KEGG   PATHWAY: metu00790
Entry
metu00790                   Pathway                                
Name
Folate biosynthesis - Methylococcus geothermalis
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
metu00790  Folate biosynthesis
metu00790

Module
metu_M00126  Tetrahydrofolate biosynthesis, GTP => THF [PATH:metu00790]
metu_M00880  Molybdenum cofactor biosynthesis, GTP => molybdenum cofactor [PATH:metu00790]
Other DBs
GO: 0046656
Organism
Methylococcus geothermalis [GN:metu]
Gene
GNH96_08170  folE; GTP cyclohydrolase I FolE [KO:K01495] [EC:3.5.4.16]
GNH96_01160  alkaline phosphatase [KO:K01077] [EC:3.1.3.1]
GNH96_03855  alkaline phosphatase [KO:K01113] [EC:3.1.3.1]
GNH96_03210  folB; dihydroneopterin aldolase [KO:K01633] [EC:4.1.2.25 5.1.99.8 1.13.11.81]
GNH96_03215  folK; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [KO:K00950] [EC:2.7.6.3]
GNH96_14385  folK; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [KO:K00950] [EC:2.7.6.3]
GNH96_14405  folP; dihydropteroate synthase [KO:K00796] [EC:2.5.1.15]
GNH96_04180  dihydrofolate reductase [KO:K00287] [EC:1.5.1.3]
GNH96_05465  folC; bifunctional tetrahydrofolate synthase/dihydrofolate synthase [KO:K11754] [EC:6.3.2.12 6.3.2.17]
GNH96_05545  ribA; GTP cyclohydrolase II [KO:K01497] [EC:3.5.4.25]
GNH96_07395  ribB; 3,4-dihydroxy-2-butanone-4-phosphate synthase [KO:K14652] [EC:4.1.99.12 3.5.4.25]
GNH96_03495  pabB; aminodeoxychorismate synthase component I [KO:K01665] [EC:2.6.1.85]
GNH96_07160  pabC; aminodeoxychorismate lyase [KO:K02619] [EC:4.1.3.38]
GNH96_15645  6-pyruvoyl tetrahydrobiopterin synthase [KO:K01737] [EC:4.2.3.12 4.1.2.50]
GNH96_00730  pterin-4-alpha-carbinolamine dehydratase [KO:K01724] [EC:4.2.1.96]
GNH96_03220  pteridine reductase [KO:K03793] [EC:1.5.1.33]
GNH96_06295  queE; 7-carboxy-7-deazaguanine synthase QueE [KO:K10026] [EC:4.3.99.3]
GNH96_06300  queC; 7-cyano-7-deazaguanine synthase QueC [KO:K06920] [EC:6.3.4.20]
GNH96_05710  queF; NADPH-dependent 7-cyano-7-deazaguanine reductase QueF [KO:K09457] [EC:1.7.1.13]
GNH96_03540  GHMP kinase [KO:K06984] [EC:2.4.2.54]
GNH96_03525  RimK family alpha-L-glutamate ligase [KO:K15740] [EC:6.3.2.33]
GNH96_08245  moaA; GTP 3',8-cyclase MoaA [KO:K03639] [EC:4.1.99.22]
GNH96_04175  moaC; cyclic pyranopterin monophosphate synthase MoaC [KO:K03637] [EC:4.6.1.17]
GNH96_02095  molybdenum cofactor biosynthesis protein MoaE [KO:K03635] [EC:2.8.1.12]
GNH96_06555  moaB; molybdenum cofactor biosynthesis protein B [KO:K03638] [EC:2.7.7.75]
GNH96_07500  molybdopterin molybdenumtransferase MoeA [KO:K03750] [EC:2.10.1.1]
GNH96_11790  mobA; molybdenum cofactor guanylyltransferase [KO:K03752] [EC:2.7.7.77]
Compound
C00044  GTP
C00101  Tetrahydrofolate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00156  4-Hydroxybenzoate
C00251  Chorismate
C00266  Glycolaldehyde
C00268  Dihydrobiopterin
C00272  Tetrahydrobiopterin
C00415  Dihydrofolate
C00504  Folate
C00568  4-Aminobenzoate
C00835  Sepiapterin
C00921  Dihydropteroate
C01217  5,6,7,8-Tetrahydromethanopterin
C01300  6-(Hydroxymethyl)-7,8-dihydropterin
C01304  2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C02587  Pyrimidodiazepine
C02953  7,8-Dihydrobiopterin
C03541  THF-polyglutamate
C03684  6-Pyruvoyltetrahydropterin
C04244  6-Lactoyl-5,6,7,8-tetrahydropterin
C04807  6-Hydroxymethyl-7,8-dihydropterin diphosphate
