Homo sapiens (human): 87
Help
Entry
87 CDS
T01001
Symbol
ACTN1, BDPLT15
Name
(RefSeq) alpha-actinin-1 isoform b
KO
K05699
actinin alpha 1/4
Organism
hsa
Homo sapiens (human)
Pathway
hsa04510
Focal adhesion
hsa04517
IgSF CAM signaling
hsa04518
Integrin signaling
hsa04519
Cadherin signaling
hsa04520
Adherens junction
hsa04530
Tight junction
hsa04670
Leukocyte transendothelial migration
hsa04810
Regulation of actin cytoskeleton
hsa05131
Shigellosis
hsa05146
Amoebiasis
hsa05203
Viral carcinogenesis
hsa05322
Systemic lupus erythematosus
Network
nt06182
Shigella
nt06546
IgSF CAM signaling
nt06548
Integrin signaling
Element
N01080
ITGA/B-TALIN/VINCULIN signaling pathway
N01082
Shigella IpaA to ITGA/B-TALIN/VINCULIN signaling pathway
N01921
Integrin alpha4beta1 signaling
N01962
ICAM1 interactions
N01965
ICAM2 interactions
N01966
ICAM3 interactions
N01973
Integrin alpha4beta7 signaling
N01974
Integrin alpha9beta1 signaling
N01975
Integrin alphaLbeta2 signaling
N01976
Integrin alphaMbeta2 signaling
N01977
Integrin alphaDbeta2 signaling
N01978
Integrin alphaEbeta2 signaling
N01979
Integrin alphaIIbbeta3 signaling
N01980
Integrin alpha5beta1 signaling
N01981
Integrin alpha8beta1 signaling
N01982
Integrin alphaVbeta1 signaling
N01983
Integrin alphaVbeta3 signaling
N01984
Integrin alphaVbeta5 signaling
N01985
Integrin alphaVbeta6 signaling
N01986
Integrin alphaVbeta8 signaling
N01987
Integrin alpha1beta1 signaling
N01988
Integrin alpha2beta1 signaling
N01989
Integrin alpha10beta1 signaling
N01990
Integrin alpha3beta1 signaling
N01991
Integrin alpha6beta1 signaling
N01992
Integrin alpha6beta4 signaling
N01996
Integrin alpha11beta1 signaling
N01997
Integrin alpha7beta1 signaling
N01998
Integrin alphaXbeta2 signaling
Disease
H01235
Bleeding disorder platelet-type
H01740
Macrothrombocytopenia
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09133 Signaling molecules and interaction
04517 IgSF CAM signaling
87 (ACTN1)
04518 Integrin signaling
87 (ACTN1)
04519 Cadherin signaling
87 (ACTN1)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
87 (ACTN1)
04520 Adherens junction
87 (ACTN1)
04530 Tight junction
87 (ACTN1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
87 (ACTN1)
09150 Organismal Systems
09151 Immune system
04670 Leukocyte transendothelial migration
87 (ACTN1)
09160 Human Diseases
09161 Cancer: overview
05203 Viral carcinogenesis
87 (ACTN1)
09171 Infectious disease: bacterial
05131 Shigellosis
87 (ACTN1)
09174 Infectious disease: parasitic
05146 Amoebiasis
87 (ACTN1)
09163 Immune disease
05322 Systemic lupus erythematosus
87 (ACTN1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
87 (ACTN1)
09183 Protein families: signaling and cellular processes
04812 Cytoskeleton proteins [BR:
hsa04812
]
87 (ACTN1)
04147 Exosome [BR:
hsa04147
]
87 (ACTN1)
Membrane trafficking [BR:
hsa04131
]
Exocytosis
Small GTPases and associated proteins
Rab associated proteins
87 (ACTN1)
Cytoskeleton proteins [BR:
hsa04812
]
Eukaryotic cytoskeleton proteins
Actin filaments / Microfilaments
Actin-binding proteins
Cross-linking proteins
87 (ACTN1)
Exosome [BR:
hsa04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
87 (ACTN1)
Exosomal proteins of colorectal cancer cells
87 (ACTN1)
Exosomal proteins of bladder cancer cells
