Homo sapiens (human): 7094 Help Entry 7094              CDS       T01001                                  Symbol TLN1, ILWEQ, TLN, talin-1 Name (RefSeq) talin 1   KO K06271   talin Organism hsa  Homo sapiens (human) Pathway hsa04015   Rap1 signaling pathway hsa04510   Focal adhesion hsa04611   Platelet activation hsa05131   Shigellosis hsa05166   Human T-cell leukemia virus 1 infection Network   Element N01080   ITGA/B-TALIN/VINCULIN signaling pathway N01081   Shigella IpaB/C/D to ITGA/B-TALIN/VINCULIN signaling pathway Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     7094 (TLN1)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     7094 (TLN1)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     7094 (TLN1)  09160 Human Diseases   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     7094 (TLN1)   09171 Infectious disease: bacterial    05131 Shigellosis     7094 (TLN1)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:hsa04147]     7094 (TLN1) Exosome [BR:hsa04147]  Exosomal proteins   Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)    7094 (TLN1)   Exosomal proteins of other cancer cells    7094 (TLN1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  VBS Talin_middle Talin_R4 I_LWEQ FERM_f0 FERM_M FERM_N ACBP IRS TrcR RA SNX17-31_F2_FERM GIT1_C Motif Other DBs NCBI-GeneID:  7094 NCBI-ProteinID:  NP_006280 OMIM:  186745 HGNC:  11845 Ensembl:  ENSG00000137076 UniProt:  Q9Y490 Structure PDB LinkDB All DBs Position 9:complement(35696948..35732195) Genome browser AA seq 2541 aa AA seqDB search MVALSLKISIGNVVKTMQFEPSTMVYDACRIIRERIPEAPAGPPSDFGLFLSDDDPKKGI WLEAGKALDYYMLRNGDTMEYRKKQRPLKIRMLDGTVKTIMVDDSKTVTDMLMTICARIG ITNHDEYSLVRELMEEKKEEITGTLRKDKTLLRDEKKMEKLKQKLHTDDELNWLDHGRTL REQGVEEHETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSFDKACEFAG FQCQIQFGPHNEQKHKAGFLDLKDFLPKEYVKQKGERKIFQAHKNCGQMSEIEAKVRYVK LARSLKTYGVSFFLVKEKMKGKNKLVPRLLGITKECVMRVDEKTKEVIQEWNLTNIKRWA ASPKSFTLDFGDYQDGYYSVQTTEGEQIAQLIAGYIDIILKKKKSKDHFGLEGDEESTML EDSVSPKKSTVLQQQYNRVGKVEHGSVALPAIMRSGASGPENFQVGSMPPAQQQITSGQM HRGHMPPLTSAQQALTGTINSSMQAVQAAQATLDDFDTLPPLGQDAASKAWRKNKMDESK HEIHSQVDAITAGTASVVNLTAGDPAETDYTAVGCAVTTISSNLTEMSRGVKLLAALLED EGGSGRPLLQAAKGLAGAVSELLRSAQPASAEPRQNLLQAAGNVGQASGELLQQIGESDT DPHFQDALMQLAKAVASAAAALVLKAKSVAQRTEDSGLQTQVIAAATQCALSTSQLVACT KVVAPTISSPVCQEQLVEAGRLVAKAVEGCVSASQAATEDGQLLRGVGAAATAVTQALNE LLQHVKAHATGAGPAGRYDQATDTILTVTENIFSSMGDAGEMVRQARILAQATSDLVNAI KADAEGESDLENSRKLLSAAKILADATAKMVEAAKGAAAHPDSEEQQQRLREAAEGLRMA TNAAAQNAIKKKLVQRLEHAAKQAAASATQTIAAAQHAASTPKASAGPQPLLVQSCKAVA EQIPLLVQGVRGSQAQPDSPSAQLALIAASQSFLQPGGKMVAAAKASVPTIQDQASAMQL SQCAKNLGTALAELRTAAQKAQEACGPLEMDSALSVVQNLEKDLQEVKAAARDGKLKPLP GETMEKCTQDLGNSTKAVSSAIAQLLGEVAQGNENYAGIAARDVAGGLRSLAQAARGVAA LTSDPAVQAIVLDTASDVLDKASSLIEEAKKAAGHPGDPESQQRLAQVAKAVTQALNRCV SCLPGQRDVDNALRAVGDASKRLLSDSLPPSTGTFQEAQSRLNEAAAGLNQAATELVQAS RGTPQDLARASGRFGQDFSTFLEAGVEMAGQAPSQEDRAQVVSNLKGISMSSSKLLLAAK ALSTDPAAPNLKSQLAAAARAVTDSINQLITMCTQQAPGQKECDNALRELETVRELLENP VQPINDMSYFGCLDSVMENSKVLGEAMTGISQNAKNGNLPEFGDAISTASKALCGFTEAA AQAAYLVGVSDPNSQAGQQGLVEPTQFARANQAIQMACQSLGEPGCTQAQVLSAATIVAK HTSALCNSCRLASARTTNPTAKRQFVQSAKEVANSTANLVKTIKALDGAFTEENRAQCRA ATAPLLEAVDNLSAFASNPEFSSIPAQISPEGRAAMEPIVISAKTMLESAGGLIQTARAL AVNPRDPPSWSVLAGHSRTVSDSIKKLITSMRDKAPGQLECETAIAALNSCLRDLDQASL AAVSQQLAPREGISQEALHTQMLTAVQEISHLIEPLANAARAEASQLGHKVSQMAQYFEP LTLAAVGAASKTLSHPQQMALLDQTKTLAESALQLLYTAKEAGGNPKQAAHTQEALEEAV QMMTEAVEDLTTTLNEAASAAGVVGGMVDSITQAINQLDEGPMGEPEGSFVDYQTTMVRT AKAIAVTVQEMVTKSNTSPEELGPLANQLTSDYGRLASEAKPAAVAAENEEIGSHIKHRV QELGHGCAALVTKAGALQCSPSDAYTKKELIECARRVSEKVSHVLAALQAGNRGTQACIT AASAVSGIIADLDTTIMFATAGTLNREGTETFADHREGILKTAKVLVEDTKVLVQNAAGS QEKLAQAAQSSVATITRLADVVKLGAASLGAEDPETQVVLINAVKDVAKALGDLISATKA AAGKVGDDPAVWQLKNSAKVMVTNVTSLLKTVKAVEDEATKGTRALEATTEHIRQELAVF CSPEPPAKTSTPEDFIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRRAIADMLRACK EAAYHPEVAPDVRLRALHYGRECANGYLELLDHVLLTLQKPSPELKQQLTGHSKRVAGSV TELIQAAEAMKGTEWVDPEDPTVIAENELLGAAAAIEAAAKKLEQLKPRAKPKEADESLN FEEQILEAAKSIAAATSALVKAASAAQRELVAQGKVGAIPANALDDGQWSQGLISAARMV AAATNNLCEAANAAVQGHASQEKLISSAKQVAASTAQLLVACKVKADQDSEAMKRLQAAG NAVKRASDNLVKAAQKAAAFEEQENETVVVKEKMVGGIAQIIAAQEEMLRKERELEEARK KLAQIRQQQYKFLPSELRDEH NT seq 7626 nt NT seq  +upstreamnt  +downstreamnt atggttgcactttcactgaagatcagcattgggaatgtggtgaagacgatgcagtttgag ccgtctaccatggtgtacgacgcctgccgcatcattcgtgagcggatcccagaggcccca gctggtcctcccagcgactttgggctctttctgtcagatgatgaccccaaaaagggtata tggctggaggctgggaaagctttggactactacatgctccgaaatggggacactatggag tacaggaagaaacagagacccctgaagatccgtatgctggatggaactgtgaagacgatc atggtggatgactctaagactgtcactgacatgctcatgaccatctgtgcccgcattggc atcaccaatcatgatgaatattcattggttcgagagctgatggaagagaaaaaggaggaa ataacagggaccttaagaaaggacaagacattgctgcgagatgaaaagaagatggagaaa ctaaagcagaaattgcacacagatgatgagttgaactggctggaccatggtcggacactg agggagcagggtgtagaggagcacgagacgctgctgctgcggaggaagttcttttactca gaccagaatgtggattcccgggaccctgtacagctgaacctcctgtatgtgcaggcacga gatgacatcctgaatggctcccaccctgtctcctttgacaaggcctgtgagtttgctggc ttccaatgccagatccagtttgggccccacaatgagcagaagcacaaggctggcttcctt gacctgaaggacttcctgcccaaggagtatgtgaagcagaagggagagcgtaagatcttc caggcacacaagaattgtgggcagatgagtgagattgaggccaaggtccgctacgtgaag ctagcccgttctctcaagacttacggtgtctccttcttcctggtgaaggaaaaaatgaaa gggaagaacaagctagtgcccaggcttctgggcatcaccaaggagtgtgtgatgcgagtg gatgagaagaccaaggaagtgatccaggagtggaacctcaccaacatcaaacgctgggct gcgtctcccaaaagcttcaccctggattttggagattaccaagatggctattactcagta