Homo sapiens (human): 8515
Help
Entry
8515 CDS
T01001
Symbol
ITGA10, PRO827
Name
(RefSeq) integrin subunit alpha 10
KO
K06586
integrin alpha 10
Organism
hsa
Homo sapiens (human)
Pathway
hsa04151
PI3K-Akt signaling pathway
hsa04510
Focal adhesion
hsa04512
ECM-receptor interaction
hsa04518
Integrin signaling
hsa04810
Regulation of actin cytoskeleton
hsa04820
Cytoskeleton in muscle cells
hsa05165
Human papillomavirus infection
hsa05410
Hypertrophic cardiomyopathy
hsa05412
Arrhythmogenic right ventricular cardiomyopathy
hsa05414
Dilated cardiomyopathy
Network
nt06167
Human cytomegalovirus (HCMV)
nt06180
Pathogenic Escherichia coli
nt06181
Salmonella
nt06182
Shigella
nt06183
Yersinia
nt06548
Integrin signaling
Element
N00393
ITGA/B-RhoGAP-RhoA signaling pathway
N00951
ITGA/B-RHOG-RAC signaling pathway
N01068
ITGA/B-FAK-RAC signaling pathway
N01070
ITGA/B-FAK-CDC42 signaling pathway
N01072
ITGA/B-RhoGEF-RhoA signaling pathway
N01080
ITGA/B-TALIN/VINCULIN signaling pathway
N01989
Integrin alpha10beta1 signaling
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04151 PI3K-Akt signaling pathway
8515 (ITGA10)
09133 Signaling molecules and interaction
04512 ECM-receptor interaction
8515 (ITGA10)
04518 Integrin signaling
8515 (ITGA10)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
8515 (ITGA10)
09142 Cell motility
04820 Cytoskeleton in muscle cells
8515 (ITGA10)
04810 Regulation of actin cytoskeleton
8515 (ITGA10)
09160 Human Diseases
09172 Infectious disease: viral
05165 Human papillomavirus infection
8515 (ITGA10)
09166 Cardiovascular disease
05410 Hypertrophic cardiomyopathy
8515 (ITGA10)
05412 Arrhythmogenic right ventricular cardiomyopathy
8515 (ITGA10)
05414 Dilated cardiomyopathy
8515 (ITGA10)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04515 Cell adhesion molecules [BR:
hsa04515
]
8515 (ITGA10)
Cell adhesion molecules [BR:
hsa04515
]
Integrins
Integrin alpha subunits
8515 (ITGA10)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
VWA
FG-GAP
Integrin_A_Ig_2
Integrin_A_Ig_1
VWA_2
FG-GAP_3
Integrin_A_Ig_3
ITGAX-like_Ig_3
vWA_SIBA-E
Motif
Other DBs
NCBI-GeneID:
8515
NCBI-ProteinID:
NP_003628
OMIM:
604042
HGNC:
6135
Ensembl:
ENSG00000143127
UniProt:
O75578
LinkDB
All DBs
Position
1:complement(145891208..145910050)
Genome browser
AA seq
1167 aa
AA seq
DB search
MELPFVTHLFLPLVFLTGLCSPFNLDEHHPRLFPGPPEAEFGYSVLQHVGGGQRWMLVGA
PWDGPSGDRRGDVYRCPVGGAHNAPCAKGHLGDYQLGNSSHPAVNMHLGMSLLETDGDGG
FMACAPLWSRACGSSVFSSGICARVDASFQPQGSLAPTAQRCPTYMDVVIVLDGSNSIYP
WSEVQTFLRRLVGKLFIDPEQIQVGLVQYGESPVHEWSLGDFRTKEEVVRAAKNLSRREG
RETKTAQAIMVACTEGFSQSHGGRPEAARLLVVVTDGESHDGEELPAALKACEAGRVTRY
