KEGG   PATHWAY: mbe00260
Entry
mbe00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Drepanopeziza brunnea
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
mbe00260  Glycine, serine and threonine metabolism
mbe00260

Module
mbe_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:mbe00260]
mbe_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:mbe00260]
mbe_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:mbe00260]
mbe_M00621  Glycine cleavage system [PATH:mbe00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Drepanopeziza brunnea [GN:mbe]
Gene
MBM_03128  aspartate kinase [KO:K00928] [EC:2.7.2.4]
MBM_04253  aspartate semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
MBM_06029  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
MBM_03799  homoserine kinase [KO:K00872] [EC:2.7.1.39]
MBM_05197  threonine synthase [KO:K01733] [EC:4.2.3.1]
MBM_06573  l-allo-threonine aldolase [KO:K01620] [EC:4.1.2.48]
MBM_05572  beta-eliminating lyase [KO:K01620] [EC:4.1.2.48]
MBM_06806  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
MBM_08091  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
MBM_00466  purine catabolism protein pucG [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
MBM_06845  phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [KO:K15633] [EC:5.4.2.12]
MBM_01705  D-glycerate 3-kinase [KO:K15918] [EC:2.7.1.31]
MBM_08183  D-isomer specific 2-hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
MBM_05736  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
MBM_00589  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
MBM_04303  hypothetical protein [KO:K16066] [EC:1.1.1.381 1.1.1.-]
MBM_00994  hypothetical protein [KO:K00643] [EC:2.3.1.37]
MBM_04717  flavin-containing amine oxidase [KO:K00274] [EC:1.4.3.4]
MBM_09344  copper amine oxidase [KO:K00276] [EC:1.4.3.21]
MBM_08181  putative copper amine oxidase [KO:K00276] [EC:1.4.3.21]
MBM_05980  peroxisomal copper amine oxidase [KO:K00276] [EC:1.4.3.21]
MBM_07599  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
MBM_05959  glycine cleavage system t protein [KO:K00605] [EC:2.1.2.10]
MBM_06865  hypothetical protein [KO:K00382] [EC:1.8.1.4]
MBM_01826  glycine cleavage H-protein [KO:K02437]
MBM_05129  FAD dependent oxidoreductase [KO:K00273] [EC:1.4.3.3]
MBM_02024  D-amino acid oxidase [KO:K00273] [EC:1.4.3.3]
MBM_09687  FAD dependent oxidoreductase [KO:K00273] [EC:1.4.3.3]
MBM_02443  D-amino acid oxidase [KO:K00273] [EC:1.4.3.3]
MBM_03167  putative D-amino acid oxidase [KO:K00273] [EC:1.4.3.3]
MBM_06874  CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
MBM_01793  betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
MBM_05862  FAD dependent oxidoreductase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
MBM_09114  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
MBM_02250  Cys/Met metabolism PLP-dependent enzyme [KO:K01758] [EC:4.4.1.1]
MBM_00930  threonine ammonia-lyase precursor [KO:K01754] [EC:4.3.1.19]
MBM_08062  threonine dehydratase catabolic [KO:K01754] [EC:4.3.1.19]
MBM_03191  serine family amino acid catabolism- protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
MBM_07784  serine family amino acid catabolism- protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
MBM_03920  putative alanine racemase domain protein [KO:K20498] [EC:4.3.1.18]
MBM_02667  putative tryptophan synthase [KO:K01694] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
mbe00010  Glycolysis / Gluconeogenesis
mbe00020  Citrate cycle (TCA cycle)
mbe00230  Purine metabolism
mbe00250  Alanine, aspartate and glutamate metabolism
mbe00270  Cysteine and methionine metabolism
mbe00290  Valine, leucine and isoleucine biosynthesis
mbe00300  Lysine biosynthesis
mbe00330  Arginine and proline metabolism
mbe00460  Cyanoamino acid metabolism
mbe00470  D-Amino acid metabolism
mbe00564  Glycerophospholipid metabolism
mbe00600  Sphingolipid metabolism
mbe00620  Pyruvate metabolism
mbe00630  Glyoxylate and dicarboxylate metabolism
mbe00640  Propanoate metabolism
mbe00680  Methane metabolism
mbe00860  Porphyrin metabolism
mbe00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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