Homo sapiens (human): 87 Help Entry 87                CDS       T01001                                  Symbol ACTN1, BDPLT15 Name (RefSeq) actinin alpha 1   KO K05699   actinin alpha 1/4 Organism hsa  Homo sapiens (human) Pathway hsa04510   Focal adhesion hsa04520   Adherens junction hsa04530   Tight junction hsa04670   Leukocyte transendothelial migration hsa04810   Regulation of actin cytoskeleton hsa05131   Shigellosis hsa05146   Amoebiasis hsa05203   Viral carcinogenesis hsa05322   Systemic lupus erythematosus Network nt06135  Cytoskeletal regulation (viruses and bacteria)   Element N01080   ITGA/B-TALIN/VINCULIN signaling pathway N01082   Shigella IpaA to ITGA/B-TALIN/VINCULIN signaling pathway Disease H01235   Bleeding disorder platelet-type H01740   Macrothrombocytopenia Brite KEGG Orthology (KO) [BR:hsa00001]  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     87 (ACTN1)    04520 Adherens junction     87 (ACTN1)    04530 Tight junction     87 (ACTN1)   09142 Cell motility    04810 Regulation of actin cytoskeleton     87 (ACTN1)  09150 Organismal Systems   09151 Immune system    04670 Leukocyte transendothelial migration     87 (ACTN1)  09160 Human Diseases   09161 Cancer: overview    05203 Viral carcinogenesis     87 (ACTN1)   09171 Infectious disease: bacterial    05131 Shigellosis     87 (ACTN1)   09174 Infectious disease: parasitic    05146 Amoebiasis     87 (ACTN1)   09163 Immune disease    05322 Systemic lupus erythematosus     87 (ACTN1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:hsa04131]     87 (ACTN1)   09183 Protein families: signaling and cellular processes    04812 Cytoskeleton proteins [BR:hsa04812]     87 (ACTN1)    04147 Exosome [BR:hsa04147]     87 (ACTN1) Membrane trafficking [BR:hsa04131]  Exocytosis   Small GTPases and associated proteins    Rab associated proteins     87 (ACTN1) Cytoskeleton proteins [BR:hsa04812]  Eukaryotic cytoskeleton proteins   Actin filaments / Microfilaments    Actin-binding proteins     Cross-linking proteins      87 (ACTN1) Exosome [BR:hsa04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    87 (ACTN1)   Exosomal proteins of colorectal cancer cells    87 (ACTN1)   Exosomal proteins of bladder cancer cells    87 (ACTN1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Spectrin CH EFhand_Ca_insen EF-hand_1 EF-hand_6 EF-hand_7 EF-hand_8 EF-hand_5 XisI Uds1 Motif Other DBs NCBI-GeneID:  87 NCBI-ProteinID:  NP_001093 OMIM:  102575 HGNC:  163 Ensembl:  ENSG00000072110 UniProt:  P12814 A0A024R694 Structure PDB LinkDB All DBs Position 14:complement(68874128..68979302) Genome browser AA seq 892 aa AA seqDB search MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFR DGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNV KMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFC ALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMT YVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENR VPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRM VSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT IEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEI NGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEM HGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQL LTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGY DIGNDPQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDK NYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL NT seq 2679 nt NT seq  +upstreamnt  +downstreamnt atggaccattatgattctcagcaaaccaacgattacatgcagccagaagaggactgggac cgggacctgctcctggacccggcctgggagaagcagcagagaaagacattcacggcatgg tgtaactcccacctccggaaggcggggacacagatcgagaacatcgaagaggacttccgg gatggcctgaagctcatgctgctgctggaggtcatctcaggtgaacgcttggccaagcca gagcgaggcaagatgagagtgcacaagatctccaacgtcaacaaggccctggatttcata gccagcaaaggcgtcaaactggtgtccatcggagccgaagaaatcgtggatgggaatgtg aagatgaccctgggcatgatctggaccatcatcctgcgctttgccatccaggacatctcc gtggaagagacttcagccaaggaagggctgctcctgtggtgtcagagaaagacagcccct tacaaaaatgtcaacatccagaacttccacataagctggaaggatggcctcggcttctgt gctttgatccaccgacaccggcccgagctgattgactacgggaagctgcggaaggatgat ccactcacaaatctgaatacggcttttgacgtggcagagaagtacctggacatccccaag atgctggatgccgaagacatcgttggaactgcccgaccggatgagaaagccatcatgact tacgtgtctagcttctaccacgccttctctggagcccagaaggcggagacagcagccaat cgcatctgcaaggtgttggccgtcaaccaggagaacgagcagcttatggaagactacgag aagctggccagtgatctgttggagtggatccgccgcacaatcccgtggctggagaaccgg gtgcccgagaacaccatgcatgccatgcaacagaagctggaggacttccgggactaccgg cgcctgcacaagccgcccaaggtgcaggagaagtgccagctggagatcaacttcaacacg ctgcagaccaagctgcggctcagcaaccggcctgccttcatgccctctgagggcaggatg gtctcggacatcaacaatgcctggggctgcctggagcaggtggagaagggctatgaggag tggttgctgaatgagatccggaggctggagcgactggaccacctggcagagaagttccgg cagaaggcctccatccacgaggcctggactgacggcaaagaggccatgctgcgacagaag gactatgagaccgccaccctctcggagatcaaggccctgctcaagaagcatgaggccttc gagagtgacctggctgcccaccaggaccgtgtggagcagattgccgccatcgcacaggag ctcaatgagctggactattatgactcacccagtgtcaacgcccgttgccaaaagatctgt gaccagtgggacaatctgggggccctaactcagaagcgaagggaagctctggagcggacc gagaaactgctggagaccattgaccagctgtacttggagtatgccaagcgggctgcaccc ttcaacaactggatggagggggccatggaggacctgcaggacaccttcattgtgcacacc attgaggagatccagggactgaccacagcccatgagcagttcaaggccaccctccctgat gccgacaaggagcgcctggccatcctgggcatccacaatgaggtgtccaagattgtccag acctaccacgtcaatatggcgggcaccaacccctacacaaccatcacgcctcaggagatc aatggcaaatgggaccacgtgcggcagctggtgcctcggagggaccaagctctgacggag gagcatgcccgacagcagcacaatgagaggctacgcaagcagtttggagcccaggccaat gtcatcgggccctggatccagaccaagatggaggagatcgggaggatctccattgagatg catgggaccctggaggaccagctcagccacctgcggcagtatgagaagagcatcgtcaac tacaagccaaagattgatcagctggagggcgaccaccagctcatccaggaggcgctcatc ttcgacaacaagcacaccaactacaccatggagcacatccgtgtgggctgggagcagctg ctcaccaccatcgccaggaccatcaatgaggtagagaaccagatcctgacccgggatgcc aagggcatcagccaggagcagatgaatgagttccgggcctccttcaaccactttgaccgg gatcactccggcacactgggtcccgaggagttcaaagcctgcctcatcagcttgggttat gatattggcaacgacccccagggagaagcagaatttgcccgcatcatgagcattgtggac cccaaccgcctgggggtagtgacattccaggccttcattgacttcatgtcccgcgagaca gccgacacagatacagcagaccaagtcatggcttccttcaagatcctggctggggacaag aactacattaccatggacgagctgcgccgcgagctgccacccgaccaggctgagtactgc atcgcgcggatggccccctacaccggccccgactccgtgccaggtgctctggactacatg tccttctccacggcgctgtacggcgagagtgacctctaa

