KEGG   Homo sapiens (human): 8644
Entry
8644              CDS       T01001                                 
Symbol
AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS
Name
(RefSeq) aldo-keto reductase family 1 member C3
  KO
K04119  aldo-keto reductase family 1 member C3 [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00140  Steroid hormone biosynthesis
hsa00590  Arachidonic acid metabolism
hsa00790  Folate biosynthesis
hsa01100  Metabolic pathways
hsa04913  Ovarian steroidogenesis
hsa05208  Chemical carcinogenesis - reactive oxygen species
Module
hsa_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
hsa_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Network
nt06019  Steroid hormone biosynthesis
nt06226  KEAP1-NRF2 signaling (cancer)
nt06251  CYP-mediated ROS formation (cancer)
  Element
N01401  Benzo[a]pyrenre to CYP-mediated metabolism
N01413  Metals to KEAP1-NRF2 signalig pathway
N01541  Testosterone biosynthesis
N01802  Dihydrotestosterone biosynthesis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    8644 (AKR1C3)
   00590 Arachidonic acid metabolism
    8644 (AKR1C3)
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    8644 (AKR1C3)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    8644 (AKR1C3)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    8644 (AKR1C3)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.51  3(or 17)beta-hydroxysteroid dehydrogenase
     8644 (AKR1C3)
    1.1.1.188  prostaglandin-F synthase
     8644 (AKR1C3)
    1.1.1.213  3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
     8644 (AKR1C3)
    1.1.1.357  3alpha-hydroxysteroid 3-dehydrogenase
     8644 (AKR1C3)
SSDB
Motif
Pfam: Aldo_ket_red
Other DBs
NCBI-GeneID: 8644
NCBI-ProteinID: NP_001240837
OMIM: 603966
HGNC: 386
Ensembl: ENSG00000196139
UniProt: P42330 A0A0A0MSS8
Structure
LinkDB
Position
10:5048781..5107686
AA seq 323 aa
MDSKHQCLKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPM
SLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKP
GLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPV
LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLD
RNLHYFNSDSFASHPNYPYSDEY
NT seq 972 nt   +upstreamnt  +downstreamnt
atggattcaaaacatcagtgtttgaagctaaatgatggtcacttcatgcctgtcctggga
tttggcacctatgcacctccagaggttccgagaagtaaagctttggaggtcacaaaatta
gcaatagaagctgggttccgccatatagattctgctcatttatacaataatgaggagcag
gttggactggccatccgaagcaagattgcagatggcagtgtgaagagagaagacatattc
tacacttcaaagctttggtccacttttcatcgaccagagttggtccgaccagccttggaa
aactcactgaagaaagctcaattggactatgttgacctctatcttattcattctccaatg
tctctaaagccaggtgaggaactttcaccaacagatgaaaatggaaaagtaatatttgac
atagtggatctctgtaccacctgggaggccatggagaagtgtaaggatgcaggattggcc
aagtccattggggtgtcaaacttcaaccgcaggcagctggagatgatcctcaacaagcca
ggactcaagtacaagcctgtctgcaaccaggtagaatgtcatccgtatttcaaccggagt
aaattgctagatttctgcaagtcgaaagatattgttctggttgcctatagtgctctggga
tctcaacgagacaaacgatgggtggacccgaactccccggtgctcttggaggacccagtc
ctttgtgccttggcaaaaaagcacaagcgaaccccagccctgattgccctgcgctaccag
ctgcagcgtggggttgtggtcctggccaagagctacaatgagcagcgcatcagacagaac
gtgcaggtttttgagttccagttgactgcagaggacatgaaagccatagatggcctagac
agaaatctccactattttaacagtgatagttttgctagccaccctaattatccatattca
gatgaatattaa

KEGG   Homo sapiens (human): 3293
Entry
3293              CDS       T01001                                 
Symbol
HSD17B3, EDH17B3, SDR12C2
Name
(RefSeq) hydroxysteroid 17-beta dehydrogenase 3
  KO
K10207  testosterone 17beta-dehydrogenase (NADP+) [EC:1.1.1.64]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00140  Steroid hormone biosynthesis
