KEGG   PATHWAY: mah00230
Entry
mah00230                    Pathway                                
Name
Purine metabolism - Methylotuvimicrobium alcaliphilum
Class
Metabolism; Nucleotide metabolism
Pathway map
mah00230  Purine metabolism
mah00230

Module
mah_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:mah00230]
mah_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:mah00230]
mah_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:mah00230]
mah_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:mah00230]
mah_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:mah00230]
mah_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:mah00230]
Other DBs
GO: 0006163 0042278
Organism
Methylotuvimicrobium alcaliphilum [GN:mah]
Gene
MEALZ_1895  nudF; ADP-ribose pyrophosphatase [KO:K01515] [EC:3.6.1.13 3.6.1.-]
MEALZ_3958  nudE; ADP compounds hydrolase nudE [KO:K08312] [EC:3.6.1.-]
MEALZ_1221  pgm; Phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
MEALZ_0132  Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I [KO:K15778] [EC:5.4.2.8 5.4.2.2]
MEALZ_3369  prs; Ribose-phosphate pyrophosphokinase (RPPK) (Phosphoribosyl pyrophosphate synthetase) (P-Rib-PP synthetase) (PRPP synthetase) [KO:K00948] [EC:2.7.6.1]
MEALZ_3129  Ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
MEALZ_1489  purF; Amidophosphoribosyltransferase (Glutamine phosphoribosylpyrophosphate amidotransferase) (ATASE) (GPATase) [KO:K00764] [EC:2.4.2.14]
MEALZ_2306  purD; phosphoribosylglycinamide synthetase (GAR synthetase) (Phosphoribosylamine--glycine ligase) (Glycinamide ribonucleotide synthetase) [KO:K01945] [EC:6.3.4.13]
MEALZ_1356  purN; putative phosphoribosylglycinamide formyltransferase/formyltetrahydrofolate deformylase [KO:K11175] [EC:2.1.2.2]
MEALZ_1778  purL; phosphoribosylformyl-glycineamide synthetase (FGAM synthetase) (FGAMS) (Formylglycinamide ribotide amidotransferase) (FGARAT) (Formylglycinamide ribotide synthetase) [KO:K01952] [EC:6.3.5.3]
MEALZ_3417  purM; Phosphoribosylformylglycinamidine cyclo-ligase (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase) [KO:K01933] [EC:6.3.3.1]
MEALZ_1365  purK; Phosphoribosylaminoimidazole carboxylase ATPase subunit [KO:K01589] [EC:6.3.4.18]
MEALZ_1364  purE; Phosphoribosylaminoimidazole carboxylase catalytic subunit (AIR carboxylase) (AIRC) [KO:K01588] [EC:5.4.99.18]
MEALZ_0128  purC; Phosphoribosylaminoimidazole-succinocarboxamide synthase (SAICAR synthetase) [KO:K01923] [EC:6.3.2.6]
MEALZ_2596  purB; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
MEALZ_2305  purH; Bifunctional purine biosynthesis protein purH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transformylase); IMP cyclohydrolase (Inosinicase) (IMP synthetase) (ATIC)] [KO:K00602] [EC:2.1.2.3 3.5.4.10]
MEALZ_3092  apt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
MEALZ_2976  Nt5c1a; Cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
MEALZ_1469  surE; 5'-nucleotidase SurE (Nucleoside 5'-monophosphate phosphohydrolase) [KO:K03787] [EC:3.1.3.5 3.1.3.6]
MEALZ_3959  conserved protein of unknown function [KO:K20881] [EC:3.1.3.-]
MEALZ_1978  conserved protein of unknown function [KO:K09913] [EC:2.4.2.1 2.4.2.2]
MEALZ_1219  conserved hypothetical protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