87 (ACTN1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Spectrin
CH
EFhand_Ca_insen
EF-hand_1
EF-hand_6
EF-hand_7
EF-hand_8
EF-hand_5
XisI
Motif
Other DBs
NCBI-GeneID:
87
NCBI-ProteinID:
NP_001093
OMIM:
102575
HGNC:
163
UniProt:
P12814
A0A024R694
Structure
PDB
PDBj
LinkDB
All DBs
Position
14:complement(68874128..68979302)
Genome browser
AA seq
892 aa
AA seq
DB search
MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFR
DGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNV
KMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFC
ALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMT
YVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENR
VPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRM
VSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK
DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC
DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT
IEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEI
NGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEM
HGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQL
LTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGY
DIGNDPQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDK
NYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL
NT seq
2679 nt
NT seq
+upstream
nt +downstream
nt
atggaccattatgattctcagcaaaccaacgattacatgcagccagaagaggactgggac
cgggacctgctcctggacccggcctgggagaagcagcagagaaagacattcacggcatgg
tgtaactcccacctccggaaggcggggacacagatcgagaacatcgaagaggacttccgg
gatggcctgaagctcatgctgctgctggaggtcatctcaggtgaacgcttggccaagcca
gagcgaggcaagatgagagtgcacaagatctccaacgtcaacaaggccctggatttcata
gccagcaaaggcgtcaaactggtgtccatcggagccgaagaaatcgtggatgggaatgtg
aagatgaccctgggcatgatctggaccatcatcctgcgctttgccatccaggacatctcc
gtggaagagacttcagccaaggaagggctgctcctgtggtgtcagagaaagacagcccct
tacaaaaatgtcaacatccagaacttccacataagctggaaggatggcctcggcttctgt
gctttgatccaccgacaccggcccgagctgattgactacgggaagctgcggaaggatgat
ccactcacaaatctgaatacggcttttgacgtggcagagaagtacctggacatccccaag
atgctggatgccgaagacatcgttggaactgcccgaccggatgagaaagccatcatgact
tacgtgtctagcttctaccacgccttctctggagcccagaaggcggagacagcagccaat
cgcatctgcaaggtgttggccgtcaaccaggagaacgagcagcttatggaagactacgag
aagctggccagtgatctgttggagtggatccgccgcacaatcccgtggctggagaaccgg
gtgcccgagaacaccatgcatgccatgcaacagaagctggaggacttccgggactaccgg
cgcctgcacaagccgcccaaggtgcaggagaagtgccagctggagatcaacttcaacacg
ctgcagaccaagctgcggctcagcaaccggcctgccttcatgccctctgagggcaggatg
gtctcggacatcaacaatgcctggggctgcctggagcaggtggagaagggctatgaggag
tggttgctgaatgagatccggaggctggagcgactggaccacctggcagagaagttccgg
cagaaggcctccatccacgaggcctggactgacggcaaagaggccatgctgcgacagaag
gactatgagaccgccaccctctcggagatcaaggccctgctcaagaagcatgaggccttc
gagagtgacctggctgcccaccaggaccgtgtggagcagattgccgccatcgcacaggag
ctcaatgagctggactattatgactcacccagtgtcaacgcccgttgccaaaagatctgt
gaccagtgggacaatctgggggccctaactcagaagcgaagggaagctctggagcggacc
gagaaactgctggagaccattgaccagctgtacttggagtatgccaagcgggctgcaccc
ttcaacaactggatggagggggccatggaggacctgcaggacaccttcattgtgcacacc
attgaggagatccagggactgaccacagcccatgagcagttcaaggccaccctccctgat
gccgacaaggagcgcctggccatcctgggcatccacaatgaggtgtccaagattgtccag
acctaccacgtcaatatggcgggcaccaacccctacacaaccatcacgcctcaggagatc
aatggcaaatgggaccacgtgcggcagctggtgcctcggagggaccaagctctgacggag
gagcatgcccgacagcagcacaatgagaggctacgcaagcagtttggagcccaggccaat
