ensembl: ENSG00000140564
UniProt: P09958
Structure
LinkDB
Position
15:90868588..90883457
AA seq 794 aa
MELRPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQI
FGDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEPTDPKFPQ
QWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDP
DPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSL
GLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREH
DSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKC
TESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKV
SHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKTVTACLGEPNH
ITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWD
EDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTAPEGLPVPPESSGCKTLTSSQACVVCE
EGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQGPALTDCL
SCPSHASLDPVEQTCSRQSQSSRESPPQQQPPRLPPEVEAGQRLRAGLLPSHLPEVVAGL
SCAFIVLVFVTVFLVLQLRSGFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDEG
RGERTAFIKDQSAL
NT seq 2385 nt   +upstreamnt  +downstreamnt
atggagctgaggccctggttgctatgggtggtagcagcaacaggaaccttggtcctgcta
gcagctgatgctcagggccagaaggtcttcaccaacacgtgggctgtgcgcatccctgga
ggcccagcggtggccaacagtgtggcacggaagcatgggttcctcaacctgggccagatc
ttcggggactattaccacttctggcatcgaggagtgacgaagcggtccctgtcgcctcac
cgcccgcggcacagccggctgcagagggagcctcaagtacagtggctggaacagcaggtg
gcaaagcgacggactaaacgggacgtgtaccaggagcccacagaccccaagtttcctcag
cagtggtacctgtctggtgtcactcagcgggacctgaatgtgaaggcggcctgggcgcag
ggctacacagggcacggcattgtggtctccattctggacgatggcatcgagaagaaccac
ccggacttggcaggcaattatgatcctggggccagttttgatgtcaatgaccaggaccct
gacccccagcctcggtacacacagatgaatgacaacaggcacggcacacggtgtgcgggg
gaagtggctgcggtggccaacaacggtgtctgtggtgtaggtgtggcctacaacgcccgc
attggaggggtgcgcatgctggatggcgaggtgacagatgcagtggaggcacgctcgctg
ggcctgaaccccaaccacatccacatctacagtgccagctggggccccgaggatgacggc
aagacagtggatgggccagcccgcctcgccgaggaggccttcttccgtggggttagccag
ggccgaggggggctgggctccatctttgtctgggcctcggggaacgggggccgggaacat
gacagctgcaactgcgacggctacaccaacagtatctacacgctgtccatcagcagcgcc
acgcagtttggcaacgtgccgtggtacagcgaggcctgctcgtccacactggccacgacc
tacagcagtggcaaccagaatgagaagcagatcgtgacgactgacttgcggcagaagtgc
acggagtctcacacgggcacctcagcctctgcccccttagcagccggcatcattgctctc
accctggaggccaataagaacctcacatggcgggacatgcaacacctggtggtacagacc
tcgaagccagcccacctcaatgccaacgactgggccaccaatggtgtgggccggaaagtg
agccactcatatggctacgggcttttggacgcaggcgccatggtggccctggcccagaat
tggaccacagtggccccccagcggaagtgcatcatcgacatcctcaccgagcccaaagac
atcgggaaacggctcgaggtgcggaagaccgtgaccgcgtgcctgggcgagcccaaccac
atcactcggctggagcacgctcaggcgcggctcaccctgtcctataatcgccgtggcgac
ctggccatccacctggtcagccccatgggcacccgctccaccctgctggcagccaggcca
catgactactccgcagatgggtttaatgactgggccttcatgacaactcattcctgggat
gaggatccctctggcgagtgggtcctagagattgaaaacaccagcgaagccaacaactat
gggacgctgaccaagttcaccctcgtactctatggcaccgcccctgaggggctgcccgta
cctccagaaagcagtggctgcaagaccctcacgtccagtcaggcctgtgtggtgtgcgag
gaaggcttctccctgcaccagaagagctgtgtccagcactgccctccagggttcgccccc
caagtcctcgatacgcactatagcaccgagaatgacgtggagaccatccgggccagcgtc
tgcgccccctgccacgcctcatgtgccacatgccaggggccggccctgacagactgcctc
agctgccccagccacgcctccttggaccctgtggagcagacttgctcccggcaaagccag
