KEGG   PATHWAY: mmar00260
Entry
mmar00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Modestobacter italicus
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
mmar00260  Glycine, serine and threonine metabolism
mmar00260

Module
mmar_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:mmar00260]
mmar_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:mmar00260]
mmar_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:mmar00260]
mmar_M00621  Glycine cleavage system [PATH:mmar00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Modestobacter italicus [GN:mmar]
Gene
MODMU_0063  glxK; Glycerate kinase [KO:K00865] [EC:2.7.1.165]
MODMU_0586  ask; Aspartokinase [KO:K00928] [EC:2.7.2.4]
MODMU_0587  asd; Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
MODMU_0671  [KO:K15634] [EC:5.4.2.11]
MODMU_0780  thrC; L-threonine synthase [KO:K01733] [EC:4.2.3.1]
MODMU_0878  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
MODMU_0988  [KO:K01754] [EC:4.3.1.19]
MODMU_1384  serB; Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
MODMU_1659  [KO:K00382] [EC:1.8.1.4]
MODMU_2097  maoI; Primary amine oxidase [KO:K00276] [EC:1.4.3.21]
MODMU_2666  gcvP; Glycine cleavage system P-protein (glycine dehydrogenase) [KO:K00281] [EC:1.4.4.2]
MODMU_2671  gcvH; Glycine cleavage system H-protein [KO:K02437]
MODMU_2884  sdaA; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
MODMU_2885  [KO:K00309]
MODMU_2886  soxG; Sarcosine oxidase gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
MODMU_2887  soxA; sarcosine oxidase, alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]
MODMU_2888  soxD; Sarcosine oxidase delta subunit [KO:K00304] [EC:1.5.3.24 1.5.3.1]
MODMU_2889  soxB; sarcosine oxidase, beta subunit [KO:K00303] [EC:1.5.3.24 1.5.3.1]
MODMU_3069  [KO:K08688] [EC:3.5.3.3]
MODMU_3071  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
MODMU_3072  soxB; sarcosine oxidase, beta subunit [KO:K00303] [EC:1.5.3.24 1.5.3.1]
MODMU_3073  soxD; Sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
MODMU_3074  soxA; sarcosine oxidase, alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]
MODMU_3075  soxG; Sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
MODMU_3076  sdaA; L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
MODMU_3405  trpA; tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
MODMU_3406  trpB; Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
MODMU_3507  ltaA; L-allo-threonine aldolase [KO:K01620] [EC:4.1.2.48]
MODMU_3546  gcvT; Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
MODMU_3549  bfmBC; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
MODMU_4206  [KO:K00276] [EC:1.4.3.21]
MODMU_4454  [KO:K01758] [EC:4.4.1.1]
MODMU_4476  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
MODMU_4549  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
MODMU_4557  thrB; Homoserine kinase [KO:K00872] [EC:2.7.1.39]
MODMU_4558  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
MODMU_4559  hom; Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
MODMU_4576  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
MODMU_4605  cbs; Cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
MODMU_5016  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
MODMU_5164  [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
MODMU_5312  ilvA; Threonine dehydratase [KO:K01754] [EC:4.3.1.19]
MODMU_5350  glyA; Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
MODMU_5430  [KO:K01754] [EC:4.3.1.19]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
mmar00010  Glycolysis / Gluconeogenesis
mmar00020  Citrate cycle (TCA cycle)
mmar00230  Purine metabolism
mmar00250  Alanine, aspartate and glutamate metabolism
mmar00270  Cysteine and methionine metabolism
mmar00290  Valine, leucine and isoleucine biosynthesis
mmar00300  Lysine biosynthesis
mmar00330  Arginine and proline metabolism
mmar00460  Cyanoamino acid metabolism
mmar00470  D-Amino acid metabolism
mmar00564  Glycerophospholipid metabolism
mmar00620  Pyruvate metabolism
mmar00630  Glyoxylate and dicarboxylate metabolism
mmar00640  Propanoate metabolism
mmar00680  Methane metabolism
mmar00860  Porphyrin metabolism
mmar00920  Sulfur metabolism
KO pathway
ko00260   

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