KEGG ORTHOLOGY: K10387

ORTHOLOGY: K10387

Entry

K10387                      KO

Symbol

PKP1

Name

plakophilin 1

Disease

H00644

Ectodermal dysplasia/skin fragility syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins
    K10387  PKP1; plakophilin 1
Cytoskeleton proteins [BR:ko04812]
Eukaryotic cytoskeleton proteins
  Intermediate filaments
   Intermediate filament-binding proteins
    K10387  PKP1; plakophilin 1

Genes

HSA:	5317(PKP1)

PTR:	457616(PKP1)

PPS:	100981577(PKP1)

GGO:	101151013(PKP1)

PON:	100461789(PKP1)

NLE:	100583273(PKP1)

HMH:	116457669(PKP1)

MCC:	708177(PKP1)

MCF:	102133972(PKP1)

MTHB:

126939541

MNI:	105484710(PKP1)

CSAB:

103230335(PKP1)

CATY:

105575242(PKP1)

PANU:

101022968(PKP1)

TGE:	112608533(PKP1)

MLEU:

105547123(PKP1)

RRO:	104661874(PKP1)

RBB:	108545105(PKP1)

TFN:	117074930(PKP1)

PTEH:

111522799(PKP1)

CANG:

105504322(PKP1)

CJC:	100395425(PKP1)

SBQ:	101043907(PKP1)

CIMI:

108283209(PKP1)

CSYR:

103269545(PKP1)

MMUR:

105859995(PKP1)

LCAT:

123626931(PKP1)

PCOQ:

105826947(PKP1)

OGA:	100940946(PKP1)

MMU:	18772(Pkp1)

MCAL:

110298727(Pkp1)

MPAH:

110322108(Pkp1)

RNO:	304822(Pkp1)

MCOC:

116099827(Pkp1)

ANU:	117716349(Pkp1)

MUN:	110548427(Pkp1)

CGE:	100764930(Pkp1)

MAUA:

101834982(Pkp1)

PROB:

127221300(Pkp1)

PLEU:

114698051(Pkp1)

MORG:

121446472(Pkp1)

MFOT:

126505050

AAMP:

119828014(Pkp1)

NGI:	103731817(Pkp1)

HGL:	101724616(Pkp1)

CPOC:

100733998(Pkp1)

CCAN:

109702739(Pkp1)

DORD:

105986479(Pkp1)

DSP:	122126764(Pkp1)

PLOP:

125359335(Pkp1)

NCAR:

124962084

MMMA:

107140656(Pkp1)

OCU:

100338080

OPI:	101528528(PKP1)

TUP:	102482852(PKP1)

GVR:

103581653

CFA:	607140(PKP1)

CLUD:

112667084(PKP1)

VVP:	112934573(PKP1)

VLG:	121497496(PKP1)

NPO:	129505746(PKP1)

AML:	100468306(PKP1)

UMR:	103657771(PKP1)

UAH:	113242559(PKP1)

UAR:	123785857(PKP1)

ELK:

111151134

LLV:

125086349

MPUF:

101673488(PKP1)

MNP:	132025592(PKP1)

MLK:	131814890(PKP1)

NVS:	122918776(PKP1)

ORO:	101386534(PKP1)

EJU:	114222015(PKP1)

ZCA:	113932797(PKP1)

MLX:	118014218(PKP1)

NSU:	110574088(PKP1)

LWW:

102746422

FCA:	101099353(PKP1)

PYU:	121021717(PKP1)

PCOO:

112857801(PKP1)

PBG:	122476566(PKP1)

PVIV:

125154933(PKP1)

LRUF:

124509830

PTG:	102950388(PKP1)

PPAD:

109250449(PKP1)

PUC:

125925384

AJU:

106974262

HHV:	120228944(PKP1)

BTA:	281405(PKP1)

BOM:	102275392(PKP1)

BBUB:

102398477(PKP1)

BBIS:

104981873(PKP1)

CHX:	102176987(PKP1)

OAS:	101109291(PKP1)

BTAX:

128061713(PKP1)