gtcatcgggccctggatccagaccaagatggaggagatcgggaggatctccattgagatg
catgggaccctggaggaccagctcagccacctgcggcagtatgagaagagcatcgtcaac
tacaagccaaagattgatcagctggagggcgaccaccagctcatccaggaggcgctcatc
ttcgacaacaagcacaccaactacaccatggagcacatccgtgtgggctgggagcagctg
ctcaccaccatcgccaggaccatcaatgaggtagagaaccagatcctgacccgggatgcc
aagggcatcagccaggagcagatgaatgagttccgggcctccttcaaccactttgaccgg
gatcactccggcacactgggtcccgaggagttcaaagcctgcctcatcagcttgggttat
gatattggcaacgacccccagggagaagcagaatttgcccgcatcatgagcattgtggac
cccaaccgcctgggggtagtgacattccaggccttcattgacttcatgtcccgcgagaca
gccgacacagatacagcagaccaagtcatggcttccttcaagatcctggctggggacaag
aactacattaccatggacgagctgcgccgcgagctgccacccgaccaggctgagtactgc
atcgcgcggatggccccctacaccggccccgactccgtgccaggtgctctggactacatg
tccttctccacggcgctgtacggcgagagtgacctctaa
Homo sapiens (human): 81
Help
Entry
81 CDS
T01001
Symbol
ACTN4, ACTININ-4, FSGS, FSGS1
Name
(RefSeq) alpha-actinin-4 isoform 1
KO
K05699
actinin alpha 1/4
Organism
hsa
Homo sapiens (human)
Pathway
hsa04510
Focal adhesion
hsa04517
IgSF CAM signaling
hsa04518
Integrin signaling
hsa04519
Cadherin signaling
hsa04520
Adherens junction
hsa04530
Tight junction
hsa04670
Leukocyte transendothelial migration
hsa04810
Regulation of actin cytoskeleton
hsa05131
Shigellosis
hsa05146
Amoebiasis
hsa05203
Viral carcinogenesis
hsa05322
Systemic lupus erythematosus
Network
nt06182
Shigella
nt06546
IgSF CAM signaling
nt06548
Integrin signaling
Element
N01080
ITGA/B-TALIN/VINCULIN signaling pathway
N01082
Shigella IpaA to ITGA/B-TALIN/VINCULIN signaling pathway
N01921
Integrin alpha4beta1 signaling
N01962
ICAM1 interactions
N01965
ICAM2 interactions
N01966
ICAM3 interactions
N01973
Integrin alpha4beta7 signaling
N01974
Integrin alpha9beta1 signaling
N01975
Integrin alphaLbeta2 signaling
N01976
Integrin alphaMbeta2 signaling
N01977
Integrin alphaDbeta2 signaling
N01978
Integrin alphaEbeta2 signaling
N01979
Integrin alphaIIbbeta3 signaling
N01980
Integrin alpha5beta1 signaling
N01981
Integrin alpha8beta1 signaling
N01982
Integrin alphaVbeta1 signaling
N01983
Integrin alphaVbeta3 signaling
N01984
Integrin alphaVbeta5 signaling
N01985
Integrin alphaVbeta6 signaling
N01986
Integrin alphaVbeta8 signaling
N01987
Integrin alpha1beta1 signaling
N01988
Integrin alpha2beta1 signaling
N01989
Integrin alpha10beta1 signaling
N01990
Integrin alpha3beta1 signaling
N01991
Integrin alpha6beta1 signaling
N01992
Integrin alpha6beta4 signaling
N01996
Integrin alpha11beta1 signaling
N01997
Integrin alpha7beta1 signaling
N01998
Integrin alphaXbeta2 signaling
Disease
H00626
Focal segmental glomerulosclerosis
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09133 Signaling molecules and interaction
04517 IgSF CAM signaling
81 (ACTN4)
04518 Integrin signaling
81 (ACTN4)
04519 Cadherin signaling
81 (ACTN4)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
81 (ACTN4)
04520 Adherens junction
81 (ACTN4)
04530 Tight junction
81 (ACTN4)
09142 Cell motility
04810 Regulation of actin cytoskeleton
81 (ACTN4)
09150 Organismal Systems
09151 Immune system
04670 Leukocyte transendothelial migration
81 (ACTN4)
09160 Human Diseases
09161 Cancer: overview
05203 Viral carcinogenesis
81 (ACTN4)
09171 Infectious disease: bacterial
05131 Shigellosis
81 (ACTN4)
09174 Infectious disease: parasitic