cagacaactgaaggggagcagattgcacagctcattgccggctacatcgatatcatcctg aagaagaaaaaaagcaaggatcactttgggctggaaggagatgaggagtctactatgctg gaggactcagtgtcccccaaaaagtcaacagtcctgcagcagcaatacaaccgggtgggg aaagtggagcatggctctgtggccctgcctgccatcatgcgctctggagcctctggtcct gagaatttccaggtgggcagcatgccccctgcccagcagcagattaccagcggccagatg caccgaggacacatgcctcctctgacttcagcccagcaggcactcactggaaccattaac tccagcatgcaggccgtgcaggctgcccaggccaccctggatgactttgacactctgccg cctcttggccaggatgctgcctctaaggcctggcgtaaaaacaagatggatgaatcaaag catgagatccactctcaggtagatgccatcacagctggtactgcgtctgtggtgaacctg acagcaggggaccctgctgagacagactataccgcagtgggctgtgcagtcaccacaatc tcctccaacctgacggagatgtcccgtggggtgaagctgctggctgccttgctggaggac gaaggcggcagtggtcggcccctgttgcaggcagcaaagggccttgcgggagcagtgtca gaactgctgcgcagtgcccaaccagccagtgctgagccccgtcagaacctgctgcaagca gctgggaacgtgggccaggccagtggggagctgttgcaacaaattggggaaagtgatact gacccccacttccaggatgcgctaatgcagctcgccaaagctgtggcaagtgctgcagct gccctggtcctcaaggccaagagtgtggcccagcggacagaggactcgggacttcagacc caagttattgctgcagcaacacagtgtgccctatccacttcccaactagtggcctgtact aaggtggtggcacctacaatcagctcacctgtctgccaagagcaactggtggaggctgga cgactggtagccaaagccgtggagggctgtgtgtctgcctcccaggcagctacagaggat gggcaactgttgcgaggggtaggagcagcagccacagctgtcacccaggccctaaatgag ctgctgcagcatgtgaaagcccatgccacaggggctgggcctgctggccgttatgaccag gctactgacaccatcctaaccgtcactgagaacatctttagctccatgggtgatgctggg gagatggtgcgacaggcccgcatcctggcccaagccacatctgacctggtcaatgccatc aaggctgatgctgagggggaaagtgatctggagaactcccgcaagctcttaagtgctgcc aagatcctagctgatgccacagccaagatggtagaggctgccaagggagcagctgcccac cctgacagtgaggagcagcagcagcggctgcgggaggcagctgaggggctgcgcatggcc accaatgcagctgcgcagaatgccatcaagaaaaagctggtgcagcgcctggagcatgca gccaagcaggctgcagcctcagccacacagaccatcgctgcagctcagcacgcagcctct acccccaaggcctctgccggcccccagcccctgctggtgcagagctgcaaggcagtggca gagcagattccactgctggtgcagggcgtccgaggaagccaagcccagcctgacagcccc agcgctcagcttgccctcattgctgccagccagagcttcctgcagccaggtgggaagatg gtggcagctgcaaaggcctcagtgccaacgattcaggaccaggcttcagccatgcagctg agtcagtgtgccaagaacctgggcaccgcgctggctgaactccggacggctgcccagaag gctcaggaagcatgtggacctttggagatggattctgcactgagtgtggtacagaatcta gagaaagatctacaggaagtgaaggcagcagctcgagatggcaagcttaaacccttacct ggggagacaatggagaagtgtacccaggacctgggcaacagcaccaaagccgtgagctca gccatcgcccagctactgggagaggttgcccagggcaatgagaattatgcaggtattgca gctcgggatgtggcaggtgggctgcggtcactggcccaggccgctaggggagtcgctgca ctgacgtcagatcctgcagtgcaggccattgtacttgatacggccagtgatgtgctggac aaggccagcagcctcattgaggaggcgaaaaaggcagctggccatccaggggaccctgag agccagcagcggcttgcccaggtggctaaagcagtgacccaggctctgaaccgctgtgtc agctgcctacctggccagcgcgatgtggataatgccctgagggcagttggagatgccagc aagcgactcctgagtgactcgcttcctcctagcactgggacatttcaagaagctcagagc cggttgaatgaagctgctgctgggctgaatcaggcagccacagaactggtgcaggcctct cggggaacccctcaggacctggctcgagcctcaggccgatttggacaggacttcagcacc ttcctggaagctggtgtggagatggcaggccaggctccgagccaggaggaccgagcccaa gttgtgtccaacttgaagggcatctccatgtcttcaagcaaacttcttctggctgccaag gccctgtccacggaccctgctgcccctaacctcaagagtcagctggctgcagctgccagg gcagtaactgacagcatcaatcagctcatcactatgtgcacccagcaggcacccggccag aaggagtgtgataacgccctgcgggaattggagacggtccgggaactcctggagaaccca gtccagcccatcaatgacatgtcctactttggttgcctggacagtgtaatggagaactca aaggtgctgggcgaggccatgactggcatctcccaaaatgccaagaacggaaacctgcca gagtttggagatgccatttccacagcctcaaaggcactttgtggcttcaccgaggcagct gcacaggctgcatatctggttggtgtctctgaccccaatagccaagctggacagcaaggg ctagtggagcccacacagtttgcccgtgcaaaccaggcaattcagatggcctgccagagt ttgggagagcctggctgtacccaggcccaggtgctctctgcagccaccattgtggctaaa cacacctctgcactgtgtaacagctgtcgcctggcttctgcccgtaccaccaatcctact gccaagcgccagtttgtacagtcagccaaggaggtggccaacagcacagctaatcttgtc aagaccatcaaggcgctagatggggccttcacagaggagaaccgtgcccagtgccgagca gcaacagcccctctgctggaggctgtggacaatctgagtgcctttgcgtccaaccctgag ttctccagcattcctgcccagatcagccctgagggtcgggctgccatggagcccattgtg atctctgccaagacaatgttagagagtgccgggggactcatccagacagcccgggccctc gcagtcaatccccgggaccccccgagctggtcggtgctggccggccactcccgtactgtc tcagactccatcaagaagctaattacaagcatgagggacaaggctccagggcagctggag tgtgaaacggccattgcagctctgaacagttgtctacgggacctagaccaggcttccctc gctgcagtcagccagcagcttgctccccgtgagggaatctctcaagaggccttgcacact cagatgctcactgcagtccaagagatctcccatctcattgagccgctggccaatgctgcc cgggctgaagcctcccagctgggacacaaggtgtcccagatggcgcagtactttgagccg ctcaccctggctgcagtgggtgctgcctccaagaccctgagccacccgcagcagatggca ctcctggaccagactaaaacattggcagagtctgccctgcagttgctatacactgccaag gaggctggtggtaacccaaagcaagcagctcacacccaggaagccctggaggaggctgtg cagatgatgaccgaggccgtagaggacctgacaacaaccctcaacgaggcagccagtgct gctggggtcgtgggtggcatggtggactccatcacccaggccatcaaccagctagatgaa ggaccaatgggtgaaccagaaggttccttcgtggattaccaaacaactatggtgcggaca gccaaggccattgcagtgaccgttcaggagatggttaccaagtcaaacaccagcccagag gagctgggccctcttgctaaccagctgaccagtgactatggccgtctggcctcggaggcc aagcctgcagcggtggctgctgaaaatgaagagataggttcccatatcaaacaccgggta caggagctgggccatggctgtgccgctctggtcaccaaggcaggcgccctgcagtgcagc cccagtgatgcctacaccaagaaggagctcatagagtgtgcccggagagtctctgagaag gtctcccacgtcctggctgcgctccaggctgggaatcgtggcacccaggcctgcatcaca gcagccagcgctgtgtctggtatcattgctgacctcgacaccaccatcatgttcgccact gctggcacgctcaatcgtgagggtactgaaactttcgctgaccaccgggagggcatcctg aagactgcgaaggtgctggtggaggacaccaaggtcctggtgcaaaacgcagctgggagc caggagaagttggcgcaggctgcccagtcctccgtggcgaccatcacccgcctcgctgat gtggtcaagctgggtgcagccagcctgggagctgaggaccctgagacccaggtggtacta atcaacgcagtgaaagatgtagccaaagccctgggagacctcatcagtgcaacgaaggct gcagctggcaaagttggagatgaccctgctgtgtggcagctaaagaactctgccaaggtg atggtgaccaatgtgacatcattgcttaagacagtaaaagccgtggaagatgaggccacc aaaggcactcgggccctggaggcaaccacagaacacatacggcaggagctggcggttttc