agcagccgagagtccccgccacagcagcagccacctcggctgcccccggaggtggaggcg
gggcaacggctgcgggcagggctgctgccctcacacctgcctgaggtggtggccggcctc
agctgcgccttcatcgtgctggtcttcgtcactgtcttcctggtcctgcagctgcgctct
ggctttagttttcggggggtgaaggtgtacaccatggaccgtggcctcatctcctacaag
gggctgccccctgaagcctggcaggaggagtgcccgtctgactcagaagaggacgagggc
cggggcgagaggaccgcctttatcaaagaccagagcgccctctga

KEGG   Homo sapiens (human): 5046
Entry
5046              CDS       T01001                                 
Symbol
PCSK6, PACE4, SPC4
Name
(RefSeq) proprotein convertase subtilisin/kexin type 6
  KO
K08672  proprotein convertase subtilisin/kexin type 6 [EC:3.4.21.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04382  Cornified envelope formation
Network
nt06545  Cornified envelope formation
  Element
N01930  Processing of profilaggrin to filaggrin and binding to keratin filaments
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09158 Development and regeneration
   04382 Cornified envelope formation
    5046 (PCSK6)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5046 (PCSK6)
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:hsa03110]
    5046 (PCSK6)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S8: subtilisin family
   5046 (PCSK6)
Chaperones and folding catalysts [BR:hsa03110]
 Intramolecular chaperones
  Subtilisin family
   5046 (PCSK6)
SSDB
Motif
Pfam: Peptidase_S8 P_proprotein S8_pro-domain GF_recep_IV Furin-like_2 PLAC VSP
Other DBs
NCBI-GeneID: 5046
NCBI-ProteinID: NP_002561
OMIM: 167405
HGNC: 8569
Ensembl: ENSG00000140479
UniProt: P29122 A2RQD9
LinkDB
Position
15:complement(101303933..101489707)
AA seq 969 aa
MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA
CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL
SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC
RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA
SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID
IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY
TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS
VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL
VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE
HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG
QWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPP
KAALSPSQVEVPEDEEDYTAQSTPGSANILQTSVCHPECGDKGCDGPNADQCLNCVHFSL
GSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTC
VTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDS
ELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRR
CDENCLSCAGSSRNCSRCKTGFTQLGTSCITNHTCSNADETFCEMVKSNRLCERKLFIQF
CCRTCLLAG
NT seq 2910 nt   +upstreamnt  +downstreamnt
atgcctccgcgcgcgccgcctgcgcccgggccccggccgccgccccgggccgccgccgcc
accgacaccgccgcgggcgcggggggcgcggggggcgcggggggcgccggcgggcccggg
ttccggccgctcgcgccgcgtccctggcgctggctgctgctgctggcgctgcctgccgcc
tgctccgcgcccccgccgcgccccgtctacaccaaccactgggcggtgcaagtgctgggc
ggcccggccgaggcggaccgcgtggcggcggcgcacgggtacctcaacttgggccagatt
ggaaacctggaagattactaccatttttatcacagcaaaacctttaaaagatcaaccttg
agtagcagaggccctcacaccttcctcagaatggacccccaggtgaaatggctccagcaa
caggaagtgaaacgaagggtgaagagacaggtgcgaagtgacccgcaggccctttacttc