Homo sapiens (human): 81 Help Entry 81                CDS       T01001                                  Symbol ACTN4, ACTININ-4, FSGS, FSGS1 Name (RefSeq) actinin alpha 4   KO K05699   actinin alpha 1/4 Organism hsa  Homo sapiens (human) Pathway hsa04510   Focal adhesion hsa04520   Adherens junction hsa04530   Tight junction hsa04670   Leukocyte transendothelial migration hsa04810   Regulation of actin cytoskeleton hsa05131   Shigellosis hsa05146   Amoebiasis hsa05203   Viral carcinogenesis hsa05322   Systemic lupus erythematosus Network nt06135  Cytoskeletal regulation (viruses and bacteria)   Element N01080   ITGA/B-TALIN/VINCULIN signaling pathway N01082   Shigella IpaA to ITGA/B-TALIN/VINCULIN signaling pathway Disease H00626   Focal segmental glomerulosclerosis Brite KEGG Orthology (KO) [BR:hsa00001]  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     81 (ACTN4)    04520 Adherens junction     81 (ACTN4)    04530 Tight junction     81 (ACTN4)   09142 Cell motility    04810 Regulation of actin cytoskeleton     81 (ACTN4)  09150 Organismal Systems   09151 Immune system    04670 Leukocyte transendothelial migration     81 (ACTN4)  09160 Human Diseases   09161 Cancer: overview    05203 Viral carcinogenesis     81 (ACTN4)   09171 Infectious disease: bacterial    05131 Shigellosis     81 (ACTN4)   09174 Infectious disease: parasitic    05146 Amoebiasis     81 (ACTN4)   09163 Immune disease    05322 Systemic lupus erythematosus     81 (ACTN4)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:hsa04131]     81 (ACTN4)   09183 Protein families: signaling and cellular processes    04812 Cytoskeleton proteins [BR:hsa04812]     81 (ACTN4)    04147 Exosome [BR:hsa04147]     81 (ACTN4) Membrane trafficking [BR:hsa04131]  Exocytosis   Small GTPases and associated proteins    Rab associated proteins     81 (ACTN4) Cytoskeleton proteins [BR:hsa04812]  Eukaryotic cytoskeleton proteins   Actin filaments / Microfilaments    Actin-binding proteins     Cross-linking proteins      81 (ACTN4) Exosome [BR:hsa04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    81 (ACTN4)   Exosomal proteins of colorectal cancer cells    81 (ACTN4)   Exosomal proteins of bladder cancer cells    81 (ACTN4) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Spectrin CH EFhand_Ca_insen EF-hand_1 EF-hand_6 EF-hand_7 EF-hand_8 XisI Motif Other DBs NCBI-GeneID:  81 NCBI-ProteinID:  NP_004915 OMIM:  604638 HGNC:  166 Ensembl:  ENSG00000130402 UniProt:  O43707 A0A0S2Z3G9 Structure PDB LinkDB All DBs Position 19:38647649..38731589 Genome browser AA seq 911 aa AA seqDB search MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWC NSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIA SKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPY KNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKM LDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEK LASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTL QTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQ KASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQEL NELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPF NNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAES NHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANV VGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIF DNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDKD HGGALGPEEFKACLISLGYDVENDRQGEAEFNRIMSLVDPNHSGLVTFQAFIDFMSRETT DTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAEYCIARMAPYQGPDAVPGALDYKS FSTALYGESDL NT seq 2736 nt NT seq  +upstreamnt  +downstreamnt