05146 Amoebiasis
81 (ACTN4)
09163 Immune disease
05322 Systemic lupus erythematosus
81 (ACTN4)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
81 (ACTN4)
09183 Protein families: signaling and cellular processes
04812 Cytoskeleton proteins [BR:
hsa04812
]
81 (ACTN4)
04147 Exosome [BR:
hsa04147
]
81 (ACTN4)
Membrane trafficking [BR:
hsa04131
]
Exocytosis
Small GTPases and associated proteins
Rab associated proteins
81 (ACTN4)
Cytoskeleton proteins [BR:
hsa04812
]
Eukaryotic cytoskeleton proteins
Actin filaments / Microfilaments
Actin-binding proteins
Cross-linking proteins
81 (ACTN4)
Exosome [BR:
hsa04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
81 (ACTN4)
Exosomal proteins of colorectal cancer cells
81 (ACTN4)
Exosomal proteins of bladder cancer cells
81 (ACTN4)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Spectrin
CH
EFhand_Ca_insen
EF-hand_1
EF-hand_6
EF-hand_7
XisI
Motif
Other DBs
NCBI-GeneID:
81
NCBI-ProteinID:
NP_004915
OMIM:
604638
HGNC:
166
Ensembl:
ENSP00000252699.2
UniProt:
O43707
A0A0S2Z3G9
Structure
PDB
PDBj
LinkDB
All DBs
Position
19:38647649..38731589
Genome browser
AA seq
911 aa
AA seq
DB search
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWC
NSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIA
SKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPY
KNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKM
LDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEK
LASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTL
QTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQ
KASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQEL
NELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPF
NNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAES
NHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANV
VGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIF
DNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDKD
HGGALGPEEFKACLISLGYDVENDRQGEAEFNRIMSLVDPNHSGLVTFQAFIDFMSRETT
DTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAEYCIARMAPYQGPDAVPGALDYKS
FSTALYGESDL
NT seq
2736 nt
NT seq
+upstream
nt +downstream
nt
atggtggactaccacgcggcgaaccagtcgtaccagtacggccccagcagcgcgggcaat
ggcgctggcggcgggggcagcatgggcgactacatggcccaggaggacgactgggaccgg
gacctgctgctggacccggcctgggagaagcagcagcgcaagaccttcacggcatggtgc
aactcccacctgcggaaggcaggcacacagatcgagaacattgatgaggacttccgagac
gggctcaagctcatgctgctcctggaggtcatatcaggggagcggttacctaagccggag
cgggggaagatgagagtgcacaaaatcaacaatgtgaacaaagcgctggactttattgcc
agcaaaggcgtcaagctggtctccatcggggcagaagagattgtggacggcaacgcaaag
atgaccctgggaatgatctggaccatcatccttaggttcgccatccaggacatctccgtg
gaagagacctcggccaaggaagggctccttctctggtgccagagaaagacagccccgtat
aagaacgtcaatgtgcagaacttccacatcagctggaaggatggtcttgccttcaatgcc
ctgatccaccggcacagaccagagctgattgagtatgacaagctgaggaaggacgaccct
gtcaccaacctgaacaatgccttcgaagtggctgagaaatacctcgacatccccaagatg
ctggatgcagaggacatcgtgaacacggcccggcccgacgagaaggccataatgacctat
gtgtccagcttctaccatgccttttcaggagcgcagaaggctgaaactgccgccaaccgg
atctgtaaggtgctggctgtcaaccaagagaacgagcacctgatggaggactacgagaag
ctggccagcgacctcctggagtggatccggcgcaccatcccctggctggaggaccgtgtg
ccccaaaagactatccaggagatgcagcagaagctggaggacttccgcgactaccggcgt
gtgcacaagccgcccaaggtgcaggagaagtgccagctggagatcaacttcaacacgctg
cagaccaagctgcgcctcagcaaccggcccgccttcatgccctccgagggcaagatggtc