ODA:	120880095(PKP1)

CCAD:

122452365(PKP1)

MBEZ:

129551188(PKP1)

SSC:	100623590(PKP1)

CFR:	102522981(PKP1)

CBAI:

105070029(PKP1)

CDK:	105103101(PKP1)

VPC:	102535360(PKP1)

BACU:

103013484(PKP1)

BMUS:

118888870(PKP1)

LVE:	103091291(PKP1)

OOR:	101271909(PKP1)

DLE:	111168327(PKP1)

PCAD:

102987680(PKP1)

PSIU:

116740681(PKP1)

NASI:

112402634(PKP1)

ECB:	100051894(PKP1)

EPZ:	103540442(PKP1)

EAI:	106832341(PKP1)

MYB:	102243834(PKP1)

MYD:	102759353(PKP1)

MMYO:

118678709(PKP1)

EFUS:

103302956(PKP1)

MNA:	107535994(PKP1)

DRO:	112318893(PKP1)

SHON:

119003938(PKP1)

AJM:	119060829(PKP1)

PDIC:

114512357(PKP1)

PHAS:

123804323(PKP1)

MMF:	118640611(PKP1)

PPAM:

129072861(PKP1)

HAI:	109380415(PKP1)

RFQ:	117018684(PKP1)

PALE:

102891177(PKP1)

PGIG:

120619267(PKP1)

PVP:	105296901(PKP1)

RAY:	107513649(PKP1)

MJV:	108405423(PKP1)

TOD:	119233619(PKP1)

SARA:

101554668(PKP1)

SETR:

126004180(PKP1)

LAV:	100670518(PKP1)

TMU:

101345879

ETF:	101659900(PKP1)

DNM:	101437993(PKP1)

MDO:	100013844(PKP1)

GAS:	123245602(PKP1)

SHR:	100926410(PKP1)

AFZ:

127562739

PCW:	110219656(PKP1)

OAA:	100077476(PKP1)

GGA:	421158(PKP1)

PCOC:

116238758(PKP1)

MGP:	100549903(PKP1)

CJO:	107324648(PKP1)

TPAI:

128090301(PKP1)

LMUT:

125684279(PKP1)

NMEL:

110388307(PKP1)

APLA:

101798848(PKP1)

ACYG:

106045889(PKP1)

CATA:

118255339(PKP1)

AFUL:

116498881(PKP1)

TGU:	100223063(PKP1)

LSR:	110469205(PKP1)

SCAN:

103822365(PKP1)

PMOA:

120497285(PKP1)

OTC:	121345621(PKP1)

PRUF:

121365390(PKP1)

GFR:	102035240(PKP1)

FAB:	101815884(PKP1)

OMA:	130263783(PKP1)

PHI:	102103216(PKP1)

PMAJ:

107214718(PKP1)

CCAE:

111939615(PKP1)

CCW:	104692461(PKP1)

CBRC:

103616506(PKP1)

ETL:	114064783(PKP1)

ZAB:	102065422(PKP1)

ACHL:

103805084(PKP1)

SVG:	106851117(PKP1)

MMEA:

130578365(PKP1)

HRT:	120762853(PKP1)

FPG:	101916602(PKP1)

FCH:	102060169(PKP1)

CLV:	102085216(PKP1)

EGZ:	104121998(PKP1)

NNI:	104011083(PKP1)

PCRI:

104027739(PKP1)

PLET:

104626817(PKP1)

EHS:	104510352(PKP1)

PCAO:

104046449(PKP1)

ACUN:

113489013(PKP1)

TALA:

104366026(PKP1)

PADL:

103913805(PKP1)

AFOR:

103901059(PKP1)

ACHC:

115335442(PKP1)

HALD:

104320297(PKP1)

HLE:	104842300(PKP1)

AGEN:

126052155

GCL:

127026303

CCRI:

104163793(PKP1)

CSTI:

104555585(PKP1)

CMAC:

104478311(PKP1)

MUI:	104544518(PKP1)

BREG:

104640592(PKP1)