GIAVLGHYLRRQRDPSSFLREIRTIASDPDERFFFNVTDEAALTDIVDALGDRIFGLEGS
HAENESSFGLEMSQIGFSTHRLKDGILFGMVGAYDWGGSVLWLEGGHRLFPPRMALEDEF
PPALQNHAAYLGYSVSSMLLRGGRRLFLSGAPRFRHRGKVIAFQLKKDGAVRVAQSLQGE
QIGSYFGSELCPLDTDRDGTTDVLLVAAPMFLGPQNKETGRVYVYLVGQQSLLTLQGTLQ
PEPPQDARFGFAMGALPDLNQDGFADVAVGAPLEDGHQGALYLYHGTQSGVRPHPAQRIA
AASMPHALSYFGRSVDGRLDLDGDDLVDVAVGAQGAAILLSSRPIVHLTPSLEVTPQAIS
VVQRDCRRRGQEAVCLTAALCFQVTSRTPGRWDHQFYMRFTASLDEWTAGARAAFDGSGQ
RLSPRRLRLSVGNVTCEQLHFHVLDTSDYLRPVALTVTFALDNTTKPGPVLNEGSPTSIQ
KLVPFSKDCGPDNECVTDLVLQVNMDIRGSRKAPFVVRGGRRKVLVSTTLENRKENAYNT
SLSLIFSRNLHLASLTPQRESPIKVECAAPSAHARLCSVGHPVFQTGAKVTFLLEFEFSC
SSLLSQVFVKLTASSDSLERNGTLQDNTAQTSAYIQYEPHLLFSSESTLHRYEVHPYGTL
PVGPGPEFKTTLRVQNLGCYVVSGLIISALLPAVAHGGNYFLSLSQVITNNASCIVQNLT
EPPGPPVHPEELQHTNRLNGSNTQCQVVRCHLGQLAKGTEVSVGLLRLVHNEFFRRAKFK
SLTVVSTFELGTEEGSVLQLTEASRWSESLLEVVQTRPILISLWILIGSVLGGLLLLALL
VFCLWKLGFFAHKKIPEEEKREEKLEQ
NT seq
3504 nt
NT seq
+upstream
nt +downstream
nt
atggaactccccttcgtcactcacctgttcttgcccctggtgttcctgacaggtctctgc
tccccctttaacctggatgaacatcacccacgcctattcccagggccaccagaagctgaa
tttggatacagtgtcttacaacatgttgggggtggacagcgatggatgctggtgggcgcc
ccctgggatgggccttcaggcgaccggaggggggacgtttatcgctgccctgtagggggg
gcccacaatgccccatgtgccaagggccacttaggtgactaccaactgggaaattcatct
catcctgctgtgaatatgcacctggggatgtctctgttagagacagatggtgatggggga
ttcatggcctgtgcccctctctggtctcgtgcttgtggcagctctgtcttcagttctggg
atatgtgcccgtgtggatgcttcattccagcctcagggaagcctggcacccactgcccaa
cgctgcccaacatacatggatgttgtcattgtcttggatggctccaacagcatctacccc
tggtctgaagttcagaccttcctacgaagactggtagggaaactgtttattgacccagaa
cagatacaggtgggactggtacagtatggggagagccctgtacatgagtggtccctggga
gatttccgaacgaaggaagaagtggtgagagcagcaaagaacctcagtcggcgggaggga
cgagaaacaaagactgcccaagcaataatggtggcctgcacagaagggttcagtcagtcc
catgggggccgacccgaggctgccaggctactggtggttgtcactgatggagagtcccat
gatggagaggagcttcctgcagcactaaaggcctgtgaggctggaagagtgacacgctat
gggattgcagtccttggtcactacctccggcggcagcgagatcccagctctttcctgaga
gaaattagaactattgccagtgatccagatgagcgattcttcttcaatgtcacagatgag
gctgctctgactgacattgtggatgcactaggagatcggatttttggccttgaagggtcc
catgcagaaaacgaaagctcctttgggctggaaatgtctcagattggtttctccactcat
cggctaaaggatgggattctttttgggatggtgggggcctatgactggggaggctctgtg
ctatggcttgaaggaggccaccgccttttccccccacgaatggcactggaagacgagttc
ccccctgcattgcagaaccatgcagcctacctgggttactctgtttcttccatgcttttg
cggggtggacgccgcctgtttctctctggggctcctcgatttagacatcgaggaaaagtc
atcgccttccagcttaagaaagatggggctgtgagggttgcccagagcctccagggggag
cagattggttcatactttggcagtgagctctgcccattggatacagatagggatggaaca
actgatgtcttacttgtggctgcccccatgttcctgggaccccagaacaaggaaacagga
cgtgtttatgtgtatctggtaggccagcagtccttgctgaccctccaaggaacacttcag
