KEGG   PATHWAY: mah00030
Entry
mah00030                    Pathway                                
Name
Pentose phosphate pathway - Methylotuvimicrobium alcaliphilum
Description
The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated [MD:M00006]. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P [MD:M00007]. Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P [MD:M00005] is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. This pathway map also shows the Entner-Doudoroff pathway where 6-P-gluconate is dehydrated and then cleaved into pyruvate and glyceraldehyde-3P [MD:M00008].
Class
Metabolism; Carbohydrate metabolism
Pathway map
mah00030  Pentose phosphate pathway
mah00030

Module
mah_M00004  Pentose phosphate pathway (Pentose phosphate cycle) [PATH:mah00030]
mah_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:mah00030]
mah_M00006  Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P [PATH:mah00030]
mah_M00007  Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:mah00030]
mah_M00008  Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate [PATH:mah00030]
mah_M00580  Pentose phosphate pathway, archaea, fructose 6P => ribose 5P [PATH:mah00030]
Other DBs
GO: 0006098
Organism
Methylotuvimicrobium alcaliphilum [GN:mah]
Gene
MEALZ_0104  pgi; Glucose-6-phosphate isomerase (GPI) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) [KO:K01810] [EC:5.3.1.9]
MEALZ_3918  zwf1; glucose-6-phosphate 1-dehydrogenase [KO:K00036] [EC:1.1.1.49 1.1.1.363]
MEALZ_4018  zwf2; glucose-6-phosphate dehydrogenase [KO:K00036] [EC:1.1.1.49 1.1.1.363]
MEALZ_3856  pgl; 6-phosphogluconolactonase [KO:K01057] [EC:3.1.1.31]
MEALZ_3917  gnd; gluconate-6-phosphate dehydrogenase, decarboxylating [KO:K00033] [EC:1.1.1.44 1.1.1.343]
MEALZ_3997  ppe; Pentose-5-phosphate 3-epimerase [KO:K01783] [EC:5.1.3.1]
MEALZ_3951  tkt; Transketolase [KO:K00615] [EC:2.2.1.1]
MEALZ_3948  tal; Transaldolase [KO:K00616] [EC:2.2.1.2]
MEALZ_1472  rpiA; Ribose-5-phosphate isomerase A [KO:K01807] [EC:5.3.1.6]
MEALZ_3436  rpiA; ribose 5-phosphate isomerase A (Phosphoriboisomerase A) (PRI) [KO:K01807] [EC:5.3.1.6]
MEALZ_3953  hps1; 3-hexulose-6-phosphate synthase [KO:K08093] [EC:4.1.2.43]
MEALZ_3952  hpi1; 3-hexulose-6-phosphate isomerase [KO:K08094] [EC:5.3.1.27]
MEALZ_1912  hpsi2; Hexulose-6-phosphate synthase and isomerase [KO:K13831] [EC:4.1.2.43 5.3.1.27]
MEALZ_2852  xfp; D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase [KO:K01621] [EC:4.1.2.9 4.1.2.22]
MEALZ_2572  xfp; D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase [KO:K01621] [EC:4.1.2.9 4.1.2.22]
MEALZ_p0114  xfp; D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase [KO:K01621] [EC:4.1.2.9 4.1.2.22]
MEALZ_1221  pgm; Phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
MEALZ_0132  Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I [KO:K15778] [EC:5.4.2.8 5.4.2.2]
MEALZ_3369  prs; Ribose-phosphate pyrophosphokinase (RPPK) (Phosphoribosyl pyrophosphate synthetase) (P-Rib-PP synthetase) (PRPP synthetase) [KO:K00948] [EC:2.7.6.1]
MEALZ_3129  Ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
MEALZ_1363  edd; 6-phosphogluconate dehydratase [KO:K01690] [EC:4.2.1.12]
MEALZ_1362  eda; 2-dehydro-3-deoxy-phosphogluconate aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
MEALZ_1699  gdhI; glucose 1-dehydrogenase 1 [KO:K00034] [EC:1.1.1.47]
MEALZ_1692  gntK; gluconokinase [KO:K00851] [EC:2.7.1.12]
MEALZ_0765  aor; Tungsten-containing aldehyde ferredoxin oxidoreductase [KO:K03738] [EC:1.2.7.5]
MEALZ_3222  gck2; Glycerate 2-kinase [KO:K11529] [EC:2.7.1.165]