FGA:	104080085(PKP1)

GSTE:

104255233(PKP1)

LDI:	104346201(PKP1)

MNB:	103781346(PKP1)

OHA:	104337053(PKP1)

NNT:	104409712(PKP1)

SHAB:

115602433(PKP1)

DPUB:

104297608(PKP1)

PGUU:

104468631(PKP1)

ACAR:

104521440(PKP1)

CPEA:

104385668(PKP1)

AVIT:

104271840(PKP1)

CVF:	104283163(PKP1)

RTD:	128900376(PKP1)

CUCA:

104058995(PKP1)

TEO:	104377065(PKP1)

BRHI:

104502104(PKP1)

AAM:	106485639(PKP1)

AROW:

112965093(PKP1)

NPD:	112959231(PKP1)

TGT:

104578608

DNE:	112983882(PKP1)

SCAM:

104139255(PKP1)

ASN:	102374956(PKP1)

AMJ:	102567363(PKP1)

CPOO:

109317578(PKP1)

GGN:	109295140(PKP1)

PSS:	102457252(PKP1)

CMY:	102942653(PKP1)

CCAY:

125624985(PKP1)

DCC:	119846473(PKP1)

CPIC:

101931529(PKP1)

TST:	117875947(PKP1)

CABI:

116831710(PKP1)

MRV:	120404732(PKP1)

ACS:	100564914(pkp1)

ASAO:

132773327(PKP1)

PVT:	110073323(PKP1)

SUND:

121929475(PKP1)

PBI:	103049943(PKP1)

PMUR:

107287794(PKP1)

CTIG:

120301770(PKP1)

TSR:	106539196(PKP1)

PGUT:

117663774(PKP1)

APRI:

131195427(PKP1)

PTEX:

113444283(PKP1)

NSS:	113420764(PKP1)

VKO:	123022980(PKP1)

PMUA:

114599412(PKP1)

PRAF:

128416228(PKP1)

ZVI:	118088481(PKP1)

HCG:	128324049(PKP1)

STOW:

125432379(PKP1)

EMC:	129330570(PKP1)

XLA:	108708149(pkp1.L) 108709438(pkp1.S)

XTR:	100496099(pkp1)

NPR:	108804913(PKP1)

RTEM:

120927211(PKP1)

BBUF:

120995134(PKP1)

BGAR:

122922734

MUO:	115481486(PKP1)

GSH:	117347718(PKP1)

DRE:	100000637(pkp1) 797838(pkp1b)

SRX:	107707382 107724517 107740273 107744366

SANH:

107666061 107673044 107696446 107697023

SGH:	107559177 107587587 107598134

CCAR:

109076538

CAUA:

113041029 113050148 113070259 113104475

CGIB:

127944204 127960006 128011978 128016013

PTET:

122328889 122347067(pkp1b)

LROH:

127155133 127167274(pkp1b)

OMC:	131531924 131542173(pkp1b)

PPRM:

120464381(pkp1b) 120465345 120491883

RKG:	130072925 130104078(pkp1b)

MAMB:

125260257 125273331(pkp1b)

CIDE:

127505261 127514727

MASI:

127419280 127419719 127445648 127448956

TROS:

130556303(pkp1b)

TDW:	130409025 130425252(pkp1b)

MANU:

129430740 129450802(pkp1b)

IPU:	108271871(pkp1b)

IFU:	128614630(pkp1b)

PHYP:

113526552(pkp1)

SMEO:

124389779(pkp1b)

TFD:	113643109(pkp1b)

TVC:	132844629(pkp1b)

AMEX:

103042330(pkp1)

CMAO:

118808526(pkp1b)

EEE:	113571572(pkp1)

CHAR:

105907439(pkp1b) 122131753

TRU:	101079355(pkp1)

TFS:

130530588

TNG:	GSTEN00028001G001

LCO:	104918385 104931935

NCC:	104941337 104941555(pkp1)

TBEN:

117489692(pkp1b) 117494061

CGOB:

115008398 115010763(pkp1)

PGEO:

117446273(pkp1b) 117450069

GACU:

117539584(pkp1b) 117541886

EMAC:

134867231 134882757(pkp1b)

ELY:	117256417 117258184

EFO:	125892383 125897774

PLEP:

121947361 121948953(pkp1b)

SLUC:

116051574(pkp1b) 116058539

ECRA:

117943664(pkp1b) 117947628

ESP:	116687880 116692431(pkp1)

PFLV:

114554328 114558339(pkp1)

GAT:	120829668 120834737(pkp1b)

PPUG:

119223136 119230222(pkp1b)

AFB:	129099293 129106298(pkp1b)

CLUM:

117730393(pkp1b) 117733434

PSWI:

130199357 130208021(pkp1b)

MSAM:

119886120 119886915 119905441

SCHU:

122882406 122884111(pkp1b)

CUD:	121507488 121518075

ALAT:

119021507(pkp1b) 119022409

MZE:	101481283(pkp1) 101488007

ONL:	100690564 100698251

OAU:	116317770(pkp1b) 116330791

OLA:	101155929(pkp1) 101168700

OML:	112145652(pkp1b) 112159183

CSAI:

133448383(pkp1b) 133457142

XMA:	102229335 111608442

XCO:	114135509 114150575

XHE:	116710566 116721842

PRET:

103464707 103467414(pkp1)

PFOR:

103134601 103149624(pkp1)

PLAI:

106946645(pkp1) 106954214

PMEI:

106921005 106925324(pkp1)

GAF:	122827972 122833479(pkp1b)

PPRL:

129372334 129372740(pkp1b)

CVG:	107089164 107101211 107104024

CTUL:

119778993(pkp1b) 119784995

GMU:	124857239 124865539

NFU:	107385037 107390950(pkp1)

KMR:	108231698 108235285

ALIM:

106518295 106524219(pkp1)

NWH:	119412810 119416930

AOCE:

111564134 111573868

MCEP:

125007130(pkp1b) 125011642

CSEM:

103384554(pkp1) 103386542

POV:	109635264(pkp1) 109635340

SSEN:

122768765(pkp1b) 122777349

HHIP:

117760990 117764003

HSP:	118105372 118111389

SMAU:

118310123(pkp1b) 118316690

LCF:	108873598(pkp1b) 108877916

SDU:	111218929(pkp1) 111219408

SLAL:

111662340 111668991(pkp1)

XGL:	120803494 120806913(pkp1b)

HCQ:	109507904 109528387(pkp1)

SSCV:

125977630 125989139

SBIA:

133496820 133507695

PEE:	133409029(pkp1b) 133412983

PTAO:

133483562 133486158

BPEC:

110164875(pkp1) 110174392

MALB:

109969456(pkp1) 109971821

BSPL:

114856208 114858542

SJO:	128355320(pkp1b) 128357864

SASA:

106566027 106582715

STRU:

115151014 115207411

OTW:	112221386 112254194

OMY:	110494716 110527744(pkp1b)

OGO:	124003929 124031604

ONE:	115123960 115135790

OKI:	109890835 109899190

OKE:	118388237 118399955

SALP:

111969729 111970468 111970554

SNH:	120020313 120065579(pkp1b)

CCLU:

121575831 121578711

ELS:	105007718 105027250

SFM:	108938168 108939380

PKI:	111853092 111855236

AANG:

118208583 118211674

LOC:	102695715(pkp1)

PSPA:

121299819 121304706

ARUT:

117398272 117966046

LCM:	102361088(PKP1)

CMK:

RTP:

CPLA:

HOC:

LERI:

Reference

PMID:9326952

Authors

McGrath JA, McMillan JR, Shemanko CS, Runswick SK, Leigh IM, Lane EB, Garrod DR, Eady RA

Title

Mutations in the plakophilin 1 gene result in ectodermal dysplasia/skin fragility syndrome.

Journal

Nat Genet 17:240-4 (1997)
DOI:10.1038/ng1097-240

Sequence

[hsa:5317]

LinkDB

DBGET integrated database retrieval system