MEALZ_3519  Phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
MEALZ_0101  guaB; Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPDH) (IMPD) [KO:K00088] [EC:1.1.1.205]
MEALZ_0500  ndk; nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase) [KO:K00940] [EC:2.7.4.6]
MEALZ_3639  HAM1 protein homolog [KO:K01519] [EC:3.6.1.66]
MEALZ_1437  xdhA; xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit [KO:K13481] [EC:1.17.1.4]
MEALZ_1436  xdhB; xanthine dehydrogenase, large subunit [KO:K13482] [EC:1.17.1.4]
MEALZ_0102  guaA; GMP synthase [glutamine-hydrolyzing] (Glutamine amidotransferase) (GMP synthetase) [KO:K01951] [EC:6.3.5.2]
MEALZ_3414  guaD; Guanine deaminase [KO:K01487] [EC:3.5.4.3]
MEALZ_0371  gmk; Guanylate kinase [KO:K00942] [EC:2.7.4.8]
MEALZ_0302  Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent (modular protein) [KO:K00525] [EC:1.17.4.1]
MEALZ_3624  conserved protein of unknown function [KO:K08722] [EC:3.1.3.89]
MEALZ_3551  spoT; Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase ((ppGpp)ase) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) [KO:K01139] [EC:2.7.6.5 3.1.7.2]
MEALZ_2669  ppx; Exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
MEALZ_0385  relA; GTP pyrophosphokinase [KO:K00951] [EC:2.7.6.5]
MEALZ_0047  putative adenylate cyclase [KO:K01768] [EC:4.6.1.1]
MEALZ_1407  conserved exported protein of unknown function [KO:K01768] [EC:4.6.1.1]
MEALZ_3324  Adenylate cyclase [KO:K01768] [EC:4.6.1.1]
MEALZ_3076  putative adenylate cyclase [KO:K05851] [EC:4.6.1.1]
MEALZ_3058  purA; adenylosuccinate synthetase (IMP--aspartate ligase) (AdSS) (AMPSase) [KO:K01939] [EC:6.3.4.4]
MEALZ_2382  pkfB; Carbohydrate kinase [KO:K00856] [EC:2.7.1.20]
MEALZ_3812  Conserved hypothetical protein, putative lysine decarboxylase [KO:K06966] [EC:3.2.2.10 3.2.2.-]
MEALZ_1438  ade; adenine deaminase [KO:K01486] [EC:3.5.4.2]
MEALZ_3530  adk; Adenylate kinase (ATP-AMP transphosphorylase) [KO:K00939] [EC:2.7.4.3]
MEALZ_2381  mazG; Nucleoside triphosphate pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
MEALZ_1793  icc; Protein icc homolog [KO:K03651] [EC:3.1.4.53]
MEALZ_3826  Metallophosphoesterase [KO:K03651] [EC:3.1.4.53]
MEALZ_3839  apaH; Bis(5'-nucleosyl)-tetraphosphatase, symmetrical [KO:K01525] [EC:3.6.1.41]
MEALZ_2757  cysC; Adenylyl-sulfate kinase [KO:K00860] [EC:2.7.1.25]
MEALZ_2866  cysNC; Bifunctional enzyme CysN/CysC [Includes: Sulfate adenylyltransferase subunit 1; Adenylyl-sulfate kinase] [KO:K00956] [EC:2.7.7.4]
MEALZ_2865  cysD; Sulfate adenylyltransferase subunit 2 (Sulfate adenylate transferase) (SAT) (ATP-sulfurylase small subunit) [KO:K00957] [EC:2.7.7.4]
MEALZ_1772  ureC; urease alpha subunit [KO:K01428] [EC:3.5.1.5]
MEALZ_1771  ureB; Urease subunit beta [KO:K01429] [EC:3.5.1.5]
MEALZ_1770  ureA; Urease subunit gamma [KO:K01430] [EC:3.5.1.5]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
mah00030  Pentose phosphate pathway
mah00220  Arginine biosynthesis
mah00250  Alanine, aspartate and glutamate metabolism
mah00260  Glycine, serine and threonine metabolism
mah00340  Histidine metabolism
mah00630  Glyoxylate and dicarboxylate metabolism
mah00730  Thiamine metabolism
mah00740  Riboflavin metabolism
mah00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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