KEGG   PATHWAY: mah00010
Entry
mah00010                    Pathway                                
Name
Glycolysis / Gluconeogenesis - Methylotuvimicrobium alcaliphilum
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
Pathway map
mah00010  Glycolysis / Gluconeogenesis
mah00010

Module
mah_M00002  Glycolysis, core module involving three-carbon compounds [PATH:mah00010]
mah_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:mah00010]
Other DBs
GO: 0006096 0006094
Organism
Methylotuvimicrobium alcaliphilum [GN:mah]
Gene
MEALZ_0701  Glucokinase [KO:K00845] [EC:2.7.1.2]
MEALZ_0104  pgi; Glucose-6-phosphate isomerase (GPI) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) [KO:K01810] [EC:5.3.1.9]
MEALZ_3302  pfp; Pyrophosphate-fructose 6-phosphate 1-phosphotransferase [KO:K00895] [EC:2.7.1.90]
MEALZ_2859  fbp; putative fructose-1,6-bisphosphatase [KO:K03841] [EC:3.1.3.11]
MEALZ_p0115  putative fructose-bisphosphate aldolase class 1 [KO:K01623] [EC:4.1.2.13]
MEALZ_3947  fbaA; fructose-bisphosphate aldolase, class II [KO:K01624] [EC:4.1.2.13]
MEALZ_3793  cbbA; fructose-bisphosphate aldolase [KO:K01624] [EC:4.1.2.13]
MEALZ_1811  tpiA; triosephosphate isomerase (TIM) (Triose-phosphate isomerase) [KO:K01803] [EC:5.3.1.1]
MEALZ_3079  gap; glyceraldehyde 3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
MEALZ_0446  putative Glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
MEALZ_3549  pgk; phosphoglycerate kinase [KO:K00927] [EC:2.7.2.3]
MEALZ_p0007  pgm; phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
MEALZ_1633  pgm3; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (iPGM) [KO:K15633] [EC:5.4.2.12]
MEALZ_1462  eno; Enolase (2-phosphoglycerate dehydratase) (2-phospho-D-glycerate hydro-lyase) [KO:K01689] [EC:4.2.1.11]
MEALZ_1860  pykA; pyruvate kinase [KO:K00873] [EC:2.7.1.40]
MEALZ_3080  pykA; pyruvate kinase II [KO:K00873] [EC:2.7.1.40]
MEALZ_1703  PPDK; Pyruvate, phosphate dikinase [KO:K01006] [EC:2.7.9.1]
MEALZ_1836  ppsA; phosphoenolpyruvate synthase (Pyruvate, water dikinase) (PEP synthase) [KO:K01007] [EC:2.7.9.2]
MEALZ_1359  pdhA; pyruvate dehydrogenase E1 component [KO:K00163] [EC:1.2.4.1]
MEALZ_1358  pdhB; pyruvate dehydrogenase E2 component; dihydrolipoamide acetyltransferase [KO:K00627] [EC:2.3.1.12]
MEALZ_1357  pdhD; dihydrolipoamide dehydrogenase E3 component of both pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes [KO:K00382] [EC:1.8.1.4]
MEALZ_1578  odhL; Dihydrolipoyl dehydrogenase (E3 component of 2-oxoglutarate dehydrogenase complex) (Dihydrolipoamide dehydrogenase) [KO:K00382] [EC:1.8.1.4]
MEALZ_3939  putative oxidoreductase, thiamine diP-binding and 4Fe-4S cluster binding protein [KO:K03737] [EC:1.2.7.1 1.2.7.-]
MEALZ_0288  korA; putative 2-oxoglutarate ferredoxin oxidoreductase, alpha subunit [KO:K00174] [EC:1.2.7.3 1.2.7.11]
MEALZ_0287  korB; putative 2-oxoglutarate ferredoxin oxidoreductase, beta subunit [KO:K00175] [EC:1.2.7.3 1.2.7.11]
MEALZ_0534  Lactate/malate dehydrogenase [KO:K00016] [EC:1.1.1.27]
MEALZ_3448  mxaF; Methanol dehydrogenase, large subunit [KO:K14028] [EC:1.1.2.7]
MEALZ_3445  mxaI; Methanol dehydrogenase, small subunit [KO:K14029] [EC:1.1.2.7]
MEALZ_2864  acsA; acetyl-coenzyme A synthetase [KO:K01895] [EC:6.2.1.1]
MEALZ_1221  pgm; Phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
MEALZ_0132  Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I [KO:K15778] [EC:5.4.2.8 5.4.2.2]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00033  Acetate
C00036  Oxaloacetate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00084  Acetaldehyde
C00085  D-Fructose 6-phosphate
C00103  D-Glucose 1-phosphate
C00111  Glycerone phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00186  (S)-Lactate
C00197  3-Phospho-D-glycerate
C00221  beta-D-Glucose
C00236  3-Phospho-D-glyceroyl phosphate
C00267  alpha-D-Glucose
C00354  D-Fructose 1,6-bisphosphate
C00469  Ethanol
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C01159  2,3-Bisphospho-D-glycerate
C01172  beta-D-Glucose 6-phosphate
C01451  Salicin
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
mah00020  Citrate cycle (TCA cycle)
mah00030  Pentose phosphate pathway
mah00500  Starch and sucrose metabolism
mah00620  Pyruvate metabolism
mah00640  Propanoate metabolism
mah00710  Carbon fixation by Calvin cycle
KO pathway
ko00010   
LinkDB

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