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ENTRY	nt06509
Name	DNA replication
Category	Pathway view; Replication and repair
Pathway	hsa04110 Cell cycle hsa03030 DNA replication
Disease	H01889 Meier-Gorlin syndrome
Display	drug-target relation   disease type

N01468    ORC = CDC6 = CDT1 = MCM → pre-RC+DDK = CDC45+TICRR+MTBP = CDK     MGORS1 ORC1*     MGORS2 ORC4*     MGORS3 ORC6*     MGORS5     CDC6*     MGORS4         CDT1*     DNFA70             MCM2*     IMD54             MCM4*     MGORS8             MCM5*     MGORS7                     CDC45*   N01469    MCIDAS ⊣ GMNN ⊣ CDT1     CILD42 MCIDAS*     MGORS6     GMNN*   N01470    TOPBP1+RECQL4 = POLE = GINS → ORC+CDC6+CDT1 = CDC45+MCM+GINS = POLE+TOPBP1+TICRR+..     RAPADILINO/RTS2/BGS RECQL4*     IMAGEI/FILIS     POLE*     IMD55         GINS1*   N01471    CMG+POLE+MCM10 = POLA+PRIM = RPA → CMG+MCM10+CTF4+POL.. = RFC+PCNA     IMD80 MCM10*     VEODS/XLPDR     POLA1*     PDIL     PRIM1*     PFBMFT6         RPA1*     CANVAS                 RFC1*     MRMNS                 RFC4*     ATLD2                 PCNA*   N01472    POLD+PCNA → DNA2 = RNaseH2 = FEN1 → LIG1     MDPL POLD1*     SCKL8/PEOA6     DNA2*     AGS4         RNASEH2A*     AGS2         RNASEH2B*     AGS3         RNASEH2C*     LIG1                 LIG1*   N01473    CMG+PIF1 → CMG+CRL2-LRR1 → CMG = MCM7+Ub → MCM7+VCP+UFD1+NPL4 N01474        CMG+TRAIP → CMG = MCM7+Ub → MCM7+VCP+UFD1+NPL4     SCKL9     TRAIP*     IBMPFD1/FTDALS6/CMT2Y                 VCP*

		Disease name	Disease category
MGORS1	H01889	Meier-Gorlin syndrome	Congenital malformation
MGORS2	H01889	Meier-Gorlin syndrome	Congenital malformation
MGORS3	H01889	Meier-Gorlin syndrome	Congenital malformation
MGORS5	H01889	Meier-Gorlin syndrome	Congenital malformation
MGORS4	H01889	Meier-Gorlin syndrome	Congenital malformation
DNFA70	H00604	Deafness, autosomal dominant	Nervous system disease
IMD54	H00094	Immunodeficiency associated with DNA repair defects	Primary immunodeficiency
MGORS8	H01889	Meier-Gorlin syndrome	Congenital malformation
MGORS7	H01889	Meier-Gorlin syndrome	Congenital malformation
CILD42	H00564	Primary ciliary dyskinesia	Respiratory system disease
MGORS6	H01889	Meier-Gorlin syndrome	Congenital malformation
RAPADILINO/RTS2/BGS	H00965	RAPADILINO syndrome	Congenital malformation
	H01734	Rothmund-Thomson syndrome	Congenital malformation
	H01993	Baller-Gerold syndrome	Congenital malformation
IMAGEI/FILIS	H02369	IMAGE-I syndrome	Congenital malformation
	H02370	FILS syndrome	Congenital malformation
IMD55	H00093	Combined immunodeficiency	Primary immunodeficiency
IMD80	H02525	Disorders of innate immunity	Immune system disease
VEODS/XLPDR	H00658	X-linked syndromic intellectual developmental disorder	Mental and behavioural disorder
	H02484	X-linked reticulate pigmentary disorder with systemic manifestations	Immune system disease
PDIL	H02625	Primordial dwarfism-immunodeficiency-lipodystrophy syndrome	Congenital malformation
PFBMFT6	H02569	Pulmonary fibrosis and/or bone marrow failure, telomere-related	Hematologic disease
CANVAS	H02366	Cerebellar ataxia, neuropathy, and vestibular areflexia syndrome	Nervous system disease
MRMNS	H02840	Morimoto-Ryu-Malicdan neuromuscular syndrome	Nervous system disease
ATLD2	H02014	Ataxia-telangiectasia-like syndrome	Immune system disease
MDPL	H01623	MDPL syndrome	Congenital malformation
SCKL8/PEOA6	H00992	Seckel syndrome	Congenital malformation
	H01118	Progressive external ophthalmoplegia	Nervous system disease
AGS4	H00290	Aicardi-Goutieres syndrome	Immune system disease
AGS2	H00290	Aicardi-Goutieres syndrome	Immune system disease
AGS3	H00290	Aicardi-Goutieres syndrome	Immune system disease
LIG1	H00094	Immunodeficiency associated with DNA repair defects	Primary immunodeficiency
SCKL9	H00992	Seckel syndrome	Congenital malformation
IBMPFD1/FTDALS6/CMT2Y	H02031	Inclusion body myopathy with Paget disease of bone and frontotemporal dementia	Nervous system disease
	H02342	Frontotemporal dementia and amyotrophic lateral sclerosis	Nervous system disease
	H00264	Charcot-Marie-Tooth disease	Neurodegenerative disease