ccagaacccccccaggatgctcggtttggctttgccatgggagctcttcctgatctgaac
caagatggttttgctgatgtggctgtgggggcgcctctggaagatgggcaccagggagca
ctgtacctgtaccatggaacccagagtggagtcaggccccatcctgcccagaggattgct
gctgcctccatgccacatgccctcagctactttggccgaagtgtggatggtcggctagat
ctggatggagatgatctggtcgatgtggctgtgggtgcccagggggcagccatcctgctc
agctcccggcccattgtccatctgaccccatcactggaggtgaccccacaggccatcagt
gtggttcagagggactgtaggcggcgaggccaagaggcagtctgtctgactgcagccctt
tgcttccaagtgacctcccgtactcctggtcgctgggatcaccaattctacatgaggttc
accgcatcactggatgaatggactgctggggcacgtgcagcatttgatggctctggccag
aggttgtcccctcggaggctccggctcagtgtggggaatgtcacttgtgagcagctacac
ttccatgtgctggatacatcagattacctccggccagtggccttgactgtgacctttgcc
ttggacaatactacaaagccagggcctgtgctgaatgagggctcacccacctctatacaa
aagctggtccccttctcaaaggattgtggccctgacaatgaatgtgtcacagacctggtg
cttcaagtgaatatggacatcagaggctccaggaaggccccatttgtggttcgaggtggc
cggcggaaagtgctggtatctacaactctggagaacagaaaggaaaatgcttacaatacg
agcctgagtctcatcttctctagaaacctccacctggccagtctcactcctcagagagag
agcccaataaaggtggaatgtgccgccccttctgctcatgcccggctctgcagtgtgggg
catcctgtcttccagactggagccaaggtgacctttctgctagagtttgagtttagctgc
tcctctctcctgagccaggtcttcgtgaagctgactgccagcagtgacagcctggagaga
aatgggacccttcaagataacacagcccagacctcagcctacatccaatatgagccccac
ctcctgttctctagtgagtctaccctgcaccgctatgaggttcacccatatgggaccctc
ccagtgggtcctggcccagaattcaaaaccactctcagggttcagaacctaggctgctat
gtggtcagtggcctcatcatctcagccctccttccagctgtggcccatgggggcaattac
ttcctatcactgtctcaagtcatcactaacaatgcaagctgcatagtgcagaacctgact
gaacccccaggcccacctgtgcatccagaggagcttcaacacacaaacagactgaatggg
agcaatactcagtgtcaggtggtgaggtgccaccttgggcagctggcaaaggggactgag
gtctctgttggactattgaggctggttcacaatgaatttttccgaagagccaagttcaag
tccctgacggtggtcagcacctttgagctgggaaccgaagagggcagtgtcctacagctg
actgaagcctcccgttggagtgagagcctcttggaggtggttcagacccggcctatcctc
atctccctgtggatcctcataggcagtgtcctgggagggttgctcctgcttgctctcctt
gtcttctgcctgtggaagcttggcttctttgcccataagaaaatccctgaggaagaaaaa
agagaagagaagttggagcaatga
Homo sapiens (human): 3688
Help
Entry
3688 CDS
T01001
Symbol
ITGB1, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB
Name
(RefSeq) integrin subunit beta 1
KO
K05719
integrin beta 1
Organism
hsa
Homo sapiens (human)
Pathway
hsa03271
Virion - Rotavirus
hsa04015
Rap1 signaling pathway
hsa04145
Phagosome
hsa04151
PI3K-Akt signaling pathway
hsa04360
Axon guidance
hsa04510
Focal adhesion
hsa04512
ECM-receptor interaction
hsa04514
Cell adhesion molecule (CAM) interaction
hsa04517
IgSF CAM signaling
hsa04518
Integrin signaling
hsa04530
Tight junction
hsa04611
Platelet activation
hsa04670
Leukocyte transendothelial migration
hsa04810
Regulation of actin cytoskeleton
hsa04820
