KEGG   PATHWAY: kpz00260
Entry
kpz00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Klebsiella pneumoniae subsp. pneumoniae KPNIH27
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
kpz00260  Glycine, serine and threonine metabolism
kpz00260

Module
kpz_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:kpz00260]
kpz_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:kpz00260]
kpz_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:kpz00260]
kpz_M00555  Betaine biosynthesis, choline => betaine [PATH:kpz00260]
kpz_M00621  Glycine cleavage system [PATH:kpz00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Klebsiella pneumoniae subsp. pneumoniae KPNIH27 [GN:kpz]
Gene
KPNIH27_01340  aspartate kinase [KO:K00928] [EC:2.7.2.4]
KPNIH27_03520  thrA; aspartate kinase [KO:K12524] [EC:2.7.2.4 1.1.1.3]
KPNIH27_00465  metL; aspartate kinase [KO:K12525] [EC:2.7.2.4 1.1.1.3]
KPNIH27_23605  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
KPNIH27_13075  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
KPNIH27_03525  serine kinase [KO:K00872] [EC:2.7.1.39]
KPNIH27_03530  threonine synthase [KO:K01733] [EC:4.2.3.1]
KPNIH27_08410  threonine aldolase [KO:K01620] [EC:4.1.2.48]
KPNIH27_18885  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
KPNIH27_09130  ghrA; bifunctional glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
KPNIH27_24195  bifunctional glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
KPNIH27_22310  glycerate kinase [KO:K00865] [EC:2.7.1.165]
KPNIH27_20360  glycerate kinase [KO:K00865] [EC:2.7.1.165]
KPNIH27_12750  glycerate kinase [KO:K00865] [EC:2.7.1.165]
KPNIH27_07475  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
KPNIH27_03480  phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
KPNIH27_24420  phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
KPNIH27_06835  dihydrofolate reductase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
KPNIH27_12415  hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
KPNIH27_21395  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
KPNIH27_08570  3-phosphoserine/phosphohydroxythreonine aminotransferase [KO:K00831] [EC:2.6.1.52]
KPNIH27_03445  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
KPNIH27_12180  malonic semialdehyde reductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
KPNIH27_24445  2-amino-3-ketobutyrate CoA ligase [KO:K00639] [EC:2.3.1.29]
KPNIH27_24440  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
KPNIH27_11540  tynA; tyramine oxidase [KO:K00276] [EC:1.4.3.21]
KPNIH27_21350  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
KPNIH27_21360  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
KPNIH27_04800  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
KPNIH27_04065  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
KPNIH27_21355  glycine cleavage system protein H [KO:K02437]
KPNIH27_19330  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
KPNIH27_06560  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
KPNIH27_06565  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
KPNIH27_21645  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
KPNIH27_21650  cystathionine beta-lyase [KO:K01758] [EC:4.4.1.1]
KPNIH27_16160  serine dehydratase [KO:K01752] [EC:4.3.1.17]
KPNIH27_20415  serine dehydratase [KO:K01752] [EC:4.3.1.17]
KPNIH27_15975  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
KPNIH27_00655  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
KPNIH27_25120  D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
KPNIH27_03170  aldolase [KO:K01753] [EC:4.3.1.18]
KPNIH27_20925  racemase [KO:K25316] [EC:5.1.1.10]
KPNIH27_10480  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
KPNIH27_10485  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
KPNIH27_13225  diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
KPNIH27_13230  2,4-diaminobutyrate decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
kpz00010  Glycolysis / Gluconeogenesis
kpz00020  Citrate cycle (TCA cycle)
kpz00230  Purine metabolism
kpz00250  Alanine, aspartate and glutamate metabolism
kpz00270  Cysteine and methionine metabolism
kpz00290  Valine, leucine and isoleucine biosynthesis
kpz00300  Lysine biosynthesis
kpz00330  Arginine and proline metabolism
kpz00460  Cyanoamino acid metabolism
kpz00470  D-Amino acid metabolism
kpz00564  Glycerophospholipid metabolism
kpz00600  Sphingolipid metabolism
kpz00620  Pyruvate metabolism
kpz00630  Glyoxylate and dicarboxylate metabolism
kpz00640  Propanoate metabolism
kpz00680  Methane metabolism
kpz00860  Porphyrin metabolism
kpz00920  Sulfur metabolism
KO pathway
ko00260   
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