MEALZ_p0115  putative fructose-bisphosphate aldolase class 1 [KO:K01623] [EC:4.1.2.13]
MEALZ_3947  fbaA; fructose-bisphosphate aldolase, class II [KO:K01624] [EC:4.1.2.13]
MEALZ_3793  cbbA; fructose-bisphosphate aldolase [KO:K01624] [EC:4.1.2.13]
MEALZ_2859  fbp; putative fructose-1,6-bisphosphatase [KO:K03841] [EC:3.1.3.11]
MEALZ_3302  pfp; Pyrophosphate-fructose 6-phosphate 1-phosphotransferase [KO:K00895] [EC:2.7.1.90]
Compound
C00022  Pyruvate
C00031  D-Glucose
C00085  D-Fructose 6-phosphate
C00117  D-Ribose 5-phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00121  D-Ribose
C00197  3-Phospho-D-glycerate
C00198  D-Glucono-1,5-lactone
C00199  D-Ribulose 5-phosphate
C00204  2-Dehydro-3-deoxy-D-gluconate
C00221  beta-D-Glucose
C00231  D-Xylulose 5-phosphate
C00257  D-Gluconic acid
C00258  D-Glycerate
C00279  D-Erythrose 4-phosphate
C00345  6-Phospho-D-gluconate
C00354  D-Fructose 1,6-bisphosphate
C00577  D-Glyceraldehyde
C00620  alpha-D-Ribose 1-phosphate
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C00672  2-Deoxy-D-ribose 1-phosphate
C00673  2-Deoxy-D-ribose 5-phosphate
C01151  D-Ribose 1,5-bisphosphate
C01172  beta-D-Glucose 6-phosphate
C01182  D-Ribulose 1,5-bisphosphate
C01218  6-Phospho-2-dehydro-D-gluconate
C01236  D-Glucono-1,5-lactone 6-phosphate
C01801  Deoxyribose
C02076  Sedoheptulose
C03752  2-Amino-2-deoxy-D-gluconate
C04442  2-Dehydro-3-deoxy-6-phospho-D-gluconate
C05382  Sedoheptulose 7-phosphate
C06019  D-arabino-Hex-3-ulose 6-phosphate
C06473  2-Keto-D-gluconic acid
C20589  D-Glucosaminate-6-phosphate
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Reference
  Authors
Hove-Jensen B, Rosenkrantz TJ, Haldimann A, Wanner BL.
  Title
Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways.
  Journal
J Bacteriol 185:2793-801 (2003)
DOI:10.1128/JB.185.9.2793-2801.2003
Reference
  Authors
Orita I, Sato T, Yurimoto H, Kato N, Atomi H, Imanaka T, Sakai Y
  Title
The ribulose monophosphate pathway substitutes for the missing pentose phosphate pathway in the archaeon Thermococcus kodakaraensis.
  Journal
J Bacteriol 188:4698-704 (2006)
DOI:10.1128/JB.00492-06
Reference
  Authors
Kato N, Yurimoto H, Thauer RK
  Title
The physiological role of the ribulose monophosphate pathway in bacteria and archaea.
  Journal
Biosci Biotechnol Biochem 70:10-21 (2006)
DOI:10.1271/bbb.70.10
Reference
  Authors
Kouril T, Wieloch P, Reimann J, Wagner M, Zaparty M, Albers SV, Schomburg D, Ruoff P, Siebers B
  Title
Unraveling the function of the two Entner-Doudoroff branches in the thermoacidophilic Crenarchaeon Sulfolobus solfataricus P2.
  Journal
FEBS J 280:1126-38 (2013)
DOI:10.1111/febs.12106
Reference
  Authors
Reher M, Schonheit P
  Title
Glyceraldehyde dehydrogenases from the thermoacidophilic euryarchaeota Picrophilus torridus and Thermoplasma acidophilum, key enzymes of the non-phosphorylative Entner-Doudoroff pathway, constitute a novel enzyme family within the aldehyde dehydrogenase superfamily.
  Journal
FEBS Lett 580:1198-204 (2006)
DOI:10.1016/j.febslet.2006.01.029
Reference
  Authors
Reher M, Fuhrer T, Bott M, Schonheit P
  Title
The nonphosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate- specific aldolase.
  Journal
J Bacteriol 192:964-74 (2010)
DOI:10.1128/JB.01281-09
Related
pathway
mah00010  Glycolysis / Gluconeogenesis
mah00040  Pentose and glucuronate interconversions
mah00052  Galactose metabolism
mah00230  Purine metabolism
mah00240  Pyrimidine metabolism
mah00340  Histidine metabolism
mah00630  Glyoxylate and dicarboxylate metabolism
mah00750  Vitamin B6 metabolism
KO pathway
ko00030   
LinkDB

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