C04874  7,8-Dihydroneopterin
C04895  7,8-Dihydroneopterin 3'-triphosphate
C05922  Formamidopyrimidine nucleoside triphosphate
C05923  2,5-Diaminopyrimidine nucleoside triphosphate
C05924  Molybdopterin
C05925  Dihydroneopterin phosphate
C05926  Neopterin
C05927  7,8-Dihydromethanopterin
C06148  2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
C06313  Biopterin
C09332  THF-L-glutamate
C11355  4-Amino-4-deoxychorismate
C15522  4a-Hydroxytetrahydrobiopterin
C15996  7-Cyano-7-carbaguanine
C16675  7-Aminomethyl-7-carbaguanine
C18237  Molybdoenzyme molybdenum cofactor
C18239  Precursor Z
C18802  Tetrahydrosarcinapterin
C19848  Adenylated molybdopterin
C19871  Guanylyl molybdenum cofactor
C20239  6-Carboxy-5,6,7,8-tetrahydropterin
C20248  7-Carboxy-7-carbaguanine
C20264  L-threo-Tetrahydrobiopterin
C20559  4-(beta-D-Ribofuranosyl)aniline 5'-phosphate
C20562  N-[(7,8-Dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate
C20566  7,8-Dihydroneopterin 2'-phosphate
C20567  7,8-Dihydroneopterin 2',3'-cyclic phosphate
C21007  5,6,7,8-Tetrahydromonapterin
C21008  7,8-Dihydromonapterin
C21065  7,8-Dihydroxanthopterin
C21094  7,8-Dihydromonapterin 3'-triphosphate
C21107  4-(beta-D-Ribofuranosyl)phenol 5'-phosphate
C21310  (8S)-3',8-Cyclo-7,8-dihydroguanosine 5'-triphosphate
C21485  Cytidylyl molybdenum cofactor
C21486  Thio-molybdenum cofactor
C21640  6-(1'-Hydroxy-2'-oxopropyl)-tetrahydropterin
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19675644
  Authors
Schwarz G, Mendel RR, Ribbe MW
  Title
Molybdenum cofactors, enzymes and pathways.
  Journal
Nature 460:839-47 (2009)
DOI:10.1038/nature08302
Reference
PMID:16632608
  Authors
Hanzelmann P, Schindelin H
  Title
Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism.
  Journal
Proc Natl Acad Sci U S A 103:6829-34 (2006)
DOI:10.1073/pnas.0510711103
Reference
PMID:18092812
  Authors
Daniels JN, Wuebbens MM, Rajagopalan KV, Schindelin H
  Title
Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency.
  Journal
Biochemistry 47:615-26 (2008)
DOI:10.1021/bi701734g
Reference
PMID:12571226
  Authors
Wuebbens MM, Rajagopalan KV
  Title
Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis.
  Journal
J Biol Chem 278:14523-32 (2003)
DOI:10.1074/jbc.M300453200
Reference
PMID:21867484
  Authors
Werner ER, Blau N, Thony B
  Title
Tetrahydrobiopterin: biochemistry and pathophysiology.
  Journal
Biochem J 438:397-414 (2011)
DOI:10.1042/BJ20110293
Reference
PMID:12893295
  Authors
Iino T, Tabata M, Takikawa S, Sawada H, Shintaku H, Ishikura S, Hara A
  Title
Tetrahydrobiopterin is synthesized from 6-pyruvoyl-tetrahydropterin by the human aldo-keto reductase AKR1 family members.
  Journal
Arch Biochem Biophys 416:180-7 (2003)
DOI:10.1016/S0003-9861(03)00295-9
Reference
PMID:1902669
  Authors
Park YS, Heizmann CW, Wermuth B, Levine RA, Steinerstauch P, Guzman J, Blau N
  Title
Human carbonyl and aldose reductases: new catalytic functions in tetrahydrobiopterin biosynthesis.
  Journal
Biochem Biophys Res Commun 175:738-44 (1991)
DOI:10.1016/0006-291X(91)91628-P
Related
pathway
metu00230  Purine metabolism
metu00362  Benzoate degradation
metu00400  Phenylalanine, tyrosine and tryptophan biosynthesis
metu00670  One carbon pool by folate
metu00680  Methane metabolism
KO pathway
ko00790   
LinkDB

DBGET integrated database retrieval system