aacgaccccatttggtccaacatgtggtacctgcattgtggcgacaagaacagtcgctgc
cggtcggaaatgaatgtccaggcagcgtggaagaggggctacacaggaaaaaacgtggtg
gtcaccatccttgatgatggcatagagagaaatcaccctgacctggccccaaattatgat
tcctacgccagctacgacgtgaacggcaatgattatgacccatctccacgatatgatgcc
agcaatgaaaataaacacggcactcgttgtgcgggagaagttgctgcttcagcaaacaat
tcctactgcatcgtgggcatagcgtacaatgccaaaataggaggcatccgcatgctggac
ggcgatgtcacagatgtggtcgaggcaaagtcgctgggcatcagacccaactacatcgac
atttacagtgccagctgggggccggacgacgacggcaagacggtggacgggcccggccga
ctggctaagcaggctttcgagtatggcattaaaaagggccggcagggcctgggctccatt
ttcgtctgggcatctgggaatggcgggagagagggggactactgctcgtgcgatggctac
accaacagcatctacaccatctccgtcagcagcgccaccgagaatggctacaagccctgg
tacctggaagagtgtgcctccaccctggccaccacctacagcagtggggccttttatgag
cgaaaaatcgtcaccacggatctgcgtcagcgctgtaccgatggccacactgggacctca
gtctctgcccccatggtggcgggcatcatcgccttggctctagaagcaaacagccagtta
acctggagggacgtccagcacctgctagtgaagacatcccggccggcccacctgaaagcg
agcgactggaaagtgaacggcgcgggtcataaagttagccatttctatggatttggtttg
gtggacgcagaagctctcgttgtggaggcaaagaagtggacagcagtgccatcgcagcac
atgtgtgtggccgcctcggacaagagacccaggagcatccccttagtgcaggtgctgcgg
actacggccctgaccagcgcctgcgcggagcactcggaccagcgggtggtctacttggag
cacgtggtggttcgcacctccatctcacacccacgccgaggagacctccagatctacctg
gtttctccctcgggaaccaagtctcaacttctggcaaagaggttgctggatctttccaat
gaagggtttacaaactgggaattcatgactgtccactgctggggagaaaaggctgaaggg
cagtggaccttggaaatccaagatctgccatcccaggtccgcaacccggagaagcaaggg
aagttgaaagaatggagcctcatactgtatggcacagcagagcacccgtaccacaccttc
agtgcccatcagtcccgctcgcggatgctggagctctcagccccagagctggagccaccc
aaggctgccctgtcaccctcccaggtggaagttcctgaagatgaggaagattacacagct
caatccaccccaggctctgctaatattttacagaccagtgtgtgccatccggagtgtggt
gacaaaggctgtgatggccccaatgcagaccagtgcttgaactgcgtccacttcagcctg
gggagtgtcaagaccagcaggaagtgcgtgagtgtgtgccccttgggctactttggggac
acagcagcaagacgctgtcgccggtgccacaaggggtgtgagacctgctccagcagagct
gcgacgcagtgcctgtcttgccgccgcgggttctatcaccaccaggagatgaacacctgt
gtgaccctctgtcctgcaggattttatgctgatgaaagtcagaaaaattgccttaaatgc
cacccaagctgtaaaaagtgcgtggatgaacctgagaaatgtactgtctgtaaagaagga
ttcagccttgcacggggcagctgcattcctgactgtgagccaggcacctactttgactca
gagctgatcagatgtggggaatgccatcacacctgcggaacctgcgtggggccaggcaga
gaagagtgcattcactgtgcgaaaaacttccacttccacgactggaagtgtgtgccagcc
tgtggtgagggcttctacccagaagagatgccgggcttgccccacaaagtgtgtcgaagg
tgtgacgagaactgcttgagctgtgcaggctccagcaggaactgtagcaggtgtaagacg
ggcttcacacagctggggacctcctgcatcaccaaccacacgtgcagcaacgctgacgag
acattctgcgagatggtgaagtccaaccggctgtgcgaacggaagctcttcattcagttc
tgctgccgcacgtgcctcctggccgggtaa

KEGG   Homo sapiens (human): 151516
Entry
151516            CDS       T01001                                 
Symbol
ASPRV1, ADLI, MUNO, SASP, SASPase, Taps
Name
(RefSeq) aspartic peptidase retroviral like 1
  KO
K24552  retroviral-like aspartic protease 1 [EC:3.4.23.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04382  Cornified envelope formation
Network
nt06545  Cornified envelope formation
  Element
N01930  Processing of profilaggrin to filaggrin and binding to keratin filaments
Disease
H02449  Autosomal dominant lamellar ichthyosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09158 Development and regeneration