tgttccccagagccacctgccaagacctctaccccagaagacttcatccgaatgaccaag ggtatcaccatggcaaccgccaaggccgttgctgctggcaattcctgtcgccaggaagat gtcattgccacagccaatctgagccgccgtgctattgcagatatgcttcgggcttgcaag gaagcagcttaccacccagaagtggcccctgatgtgcggcttcgagccctgcactatggc cgggagtgtgccaatggctacctggaactgctggaccatgtactgctgaccctgcagaag ccaagcccagaactgaagcagcagttgacaggacattcaaagcgtgtggctggttccgtc actgagctcatccaggctgctgaagccatgaagggaacagaatgggtagacccagaggac cccacagtcattgctgagaatgagctcctgggagctgcagccgccattgaggctgcagcc aaaaagctagagcagctgaagccccgggccaaacccaaggaggcagatgagtccttgaac tttgaggagcagatactagaagctgccaagtccattgcagcagccaccagtgcactggta aaggctgcgtcggctgcccagagagaactagtggcccaagggaaggtgggtgccattcca gccaatgcactggacgatgggcagtggtcccagggcctcatttctgctgcccggatggtg gctgcggccaccaacaatctgtgtgaggcagccaatgcagctgtacaaggccatgccagc caggagaagctcatctcatcagccaagcaggtagctgcctccacagcccagctccttgtg gcctgcaaggtcaaggctgaccaggactcggaggcaatgaaacgacttcaggctgctggc aacgcagtgaagcgagcctcagataatctggtgaaagcagcacagaaggctgcagccttt gaagagcaggagaatgagacagtggtggtgaaagagaagatggttggcggcattgcccag atcatcgcagcacaggaagaaatgcttcggaaggaacgagagctggaagaggcgcggaag aaactggcccagatccggcagcagcagtacaagtttctgccttcagagcttcgagatgag cactaa

Homo sapiens (human): 83660 Help Entry 83660             CDS       T01001                                  Symbol TLN2, ILWEQ Name (RefSeq) talin 2   KO K06271   talin Organism hsa  Homo sapiens (human) Pathway hsa04015   Rap1 signaling pathway hsa04510   Focal adhesion hsa04611   Platelet activation hsa05131   Shigellosis hsa05166   Human T-cell leukemia virus 1 infection Network   Element N01080   ITGA/B-TALIN/VINCULIN signaling pathway N01081   Shigella IpaB/C/D to ITGA/B-TALIN/VINCULIN signaling pathway Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     83660 (TLN2)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     83660 (TLN2)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     83660 (TLN2)  09160 Human Diseases   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     83660 (TLN2)   09171 Infectious disease: bacterial    05131 Shigellosis     83660 (TLN2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:hsa04147]     83660 (TLN2) Exosome [BR:hsa04147]  Exosomal proteins   Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)    83660 (TLN2)   Exosomal proteins of other cancer cells    83660 (TLN2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  VBS Talin_middle I_LWEQ Talin_R4 FERM_f0 FERM_M FERM_N IRS ACBP OTU1_UBXL Motif Other DBs NCBI-GeneID:  83660 NCBI-ProteinID:  NP_055874 OMIM:  607349 HGNC:  15447 Ensembl:  ENSG00000171914 UniProt:  Q9Y4G6 Structure PDB LinkDB All DBs Position 15:62390550..62844631 Genome browser AA seq 2542 aa AA seqDB search MVALSLKICVRHCNVVKTMQFEPSTAVYDACRVIRERVPEAQTGQASDYGLFLSDEDPRK GIWLEAGRTLDYYMLRNGDILEYKKKQRPQKIRMLDGSVKTVMVDDSKTVGELLVTICSR IGITNYEEYSLIQETIEEKKEEGTGTLKKDRTLLRDERKMEKLKAKLHTDDDLNWLDHSR TFREQGVDENETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSFEKACEF GGFQAQIQFGPHVEHKHKPGFLDLKEFLPKEYIKQRGAEKRIFQEHKNCGEMSEIEAKVK YVKLARSLRTYGVSFFLVKEKMKGKNKLVPRLLGITKDSVMRVDEKTKEVLQEWPLTTVK RWAASPKSFTLDFGEYQESYYSVQTTEGEQISQLIAGYIDIILKKKQSKDRFGLEGDEES TMLEESVSPKKSTILQQQFNRTGKAEHGSVALPAVMRSGSSGPETFNVGSMPSPQQQVMV GQMHRGHMPPLTSAQQALMGTINTSMHAVQQAQDDLSELDSLPPLGQDMASRVWVQNKVD ESKHEIHSQVDAITAGTASVVNLTAGDPADTDYTAVGCAITTISSNLTEMSKGVKLLAAL MDDEVGSGEDLLRAARTLAGAVSDLLKAVQPTSGEPRQTVLTAAGSIGQASGDLLRQIGE NETDERFQDVLMSLAKAVANAAAMLVLKAKNVAQVAEDTVLQNRVIAAATQCALSTSQLV ACAKVVSPTISSPVCQEQLIEAGKLVDRSVENCVRACQAATTDSELLKQVSAAASVVSQA LHDLLQHVRQFASRGEPIGRYDQATDTIMCVTESIFSSMGDAGEMVRQARVLAQATSDLV NAMRSDAEAEIDMENSKKLLAAAKLLADSTARMVEAAKGAAANPENEDQQQRLREAAEGL RVATNAAAQNAIKKKIVNRLEVAAKQAAAAATQTIAASQNAAVSNKNPAAQQQLVQSCKA VADHIPQLVQGVRGSQAQAEDLSAQLALIISSQNFLQPGSKMVSSAKAAVPTVSDQAAAM QLSQCAKNLATSLAELRTASQKAHEACGPMEIDSALNTVQTLKNELQDAKMAAVESQLKP LPGETLEKCAQDLGSTSKAVGSSMAQLLTCAAQGNEHYTGVAARETAQALKTLAQAARGV AASTTDPAAAHAMLDSARDVMEGSAMLIQEAKQALIAPGDAERQQRLAQVAKAVSHSLNN CVNCLPGQKDVDVALKSIGESSKKLLVDSLPPSTKPFQEAQSELNQAAADLNQSAGEVVH ATRGQSGELAAASGKFSDDFDEFLDAGIEMAGQAQTKEDQIQVIGNLKNISMASSKLLLA AKSLSVDPGAPNAKNLLAAAARAVTESINQLITLCTQQAPGQKECDNALRELETVKGMLD NPNEPVSDLSYFDCIESVMENSKVLGESMAGISQNAKTGDLPAFGECVGIASKALCGLTE AAAQAAYLVGISDPNSQAGHQGLVDPIQFARANQAIQMACQNLVDPGSSPSQVLSAATIV AKHTSALCNACRIASSKTANPVAKRHFVQSAKEVANSTANLVKTIKALDGDFSEDNRNKC RIATAPLIEAVENLTAFASNPEFVSIPAQISSEGSQAQEPILVSAKTMLESSSYLIRTAR SLAINPKDPPTWSVLAGHSHTVSDSIKSLITSIRDKAPGQRECDYSIDGINRCIRDIEQA SLAAVSQSLATRDDISVEALQEQLTSVVQEIGHLIDPIATAARGEAAQLGHKVTQLASYF EPLILAAVGVASKILDHQQQMTVLDQTKTLAESALQMLYAAKEGGGNPKAQHTHDAITEA AQLMKEAVDDIMVTLNEAASEVGLVGGMVDAIAEAMSKLDEGTPPEPKGTFVDYQTTVVK YSKAIAVTAQEMMTKSVTNPEELGGLASQMTSDYGHLAFQGQMAAATAEPEEIGFQIRTR VQDLGHGCIFLVQKAGALQVCPTDSYTKRELIECARAVTEKVSLVLSALQAGNKGTQACI TAATAVSGIIADLDTTIMFATAGTLNAENSETFADHRENILKTAKALVEDTKLLVSGAAS TPDKLAQAAQSSAATITQLAEVVKLGAASLGSDDPETQVVLINAIKDVAKALSDLISATK GAASKPVDDPSMYQLKGAAKVMVTNVTSLLKTVKAVEDEATRGTRALEATIECIKQELTV FQSKDVPEKTSSPEESIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRKAVSDMLTAC KQASFHPDVSDEVRTRALRFGTECTLGYLDLLEHVLVILQKPTPEFKQQLAAFSKRVAGA VTELIQAAEAMKGTEWVDPEDPTVIAETELLGAAASIEAAAKKLEQLKPRAKPKQADETL DFEEQILEAAKSIAAATSALVKSASAAQRELVAQGKVGSIPANAADDGQWSQGLISAARM VAAATSSLCEAANASVQGHASEEKLISSAKQVAASTAQLLVACKVKADQDSEAMRRLQAA GNAVKRASDNLVRAAQKAAFGKADDDDVVVKTKFVGGIAQIIAAQEEMLKKERELEEARK KLAQIRQQQYKFLPTELREDEG NT seq 7629 nt NT seq  +upstreamnt  +downstreamnt atggtggccctgtccttaaagatttgtgtgcgccactgcaacgtggtgaagaccatgcag