KEGG   PATHWAY: mlx03440
Entry
mlx03440                    Pathway                                
Name
Homologous recombination - Mirounga leonina (Southern elephant seal)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
mlx03440  Homologous recombination
mlx03440

Other DBs
GO: 0000724
Organism
Mirounga leonina (Southern elephant seal) [GN:mlx]
Gene
117998263  POLD1; DNA polymerase delta catalytic subunit isoform X1 [KO:K02327] [EC:2.7.7.7]
117998824  SYCP3; synaptonemal complex protein 3 [KO:K19528]
117999125  PALB2; partner and localizer of BRCA2 isoform X1 [KO:K10897]
117999829  TOP3B; DNA topoisomerase 3-beta-1 [KO:K03165] [EC:5.6.2.1]
118000136  TOP3A; DNA topoisomerase 3-alpha [KO:K03165] [EC:5.6.2.1]
118001023  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
118002577  XRCC3; DNA repair protein XRCC3 isoform X1 [KO:K10880]
118002691  RAD51B; DNA repair protein RAD51 homolog 2 isoform X1 [KO:K10869]
118002999  RAD51; DNA repair protein RAD51 homolog 1 isoform X1 [KO:K04482]
118003804  TOPBP1; DNA topoisomerase 2-binding protein 1 isoform X1 [KO:K10728]
118003909  POLD3; DNA polymerase delta subunit 3 isoform X1 [KO:K03504]
118004674  RBBP8; DNA endonuclease RBBP8 [KO:K20773] [EC:3.1.-.-]
118005245  BABAM1; BRISC and BRCA1-A complex member 1 isoform X1 [KO:K20776]
118007719  BABAM2; BRISC and BRCA1-A complex member 2 isoform X1 [KO:K12173]
118009525  BRCA2; breast cancer type 2 susceptibility protein [KO:K08775]
118010376  ABRAXAS1; BRCA1-A complex subunit Abraxas 1 [KO:K20774]
118012076  BARD1; BRCA1-associated RING domain protein 1 [KO:K10683]
118013186  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
118013438  MRE11; double-strand break repair protein MRE11 [KO:K10865]
118013658  [KO:K10865]
118014341  BRCC3; lys-63-specific deubiquitinase BRCC36 isoform X1 [KO:K11864] [EC:3.4.19.-]
118014693  [KO:K19528]
118014998  NBN; nibrin isoform X1 [KO:K10867]
118015027  RAD54B; DNA repair and recombination protein RAD54B isoform X1 [KO:K10877] [EC:5.6.2.-]
118015555  [KO:K10740]
118015627  [KO:K10740]
118016068  MUS81; crossover junction endonuclease MUS81 isoform X1 [KO:K08991] [EC:3.1.22.-]
118016122  POLD4; DNA polymerase delta subunit 4 isoform X1 [KO:K03505]
118016622  RAD50; LOW QUALITY PROTEIN: DNA repair protein RAD50 [KO:K10866] [EC:3.6.-.-]
118016914  [KO:K03111]
118017107  UIMC1; BRCA1-A complex subunit RAP80 isoform X1 [KO:K20775]
118019462  RAD54L; DNA repair and recombination protein RAD54-like [KO:K10875] [EC:5.6.2.-]
118019808  RPA2; replication protein A 32 kDa subunit isoform X1 [KO:K10739]
118020805  RPA3; replication protein A 14 kDa subunit [KO:K10740]
118021179  SSBP1; single-stranded DNA-binding protein, mitochondrial isoform X1 [KO:K03111]
118023070  [KO:K03111]
118023077  BLM; Bloom syndrome protein isoform X1 [KO:K10901] [EC:5.6.2.4]
118024492  POLD2; DNA polymerase delta subunit 2 isoform X1 [KO:K02328]
118024619  RAD51D; DNA repair protein RAD51 homolog 4 isoform X1 [KO:K10871]
118024669  BRIP1; Fanconi anemia group J protein [KO:K15362] [EC:5.6.2.3]
118024694  RAD51C; DNA repair protein RAD51 homolog 3 [KO:K10870]
118024766  EME1; crossover junction endonuclease EME1 isoform X1 [KO:K10882] [EC:3.1.22.-]
118024950  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
118025212  RPA1; replication protein A 70 kDa DNA-binding subunit [KO:K07466]
118025452  RAD52; DNA repair protein RAD52 homolog [KO:K10873]
118026090  RPA4; LOW QUALITY PROTEIN: replication protein A 30 kDa subunit [KO:K10741]
118026828  XRCC2; DNA repair protein XRCC2 [KO:K10879]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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