KEGG   PATHWAY: ko04612
Entry
ko04612                     Pathway                                
Name
Antigen processing and presentation
Class
Organismal Systems; Immune system
Pathway map
ko04612  Antigen processing and presentation
ko04612

Other DBs
GO: 0019885 0019886 0042591
Orthology
K01363  CTSB; cathepsin B [EC:3.4.22.1]
K01365  CTSL; cathepsin L [EC:3.4.22.15]
K01368  CTSS; cathepsin S [EC:3.4.22.27]
K01369  LGMN; legumain [EC:3.4.22.34]
K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
K03283  HSPA1_6_8; heat shock 70kDa protein 1/6/8
K04079  HSP90A, htpG; molecular chaperone HtpG
K04687  IFNG; interferon gamma
K05653  ABCB2, TAP1; ATP-binding cassette, subfamily B (MDR/TAP), member 2 [EC:7.4.2.14]
K05654  ABCB3, TAP2; ATP-binding cassette, subfamily B (MDR/TAP), member 3 [EC:7.4.2.14]
K05870  CREB1; cyclic AMP-responsive element-binding protein 1
K06454  CD4; T-cell surface glycoprotein CD4
K06458  CD8A; T-cell surface glycoprotein CD8 alpha chain
K06459  CD8B; T-cell surface glycoprotein CD8 beta chain
K06505  CD74, DHLAG; CD74 antigen
K06516  KLRD1, CD94; killer cell lectin-like receptor subfamily D member 1
K06541  KLRC1, NKG2A; killer cell lectin-like receptor subfamily C1
K06696  PSME1; proteasome activator subunit 1 (PA28 alpha)
K06697  PSME2; proteasome activator subunit 2 (PA28 beta)
K06698  PSME3; proteasome activator subunit 3 (PA28 gamma)
K06751  MHC1; MHC class I antigen
K06752  MHC2; MHC class II antigen
K07980  KIR3DL, CD158; killer cell immunoglobulin-like receptor 3DL
K07981  KIR2DL1_2_3, CD158A_B; killer cell immunoglobulin-like receptor 2DL1/2/3
K07982  KIR2DS, CD158; killer cell immunoglobulin-like receptor 2DS
K08054  CANX; calnexin
K08055  B2M; beta-2-microglobulin
K08056  PDIA3, GRP58; protein disulfide-isomerase A3 [EC:5.3.4.1]
K08057  CALR; calreticulin
K08058  TAPBP; TAP binding protein (tapasin)
K08059  IFI30, GILT; interferon, gamma-inducible protein 30
K08060  CIITA; MHC class II transactivator [EC:2.7.11.1]
K08061  RFX5; regulatory factor X 5
K08062  RFXANK; regulatory factor X-associated ankyrin-containing protein
K08063  RFXAP; regulatory factor X-associated protein
K08064  NFYA, HAP2; nuclear transcription factor Y, alpha
K08065  NFYB, HAP3; nuclear transcription Y subunit beta
K08066  NFYC, HAP5; nuclear transcription factor Y, gamma
K09489  HSPA4; heat shock 70kDa protein 4
K09490  HSPA5, BIP; endoplasmic reticulum chaperone BiP [EC:3.6.4.10]
K10784  TRAV; T cell receptor alpha chain V region
K10785  TRBV; T-cell receptor beta chain V region
K24231  KIR2DL4, CD158D; killer cell immunoglobulin-like receptor 2DL4
K24232  KIR2DL5, CD158F; killer cell immunoglobulin-like receptor 2DL5
K24233  KLRC2_3, NKG2C_E; killer cell lectin-like receptor subfamily C2/3
K24234  KLRC4, NKG2F; killer cell lectin-like receptor subfamily C4
K26598  HSPA2; heat shock 70kDa protein 2
Reference
PMID:15771591
  Authors
Trombetta ES, Mellman I.
  Title
Cell biology of antigen processing in vitro and in vivo.
  Journal
Annu Rev Immunol 23:975-1028 (2005)
DOI:10.1146/annurev.immunol.22.012703.104538
Reference
PMID:15814328
  Authors
Inaba K, Inaba M.
  Title
Antigen recognition and presentation by dendritic cells.
  Journal
Int J Hematol 81:181-7 (2005)
DOI:10.1532/IJH97.04200
Reference
PMID:11905820
  Authors
Heath WR, Carbone FR.
  Title
Cross-presentation in viral immunity and self-tolerance.
  Journal
Nat Rev Immunol 1:126-34 (2001)
DOI:10.1038/35100512
Reference
PMID:15304636
  Authors
Abele R, Tampe R.
  Title
The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing.
  Journal
Physiology (Bethesda) 19:216-24 (2004)
DOI:10.1152/physiol.00002.2004
Reference
PMID:16200082
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
PMID:12776207
  Authors
Honey K, Rudensky AY.
  Title
Lysosomal cysteine proteases regulate antigen presentation.
  Journal
Nat Rev Immunol 3:472-82 (2003)
DOI:10.1038/nri1110
Reference
PMID:12974477
  Authors
Sercarz EE, Maverakis E.
  Title
Mhc-guided processing: binding of large antigen fragments.
  Journal
Nat Rev Immunol 3:621-9 (2003)
DOI:10.1038/nri1149
Reference
PMID:15224093
  Authors
Ackerman AL, Cresswell P.
  Title
Cellular mechanisms governing cross-presentation of exogenous antigens.
  Journal
Nat Immunol 5:678-84 (2004)
DOI:10.1038/ni1082
Reference
PMID:16181333
  Authors
Cresswell P, Ackerman AL, Giodini A, Peaper DR, Wearsch PA.
  Title
Mechanisms of MHC class I-restricted antigen processing and cross-presentation.
  Journal
Immunol Rev 207:145-57 (2005)
DOI:10.1111/j.0105-2896.2005.00316.x
Reference
PMID:15653312
  Authors
Zika E, Ting JP.
  Title
Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes.
  Journal
Curr Opin Immunol 17:58-64 (2005)
DOI:10.1016/j.coi.2004.11.008
Reference
PMID:11244040
  Authors
Reith W, Mach B.
  Title
The bare lymphocyte syndrome and the regulation of MHC expression.
  Journal
Annu Rev Immunol 19:331-73 (2001)
DOI:10.1146/annurev.immunol.19.1.331
Reference
PMID:15745856
  Authors
Lizee G, Basha G, Jefferies WA.
  Title
Tails of wonder: endocytic-sorting motifs key for exogenous antigen presentation.
  Journal
Trends Immunol 26:141-9 (2005)
DOI:10.1016/j.it.2005.01.005
Reference
PMID:15224094
  Authors
Watts C.
  Title
The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules.
  Journal
Nat Immunol 5:685-92 (2004)
DOI:10.1038/ni1088
Reference
PMID:15653315
  Authors
Kaufmann SH, Schaible UE.
  Title
Antigen presentation and recognition in bacterial infections.
  Journal
Curr Opin Immunol 17:79-87 (2005)
DOI:10.1016/j.coi.2004.12.004
Reference
PMID:20010787
  Authors
Groettrup M, Kirk CJ, Basler M
  Title
Proteasomes in immune cells: more than peptide producers?
  Journal
Nat Rev Immunol 10:73-8 (2010)
DOI:10.1038/nri2687
Related
pathway
ko03050  Proteasome
ko04650  Natural killer cell mediated cytotoxicity
ko04660  T cell receptor signaling pathway

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