tcggacatcaacaatggctggcagcacttggagcaggctgagaagggctacgaggagtgg
ctgctgaatgagatccgcaggctggagcggctcgaccacctggcagagaagttccggcag
aaggcctccatccacgaggcctggactgacgggaaggaagccatgctgaagcaccgggac
tacgagacggccacactatcggacatcaaagccctcattcgcaagcacgaggccttcgag
agcgacctggctgcgcaccaggaccgcgtggagcagatcgccgccattgcccaggagctc
aacgagctggattactacgactcccacaatgtcaacacccggtgccagaagatctgtgac
cagtgggacgccctcggctctctgacacatagtcgcagggaagccctggagaaaacagag
aagcagctggaggccatcgaccagctgcacctggaatacgccaagcgcgcggcccccttc
aacaactggatggagagcgccatggaggacctccaggacatgttcatcgtccataccatc
gaggagattgagggcctgatctcagcccatgaccagttcaagtccaccctgccggacgcc
gatagggagcgcgaggccatcctggccatccacaaggaggcccagaggatcgctgagagc
aaccacatcaagctgtcgggcagcaacccctacaccaccgtcaccccgcaaatcatcaac
tccaagtgggagaaggtgcagcagctggtgccaaaacgggaccatgccctcctggaggag
cagagcaagcagcagtccaacgagcacctgcgccgccagttcgccagccaggccaatgtt
gtggggccctggatccagaccaagatggaggagatcgggcgcatctccattgagatgaac
gggaccctggaggaccagctgagccacctgaagcagtatgaacgcagcatcgtggactac
aagcccaacctggacctgctggagcagcagcaccagctcatccaggaggccctcatcttc
gacaacaagcacaccaactataccatggagcacatccgcgtgggctgggagcagctgctc
accaccattgcccgcaccatcaacgaggtggagaaccagatcctcacccgcgacgccaag
ggcatcagccaggagcagatgcaggagttccgggcgtccttcaaccacttcgacaaggat
catggcggggcgctggggcccgaggagttcaaggcctgcctcatcagcctgggctacgac
gtggagaacgaccggcagggtgaggccgagttcaaccgcatcatgagcctggtcgacccc
aaccatagcggccttgtgaccttccaagccttcatcgacttcatgtcgcgggagaccacc
gacacggacacggctgaccaggtcatcgcttccttcaaggtcttagcaggggacaagaac
ttcatcacagctgaggagctgcggagagagctgccccccgaccaggccgagtactgcatc
gcccgcatggcgccataccagggccctgacgccgtgcccggtgccctcgactacaagtcc
ttctccacggccttgtatggcgagagcgacctgtga
Homo sapiens (human): 7414
Help
Entry
7414 CDS
T01001
Symbol
VCL, CMD1W, CMH15, HEL114, MV, MVCL, VINC
Name
(RefSeq) vinculin isoform meta-VCL
KO
K05700
vinculin
Organism
hsa
Homo sapiens (human)
Pathway
hsa04510
Focal adhesion
hsa04517
IgSF CAM signaling
hsa04518
Integrin signaling
hsa04519
Cadherin signaling
hsa04520
Adherens junction
hsa04670
Leukocyte transendothelial migration
hsa04810
Regulation of actin cytoskeleton
hsa04820
Cytoskeleton in muscle cells
hsa05100
Bacterial invasion of epithelial cells
hsa05131
Shigellosis
hsa05146
Amoebiasis
Network
nt06182
Shigella
nt06539
Cytoskeleton in muscle cells
nt06548
Integrin signaling
Element
N01080
ITGA/B-TALIN/VINCULIN signaling pathway
N01081
Shigella IpaB/C/D to ITGA/B-TALIN/VINCULIN signaling pathway
N01082
Shigella IpaA to ITGA/B-TALIN/VINCULIN signaling pathway
N01815
Vinculin-talin-integrin macromolecular complex
N01921
Integrin alpha4beta1 signaling
N01973
Integrin alpha4beta7 signaling
N01974
Integrin alpha9beta1 signaling
N01975
Integrin alphaLbeta2 signaling
N01976
Integrin alphaMbeta2 signaling
N01977
Integrin alphaDbeta2 signaling
N01978
Integrin alphaEbeta2 signaling
N01979
Integrin alphaIIbbeta3 signaling
N01980
Integrin alpha5beta1 signaling
N01981
Integrin alpha8beta1 signaling
N01982
Integrin alphaVbeta1 signaling
N01983
Integrin alphaVbeta3 signaling
N01984
Integrin alphaVbeta5 signaling
N01985
Integrin alphaVbeta6 signaling
N01986
Integrin alphaVbeta8 signaling
N01987
Integrin alpha1beta1 signaling
N01988
Integrin alpha2beta1 signaling
N01989
Integrin alpha10beta1 signaling
N01990
Integrin alpha3beta1 signaling
N01991