tttgaaccatctacagctgtgtacgatgcgtgtcgagtcattcgggaacgggtgcctgag gcacaaactgggcaagcttctgactatggactctttctttcggatgaagacccgaggaaa gggatttggctggaagcgggcagaacactggattactacatgttgcggaatggggatatt ttggaatataaaaagaaacagagacctcagaaaatccggatgctggatggatctgtgaag acagtgatggtggatgattccaagactgtgggggagctcctggtcactatttgtagcaga ataggaataacaaattatgaagaatactccttaatccaagaaactattgaagaaaagaaa gaggaaggaacgggcacactcaaaaaagacaggacactgttacgagatgagaggaaaatg gagaagttgaaggccaagctgcacacagatgatgacctaaattggctggatcacagccga acattcagagaacaaggagtagatgaaaacgaaacgttgctgcttagacggaagttcttt tactctgatcagaatgtagattcgagagaccccgtgcagctgaacttgctttatgttcag gcacgggatgacatcctgaatggctctcaccctgtctccttcgagaaagcttgtgagttt ggtggatttcaagcccagatacaatttggacctcatgtggaacataaacacaaacctgga tttttagatctgaaggaattcctgcccaaagaatatatcaagcagagaggagctgaaaag aggatctttcaggagcataagaactgcggagagatgagtgagatagaagccaaggtcaag tacgtcaaactcgcacggtccctccgcacatatggcgtgtccttcttcctggtgaaggag aagatgaaaggcaagaacaagctggtgcctcgcctgctggggatcaccaaagactcggtg atgcgcgtggatgagaagaccaaggaagtgctgcaggagtggcccctcaccaccgtcaag cgctgggcagcctcacccaagagcttcacactggattttggggagtatcaggaaagctac tattcagtacaaaccaccgagggagagcagatatcccagctgattgcaggctacattgac atcatcctgaaaaagaaacaaagtaaagatcgatttggactagaaggtgatgaggagtca accatgttagaagagtccgtttccccaaaaaagtccaccatcttgcagcagcagttcaac cggaccgggaaggcagagcacggctcagtggcgctgccggccgtgatgcgctcgggctcc agcgggcctgagaccttcaacgttggcagcatgccctcgccacagcagcaggtcatggtt gggcagatgcaccgaggccacatgccgccactgacctcagcccagcaggccctgatgggg accatcaacacaagcatgcacgccgtccagcaggcccaggatgatctcagtgagctcgac tcgctgccacctctcggccaggatatggcatctagggtatgggttcagaacaaagtcgac gaatccaaacacgaaatccattctcaagttgatgctatcacggccggaacggcttcagtt gttaacctcacagctggtgaccctgcagacactgactacacagctgtgggatgtgcgatc accactatttcttccaacctgacggagatgtccaagggtgtgaagctattggccgccctc atggatgatgaggtgggcagcggggaggacttgctcagagctgccaggaccctcgctggg gcggtgtcagacttgctgaaagctgtgcagcctacttctggagagcctcgacagacagtt ttgactgctgctggcagcatcggacaagccagtggggatcttctgagacagattggagag aatgagactgatgagcgattccaggatgttttaatgagtttggccaaagctgttgccaat gcagctgccatgttggtactaaaggcaaagaatgttgcccaagtggccgaagacactgtc ctacagaacagggtaattgctgctgccacccagtgtgccctctccacctcccagcttgtg gcatgtgccaaggttgtgagccccactattagctcccctgtgtgccaggagcagctgatt gaagcagggaagctggtggaccgctcggtggagaactgtgtccgtgcctgccaggcggcc actaccgatagtgagctcctgaagcaggtcagcgcagcggccagcgtggtcagccaggcc ctccatgatctcctgcagcatgtgcggcagtttgccagccgaggcgagcccatcggccgc tacgaccaggctactgacaccatcatgtgtgtcaccgagagcatcttcagctccatgggt gacgctggtgaaatggtgcgccaggcgcgggttctggcccaagccacatcagacctcgtc aatgccatgaggtcagatgcagaagccgaaatcgacatggagaattcaaagaagctcctg gcagcagcaaaactcttagctgactccactgctcgcatggtggaagctgcaaagggggct gcagccaacccagagaatgaggaccagcagcaaaggctgagagaagctgcagaaggcctc cgggtagcaaccaacgcagctgcccagaatgctattaagaaaaaaattgtcaaccgactg gaggttgcagccaagcaggccgcagcggcagccacacagaccatcgccgcctcccagaat gcagctgtttccaacaagaaccctgcggcccagcagcagctggtccagagttgcaaggca gtggctgatcacatccctcagctggtccagggagtgagggggagccaagctcaagctgaa gacctgagtgcccagctggctctcatcatctccagccagaacttcctccagcctggaagc aagatggtgtcctctgccaaagccgcagtgcccaccgtgagtgaccaggccgcagccatg cagctgagccagtgtgccaagaacctggccaccagcttggcggagctgcgtaccgcctcg cagaaggcccatgaagcttgtggtccgatggaaatcgattcagctctgaatacggtgcag acgcttaagaatgaactgcaggatgccaagatggcagccgtggagagccagctgaagcca cttccaggggaaacgctggaaaaatgtgctcaggacctgggaagcacatccaaggcggtg ggctcctccatggcacagctgctgacctgtgctgctcaaggcaacgaacactacacaggg gtggctgctagagagacggcccaagctctgaaaacactggcccaggccgcccgtggagtg gctgcatcgacaaccgaccccgcggccgcccatgccatgttagattctgctcgagacgtg atggagggctccgccatgctcattcaagaggccaagcaggccctgattgcacctggagat gcagagcgtcaacaaagactggctcaggtggctaaagccgtctcacactccttgaataac tgcgtaaattgcctccctgggcagaaggatgtggacgtggccttgaagagcatcggggag tccagcaagaagctgcttgtggattcgctacctccaagcacgaagcctttccaggaagcc cagagtgaactgaaccaggcagcagctgatctgaaccagtctgctggggaagtggtccat gccacccggggccagagtggagagttggctgcagcctctggaaagttcagtgatgatttt gatgaattcctcgatgctggcattgagatggctggccaagctcagacaaaagaagaccag atccaagtgatagggaacctcaagaatatctcgatggcatccagcaagctgctgttagct gccaagtctctctctgtagatccaggagctcccaatgcgaaaaatctcctggctgcagct gcaagagctgtgacagagagcatcaatcaactcatcactctgtgtacccaacaagctccg ggccagaaagagtgcgataatgccctgcgggagctcgagactgtgaaggggatgttggac aatcctaatgaacctgttagtgacctctcttactttgactgcattgagagtgtgatggaa aactccaaggttctgggtgaatcgatggcagggatttcacagaatgccaagaccggagac ctccctgcctttggggaatgtgtggggattgcatccaaggctctctgtgggctgacagag gctgcagcccaggctgcatacttggttggcatctctgatccaaacagccaggcaggccac cagggcctggtggaccccatccagtttgccagggctaaccaggccatccagatggcatgc cagaacttggtggaccctggcagcagcccatcacaggtcctgtcagccgccacaattgtt gccaagcacacgtcagccttgtgcaatgcctgccgcatcgcctcatccaagacggccaac ccagtagccaagaggcacttcgtccagtcagccaaggaagtcgccaacagcactgccaac ctggtgaagaccatcaaggccctggatggggatttctctgaagacaaccgcaataagtgt cgcatcgccaccgcacccttgattgaagctgtggagaacctgacagcgttcgcctcaaac cctgagtttgtcagcattcctgcccagatcagctccgagggttcccaggcacaggaacca atcctggtctcagccaagaccatgctggagagttcatcgtacctcattcgcactgcacgc tctctggccatcaaccccaaagacccacccacctggtctgtactggctggacattcccat acagtgtccgactccatcaagagtctcatcacttctatcagggacaaggcccctggacag agggagtgtgattactccatcgatggcatcaaccggtgcatccgggacatcgagcaggcc tcgctggccgccgtcagccagagcctggccacgagggacgacatctctgtggaggccctg caggagcagctgacttcggtggtccaggaaatcggacaccttatcgatcccatcgccaca gcggctcggggagaagcagctcagctgggacataaggtgacacaactggcaagctatttt gagcccttgatcttagccgcagttggtgtggcctccaagattcttgatcatcagcagcag atgacggtgctggaccagaccaagactctcgcagagtctgccttgcagatgttgtatgca