Cytoskeleton in muscle cells
hsa05100
Bacterial invasion of epithelial cells
hsa05130
Pathogenic Escherichia coli infection
hsa05131
Shigellosis
hsa05133
Pertussis
hsa05135
Yersinia infection
hsa05140
Leishmaniasis
hsa05145
Toxoplasmosis
hsa05165
Human papillomavirus infection
hsa05200
Pathways in cancer
hsa05205
Proteoglycans in cancer
hsa05222
Small cell lung cancer
hsa05410
Hypertrophic cardiomyopathy
hsa05412
Arrhythmogenic right ventricular cardiomyopathy
hsa05414
Dilated cardiomyopathy
Network
nt06167
Human cytomegalovirus (HCMV)
nt06180
Pathogenic Escherichia coli
nt06181
Salmonella
nt06182
Shigella
nt06183
Yersinia
nt06539
Cytoskeleton in muscle cells
nt06546
IgSF CAM signaling
nt06548
Integrin signaling
Element
N00393
ITGA/B-RhoGAP-RhoA signaling pathway
N00951
ITGA/B-RHOG-RAC signaling pathway
N01068
ITGA/B-FAK-RAC signaling pathway
N01070
ITGA/B-FAK-CDC42 signaling pathway
N01072
ITGA/B-RhoGEF-RhoA signaling pathway
N01080
ITGA/B-TALIN/VINCULIN signaling pathway
N01081
Shigella IpaB/C/D to ITGA/B-TALIN/VINCULIN signaling pathway
N01815
Vinculin-talin-integrin macromolecular complex
N01921
Integrin alpha4beta1 signaling
N01957
JAM2 interactions
N01974
Integrin alpha9beta1 signaling
N01980
Integrin alpha5beta1 signaling
N01981
Integrin alpha8beta1 signaling
N01982
Integrin alphaVbeta1 signaling
N01987
Integrin alpha1beta1 signaling
N01988
Integrin alpha2beta1 signaling
N01989
Integrin alpha10beta1 signaling
N01990
Integrin alpha3beta1 signaling
N01991
Integrin alpha6beta1 signaling
N01996
Integrin alpha11beta1 signaling
N01997
Integrin alpha7beta1 signaling
Drug target
Bexotegrast:
D12722
Carotegrast methyl:
D09799
<JP>
Valategrast hydrochloride:
D10028
Volociximab:
D06319
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09125 Information processing in viruses
03271 Virion - Rotavirus
3688 (ITGB1)
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
3688 (ITGB1)
04151 PI3K-Akt signaling pathway
3688 (ITGB1)
09133 Signaling molecules and interaction
04512 ECM-receptor interaction
3688 (ITGB1)
04514 Cell adhesion molecule (CAM) interaction
3688 (ITGB1)
04517 IgSF CAM signaling
3688 (ITGB1)
04518 Integrin signaling
3688 (ITGB1)
09140 Cellular Processes
09141 Transport and catabolism
04145 Phagosome
3688 (ITGB1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
3688 (ITGB1)
04530 Tight junction
3688 (ITGB1)
09142 Cell motility
04820 Cytoskeleton in muscle cells
3688 (ITGB1)
04810 Regulation of actin cytoskeleton
3688 (ITGB1)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
3688 (ITGB1)
04670 Leukocyte transendothelial migration
3688 (ITGB1)