atggtggactaccacgcggcgaaccagtcgtaccagtacggccccagcagcgcgggcaat ggcgctggcggcgggggcagcatgggcgactacatggcccaggaggacgactgggaccgg gacctgctgctggacccggcctgggagaagcagcagcgcaagaccttcacggcatggtgc aactcccacctgcggaaggcaggcacacagatcgagaacattgatgaggacttccgagac gggctcaagctcatgctgctcctggaggtcatatcaggggagcggttacctaagccggag cgggggaagatgagagtgcacaaaatcaacaatgtgaacaaagcgctggactttattgcc agcaaaggcgtcaagctggtctccatcggggcagaagagattgtggacggcaacgcaaag atgaccctgggaatgatctggaccatcatccttaggttcgccatccaggacatctccgtg gaagagacctcggccaaggaagggctccttctctggtgccagagaaagacagccccgtat aagaacgtcaatgtgcagaacttccacatcagctggaaggatggtcttgccttcaatgcc ctgatccaccggcacagaccagagctgattgagtatgacaagctgaggaaggacgaccct gtcaccaacctgaacaatgccttcgaagtggctgagaaatacctcgacatccccaagatg ctggatgcagaggacatcgtgaacacggcccggcccgacgagaaggccataatgacctat gtgtccagcttctaccatgccttttcaggagcgcagaaggctgaaactgccgccaaccgg atctgtaaggtgctggctgtcaaccaagagaacgagcacctgatggaggactacgagaag ctggccagcgacctcctggagtggatccggcgcaccatcccctggctggaggaccgtgtg ccccaaaagactatccaggagatgcagcagaagctggaggacttccgcgactaccggcgt gtgcacaagccgcccaaggtgcaggagaagtgccagctggagatcaacttcaacacgctg cagaccaagctgcgcctcagcaaccggcccgccttcatgccctccgagggcaagatggtc tcggacatcaacaatggctggcagcacttggagcaggctgagaagggctacgaggagtgg ctgctgaatgagatccgcaggctggagcggctcgaccacctggcagagaagttccggcag aaggcctccatccacgaggcctggactgacgggaaggaagccatgctgaagcaccgggac tacgagacggccacactatcggacatcaaagccctcattcgcaagcacgaggccttcgag agcgacctggctgcgcaccaggaccgcgtggagcagatcgccgccattgcccaggagctc aacgagctggattactacgactcccacaatgtcaacacccggtgccagaagatctgtgac cagtgggacgccctcggctctctgacacatagtcgcagggaagccctggagaaaacagag aagcagctggaggccatcgaccagctgcacctggaatacgccaagcgcgcggcccccttc aacaactggatggagagcgccatggaggacctccaggacatgttcatcgtccataccatc gaggagattgagggcctgatctcagcccatgaccagttcaagtccaccctgccggacgcc gatagggagcgcgaggccatcctggccatccacaaggaggcccagaggatcgctgagagc aaccacatcaagctgtcgggcagcaacccctacaccaccgtcaccccgcaaatcatcaac tccaagtgggagaaggtgcagcagctggtgccaaaacgggaccatgccctcctggaggag cagagcaagcagcagtccaacgagcacctgcgccgccagttcgccagccaggccaatgtt gtggggccctggatccagaccaagatggaggagatcgggcgcatctccattgagatgaac gggaccctggaggaccagctgagccacctgaagcagtatgaacgcagcatcgtggactac aagcccaacctggacctgctggagcagcagcaccagctcatccaggaggccctcatcttc gacaacaagcacaccaactataccatggagcacatccgcgtgggctgggagcagctgctc accaccattgcccgcaccatcaacgaggtggagaaccagatcctcacccgcgacgccaag ggcatcagccaggagcagatgcaggagttccgggcgtccttcaaccacttcgacaaggat catggcggggcgctggggcccgaggagttcaaggcctgcctcatcagcctgggctacgac gtggagaacgaccggcagggtgaggccgagttcaaccgcatcatgagcctggtcgacccc aaccatagcggccttgtgaccttccaagccttcatcgacttcatgtcgcgggagaccacc gacacggacacggctgaccaggtcatcgcttccttcaaggtcttagcaggggacaagaac ttcatcacagctgaggagctgcggagagagctgccccccgaccaggccgagtactgcatc gcccgcatggcgccataccagggccctgacgccgtgcccggtgccctcgactacaagtcc ttctccacggccttgtatggcgagagcgacctgtga