Integrin alpha6beta1 signaling
N01992
Integrin alpha6beta4 signaling
N01996
Integrin alpha11beta1 signaling
N01997
Integrin alpha7beta1 signaling
N01998
Integrin alphaXbeta2 signaling
Disease
H00292
Hypertrophic cardiomyopathy
H00294
Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09133 Signaling molecules and interaction
04517 IgSF CAM signaling
7414 (VCL)
04518 Integrin signaling
7414 (VCL)
04519 Cadherin signaling
7414 (VCL)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
7414 (VCL)
04520 Adherens junction
7414 (VCL)
09142 Cell motility
04820 Cytoskeleton in muscle cells
7414 (VCL)
04810 Regulation of actin cytoskeleton
7414 (VCL)
09150 Organismal Systems
09151 Immune system
04670 Leukocyte transendothelial migration
7414 (VCL)
09160 Human Diseases
09171 Infectious disease: bacterial
05131 Shigellosis
7414 (VCL)
05100 Bacterial invasion of epithelial cells
7414 (VCL)
09174 Infectious disease: parasitic
05146 Amoebiasis
7414 (VCL)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04812 Cytoskeleton proteins [BR:
hsa04812
]
7414 (VCL)
04147 Exosome [BR:
hsa04147
]
7414 (VCL)
Cytoskeleton proteins [BR:
hsa04812
]
Eukaryotic cytoskeleton proteins
Actin filaments / Microfilaments
Actin-binding proteins
Cross-linking proteins
7414 (VCL)
Exosome [BR:
hsa04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
7414 (VCL)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Vinculin
Talin_IBS2B
VMAP-M0
WHD_2nd_SelB_bact
Motif
Other DBs
NCBI-GeneID:
7414
NCBI-ProteinID:
NP_054706
OMIM:
193065
HGNC:
12665
Ensembl:
ENSP00000211998.5
UniProt:
P18206
V9HWK2
B3KXA2
Structure
PDB
PDBj
LinkDB
All DBs
Position
10:73998116..74121363
Genome browser
AA seq
1134 aa
AA seq
DB search
MPVFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKE
TVQTTEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTS
DLLLTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQ
ELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAE
INEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAKGWLRDPSASPGDAGEQAIR
QILDEAGKVGELCAGKERREILGTCKMLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGL
DVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAE
LCDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRA
VANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQD
LLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAMTQEVSDVFS
DTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEG
IQASVKTARELTPQVVSAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGLVDEAIDTK
SLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILLVAKREVENSEDPKFR
EAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPQEP
DFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEVINQPMMM
AARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPVPPDMEDDYEPELLLMPSNQ
PVNQPILAAAQSLHREATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGTKRALIQCAK
DIAKASDEVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNIS
DEESEQATEMLVHNAQNLMQSVKETVREAEAASIKIRTDAGFTLRWVRKTPWYQ
NT seq
3405 nt
NT seq
+upstream
nt +downstream
nt
atgccagtgtttcatacgcgcacgatcgagagcatcctggagccggtggcacagcagatc
tcccacctggtgataatgcacgaggagggcgaggtggacggcaaagccattcctgacctc
accgcgcccgtggccgccgtgcaggcggccgtcagcaacctcgtccgggttggaaaagag
actgttcaaaccactgaggatcagattttgaagagagatatgccaccagcatttattaag
