KEGG   PATHWAY: mmed00260
Entry
mmed00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Martelella mediterranea
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
mmed00260  Glycine, serine and threonine metabolism
mmed00260

Module
mmed_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:mmed00260]
mmed_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:mmed00260]
mmed_M00555  Betaine biosynthesis, choline => betaine [PATH:mmed00260]
mmed_M00621  Glycine cleavage system [PATH:mmed00260]
mmed_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:mmed00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Martelella mediterranea [GN:mmed]
Gene
Mame_01312  lysC; Aspartokinase [KO:K00928] [EC:2.7.2.4]
Mame_02242  asd2; Aspartate-semialdehyde dehydrogenase 2 [KO:K00133] [EC:1.2.1.11]
Mame_03090  hom; Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
Mame_03382  thrB; Homoserine kinase [KO:K02204] [EC:2.7.1.39]
Mame_03371  thrC; Threonine synthase [KO:K01733] [EC:4.2.3.1]
Mame_00993  ltaE; Low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
Mame_03609  glyA1; Serine hydroxymethyltransferase 1 [KO:K00600] [EC:2.1.2.1]
Mame_00574  Putative 2-hydroxyacid dehydrogenase [KO:K00018] [EC:1.1.1.29]
Mame_04620  ghrA_2; Glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
Mame_01302  ghrA_1; Glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
Mame_02237  ttuD; Putative hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
Mame_01262  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
Mame_02433  serA_2; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Mame_02431  serC; Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
Mame_02724  serB; Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
Mame_01039  hemA; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
Mame_02945  gcvP; Glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
Mame_02947  gcvT_1; Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
Mame_02763  lpd_1; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
Mame_02098  lpd3; Dihydrolipoyl dehydrogenase 3 [KO:K00382] [EC:1.8.1.4]
Mame_04651  lpdA; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
Mame_02946  gcvH; Glycine cleavage system H protein [KO:K02437]
Mame_02389  Creatinase [KO:K08688] [EC:3.5.3.3]
Mame_02640  CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
Mame_00833  betA_2; Choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
Mame_05099  phdK; 2-formylbenzoate dehydrogenase [KO:K00130] [EC:1.2.1.8]
Mame_00834  betB_1; Betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
Mame_00849  gbsA_1; Betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
Mame_01060  antA; Anthranilate 1,2-dioxygenase large subunit [KO:K00479] [EC:1.14.13.251]
Mame_01061  hcr; NADH oxidoreductase hcr [KO:K21832] [EC:1.14.13.251]
Mame_04001  gcvT_3; Aminomethyltransferase [KO:K00315] [EC:1.5.8.4]
Mame_03850  gcvT_2; Aminomethyltransferase [KO:K00302] [EC:1.5.3.24 1.5.3.1]
Mame_03853  soxB; Sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
Mame_03849  sarcosine oxidase, gamma subunit family [KO:K00305] [EC:1.5.3.24 1.5.3.1]
Mame_03851  sarcosine oxidase, delta subunit family [KO:K00304] [EC:1.5.3.24 1.5.3.1]
Mame_03517  tdcG; L-serine dehydratase TdcG [KO:K01752] [EC:4.3.1.17]
Mame_03341  ilvA_2; L-threonine dehydratase biosynthetic IlvA [KO:K01754] [EC:4.3.1.19]
Mame_02828  tdcB_1; L-threonine dehydratase catabolic TdcB [KO:K01754] [EC:4.3.1.19]
Mame_03041  ilvA_1; L-threonine dehydratase biosynthetic IlvA [KO:K01754] [EC:4.3.1.19]
Mame_05165  tdcB_2; L-threonine dehydratase catabolic TdcB [KO:K01754] [EC:4.3.1.19]
Mame_04151  trpA_2; Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
Mame_04157  trpA_3; Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
Mame_00711  trpA_1; Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
Mame_04152  trpB_2; Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
Mame_00708  trpB_1; Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
Mame_04795  trpB_3; Tryptophan synthase beta chain [KO:K06001] [EC:4.2.1.20]
Mame_00077  putative peptidase [KO:K15783] [EC:3.5.4.44]
Mame_02830  pepQ_3; Xaa-Pro dipeptidase [KO:K15783] [EC:3.5.4.44]
Mame_00076  tpa; Taurine--pyruvate aminotransferase [KO:K15785] [EC:2.6.1.76]
Mame_02819  bioK_2; L-Lysine-8-amino-7-oxononanoate aminotransferase [KO:K15785] [EC:2.6.1.76]
Mame_02820  gabD_3; Succinate-semialdehyde dehydrogenase [NADP(+)] GabD [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
mmed00010  Glycolysis / Gluconeogenesis
mmed00020  Citrate cycle (TCA cycle)
mmed00230  Purine metabolism
mmed00250  Alanine, aspartate and glutamate metabolism
mmed00270  Cysteine and methionine metabolism
mmed00290  Valine, leucine and isoleucine biosynthesis
mmed00300  Lysine biosynthesis
mmed00330  Arginine and proline metabolism
mmed00460  Cyanoamino acid metabolism
mmed00470  D-Amino acid metabolism
mmed00564  Glycerophospholipid metabolism
mmed00600  Sphingolipid metabolism
mmed00620  Pyruvate metabolism
mmed00630  Glyoxylate and dicarboxylate metabolism
mmed00640  Propanoate metabolism
mmed00680  Methane metabolism
mmed00860  Porphyrin metabolism
mmed00920  Sulfur metabolism
KO pathway
ko00260   
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