Homo sapiens (human): 7414 Help Entry 7414              CDS       T01001                                  Symbol VCL, CMD1W, CMH15, HEL114, MV, MVCL Name (RefSeq) vinculin   KO K05700   vinculin Organism hsa  Homo sapiens (human) Pathway hsa04510   Focal adhesion hsa04520   Adherens junction hsa04670   Leukocyte transendothelial migration hsa04810   Regulation of actin cytoskeleton hsa05100   Bacterial invasion of epithelial cells hsa05131   Shigellosis hsa05146   Amoebiasis Network nt06135  Cytoskeletal regulation (viruses and bacteria)   Element N01080   ITGA/B-TALIN/VINCULIN signaling pathway N01081   Shigella IpaB/C/D to ITGA/B-TALIN/VINCULIN signaling pathway N01082   Shigella IpaA to ITGA/B-TALIN/VINCULIN signaling pathway Disease H00292   Hypertrophic cardiomyopathy H00294   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:hsa00001]  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     7414 (VCL)    04520 Adherens junction     7414 (VCL)   09142 Cell motility    04810 Regulation of actin cytoskeleton     7414 (VCL)  09150 Organismal Systems   09151 Immune system    04670 Leukocyte transendothelial migration     7414 (VCL)  09160 Human Diseases   09171 Infectious disease: bacterial    05131 Shigellosis     7414 (VCL)    05100 Bacterial invasion of epithelial cells     7414 (VCL)   09174 Infectious disease: parasitic    05146 Amoebiasis     7414 (VCL)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04812 Cytoskeleton proteins [BR:hsa04812]     7414 (VCL)    04147 Exosome [BR:hsa04147]     7414 (VCL) Cytoskeleton proteins [BR:hsa04812]  Eukaryotic cytoskeleton proteins   Actin filaments / Microfilaments    Actin-binding proteins     Cross-linking proteins      7414 (VCL) Exosome [BR:hsa04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    7414 (VCL) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Vinculin VMAP-M0 Motif Other DBs NCBI-GeneID:  7414 NCBI-ProteinID:  NP_054706 OMIM:  193065 HGNC:  12665 Ensembl:  ENSG00000035403 UniProt:  P18206 V9HWK2 B3KXA2 Structure PDB LinkDB All DBs Position 10:73998116..74121363 Genome browser AA seq 1134 aa AA seqDB search MPVFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKE TVQTTEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTS DLLLTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQ ELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAE INEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAKGWLRDPSASPGDAGEQAIR QILDEAGKVGELCAGKERREILGTCKMLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGL DVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAE LCDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRA VANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQD LLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAMTQEVSDVFS DTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEG IQASVKTARELTPQVVSAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGLVDEAIDTK SLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILLVAKREVENSEDPKFR EAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPQEP DFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEVINQPMMM AARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPVPPDMEDDYEPELLLMPSNQ PVNQPILAAAQSLHREATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGTKRALIQCAK DIAKASDEVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNIS DEESEQATEMLVHNAQNLMQSVKETVREAEAASIKIRTDAGFTLRWVRKTPWYQ NT seq 3405 nt NT seq  +upstreamnt  +downstreamnt atgccagtgtttcatacgcgcacgatcgagagcatcctggagccggtggcacagcagatc tcccacctggtgataatgcacgaggagggcgaggtggacggcaaagccattcctgacctc accgcgcccgtggccgccgtgcaggcggccgtcagcaacctcgtccgggttggaaaagag actgttcaaaccactgaggatcagattttgaagagagatatgccaccagcatttattaag