KEGG   PATHWAY: lve03013
Entry
lve03013                    Pathway                                
Name
Nucleocytoplasmic transport - Lipotes vexillifer (Yangtze River dolphin)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
lve03013  Nucleocytoplasmic transport
lve03013

Other DBs
GO: 0050658
Organism
Lipotes vexillifer (Yangtze River dolphin) [GN:lve]
Gene
103068724  [KO:K14284]
103069173  UPF2; regulator of nonsense transcripts 2 [KO:K14327]
103069206  NXT2; NTF2-related export protein 2 [KO:K14285]
103069211  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
103069225  NUP205; nuclear pore complex protein Nup205 [KO:K14310]
103069234  KPNA7; importin subunit alpha-8 [KO:K15043]
103069254  NUP88; nuclear pore complex protein Nup88 [KO:K14318]
103069346  [KO:K12160]
103069469  [KO:K13171]
103069650  IPO9; importin-9 [KO:K20224]
103069667  [KO:K14284]
103069920  TMEM33; transmembrane protein 33 [KO:K20724]
103070012  [KO:K12160]
103070045  XPO4; exportin-4 [KO:K25203]
103070113  [KO:K12160]
103070167  [KO:K07936]
103070544  NUP214; nuclear pore complex protein Nup214 [KO:K14317]
103070674  RANBP17; ran-binding protein 17 [KO:K24115]
103070880  IPO4; importin-4 [KO:K20221]
103070913  NUP160; nuclear pore complex protein Nup160 [KO:K14303]
103070998  GLE1; nucleoporin GLE1 [KO:K18723]
103071542  KPNA1; importin subunit alpha-5 [KO:K23940]
103071752  RANBP2; E3 SUMO-protein ligase RanBP2 isoform X1 [KO:K12172] [EC:2.3.2.-]
103071918  SENP2; sentrin-specific protease 2 isoform X1 [KO:K03345] [EC:3.4.22.68]
103072080  [KO:K12160]
103072583  NUP43; nucleoporin Nup43 [KO:K14305]
103072768  NXF1; nuclear RNA export factor 1 isoform X1 [KO:K14284]
103072846  NUP54; nuclear pore complex protein Nup54 isoform X1 [KO:K14308]
103074005  NUP37; nucleoporin Nup37 [KO:K14302]
103074166  THOC7; THO complex subunit 7 homolog isoform X1 [KO:K13176]
103074663  MAGOHB; protein mago nashi homolog 2 [KO:K12877]
103074671  IPO11; importin-11 [KO:K25201]
103074937  AHCTF1; protein ELYS-like [KO:K25129]
103075114  UPF3A; regulator of nonsense transcripts 3A [KO:K14328]
103075274  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
103075430  UPF3B; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
103075438  NUP188; nucleoporin NUP188 homolog [KO:K14311]
103075696  [KO:K14004]
103076205  [KO:K12882]
103076323  NUP93; nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
103076389  NUP62; nuclear pore glycoprotein p62 [KO:K14306]
103076695  [KO:K12883]
103077382  ALYREF; THO complex subunit 4 [KO:K12881]
103077450  THOC6; THO complex subunit 6 homolog isoform X1 [KO:K13175]
103077821  XPO5; exportin-5 [KO:K14289]
103077984  IPO8; importin-8 [KO:K18755]
103078177  RANGAP1; ran GTPase-activating protein 1 [KO:K14319]
103078467  [KO:K14316]
103078699  NUP133; nuclear pore complex protein Nup133 [KO:K14300]
103078847  [KO:K14284]
103080254  KPNA3; importin subunit alpha-4 [KO:K23583]
103080802  CASC3; LOW QUALITY PROTEIN: cancer susceptibility candidate 3 [KO:K14323]
103080840  NDC1; nucleoporin NDC1 isoform X1 [KO:K14315]
103080880  XPO1; exportin-1 [KO:K14290]
103080899  AAAS; aladin [KO:K14320]
103081048  KPNA2; importin subunit alpha-1 isoform X1 [KO:K15043]
103081225  KPNA4; importin subunit alpha-3 [KO:K23583]
103081357  NCBP2; nuclear cap-binding protein subunit 2 [KO:K12883]
103081497  NUP85; nuclear pore complex protein Nup85 isoform X1 [KO:K14304]