gccaaagaaggtggcggaaaccccaaggcacaacacacccatgacgccatcacagaggcc gcccagttgatgaaggaagccgtggatgacatcatggtgacgctgaacgaagctgccagt gaagtggggctggttgggggcatggtggacgccattgcagaagccatgagcaagctggat gaaggcactcctccagaaccaaagggaacatttgtcgactatcagacgactgtggttaaa tactccaaagccattgcggtgacagctcaggaaatgatgactaagtcggttactaacccg gaggagttgggaggactggcttcacaaatgaccagtgactatgggcacctggctttccag ggccagatggcagcagccacggcggaaccagaggagatcggattccagattcgcactcgt gtgcaggacctgggccacggctgtatcttcctggtgcagaaggcaggggccctccaggtc tgccccacagacagctacaccaagagggagctgatcgaatgcgcccgtgccgtcacggaa aaggtctccttggtgctctcggctctccaggccgggaacaaaggaacccaggcatgcatt acagccgccaccgctgtgtctgggatcattgccgacctggacaccaccattatgtttgca acagcggggacgctgaatgcagagaacagtgagaccttcgcagaccacagggagaacatt ctcaagacggccaaggccttggtagaagacacgaaactacttgtgtcaggagctgcgtcc actcctgacaagctggcccaggcggcccagtcctcagcagccaccatcacccagctcgca gaagtggtcaagctgggggcagccagcctgggctccgacgaccccgagacccaggtggtt ttgatcaatgccatcaaagatgtggccaaggccctttctgatctcatcagtgctaccaag ggagctgccagcaagccagtggacgacccttccatgtaccagctcaagggggctgccaag gtgatggtgaccaatgtcacctcgctcctcaagactgtaaaggcagtggaggatgaggcc acccggggcaccagggcgcttgaggccacaattgaatgcataaagcaggagcttacggtg ttccagtcaaaagacgtacctgaaaagacatcatcacctgaagaatccataaggatgacg aaaggcatcaccatggcaacagccaaagccgtggcagctgggaactcatgtagacaggag gacgtgattgctactgccaacctgagccggaaagccgtgtcagatatgttgacggcttgc aagcaagcatccttccaccccgatgtcagtgacgaggtgagaaccagagccttgcgtttc gggacggagtgcacccttggctacttggacctcctggagcacgtcttggtgattcttcag aaaccaaccccagaattcaagcagcagctggccgctttctccaagcgagtcgccggcgct gtgacagagctcatccaggcggcggaagccatgaaaggaacagagtgggtggatccagaa gacccaactgtcattgcagaaacagagttactgggggctgcagcatccatcgaagctgct gctaagaagttagagcaactgaagccaagagcaaaaccaaaacaagcggatgagaccctg gactttgaggaacagatcttggaagctgctaaatccattgctgctgccacaagcgccctg gtcaaatcggcctcagcagcccagagggagctggtggcccaaggaaaggtgggctccatc cctgccaatgctgcagacgacggacagtggtcacaggggctgatttctgctgcccggatg gtggcggctgcgaccagcagtctctgtgaggcggccaatgcctccgttcagggacacgcc agcgaggagaagctcatctcatctgccaagcaggtcgccgcttccacggctcagctgctg gtggcctgcaaggtgaaggccgaccaggattcagaggccatgaggcggctacaggcggca ggaaatgctgtgaaaagagcctcagacaatcttgtccgtgcagcccagaaggcagctttt ggcaaagctgatgacgacgatgttgtagtgaaaaccaagtttgtggggggcattgctcag atcatcgccgcccaggaagaaatgctaaagaaagagcgagaactggaagaagcaaggaaa aaactggcccaaatccgccagcagcagtataagtttttacccaccgagctgagggaagat gagggctaa

Homo sapiens (human): 87 Help Entry 87                CDS       T01001                                  Symbol ACTN1, BDPLT15 Name (RefSeq) actinin alpha 1   KO K05699   actinin alpha 1/4 Organism hsa  Homo sapiens (human) Pathway hsa04510   Focal adhesion hsa04520   Adherens junction hsa04530   Tight junction hsa04670   Leukocyte transendothelial migration hsa04810   Regulation of actin cytoskeleton hsa05131   Shigellosis hsa05146   Amoebiasis hsa05203   Viral carcinogenesis hsa05322   Systemic lupus erythematosus Network   Element N01080   ITGA/B-TALIN/VINCULIN signaling pathway N01082   Shigella IpaA to ITGA/B-TALIN/VINCULIN signaling pathway Disease H01235   Bleeding disorder platelet-type H01740   Macrothrombocytopenia Brite KEGG Orthology (KO) [BR:hsa00001]  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     87 (ACTN1)    04520 Adherens junction     87 (ACTN1)    04530 Tight junction     87 (ACTN1)   09142 Cell motility    04810 Regulation of actin cytoskeleton     87 (ACTN1)  09150 Organismal Systems   09151 Immune system    04670 Leukocyte transendothelial migration     87 (ACTN1)  09160 Human Diseases   09161 Cancer: overview    05203 Viral carcinogenesis     87 (ACTN1)   09171 Infectious disease: bacterial    05131 Shigellosis     87 (ACTN1)   09174 Infectious disease: parasitic    05146 Amoebiasis     87 (ACTN1)   09163 Immune disease    05322 Systemic lupus erythematosus     87 (ACTN1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:hsa04131]     87 (ACTN1)   09183 Protein families: signaling and cellular processes    04812 Cytoskeleton proteins [BR:hsa04812]     87 (ACTN1)    04147 Exosome [BR:hsa04147]     87 (ACTN1) Membrane trafficking [BR:hsa04131]  Exocytosis   Small GTPases and associated proteins    Rab associated proteins     87 (ACTN1) Cytoskeleton proteins [BR:hsa04812]  Eukaryotic cytoskeleton proteins   Actin filaments / Microfilaments    Actin-binding proteins     Cross-linking proteins      87 (ACTN1) Exosome [BR:hsa04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    87 (ACTN1)   Exosomal proteins of colorectal cancer cells    87 (ACTN1)   Exosomal proteins of bladder cancer cells    87 (ACTN1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Spectrin CH EFhand_Ca_insen EF-hand_1 EF-hand_6 EF-hand_7 EF-hand_8 EF-hand_5 XisI Uds1 Motif Other DBs NCBI-GeneID:  87 NCBI-ProteinID:  NP_001093 OMIM:  102575 HGNC:  163 Ensembl:  ENSG00000072110 UniProt:  P12814 A0A024R694 Structure PDB LinkDB All DBs Position 14:complement(68874128..68979302) Genome browser AA seq 892 aa AA seqDB search MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFR DGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNV KMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFC ALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMT YVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENR VPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRM VSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT IEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEI NGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEM HGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQL LTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGY DIGNDPQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDK NYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL NT seq 2679 nt NT seq  +upstreamnt  +downstreamnt atggaccattatgattctcagcaaaccaacgattacatgcagccagaagaggactgggac cgggacctgctcctggacccggcctgggagaagcagcagagaaagacattcacggcatgg tgtaactcccacctccggaaggcggggacacagatcgagaacatcgaagaggacttccgg gatggcctgaagctcatgctgctgctggaggtcatctcaggtgaacgcttggccaagcca gagcgaggcaagatgagagtgcacaagatctccaacgtcaacaaggccctggatttcata gccagcaaaggcgtcaaactggtgtccatcggagccgaagaaatcgtggatgggaatgtg aagatgaccctgggcatgatctggaccatcatcctgcgctttgccatccaggacatctcc gtggaagagacttcagccaaggaagggctgctcctgtggtgtcagagaaagacagcccct tacaaaaatgtcaacatccagaacttccacataagctggaaggatggcctcggcttctgt gctttgatccaccgacaccggcccgagctgattgactacgggaagctgcggaaggatgat ccactcacaaatctgaatacggcttttgacgtggcagagaagtacctggacatccccaag atgctggatgccgaagacatcgttggaactgcccgaccggatgagaaagccatcatgact tacgtgtctagcttctaccacgccttctctggagcccagaaggcggagacagcagccaat cgcatctgcaaggtgttggccgtcaaccaggagaacgagcagcttatggaagactacgag aagctggccagtgatctgttggagtggatccgccgcacaatcccgtggctggagaaccgg gtgcccgagaacaccatgcatgccatgcaacagaagctggaggacttccgggactaccgg cgcctgcacaagccgcccaaggtgcaggagaagtgccagctggagatcaacttcaacacg ctgcagaccaagctgcggctcagcaaccggcctgccttcatgccctctgagggcaggatg gtctcggacatcaacaatgcctggggctgcctggagcaggtggagaagggctatgaggag tggttgctgaatgagatccggaggctggagcgactggaccacctggcagagaagttccgg cagaaggcctccatccacgaggcctggactgacggcaaagaggccatgctgcgacagaag gactatgagaccgccaccctctcggagatcaaggccctgctcaagaagcatgaggccttc gagagtgacctggctgcccaccaggaccgtgtggagcagattgccgccatcgcacaggag ctcaatgagctggactattatgactcacccagtgtcaacgcccgttgccaaaagatctgt gaccagtgggacaatctgggggccctaactcagaagcgaagggaagctctggagcggacc gagaaactgctggagaccattgaccagctgtacttggagtatgccaagcgggctgcaccc ttcaacaactggatggagggggccatggaggacctgcaggacaccttcattgtgcacacc attgaggagatccagggactgaccacagcccatgagcagttcaaggccaccctccctgat gccgacaaggagcgcctggccatcctgggcatccacaatgaggtgtccaagattgtccag acctaccacgtcaatatggcgggcaccaacccctacacaaccatcacgcctcaggagatc aatggcaaatgggaccacgtgcggcagctggtgcctcggagggaccaagctctgacggag gagcatgcccgacagcagcacaatgagaggctacgcaagcagtttggagcccaggccaat gtcatcgggccctggatccagaccaagatggaggagatcgggaggatctccattgagatg catgggaccctggaggaccagctcagccacctgcggcagtatgagaagagcatcgtcaac tacaagccaaagattgatcagctggagggcgaccaccagctcatccaggaggcgctcatc ttcgacaacaagcacaccaactacaccatggagcacatccgtgtgggctgggagcagctg ctcaccaccatcgccaggaccatcaatgaggtagagaaccagatcctgacccgggatgcc aagggcatcagccaggagcagatgaatgagttccgggcctccttcaaccactttgaccgg gatcactccggcacactgggtcccgaggagttcaaagcctgcctcatcagcttgggttat gatattggcaacgacccccagggagaagcagaatttgcccgcatcatgagcattgtggac cccaaccgcctgggggtagtgacattccaggccttcattgacttcatgtcccgcgagaca gccgacacagatacagcagaccaagtcatggcttccttcaagatcctggctggggacaag aactacattaccatggacgagctgcgccgcgagctgccacccgaccaggctgagtactgc atcgcgcggatggccccctacaccggccccgactccgtgccaggtgctctggactacatg tccttctccacggcgctgtacggcgagagtgacctctaa

Homo sapiens (human): 81 Help Entry 81                CDS       T01001                                  Symbol ACTN4, ACTININ-4, FSGS, FSGS1 Name (RefSeq) actinin alpha 4   KO K05699   actinin alpha 1/4 Organism hsa  Homo sapiens (human) Pathway hsa04510   Focal adhesion hsa04520   Adherens junction hsa04530   Tight junction hsa04670   Leukocyte transendothelial migration hsa04810   Regulation of actin cytoskeleton hsa05131   Shigellosis hsa05146   Amoebiasis hsa05203   Viral carcinogenesis hsa05322   Systemic lupus erythematosus Network   Element N01080   ITGA/B-TALIN/VINCULIN signaling pathway N01082   Shigella IpaA to ITGA/B-TALIN/VINCULIN signaling pathway Disease H00626   Focal segmental glomerulosclerosis Brite KEGG Orthology (KO) [BR:hsa00001]  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     81 (ACTN4)    04520 Adherens junction     81 (ACTN4)    04530 Tight junction     81 (ACTN4)   09142 Cell motility    04810 Regulation of actin cytoskeleton     81 (ACTN4)  09150 Organismal Systems   09151 Immune system    04670 Leukocyte transendothelial migration     81 (ACTN4)  09160 Human Diseases   09161 Cancer: overview    05203 Viral carcinogenesis     81 (ACTN4)   09171 Infectious disease: bacterial    05131 Shigellosis     81 (ACTN4)   09174 Infectious disease: parasitic    05146 Amoebiasis     81 (ACTN4)   09163 Immune disease    05322 Systemic lupus erythematosus     81 (ACTN4)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:hsa04131]     81 (ACTN4)   09183 Protein families: signaling and cellular processes    04812 Cytoskeleton proteins [BR:hsa04812]     81 (ACTN4)    04147 Exosome [BR:hsa04147]     81 (ACTN4) Membrane trafficking [BR:hsa04131]  Exocytosis   Small GTPases and associated proteins    Rab associated proteins     81 (ACTN4) Cytoskeleton proteins [BR:hsa04812]  Eukaryotic cytoskeleton proteins   Actin filaments / Microfilaments    Actin-binding proteins     Cross-linking proteins      81 (ACTN4) Exosome [BR:hsa04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    81 (ACTN4)   Exosomal proteins of colorectal cancer cells    81 (ACTN4)   Exosomal proteins of bladder cancer cells    81 (ACTN4) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Spectrin CH EFhand_Ca_insen EF-hand_1 EF-hand_6 EF-hand_7 EF-hand_8 XisI Motif Other DBs NCBI-GeneID:  81 NCBI-ProteinID:  NP_004915 OMIM:  604638 HGNC:  166 Ensembl:  