hsa01100  Metabolic pathways
Module
hsa_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
hsa_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Network
nt06019  Steroid hormone biosynthesis
  Element
N01541  Testosterone biosynthesis
N01802  Dihydrotestosterone biosynthesis
Disease
H00608  46,XY disorder of sex development due to testosterone secretion defect
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    3293 (HSD17B3)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.64  testosterone 17beta-dehydrogenase (NADP+)
     3293 (HSD17B3)
SSDB
Motif
Pfam: adh_short adh_short_C2 KR Sacchrp_dh_NADP ApbA Shikimate_DH DUF3993
Other DBs
NCBI-GeneID: 3293
NCBI-ProteinID: NP_000188
OMIM: 605573
HGNC: 5212
Ensembl: ENSG00000130948
UniProt: P37058 Q6FH62
LinkDB
Position
9:complement(96235306..96302176)
AA seq 310 aa
MGDVLEQFFILTGLLVCLACLAKCVRFSRCVLLNYWKVLPKSFLRSMGQWAVITGAGDGI
GKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADFTKDDIYEHIKEKL
AGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVKMTQLILKHMESRQKGLI
LNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQVLTPYAVSTAMTKYLN
TNVITKTADEFVKESLNYVTIGGETCGCLAHEILAGFLSLIPAWAFYSGAFQRLLLTHYV
AYLKLNTKVR
NT seq 933 nt   +upstreamnt  +downstreamnt
atgggggacgtcctggaacagttcttcatcctcacagggctgctggtgtgcctggcctgc
ctggcgaagtgcgtgagattctccagatgtgttttactgaactactggaaagttttgcca
aagtctttcttgcggtcaatgggacagtgggcagtgatcactggagcaggcgatggaatt
gggaaagcgtactcgttcgagctagcaaaacgtggactcaatgttgtccttattagccgg
acgctggaaaaactagaggccattgccacagagatcgagcggactacagggaggagtgtg
aagattatacaagcagattttacaaaagatgacatctacgagcatattaaagaaaaactt
gcaggcttagaaattggaattttagtcaacaatgtcggaatgcttccaaaccttctccca
agccatttcctgaacgcaccggatgaaatccagagcctcatccattgtaacatcacctcc
gtagtcaagatgacacagctaattctgaaacatatggaatcaaggcagaaaggtctcatc
ctgaacatttcttctgggatagccctgtttccttggcctctctactccatgtactcagct
tccaaggcgtttgtgtgcgcattttccaaggccctgcaagaggaatataaagcaaaagaa
gtcatcatccaggtgctgaccccatatgctgtctcgactgcaatgacaaagtatctaaat
acaaatgtgataaccaagactgctgatgagtttgtcaaagagtcattgaattatgtcaca
attggaggtgaaacctgtggctgccttgcccatgaaatcttggcgggctttctgagcctg
atcccggcctgggccttctacagcggtgccttccaaaggctgctcctgacacactatgtg
gcatacctgaagctcaacaccaaggtcaggtag

KEGG   Homo sapiens (human): 3294
Entry
3294              CDS       T01001                                 
Symbol
HSD17B2, EDH17B2, HSD17, SDR9C2
Name
(RefSeq) hydroxysteroid 17-beta dehydrogenase 2
  KO
K13368  17beta-estradiol 17-dehydrogenase / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) [EC:1.1.1.62 1.1.1.239]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00140  Steroid hormone biosynthesis
hsa01100  Metabolic pathways
hsa04913  Ovarian steroidogenesis
Module
hsa_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
Network
nt06019  Steroid hormone biosynthesis
  Element
N01541  Testosterone biosynthesis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    3294 (HSD17B2)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    3294 (HSD17B2)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.62  17beta-estradiol 17-dehydrogenase
     3294 (HSD17B2)
    1.1.1.239  3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
     3294 (HSD17B2)
SSDB
Motif
Pfam: adh_short adh_short_C2 KR Ins_allergen_rp Epimerase DUF6056
Other DBs
NCBI-GeneID: 3294
NCBI-ProteinID: NP_002144
OMIM: 109685
HGNC: 5211
Ensembl: ENSG00000086696
UniProt: P37059
LinkDB
Position
16:82035253..82098534
AA seq 387 aa
MSTFFSDTAWICLAVPTVLCGTVFCKYKKSSGQLWSWMVCLAGLCAVCLLILSPFWGLIL
FSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPG
AEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELL
LMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVT
MFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYI
LAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWICLAHYLPIGIYD
YFAKRHFGQDKPMPRALRMPNYKKKAT
NT seq 1164 nt   +upstreamnt  +downstreamnt
atgagcactttcttctcggacacagcatggatctgcctggctgtccccacagtactatgt
gggacagtattttgcaaatacaagaagagctcagggcagctgtggagctggatggtctgc
ctggcaggcctctgtgcagtctgcctgctcatcctgtcccctttttggggcttgatcctc
ttctcggtgtcatgcttcctcatgtatacttacttatctggccaagaattgttacctgtg
gatcagaaggcagtcctggtgacaggtggtgattgcgggcttggccatgctttgtgcaag
tatctggatgagctgggcttcacggtatttgccggagttttgaatgaaaatggcccagga
gctgaggaattgcgaagaacctgctctccgcgcctctcggtgctccaaatggacatcacg
aagccagtgcagataaaagatgcttacagcaaggttgcagcaatgctgcaggacagagga
ctgtgggctgtgatcaacaatgctggggtgcttggctttccaactgatggggagcttctt
cttatgactgactacaaacaatgcatggccgtgaacttctttggaactgtggaggtcaca
aagacgtttttgcctcttcttagaaaatccaaagggaggctggtgaatgtcagcagcatg
ggaggaggggccccaatggaaaggctggcatcttatggctcatcaaaggcggctgtgacc
atgttctcatcagttatgagactggagctttccaagtggggaattaaagttgcttccatc
caacctggaggcttcctaacaaatatcgcaggcaccagtgacaagtgggaaaagctggag
aaggacattctggaccacctccccgctgaggtacaggaagactacggccaggactacatc
ttagcacagcggaatttcctcctattgatcaactcgttagccagcaaggacttctctccg
gtgctgcgggacatccagcatgctatcttggcgaagagcccttttgcctattacacgcca
gggaaaggcgcttacttgtggatctgccttgctcactatttgcctattggcatatatgat
tactttgctaaaagacattttggccaagacaagcccatgcccagagctctaagaatgcct
aactacaagaaaaaggccacctag

KEGG   Homo sapiens (human): 7923
Entry
7923              CDS       T01001                                 
Symbol
HSD17B8, D6S2245E, FABG, FABGL, H2-KE6, HKE6, KE6, RING2, SDR30C1, dJ1033B10.9
Name
(RefSeq) hydroxysteroid 17-beta dehydrogenase 8
  KO
K13370  17beta-estradiol 17-dehydrogenase / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) / 3-oxoacyl-[acyl-carrier protein] reductase alpha subunit [EC:1.1.1.62 1.1.1.239]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00061  Fatty acid biosynthesis
hsa00140  Steroid hormone biosynthesis
hsa01100  Metabolic pathways
hsa01212  Fatty acid metabolism
Module
hsa_M00873  Fatty acid biosynthesis in mitochondria, animals
hsa_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
Network
nt06019  Steroid hormone biosynthesis
  Element
N01541  Testosterone biosynthesis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00061 Fatty acid biosynthesis
    7923 (HSD17B8)
   00140 Steroid hormone biosynthesis
    7923 (HSD17B8)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.62  17beta-estradiol 17-dehydrogenase
     7923 (HSD17B8)
    1.1.1.239  3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
     7923 (HSD17B8)
SSDB
Motif
Pfam: adh_short_C2 adh_short KR Epimerase RmlD_sub_bind RNA_pol_Rpb1_4
Other DBs
NCBI-GeneID: 7923
NCBI-ProteinID: NP_055049
OMIM: 601417
HGNC: 3554
Ensembl: ENSG00000204228
UniProt: Q92506 A0A1U9X7U3
Structure
LinkDB
Position
6:33204655..33206831
AA seq 261 aa
MASQLQNRLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGS
KEGPPRGNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDW
DKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLT
QTAARELGRHGIRCNSVLPGFIATPMTQKVPQKVVDKITEMIPMGHLGDPEDVADVVAFL
ASEDSGYITGTSVEVTGGLFM
NT seq 786 nt   +upstreamnt  +downstreamnt
atggcgtctcagctccagaaccgactccgctccgcactggccttggtcacaggtgcgggg
agcggcatcggccgagcggtcagtgtacgcctggccggagagggggccaccgtagctgcc