103081543  XPOT; exportin-T [KO:K14288]
103081546  NUP155; nuclear pore complex protein Nup155 isoform X1 [KO:K14312]
103081938  SUMO2; small ubiquitin-related modifier 2 isoform X1 [KO:K12160]
103082004  POM121C; nuclear envelope pore membrane protein POM 121C [KO:K14316]
103082037  NMD3; 60S ribosomal export protein NMD3 [KO:K07562]
103082098  RAE1; mRNA export factor [KO:K14298]
103082143  [KO:K12160]
103082198  MAGOH; protein mago nashi homolog isoform X1 [KO:K12877]
103082339  DDX19B; ATP-dependent RNA helicase DDX19B-like isoform X1 [KO:K18655] [EC:5.6.2.7]
103082587  RAN; GTP-binding nuclear protein Ran isoform X1 [KO:K07936]
103082780  UPF1; regulator of nonsense transcripts 1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
103082863  [KO:K14314]
103082885  PNN; pinin isoform X1 [KO:K13114]
103082890  NUPL2; nucleoporin-like protein 2 [KO:K14321]
103083147  NUP107; nuclear pore complex protein Nup107 [KO:K14301]
103083515  [KO:K18655] [EC:5.6.2.7]
103083639  THOC1; THO complex subunit 1 [KO:K12878]
103083682  EEF1A1; elongation factor 1-alpha 1 [KO:K03231]
103083961  THOC5; THO complex subunit 5 homolog [KO:K13174]
103084249  NUP98; nuclear pore complex protein Nup98-Nup96 [KO:K14297]
103084592  RNPS1; RNA-binding protein with serine-rich domain 1 [KO:K14325]
103084671  XPO6; exportin-6 [KO:K25204]
103084693  NUP210L; nuclear pore membrane glycoprotein 210-like isoform X1 [KO:K14314]
103084702  DDX39B; spliceosome RNA helicase DDX39B isoform X1 [KO:K12812] [EC:5.6.2.7]
103084801  EEF1A2; elongation factor 1-alpha 2 [KO:K03231]
103084808  [KO:K12160]
103084965  TNPO1; transportin-1 isoform X1 [KO:K18752]
103085057  KPNA5; importin subunit alpha-6 isoform X1 [KO:K15042]
103085374  THOC2; THO complex subunit 2 [KO:K12879]
103085427  [KO:K14306]
103085439  SEH1L; nucleoporin SEH1 isoform X1 [KO:K14299]
103085756  IPO13; importin-13 [KO:K25202]
103086038  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
103086178  NXT1; NTF2-related export protein 1 [KO:K14285]
103086249  IPO7; importin-7 [KO:K20223]
103086513  TNPO2; transportin-2 [KO:K18727]
103086625  [KO:K12160]
103086810  NUP50; LOW QUALITY PROTEIN: nuclear pore complex protein Nup50 [KO:K14295]
103087339  SNUPN; snurportin-1 isoform X1 [KO:K13151]
103087561  [KO:K03231]
103087692  IPO5; importin-5 isoform X1 [KO:K20222]
103087850  PHAX; phosphorylated adapter RNA export protein [KO:K14291]
103087985  XPO7; exportin-7 [KO:K18460]
103088259  TNPO3; transportin-3 isoform X1 [KO:K15436]
103088572  THOC3; THO complex subunit 3 [KO:K12880]
103089031  KPNB1; importin subunit beta-1 isoform X1 [KO:K14293]
103089249  NUPL1; nucleoporin p58/p45 [KO:K14307]
103090058  NUP153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
103090145  NUP210; nuclear pore membrane glycoprotein 210-like [KO:K14314]
103090269  KPNA6; importin subunit alpha-7 isoform X1 [KO:K15042]
103090422  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
103090438  [KO:K14284]
103090524  CSE1L; exportin-2 isoform X1 [KO:K18423]
103090552  SUMO1; small ubiquitin-related modifier 1 [KO:K12160]
103090710  WIBG; partner of Y14 and mago [KO:K14294]
103090894  TPR; nucleoprotein TPR [KO:K09291]
103090917  NUP35; nucleoporin NUP53 [KO:K14313]
103090930  [KO:K12160]
103090932  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
lve03015  mRNA surveillance pathway
KO pathway
ko03013   

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