09158 Development and regeneration
04360 Axon guidance
3688 (ITGB1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
3688 (ITGB1)
05205 Proteoglycans in cancer
3688 (ITGB1)
09162 Cancer: specific types
05222 Small cell lung cancer
3688 (ITGB1)
09172 Infectious disease: viral
05165 Human papillomavirus infection
3688 (ITGB1)
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
3688 (ITGB1)
05131 Shigellosis
3688 (ITGB1)
05135 Yersinia infection
3688 (ITGB1)
05133 Pertussis
3688 (ITGB1)
05100 Bacterial invasion of epithelial cells
3688 (ITGB1)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
3688 (ITGB1)
05140 Leishmaniasis
3688 (ITGB1)
09166 Cardiovascular disease
05410 Hypertrophic cardiomyopathy
3688 (ITGB1)
05412 Arrhythmogenic right ventricular cardiomyopathy
3688 (ITGB1)
05414 Dilated cardiomyopathy
3688 (ITGB1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
3688 (ITGB1)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
hsa04147
]
3688 (ITGB1)
04515 Cell adhesion molecules [BR:
hsa04515
]
3688 (ITGB1)
04090 CD molecules [BR:
hsa04090
]
3688 (ITGB1)
Membrane trafficking [BR:
hsa04131
]
Endocytosis
Phagocytosis
Integrins (complement receptors)
3688 (ITGB1)
Exosome [BR:
hsa04147
]
Exosomal proteins
Proteins found in most exosomes
3688 (ITGB1)
Cell adhesion molecules [BR:
hsa04515
]
Integrins
Integrin beta subunits
3688 (ITGB1)
CD molecules [BR:
hsa04090
]
Proteins
3688 (ITGB1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Integrin_beta
Integrin_B_tail
Integrin_b_cyt
EGF_integrin
PSI_integrin
I-EGF_1
EGF_2
EGF_Teneurin
vWA_SIBA-E
Motif
Other DBs
NCBI-GeneID:
3688
NCBI-ProteinID:
NP_002202
OMIM:
135630
HGNC:
6153
Ensembl:
ENSG00000150093
UniProt:
P05556
Structure
PDB
PDBj
LinkDB
All DBs
Position
10:complement(32900318..32958230)
Genome browser
AA seq
798 aa
AA seq
DB search
MNLQPIFWIGLISSVCCVFAQTDENRCLKANAKSCGECIQAGPNCGWCTNSTFLQEGMPT
SARCDDLEALKKKGCPPDDIENPRGSKDIKKNKNVTNRSKGTAEKLKPEDITQIQPQQLV
LRLRSGEPQTFTLKFKRAEDYPIDLYYLMDLSYSMKDDLENVKSLGTDLMNEMRRITSDF
RIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTSPFSYKNVLSLTNKGEVFNELVGKQR
ISGNLDSPEGGFDAIMQVAVCGSLIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGQ
CHLENNMYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAVGTL
SANSSNVIQLIIDAYNSLSSEVILENGKLSEGVTISYKSYCKNGVNGTGENGRKCSNISI
GDEVQFEISITSNKCPKKDSDSFKIRPLGFTEEVEVILQYICECECQSEGIPESPKCHEG
NGTFECGACRCNEGRVGRHCECSTDEVNSEDMDAYCRKENSSEICSNNGECVCGQCVCRK
RDNTNEIYSGKFCECDNFNCDRSNGLICGGNGVCKCRVCECNPNYTGSACDCSLDTSTCE
ASNGQICNGRGICECGVCKCTDPKFQGQTCEMCQTCLGVCAEHKECVQCRAFNKGEKKDT
CTQECSYFNITKVESRDKLPQPVQPDPVSHCKEKDVDDCWFYFTYSVNGNNEVMVHVVEN
PECPTGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTGEN
PIYKSAVTTVVNPKYEGK
NT seq
2397 nt
NT seq
+upstream
nt +downstream
nt
atgaatttacaaccaattttctggattggactgatcagttcagtttgctgtgtgtttgct
caaacagatgaaaatagatgtttaaaagcaaatgccaaatcatgtggagaatgtatacaa
gcagggccaaattgtgggtggtgcacaaattcaacatttttacaggaaggaatgcctact
tctgcacgatgtgatgatttagaagccttaaaaaagaagggttgccctccagatgacata
gaaaatcccagaggctccaaagatataaagaaaaataaaaatgtaaccaaccgtagcaaa
ggaacagcagagaagctcaagccagaggatattactcagatccaaccacagcagttggtt
ttgcgattaagatcaggggagccacagacatttacattaaaattcaagagagctgaagac
tatcccattgacctctactaccttatggacctgtcttactcaatgaaagacgatttggag
aatgtaaaaagtcttggaacagatctgatgaatgaaatgaggaggattacttcggacttc
agaattggatttggctcatttgtggaaaagactgtgatgccttacattagcacaacacca
gctaagctcaggaacccttgcacaagtgaacagaactgcaccagcccatttagctacaaa
aatgtgctcagtcttactaataaaggagaagtatttaatgaacttgttggaaaacagcgc
atatctggaaatttggattctccagaaggtggtttcgatgccatcatgcaagttgcagtt
tgtggatcactgattggctggaggaatgttacacggctgctggtgttttccacagatgcc
gggtttcactttgctggagatgggaaacttggtggcattgttttaccaaatgatggacaa
tgtcacctggaaaataatatgtacacaatgagccattattatgattatccttctattgct
caccttgtccagaaactgagtgaaaataatattcagacaatttttgcagttactgaagaa
tttcagcctgtttacaaggagctgaaaaacttgatccctaagtcagcagtaggaacatta
tctgcaaattctagcaatgtaattcagttgatcattgatgcatacaattccctttcctca
gaagtcattttggaaaacggcaaattgtcagaaggcgtaacaataagttacaaatcttac
tgcaagaacggggtgaatggaacaggggaaaatggaagaaaatgttccaatatttccatt
ggagatgaggttcaatttgaaattagcataacttcaaataagtgtccaaaaaaggattct
gacagctttaaaattaggcctctgggctttacggaggaagtagaggttattcttcagtac
atctgtgaatgtgaatgccaaagcgaaggcatccctgaaagtcccaagtgtcatgaagga
aatgggacatttgagtgtggcgcgtgcaggtgcaatgaagggcgtgttggtagacattgt
gaatgcagcacagatgaagttaacagtgaagacatggatgcttactgcaggaaagaaaac
agttcagaaatctgcagtaacaatggagagtgcgtctgcggacagtgtgtttgtaggaag
agggataatacaaatgaaatttattctggcaaattctgcgagtgtgataatttcaactgt
gatagatccaatggcttaatttgtggaggaaatggtgtttgcaagtgtcgtgtgtgtgag
tgcaaccccaactacactggcagtgcatgtgactgttctttggatactagtacttgtgaa
gccagcaacggacagatctgcaatggccggggcatctgcgagtgtggtgtctgtaagtgt
acagatccgaagtttcaagggcaaacgtgtgagatgtgtcagacctgccttggtgtctgt
gctgagcataaagaatgtgttcagtgcagagccttcaataaaggagaaaagaaagacaca
tgcacacaggaatgttcctattttaacattaccaaggtagaaagtcgggacaaattaccc
cagccggtccaacctgatcctgtgtcccattgtaaggagaaggatgttgacgactgttgg
ttctattttacgtattcagtgaatgggaacaacgaggtcatggttcatgttgtggagaat
ccagagtgtcccactggtccagacatcattccaattgtagctggtgtggttgctggaatt
gttcttattggccttgcattactgctgatatggaagcttttaatgataattcatgacaga
agggagtttgctaaatttgaaaaggagaaaatgaatgccaaatgggacacgggtgaaaat
cctatttataagagtgccgtaacaactgtggtcaatccgaagtatgagggaaaatga
DBGET
integrated database retrieval system