ENSG00000130402 UniProt:  O43707 A0A0S2Z3G9 Structure PDB LinkDB All DBs Position 19:38647649..38731589 Genome browser AA seq 911 aa AA seqDB search MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWC NSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIA SKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPY KNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKM LDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEK LASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTL QTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQ KASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQEL NELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPF NNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAES NHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANV VGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIF DNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDKD HGGALGPEEFKACLISLGYDVENDRQGEAEFNRIMSLVDPNHSGLVTFQAFIDFMSRETT DTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAEYCIARMAPYQGPDAVPGALDYKS FSTALYGESDL NT seq 2736 nt NT seq  +upstreamnt  +downstreamnt atggtggactaccacgcggcgaaccagtcgtaccagtacggccccagcagcgcgggcaat ggcgctggcggcgggggcagcatgggcgactacatggcccaggaggacgactgggaccgg gacctgctgctggacccggcctgggagaagcagcagcgcaagaccttcacggcatggtgc aactcccacctgcggaaggcaggcacacagatcgagaacattgatgaggacttccgagac gggctcaagctcatgctgctcctggaggtcatatcaggggagcggttacctaagccggag cgggggaagatgagagtgcacaaaatcaacaatgtgaacaaagcgctggactttattgcc agcaaaggcgtcaagctggtctccatcggggcagaagagattgtggacggcaacgcaaag atgaccctgggaatgatctggaccatcatccttaggttcgccatccaggacatctccgtg gaagagacctcggccaaggaagggctccttctctggtgccagagaaagacagccccgtat aagaacgtcaatgtgcagaacttccacatcagctggaaggatggtcttgccttcaatgcc ctgatccaccggcacagaccagagctgattgagtatgacaagctgaggaaggacgaccct gtcaccaacctgaacaatgccttcgaagtggctgagaaatacctcgacatccccaagatg ctggatgcagaggacatcgtgaacacggcccggcccgacgagaaggccataatgacctat gtgtccagcttctaccatgccttttcaggagcgcagaaggctgaaactgccgccaaccgg atctgtaaggtgctggctgtcaaccaagagaacgagcacctgatggaggactacgagaag ctggccagcgacctcctggagtggatccggcgcaccatcccctggctggaggaccgtgtg ccccaaaagactatccaggagatgcagcagaagctggaggacttccgcgactaccggcgt gtgcacaagccgcccaaggtgcaggagaagtgccagctggagatcaacttcaacacgctg cagaccaagctgcgcctcagcaaccggcccgccttcatgccctccgagggcaagatggtc tcggacatcaacaatggctggcagcacttggagcaggctgagaagggctacgaggagtgg ctgctgaatgagatccgcaggctggagcggctcgaccacctggcagagaagttccggcag aaggcctccatccacgaggcctggactgacgggaaggaagccatgctgaagcaccgggac tacgagacggccacactatcggacatcaaagccctcattcgcaagcacgaggccttcgag agcgacctggctgcgcaccaggaccgcgtggagcagatcgccgccattgcccaggagctc aacgagctggattactacgactcccacaatgtcaacacccggtgccagaagatctgtgac cagtgggacgccctcggctctctgacacatagtcgcagggaagccctggagaaaacagag aagcagctggaggccatcgaccagctgcacctggaatacgccaagcgcgcggcccccttc aacaactggatggagagcgccatggaggacctccaggacatgttcatcgtccataccatc gaggagattgagggcctgatctcagcccatgaccagttcaagtccaccctgccggacgcc gatagggagcgcgaggccatcctggccatccacaaggaggcccagaggatcgctgagagc aaccacatcaagctgtcgggcagcaacccctacaccaccgtcaccccgcaaatcatcaac tccaagtgggagaaggtgcagcagctggtgccaaaacgggaccatgccctcctggaggag cagagcaagcagcagtccaacgagcacctgcgccgccagttcgccagccaggccaatgtt gtggggccctggatccagaccaagatggaggagatcgggcgcatctccattgagatgaac gggaccctggaggaccagctgagccacctgaagcagtatgaacgcagcatcgtggactac aagcccaacctggacctgctggagcagcagcaccagctcatccaggaggccctcatcttc gacaacaagcacaccaactataccatggagcacatccgcgtgggctgggagcagctgctc accaccattgcccgcaccatcaacgaggtggagaaccagatcctcacccgcgacgccaag ggcatcagccaggagcagatgcaggagttccgggcgtccttcaaccacttcgacaaggat catggcggggcgctggggcccgaggagttcaaggcctgcctcatcagcctgggctacgac gtggagaacgaccggcagggtgaggccgagttcaaccgcatcatgagcctggtcgacccc aaccatagcggccttgtgaccttccaagccttcatcgacttcatgtcgcgggagaccacc gacacggacacggctgaccaggtcatcgcttccttcaaggtcttagcaggggacaagaac ttcatcacagctgaggagctgcggagagagctgccccccgaccaggccgagtactgcatc gcccgcatggcgccataccagggccctgacgccgtgcccggtgccctcgactacaagtcc ttctccacggccttgtatggcgagagcgacctgtga

Homo sapiens (human): 7414 Help Entry 7414              CDS       T01001                                  Symbol VCL, CMD1W, CMH15, HEL114, MV, MVCL, VINC Name (RefSeq) vinculin   KO K05700   vinculin Organism hsa  Homo sapiens (human) Pathway hsa04510   Focal adhesion hsa04520   Adherens junction hsa04670   Leukocyte transendothelial migration hsa04810   Regulation of actin cytoskeleton hsa05100   Bacterial invasion of epithelial cells hsa05131   Shigellosis hsa05146   Amoebiasis Network   Element N01080   ITGA/B-TALIN/VINCULIN signaling pathway N01081   Shigella IpaB/C/D to ITGA/B-TALIN/VINCULIN signaling pathway N01082   Shigella IpaA to ITGA/B-TALIN/VINCULIN signaling pathway Disease H00292   Hypertrophic cardiomyopathy H00294   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:hsa00001]  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     7414 (VCL)    04520 Adherens junction     7414 (VCL)   09142 Cell motility    04810 Regulation of actin cytoskeleton     7414 (VCL)  09150 Organismal Systems   09151 Immune system    04670 Leukocyte transendothelial migration     7414 (VCL)  09160 Human Diseases   09171 Infectious disease: bacterial    05131 Shigellosis     7414 (VCL)    05100 Bacterial invasion of epithelial cells     7414 (VCL)   09174 Infectious disease: parasitic    05146 Amoebiasis     7414 (VCL)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04812 Cytoskeleton proteins [BR:hsa04812]     7414 (VCL)    04147 Exosome [BR:hsa04147]     7414 (VCL) Cytoskeleton