   04382 Cornified envelope formation
    151516 (ASPRV1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    151516 (ASPRV1)
Peptidases and inhibitors [BR:hsa01002]
 Aspartic peptidases
  Family A28
   151516 (ASPRV1)
SSDB
Motif
Pfam: gag-asp_proteas Asp_protease_2 Asp_protease RVP
Other DBs
NCBI-GeneID: 151516
NCBI-ProteinID: NP_690005
OMIM: 611765
HGNC: 26321
Ensembl: ENSG00000293615
UniProt: Q53RT3
LinkDB
Position
2:complement(69932717..70087375)
AA seq 259 aa
MAGSGARSEEGRRQHAFVPEPFDGANVVPNLWLHSFEVINDLNHWDHITKLRFLKESLRG
EALGVYNRLSPQDQGDYGTVKEALLKAFGVPGAAPSHLPKEIVFANSMGKGYYLKGKIGK
VPVRFLVDSGAQVSVVHPNLWEEVTDGDLDTLQPFENVVKVANGAEMKILGVWDTAVSLG
KLKLKAQFLVANASAEEAIIGTDVLQDHNAILDFEHRTCTLKGKKFRLLPVGGSLEDEFD
LELIEEDPSSEEGRQELSH
NT seq 780 nt   +upstreamnt  +downstreamnt
atggccgggagcggagccaggagtgaggaaggccgccggcagcatgccttcgtcccggaa
ccttttgatggggccaatgtcgtcccaaacctctggctgcacagctttgaagtcatcaat
gacctcaaccattgggaccatatcaccaagctaaggttcctgaaagagtccctcagagga
gaggccctgggtgtctacaataggctcagtccccaggaccagggagactatgggactgtg
aaagaggccctcctgaaggcctttggggtccctggggctgcccccagccacctgcccaaa
gagatcgtctttgccaacagcatgggtaagggctactatctcaaggggaagattggcaaa
gtgcccgtgaggttcctggtggactctggggcccaggtctctgtggtccacccaaacttg
tgggaggaggtcactgatggcgatctggacaccctgcagccctttgagaatgtggtaaag
gtggccaatggtgctgaaatgaagatcctgggtgtctgggatacagcggtgtccctaggc
aagctgaagctgaaggcacagttcctagtggccaatgcgagtgccgaggaagccatcatt
ggcactgatgtgctccaggaccacaatgctatcctggactttgagcaccgcacatgcacc
ctgaaagggaagaagtttcgccttctgcctgtgggagggtccctggaagatgagtttgac
ctggagctcatagaggaggacccctcctcagaagaagggcggcaggagctatcccactga

KEGG   Homo sapiens (human): 5652
Entry
5652              CDS       T01001                                 
Symbol
PRSS8, CAP1, PROSTASIN
Name
(RefSeq) serine protease 8
  KO
K08664  prostasin [EC:3.4.21.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04382  Cornified envelope formation
Network
nt06545  Cornified envelope formation
  Element
N01930  Processing of profilaggrin to filaggrin and binding to keratin filaments
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09158 Development and regeneration
   04382 Cornified envelope formation
    5652 (PRSS8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5652 (PRSS8)
  09183 Protein families: signaling and cellular processes
   00537 Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:hsa00537]
    5652 (PRSS8)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S1: chymotrypsin family
   5652 (PRSS8)
Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:hsa00537]
 Enzymes
  5652 (PRSS8)
SSDB
Motif
Pfam: Trypsin DUF1986 Trypsin_2
Other DBs
NCBI-GeneID: 5652
NCBI-ProteinID: NP_002764
OMIM: 600823
HGNC: 9491
Ensembl: ENSG00000052344
UniProt: Q16651
Structure
LinkDB
Position
16:complement(31131433..31135727)
AA seq 343 aa
MAQKGVLGPGQLGAVAILLYLGLLRSGTGAEGAEAPCGVAPQARITGGSSAVAGQWPWQV
SITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHKEAYEVKLGAHQLDSYSEDAKVSTLKDI
IPHPSYLQEGSQGDIALLQLSRPITFSRYIRPICLPAANASFPNGLHCTVTGWGHVAPSV
SLLTPKPLQQLEVPLISRETCNCLYNIDAKPEEPHFVQEDMVCAGYVEGGKDACQGDSGG
