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ENTRY	nt06182
Name	Shigella
Category	Disease view; Bacterial infection
Pathway	hsa05131 Shigellosis
Disease	H00299 Shigellosis
Display	drug-target relation   disease type

TNF signaling N00151    TNF → TNFRSF1A → (RIPK1+TRADD+TRAF2.. → (TAB1/2/3+TAK1) → IKK → NFKBIA → NFKB N00944    OspI ⊣ UBC13 → TRAF2 N00945    IpaH1.4/2.5 ⊣ RFN31 → RIPK1 N00927            NleE ⊣ (TAB2/3) N00942                OspG ⊣ (UBE2D2+(RBX1+CUL1.. → NFKBIA N00943                        IpaH4.5 ⊣ RELA   Autophagy N00156    LC3 − ATG4 ⇉ ATG7 ⇉ ATG3 ⇉ (ATG12+ATG5+ATG16L.. → LC3-II N01284            IcsP ⊣ C3 = ATG16L   TLR signaling N00438    (TLR2,TLR4) → (TIRAP+MYD88) → (IRAK4+IRAK1) → (TRAF6+TAK1+TAB2) → (MEK,MKK3/6,MKK4/7.. → (ERK,p38,JNK) → AP1 N01283                    OspF ⊣ (ERK,p38)   NLR signaling N00940    (NOD1,NOD2) → RIPK2 → IKK → NFKBIA → NFKB N00941        (IpaH9.8+TNIP1) ⊣ IKBKG N00742            (NLRP3+PYCARD) → CASP1 → (IL1B,IL18,IL33) N00948    IpaH7.8 ⊣ GLMN ⊣ (NLRP3+PYCARD) → CASP1 → IL1B N00867            (NLRC4+PYCARD) → CASP1 → (IL1B,IL18) N00949    IpaB → K+ → (NLRC4+PYCARD) → CASP1 → IL1B   CGAS-STING signaling N00395    DNA → CGAS → cGAMP → STING1 → TBK1 → IRF3 ⇒ (IFNA,IFNB) N00946        IpaJ ⊣ ARF1 → STING1 N00947                Ipa4.5 ⊣ TBK1   Cytoskeletal regulation N01072    FN1 → (ITGA+ITGB) → PTK2 → ARHGEF28 → RHOA N01074                IpaA → RHOA → ROCK1/2 → MLC N01073                IpgB2 → RHOA N01075                IcsB ⊣ RHOA N01068    FN1 → (ITGA+ITGB) → (SRC,PTK2) → (PXN,CRK+BCAR1) → (DOCK1+ELMO1) → RAC N01069                    IpgB1 → RAC1 N01077                    IcsB ⊣ RAC1 N00952                IpgB1 → (DOCK1+ELMO) → RAC1 N01070    FN1 → (ITGA+ITGB) → (SRC,PTK2) → PXN → (GIT2+ARHGEF7) → CDC42 N01071                    IpgB1 → CDC42 N01076                    IcsB ⊣ CDC42 N01066                    ARNO → ARF6 → ARF1 → (WASF+ABI1+HSPC300.. → ARP2/3 → (ACTB,ACTG1) N01067    IpgD → PI(5)P → PI3K → PIP3 → ARNO → ARF6 → ARF1 → (WASF+ABI1+HSPC300.. → ARP2/3 → (ACTB,ACTG1) N01078    EGF → EGFR → SRC → CTTN → NCK → (WASL+WIPF) → ARP2/3 → (ACTB,ACTG1) N01079        IpaC → SRC → CTTN → ARP2/3 → (ACTB,ACTG1) N01080    FN1 → (ITGA+ITGB) → (PTK2+PXN+ILK) → (TLN+ACTN1/4+VCN) → (ACTB,ACTG1) N01081    (IpaB+IpaC,IpaD) → (ITGA5+ITGB1) → (PTK2+PXN) → (TLN+VCN) → (ACTB,ACTG1) N01083        OspE ⊣ (PTK2+PXN+ILK) N01082            IpaA → (ACTN1/4+VCN)