tgcgacctggaccgggcagcggcacaggagacggtgcggctgctgggcgggccagggagc
aaggaggggccgccccgagggaaccatgctgccttccaggctgacgtgtctgaggccagg
gccgccaggtgcctgctggaacaagtgcaggcctgcttttctcgcccaccatctgtcgtt
gtgtcctgtgcgggcatcacccaggatgagtttctgctgcacatgtctgaggatgactgg
gacaaagtcatagctgtcaacctcaagggcaccttcctagtcactcaggctgcagcacaa
gccctggtgtccaatggttgtcgtggttccatcatcaacatcagtagcatcgtaggaaag
gtggggaacgtggggcagacaaactatgcagcatccaaggctggagtgattgggctgacc
cagaccgcagcccgggagcttggacgacatgggatccgctgtaactctgtcctcccaggg
ttcattgcaacacccatgacacagaaagtgccacagaaagtggtggacaagattactgaa
atgatcccgatgggacacttgggggaccctgaggatgtggcagatgtggtcgcattcttg
gcatctgaagatagtggatacatcacagggacctcagtggaagtcactggaggtcttttc
atgtaa

KEGG   Homo sapiens (human): 8630
Entry
8630              CDS       T01001                                 
Symbol
HSD17B6, HSE, RODH, SDR9C6
Name
(RefSeq) hydroxysteroid 17-beta dehydrogenase 6
  KO
K13369  17beta-estradiol 17-dehydrogenase / all-trans-retinol dehydrogenase (NAD+) / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) [EC:1.1.1.62 1.1.1.105 1.1.1.239]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00140  Steroid hormone biosynthesis
hsa00830  Retinol metabolism
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
Module
hsa_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
hsa_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Network
nt06019  Steroid hormone biosynthesis
  Element
N01541  Testosterone biosynthesis
N01802  Dihydrotestosterone biosynthesis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    8630 (HSD17B6)
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    8630 (HSD17B6)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.62  17beta-estradiol 17-dehydrogenase
     8630 (HSD17B6)
    1.1.1.105  all-trans-retinol dehydrogenase (NAD+)
     8630 (HSD17B6)
    1.1.1.239  3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
     8630 (HSD17B6)
SSDB
Motif
Pfam: adh_short adh_short_C2 KR
Other DBs
NCBI-GeneID: 8630
NCBI-ProteinID: NP_003716
OMIM: 606623
HGNC: 23316
Ensembl: ENSG00000025423
UniProt: O14756
LinkDB
Position
12:56763324..56787790
AA seq 317 aa
MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAAC
LTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPIT
LCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSK
YGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQ
QYFDALYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTS
LADYILTRSWPKPAQAV
NT seq 954 nt   +upstreamnt  +downstreamnt
atgtggctctacctggcggccttcgtgggcctgtactaccttctgcactggtaccgggag
aggcaggtggtgagccacctccaagacaagtatgtctttatcacgggctgtgactcgggc
tttgggaacctgctggccagacagctggatgcacgaggcttgagagtgctggctgcgtgt
ctgacggagaagggggccgagcagctgaggggccagacgtctgacaggctggagacggtg
accctggatgttaccaagatggagagcatcgctgcagctactcagtgggtgaaggagcat
gtgggggacagaggactctggggactggtgaacaatgcaggcattcttacaccaattacc
ttatgtgagtggctgaacactgaggactctatgaatatgctcaaagtgaacctcattggt
gtgatccaggtgaccttgagcatgcttcctttggtgaggagagcacggggaagaattgtc
aatgtctccagcattctgggaagagttgctttctttgtaggaggctactgtgtctccaag
tatggagtggaagccttttcagatattctgaggcgtgagattcaacattttggggtgaaa
atcagcatagttgaacctggctacttcagaacgggaatgacaaacatgacacagtcctta
gagcgaatgaagcaaagttggaaagaagcccccaagcatattaaggagacctatggacag
cagtattttgatgccctttacaatatcatgaaggaagggctgttgaattgtagcacaaac
ctgaacctggtcactgactgcatggaacatgctctgacatcggtgcatccgcgaactcga
tattcagctggctgggatgctaaatttttcttcatccctctatcttatttacctacatca
ctggcagactacattttgactagatcttggcccaaaccagcccaggcagtctaa

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