gttgagaatgcttgcaccaagcttgtccaggcagctcagatgcttcagtcagacccttac tcagtgcctgctcgagattatctaattgatgggtcaaggggcatcctctctggaacatca gacctgctccttaccttcgatgaggctgaggtccgtaaaattattagagtttgcaaagga attttggaatatcttacagtggcagaggtggtggagactatggaagatttggtcacttac acaaagaatcttgggccaggaatgactaagatggccaagatgattgacgagagacagcag gagctcactcaccaggagcaccgagtgatgttggtgaactcgatgaacaccgtgaaagag ttgctgccagttctcatttcagctatgaagatttttgtaacaactaaaaactcaaaaaac caaggcatagaggaagctttaaaaaatcgcaattttactgtagaaaaaatgagtgctgaa attaatgagataattcgtgtgttacaactcacctcttgggatgaagatgcctgggccagc aaggacactgaagccatgaagagagcattggcctccatagactccaaactgaaccaggcc aaaggttggctccgtgaccctagtgcctccccaggggatgctggtgagcaggccatcaga cagatcttagatgaagctggaaaagttggtgaactctgtgcaggcaaagaacgcagggag attctgggaacttgcaaaatgctagggcagatgactgatcaagtggctgacctccgtgcc agaggacaaggatcctcaccggtggccatgcagaaagctcagcaggtatctcagggtctg gatgtgctcacagcaaaagtggaaaatgcagctcgcaagctggaagccatgaccaactca aagcagagcattgcaaagaagatcgatgctgctcagaactggcttgcagatccaaatggt ggaccggaaggagaagagcagattcgaggtgctttggctgaagctcggaaaatagcagaa ttatgtgatgatcctaaagaaagagatgacattctacgttcccttggggaaatatctgct ctgacttctaaattagcagatctacgaagacaggggaaaggagattctccagaggctcga gccttggccaaacaggtggccacggccctgcagaacctgcagaccaaaaccaaccgggct gtggccaacagcagaccggccaaagcagctgtacaccttgagggcaagattgagcaagca cagcggtggattgataatcccacagtggatgaccgtggagtcggtcaggctgccatccgg gggcttgtggccgaagggcatcgtctggctaatgttatgatggggccttatcggcaagat cttctcgccaagtgtgaccgagtggaccagctgacagcccagctggctgacctggctgcc agaggggaaggggagagtcctcaggcacgagcacttgcatctcagctccaagactcctta aaggatctaaaagctcggatgcaggaggccatgactcaggaagtgtcagatgttttcagc gataccacaactcccatcaagctgttggcagtggcagccacggcgcctcctgatgcgcct aacagggaagaggtatttgatgagagggcagctaactttgaaaaccattcaggaaagctt ggtgctacggccgagaaggcggctgcggttggtactgctaataaatcaacagtggaaggc attcaggcctcagtgaagacggcccgagaactcacaccccaggtggtctcggctgctcgt atcttacttaggaaccctggaaatcaagctgcttatgaacattttgagaccatgaagaac cagtggatcgataatgttgaaaaaatgacagggctggtggacgaagccattgataccaaa tctctgttggatgcttcagaagaagcaattaaaaaagacctggacaagtgcaaggtagct atggccaacattcagcctcagatgctggttgctggggcaaccagtattgctcgtcgggcc aaccggatcctgctggtggctaagagggaggtggagaattccgaggatcccaagttccgt gaggctgtgaaagctgcctctgatgaattgagcaaaaccatctccccgatggtgatggat gcaaaagctgtggctggaaacatttccgaccctggactgcaaaagagcttcctggactca ggatatcggatcctgggagctgtggccaaggtcagagaagccttccaacctcaggagcct gacttcccgccgcctccaccagaccttgaacaactccgactaacagatgagcttgctcct cccaaaccacctctgcctgaaggtgaggtccctccacctaggcctccaccaccagaggaa aaggatgaagagttccctgagcagaaggccggggaggtgattaaccagccaatgatgatg gctgccagacagctccatgatgaagctcgcaaatggtccagcaagccgggcatcccagcc gctgaggtgggtataggtgttgtagctgaggcagatgcggccgatgctgctggcttccct gtcccccctgacatggaagacgattacgaacctgagctgctgttaatgccatccaatcag ccggtcaaccagcccattctggccgcggctcagtccttgcatcgggaagctaccaagtgg tctagtaagggcaatgacatcattgcagcagccaagcgcatggctctgctgatggctgag atgtctcggctggtaagagggggcagtggtaccaagcgggcactcattcagtgtgccaag gacatcgccaaggcctcagatgaggtgactcggttggccaaggaggttgccaagcagtgc acagataaacggattagaaccaacctcttacaggtatgtgagcgaatcccaaccataagc acccagctcaaaatcctgtccacagtgaaggccaccatgctgggccggaccaacatcagt gatgaggagtctgagcaggccacagagatgctggttcacaatgcccagaacctcatgcag tctgtgaaggagactgtgcgggaagctgaagctgcttcaatcaaaattcgaacagatgct ggatttacactgcgctgggttagaaagactccctggtaccagtag

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