proteins [BR:hsa04812]  Eukaryotic cytoskeleton proteins   Actin filaments / Microfilaments    Actin-binding proteins     Cross-linking proteins      7414 (VCL) Exosome [BR:hsa04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    7414 (VCL) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Vinculin VMAP-M0 Motif Other DBs NCBI-GeneID:  7414 NCBI-ProteinID:  NP_054706 OMIM:  193065 HGNC:  12665 Ensembl:  ENSG00000035403 UniProt:  P18206 V9HWK2 B3KXA2 Structure PDB LinkDB All DBs Position 10:73998116..74121363 Genome browser AA seq 1134 aa AA seqDB search MPVFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKE TVQTTEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTS DLLLTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQ ELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAE INEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAKGWLRDPSASPGDAGEQAIR QILDEAGKVGELCAGKERREILGTCKMLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGL DVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAE LCDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRA VANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQD LLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAMTQEVSDVFS DTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEG IQASVKTARELTPQVVSAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGLVDEAIDTK SLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILLVAKREVENSEDPKFR EAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPQEP DFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEVINQPMMM AARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPVPPDMEDDYEPELLLMPSNQ PVNQPILAAAQSLHREATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGTKRALIQCAK DIAKASDEVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNIS DEESEQATEMLVHNAQNLMQSVKETVREAEAASIKIRTDAGFTLRWVRKTPWYQ NT seq 3405 nt NT seq  +upstreamnt  +downstreamnt atgccagtgtttcatacgcgcacgatcgagagcatcctggagccggtggcacagcagatc tcccacctggtgataatgcacgaggagggcgaggtggacggcaaagccattcctgacctc accgcgcccgtggccgccgtgcaggcggccgtcagcaacctcgtccgggttggaaaagag actgttcaaaccactgaggatcagattttgaagagagatatgccaccagcatttattaag gttgagaatgcttgcaccaagcttgtccaggcagctcagatgcttcagtcagacccttac tcagtgcctgctcgagattatctaattgatgggtcaaggggcatcctctctggaacatca gacctgctccttaccttcgatgaggctgaggtccgtaaaattattagagtttgcaaagga attttggaatatcttacagtggcagaggtggtggagactatggaagatttggtcacttac acaaagaatcttgggccaggaatgactaagatggccaagatgattgacgagagacagcag gagctcactcaccaggagcaccgagtgatgttggtgaactcgatgaacaccgtgaaagag ttgctgccagttctcatttcagctatgaagatttttgtaacaactaaaaactcaaaaaac caaggcatagaggaagctttaaaaaatcgcaattttactgtagaaaaaatgagtgctgaa attaatgagataattcgtgtgttacaactcacctcttgggatgaagatgcctgggccagc aaggacactgaagccatgaagagagcattggcctccatagactccaaactgaaccaggcc aaaggttggctccgtgaccctagtgcctccccaggggatgctggtgagcaggccatcaga cagatcttagatgaagctggaaaagttggtgaactctgtgcaggcaaagaacgcagggag attctgggaacttgcaaaatgctagggcagatgactgatcaagtggctgacctccgtgcc agaggacaaggatcctcaccggtggccatgcagaaagctcagcaggtatctcagggtctg gatgtgctcacagcaaaagtggaaaatgcagctcgcaagctggaagccatgaccaactca aagcagagcattgcaaagaagatcgatgctgctcagaactggcttgcagatccaaatggt ggaccggaaggagaagagcagattcgaggtgctttggctgaagctcggaaaatagcagaa ttatgtgatgatcctaaagaaagagatgacattctacgttcccttggggaaatatctgct ctgacttctaaattagcagatctacgaagacaggggaaaggagattctccagaggctcga gccttggccaaacaggtggccacggccctgcagaacctgcagaccaaaaccaaccgggct gtggccaacagcagaccggccaaagcagctgtacaccttgagggcaagattgagcaagca cagcggtggattgataatcccacagtggatgaccgtggagtcggtcaggctgccatccgg gggcttgtggccgaagggcatcgtctggctaatgttatgatggggccttatcggcaagat cttctcgccaagtgtgaccgagtggaccagctgacagcccagctggctgacctggctgcc agaggggaaggggagagtcctcaggcacgagcacttgcatctcagctccaagactcctta aaggatctaaaagctcggatgcaggaggccatgactcaggaagtgtcagatgttttcagc gataccacaactcccatcaagctgttggcagtggcagccacggcgcctcctgatgcgcct aacagggaagaggtatttgatgagagggcagctaactttgaaaaccattcaggaaagctt ggtgctacggccgagaaggcggctgcggttggtactgctaataaatcaacagtggaaggc attcaggcctcagtgaagacggcccgagaactcacaccccaggtggtctcggctgctcgt atcttacttaggaaccctggaaatcaagctgcttatgaacattttgagaccatgaagaac cagtggatcgataatgttgaaaaaatgacagggctggtggacgaagccattgataccaaa tctctgttggatgcttcagaagaagcaattaaaaaagacctggacaagtgcaaggtagct atggccaacattcagcctcagatgctggttgctggggcaaccagtattgctcgtcgggcc aaccggatcctgctggtggctaagagggaggtggagaattccgaggatcccaagttccgt gaggctgtgaaagctgcctctgatgaattgagcaaaaccatctccccgatggtgatggat gcaaaagctgtggctggaaacatttccgaccctggactgcaaaagagcttcctggactca ggatatcggatcctgggagctgtggccaaggtcagagaagccttccaacctcaggagcct gacttcccgccgcctccaccagaccttgaacaactccgactaacagatgagcttgctcct cccaaaccacctctgcctgaaggtgaggtccctccacctaggcctccaccaccagaggaa aaggatgaagagttccctgagcagaaggccggggaggtgattaaccagccaatgatgatg gctgccagacagctccatgatgaagctcgcaaatggtccagcaagccgggcatcccagcc gctgaggtgggtataggtgttgtagctgaggcagatgcggccgatgctgctggcttccct gtcccccctgacatggaagacgattacgaacctgagctgctgttaatgccatccaatcag ccggtcaaccagcccattctggccgcggctcagtccttgcatcgggaagctaccaagtgg tctagtaagggcaatgacatcattgcagcagccaagcgcatggctctgctgatggctgag atgtctcggctggtaagagggggcagtggtaccaagcgggcactcattcagtgtgccaag gacatcgccaaggcctcagatgaggtgactcggttggccaaggaggttgccaagcagtgc acagataaacggattagaaccaacctcttacaggtatgtgagcgaatcccaaccataagc acccagctcaaaatcctgtccacagtgaaggccaccatgctgggccggaccaacatcagt gatgaggagtctgagcaggccacagagatgctggttcacaatgcccagaacctcatgcag tctgtgaaggagactgtgcgggaagctgaagctgcttcaatcaaaattcgaacagatgct ggatttacactgcgctgggttagaaagactccctggtaccagtag

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