PLSCPVEGLWYLTGIVSWGDACGARNRPGVYTLASSYASWIQSKVTELQPRVVPQTQESQ
PDSNLCGSHLAFSSAPAQGLLRPILFLPLGLALGLLSPWLSEH
NT seq 1032 nt   +upstreamnt  +downstreamnt
atggcccagaagggggtcctggggcctgggcagctgggggctgtggccattctgctctat
cttggattactccggtcggggacaggagcggaaggggcagaagctccctgcggtgtggcc
ccccaagcacgcatcacaggtggcagcagtgcagtcgccggtcagtggccctggcaggtc
agcatcacctatgaaggcgtccatgtgtgtggtggctctctcgtgtctgagcagtgggtg
ctgtcagctgctcactgcttccccagcgagcaccacaaggaagcctatgaggtcaagctg
ggggcccaccagctagactcctactccgaggacgccaaggtcagcaccctgaaggacatc
atcccccaccccagctacctccaggagggctcccagggcgacattgcactcctccaactc
agcagacccatcaccttctcccgctacatccggcccatctgcctccctgcagccaacgcc
tccttccccaacggcctccactgcactgtcactggctggggtcatgtggccccctcagtg
agcctcctgacgcccaagccactgcagcaactcgaggtgcctctgatcagtcgtgagacg
tgtaactgcctgtacaacatcgacgccaagcctgaggagccgcactttgtccaagaggac
atggtgtgtgctggctatgtggaggggggcaaggacgcctgccagggtgactctgggggc
ccactctcctgccctgtggagggtctctggtacctgacgggcattgtgagctggggagat
gcctgtggggcccgcaacaggcctggtgtgtacactctggcctccagctatgcctcctgg
atccaaagcaaggtgacagaactccagcctcgtgtggtgccccaaacccaggagtcccag
cccgacagcaacctctgtggcagccacctggccttcagctctgccccagcccagggcttg
ctgaggcccatccttttcctgcctctgggcctggctctgggcctcctctccccatggctc
agcgagcactga

KEGG   Homo sapiens (human): 6768
Entry
6768              CDS       T01001                                 
Symbol
ST14, ARCI11, CAP3, HAI, MT-SP1, MTSP1, PRSS14, SNC19, TADG15, TMPRSS14
Name
(RefSeq) ST14 transmembrane serine protease matriptase
  KO
K08670  suppressor of tumorigenicity protein 14 [EC:3.4.21.109]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04382  Cornified envelope formation
hsa05206  MicroRNAs in cancer
Network
nt06545  Cornified envelope formation
  Element
N01930  Processing of profilaggrin to filaggrin and binding to keratin filaments
Disease
H00734  Autosomal recessive congenital ichthyosis
H00739  Ichthyosis with hypotrichosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09158 Development and regeneration
   04382 Cornified envelope formation
    6768 (ST14)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    6768 (ST14)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    6768 (ST14)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.109  matriptase
     6768 (ST14)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S1: chymotrypsin family
   6768 (ST14)
SSDB
Motif
Pfam: Trypsin CUB Ldl_recept_a SEA CUB_2 DUF1986 CDCP1_CUB_6
Other DBs
NCBI-GeneID: 6768
NCBI-ProteinID: NP_068813
OMIM: 606797
HGNC: 11344
Ensembl: ENSG00000149418
UniProt: Q9Y5Y6
Structure
LinkDB
Position
11:130159782..130210362
AA seq 855 aa
MGSDRARKGGGGPKDFGAGLKYNSRHEKVNGLEEGVEFLPVNNVKKVEKHGPGRWVVLAA
VLIGLLLVLLGIGFLVWHLQYRDVRVQKVFNGYMRITNENFVDAYENSNSTEFVSLASKV
KDALKLLYSGVPFLGPYHKESAVTAFSEGSVIAYYWSEFSIPQHLVEEAERVMAEERVVM
LPPRARSLKSFVVTSVVAFPTDSKTVQRTQDNSCSFGLHARGVELMRFTTPGFPDSPYPA
HARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEPHALVQLCGTYPPS
YNLTFHSSQNVLLITLITNTERRHPGFEATFFQLPRMSSCGGRLRKAQGTFNSPYYPGHY
PPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKDYVEINGEKYCGERSQFVVTS
NSNKITVRFHSDQSYTDTGFLAEYLSYDSSDPCPGQFTCRTGRCIRKELRCDGWADCTDH
SDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPAQTFRCSNGKCLSK
SQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEK
DCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYID
DRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKP
AEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLL
PQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYT
RLPLFRDWIKENTGV
NT seq 2568 nt   +upstreamnt  +downstreamnt
atggggagcgatcgggcccgcaagggcggagggggcccgaaggacttcggcgcgggactc
aagtacaactcccggcacgagaaagtgaatggcttggaggaaggcgtggagttcctgcca
gtcaacaacgtcaagaaggtggaaaagcatggcccggggcgctgggtggtgctggcagcc
gtgctgatcggcctcctcttggtcttgctggggatcggcttcctggtgtggcatttgcag
taccgggacgtgcgtgtccagaaggtcttcaatggctacatgaggatcacaaatgagaat
tttgtggatgcctacgagaactccaactccactgagtttgtaagcctggccagcaaggtg
aaggacgcgctgaagctgctgtacagcggagtcccattcctgggcccctaccacaaggag
tcggctgtgacggccttcagcgagggcagcgtcatcgcctactactggtctgagttcagc
atcccgcagcacctggtggaggaggccgagcgcgtcatggccgaggagcgcgtagtcatg
ctgcccccgcgggcgcgctccctgaagtcctttgtggtcacctcagtggtggctttcccc
acggactccaaaacagtacagaggacccaggacaacagctgcagctttggcctgcacgcc
cgcggtgtggagctgatgcgcttcaccacgcccggcttccctgacagcccctaccccgct
catgcccgctgccagtgggccctgcggggggacgccgactcagtgctgagcctcaccttc
cgcagctttgaccttgcgtcctgcgacgagcgcggcagcgacctggtgacggtgtacaac
accctgagccccatggagccccacgccctggtgcagttgtgtggcacctaccctccctcc
tacaacctgaccttccactcctcccagaacgtcctgctcatcacactgataaccaacact
gagcggcggcatcccggctttgaggccaccttcttccagctgcctaggatgagcagctgt
ggaggccgcttacgtaaagcccaggggacattcaacagcccctactacccaggccactac
ccacccaacattgactgcacatggaacattgaggtgcccaacaaccagcatgtgaaggtg
cgcttcaaattcttctacctgctggagcccggcgtgcctgcgggcacctgccccaaggac
tacgtggagatcaacggggagaaatactgcggagagaggtcccagttcgtcgtcaccagc
aacagcaacaagatcacagttcgcttccactcagatcagtcctacaccgacaccggcttc
ttagctgaatacctctcctacgactccagtgacccatgcccggggcagttcacgtgccgc
acggggcggtgtatccggaaggagctgcgctgtgatggctgggccgactgcaccgaccac
agcgatgagctcaactgcagttgcgacgccggccaccagttcacgtgcaagaacaagttc
tgcaagcccctcttctgggtctgcgacagtgtgaacgactgcggagacaacagcgacgag
caggggtgcagttgtccggcccagaccttcaggtgttccaatgggaagtgcctctcgaaa
agccagcagtgcaatgggaaggacgactgtggggacgggtccgacgaggcctcctgcccc
aaggtgaacgtcgtcacttgtaccaaacacacctaccgctgcctcaatgggctctgcttg
agcaagggcaaccctgagtgtgacgggaaggaggactgtagcgacggctcagatgagaag
gactgcgactgtgggctgcggtcattcacgagacaggctcgtgttgttgggggcacggat
gcggatgagggcgagtggccctggcaggtaagcctgcatgctctgggccagggccacatc
tgcggtgcttccctcatctctcccaactggctggtctctgccgcacactgctacatcgat
gacagaggattcaggtactcagaccccacgcagtggacggccttcctgggcttgcacgac
cagagccagcgcagcgcccctggggtgcaggagcgcaggctcaagcgcatcatctcccac
cccttcttcaatgacttcaccttcgactatgacatcgcgctgctggagctggagaaaccg
gcagagtacagctccatggtgcggcccatctgcctgccggacgcctcccatgtcttccct
gccggcaaggccatctgggtcacgggctggggacacacccagtatggaggcactggcgcg
ctgatcctgcaaaagggtgagatccgcgtcatcaaccagaccacctgcgagaacctcctg
ccgcagcagatcacgccgcgcatgatgtgcgtgggcttcctcagcggcggcgtggactcc
tgccagggtgattccgggggacccctgtccagcgtggaggcggatgggcggatcttccag
gccggtgtggtgagctggggagacggctgcgctcagaggaacaagccaggcgtgtacaca
aggctccctctgtttcgggactggatcaaagagaacactggggtatag

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