gttgagaatgcttgcaccaagcttgtccaggcagctcagatgcttcagtcagacccttac
tcagtgcctgctcgagattatctaattgatgggtcaaggggcatcctctctggaacatca
gacctgctccttaccttcgatgaggctgaggtccgtaaaattattagagtttgcaaagga
attttggaatatcttacagtggcagaggtggtggagactatggaagatttggtcacttac
acaaagaatcttgggccaggaatgactaagatggccaagatgattgacgagagacagcag
gagctcactcaccaggagcaccgagtgatgttggtgaactcgatgaacaccgtgaaagag
ttgctgccagttctcatttcagctatgaagatttttgtaacaactaaaaactcaaaaaac
caaggcatagaggaagctttaaaaaatcgcaattttactgtagaaaaaatgagtgctgaa
attaatgagataattcgtgtgttacaactcacctcttgggatgaagatgcctgggccagc
aaggacactgaagccatgaagagagcattggcctccatagactccaaactgaaccaggcc
aaaggttggctccgtgaccctagtgcctccccaggggatgctggtgagcaggccatcaga
cagatcttagatgaagctggaaaagttggtgaactctgtgcaggcaaagaacgcagggag
attctgggaacttgcaaaatgctagggcagatgactgatcaagtggctgacctccgtgcc
agaggacaaggatcctcaccggtggccatgcagaaagctcagcaggtatctcagggtctg
gatgtgctcacagcaaaagtggaaaatgcagctcgcaagctggaagccatgaccaactca
aagcagagcattgcaaagaagatcgatgctgctcagaactggcttgcagatccaaatggt
ggaccggaaggagaagagcagattcgaggtgctttggctgaagctcggaaaatagcagaa
ttatgtgatgatcctaaagaaagagatgacattctacgttcccttggggaaatatctgct
ctgacttctaaattagcagatctacgaagacaggggaaaggagattctccagaggctcga
gccttggccaaacaggtggccacggccctgcagaacctgcagaccaaaaccaaccgggct
gtggccaacagcagaccggccaaagcagctgtacaccttgagggcaagattgagcaagca
cagcggtggattgataatcccacagtggatgaccgtggagtcggtcaggctgccatccgg
gggcttgtggccgaagggcatcgtctggctaatgttatgatggggccttatcggcaagat
cttctcgccaagtgtgaccgagtggaccagctgacagcccagctggctgacctggctgcc
agaggggaaggggagagtcctcaggcacgagcacttgcatctcagctccaagactcctta
aaggatctaaaagctcggatgcaggaggccatgactcaggaagtgtcagatgttttcagc
gataccacaactcccatcaagctgttggcagtggcagccacggcgcctcctgatgcgcct
aacagggaagaggtatttgatgagagggcagctaactttgaaaaccattcaggaaagctt
ggtgctacggccgagaaggcggctgcggttggtactgctaataaatcaacagtggaaggc
attcaggcctcagtgaagacggcccgagaactcacaccccaggtggtctcggctgctcgt
atcttacttaggaaccctggaaatcaagctgcttatgaacattttgagaccatgaagaac
cagtggatcgataatgttgaaaaaatgacagggctggtggacgaagccattgataccaaa
tctctgttggatgcttcagaagaagcaattaaaaaagacctggacaagtgcaaggtagct
atggccaacattcagcctcagatgctggttgctggggcaaccagtattgctcgtcgggcc
aaccggatcctgctggtggctaagagggaggtggagaattccgaggatcccaagttccgt
gaggctgtgaaagctgcctctgatgaattgagcaaaaccatctccccgatggtgatggat
gcaaaagctgtggctggaaacatttccgaccctggactgcaaaagagcttcctggactca
ggatatcggatcctgggagctgtggccaaggtcagagaagccttccaacctcaggagcct
gacttcccgccgcctccaccagaccttgaacaactccgactaacagatgagcttgctcct
cccaaaccacctctgcctgaaggtgaggtccctccacctaggcctccaccaccagaggaa
aaggatgaagagttccctgagcagaaggccggggaggtgattaaccagccaatgatgatg
gctgccagacagctccatgatgaagctcgcaaatggtccagcaagccgggcatcccagcc
gctgaggtgggtataggtgttgtagctgaggcagatgcggccgatgctgctggcttccct
gtcccccctgacatggaagacgattacgaacctgagctgctgttaatgccatccaatcag
ccggtcaaccagcccattctggccgcggctcagtccttgcatcgggaagctaccaagtgg
tctagtaagggcaatgacatcattgcagcagccaagcgcatggctctgctgatggctgag
atgtctcggctggtaagagggggcagtggtaccaagcgggcactcattcagtgtgccaag
gacatcgccaaggcctcagatgaggtgactcggttggccaaggaggttgccaagcagtgc
acagataaacggattagaaccaacctcttacaggtatgtgagcgaatcccaaccataagc
acccagctcaaaatcctgtccacagtgaaggccaccatgctgggccggaccaacatcagt
gatgaggagtctgagcaggccacagagatgctggttcacaatgcccagaacctcatgcag
tctgtgaaggagactgtgcgggaagctgaagctgcttcaatcaaaattcgaacagatgct
ggatttacactgcgctgggttagaaagactccctggtaccagtag
DBGET
integrated database retrieval system
