KEGG   PATHWAY: mmu03008
Entry
mmu03008                    Pathway                                
Name
Ribosome biogenesis in eukaryotes - Mus musculus (house mouse)
Description
Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage.
Class
Genetic Information Processing; Translation
Pathway map
mmu03008  Ribosome biogenesis in eukaryotes
mmu03008

Organism
Mus musculus (house mouse) [GN:mmu]
Gene
100019  Mdn1; midasin [KO:K14572]
100861471  n-R5s100; nuclear encoded rRNA 5S 100 [KO:K01981]
100861472  n-R5s103; nuclear encoded rRNA 5S 103 [KO:K01981]
100861473  n-R5s104; nuclear encoded rRNA 5S 104 [KO:K01981]
100861474  n-R5s105; nuclear encoded rRNA 5S 105 [KO:K01981]
100861475  n-R5s108; nuclear encoded rRNA 5S 108 [KO:K01981]
100861477  n-R5s110; nuclear encoded rRNA 5S 110 [KO:K01981]
100861478  n-R5s111; nuclear encoded rRNA 5S 111 [KO:K01981]
100861479  n-R5s113; nuclear encoded rRNA 5S 113 [KO:K01981]
100861480  Gm25018; predicted gene, 25018 [KO:K01981]
100861481  n-R5s117; nuclear encoded rRNA 5S 117 [KO:K01981]
100861482  n-R5s121; nuclear encoded rRNA 5S 121 [KO:K01981]
100861483  n-R5s122; nuclear encoded rRNA 5S 122 [KO:K01981]
100861484  n-R5s123; nuclear encoded rRNA 5S 123 [KO:K01981]
100861486  n-R5s124; nuclear encoded rRNA 5S 124 [KO:K01981]
100861487  n-R5s128; nuclear encoded rRNA 5S 128 [KO:K01981]
100861488  Gm26391; predicted gene, 26391 [KO:K01981]
100861489  n-R5s133; nuclear encoded rRNA 5S 133 [KO:K01981]
100861490  n-R5s134; nuclear encoded rRNA 5S 134 [KO:K01981]
100861491  n-R5s136; nuclear encoded rRNA 5S 136 [KO:K01981]
100861492  n-R5s138; nuclear encoded rRNA 5S 138 [KO:K01981]
100861493  n-R5s139; nuclear encoded rRNA 5S 139 [KO:K01981]
100861494  Gm22109; predicted gene, 22109 [KO:K01981]
100861495  n-R5s141; nuclear encoded rRNA 5S 141 [KO:K01981]
100861496  n-R5s142; nuclear encoded rRNA 5S 142 [KO:K01981]
100861497  n-R5s143; nuclear encoded rRNA 5S 143 [KO:K01981]
100861498  n-R5s144; nuclear encoded rRNA 5S 144 [KO:K01981]
100861499  Gm25212; predicted gene, 25212 [KO:K01981]
100861500  n-R5s146; nuclear encoded rRNA 5S 146 [KO:K01981]
100861501  Gm22291; predicted gene, 22291 [KO:K01981]
100861502  Gm23284; predicted gene, 23284 [KO:K01981]
100861503  n-R5s149; nuclear encoded rRNA 5S 149 [KO:K01981]
101592  Efl1; elongation factor-like GTPase 1 [KO:K14536] [EC:3.6.5.-]
102216272  Ak6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
102462  Imp3; U3 small nucleolar ribonucleoprotein protein IMP3 [KO:K14560]
102614  Rpp25; ribonuclease P protein subunit p25 [KO:K14525] [EC:3.1.26.5]
102635936  Gm33146; H/ACA ribonucleoprotein complex subunit 3-like [KO:K11130]
103573  Xpo1; exportin-1 [KO:K14290]
104444  Rexo2; oligoribonuclease, mitochondrial isoform 1 precursor [KO:K13288] [EC:3.1.-.-]
105372  Utp15; U3 small nucleolar RNA-associated protein 15 homolog [KO:K14549]
108168301  Gm46562; H/ACA ribonucleoprotein complex subunit 3-like [KO:K11130]
110816  Pwp2; periodic tryptophan protein 2 homolog [KO:K14558]
115486558  n-R5s151; 5S ribosomal RNA [KO:K01981]
115486994  Gm57524; small nucleolar RNA U3 [KO:K14483]
115487061  n-R5s106; 5S ribosomal RNA [KO:K01981]
115487062  n-R5s118; 5S ribosomal RNA [KO:K01981]
115487063  Gm24312; 5S ribosomal RNA [KO:K01981]
115487064  n-R5s130; 5S ribosomal RNA [KO:K01981]
115487065  n-R5s101; 5S ribosomal RNA [KO:K01981]
115487066  n-R5s129; 5S ribosomal RNA [KO:K01981]
115487067  n-R5s112; 5S ribosomal RNA [KO:K01981]
115487068  n-R5s120; 5S ribosomal RNA [KO:K01981]
115487069  n-R5s125; 5S ribosomal RNA [KO:K01981]
115487070  n-R5s102; 5S ribosomal RNA [KO:K01981]
115487071  n-R5s114; 5S ribosomal RNA [KO:K01981]
115487072  n-R5s119; 5S ribosomal RNA [KO:K01981]
115487073  n-R5s107; 5S ribosomal RNA [KO:K01981]
115487074  n-R5s131; 5S ribosomal RNA [KO:K01981]
115487075  n-R5s115; 5S ribosomal RNA [KO:K01981]
115487076  n-R5s109; 5S ribosomal RNA [KO:K01981]
115487577  n-R5s211; 5S ribosomal RNA [KO:K01981]
115487696  Gm24826; small nucleolar RNA U3 [KO:K14483]
115487926  Gm24949; small nucleolar RNA U3 [KO:K14483]
115487929  Gm57586; small nucleolar RNA U3 [KO:K14483]
115488032  n-R5s58; 5S ribosomal RNA [KO:K01981]
115488082  n-R5s64; 5S ribosomal RNA [KO:K01981]
115488090  Gm25203; small nucleolar RNA U3 [KO:K14483]
115488675  n-R5s33; 5S ribosomal RNA [KO:K01981]
115488828  n-R5s28; 5S ribosomal RNA [KO:K01981]
115488945  n-R5s25; 5S ribosomal RNA [KO:K01981]
115489156  n-R5s2; 5S ribosomal RNA [KO:K01981]
115489235  n-R5s13; 5S ribosomal RNA [KO:K01981]
115489751  n-R5s194; 5S ribosomal RNA [KO:K01981]
115489841  n-R5s195; 5S ribosomal RNA [KO:K01981]
115490001  n-R5s185; 5S ribosomal RNA [KO:K01981]
115490446  n-R5s162; 5S ribosomal RNA [KO:K01981]
117109  Pop5; ribonuclease P/MRP protein subunit POP5 isoform 1 [KO:K03537] [EC:3.1.26.5]
118568469  [KO:K12845]
12995  Csnk2a1; casein kinase II subunit alpha isoform 1 [KO:K03097] [EC:2.7.11.1]
13000  Csnk2a2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
13001  Csnk2b; casein kinase II subunit beta isoform 2 [KO:K03115]
14000  Drosha; ribonuclease 3 [KO:K03685] [EC:3.1.26.3]
14113  Fbl; rRNA 2'-O-methyltransferase fibrillarin isoform 1 [KO:K14563] [EC:2.1.1.-]
14791  Emg1; ribosomal RNA small subunit methyltransferase NEP1 isoform 1 [KO:K14568] [EC:2.1.1.260]
16418  Eif6; eukaryotic translation initiation factor 6 [KO:K03264]
170722  Nxf7; nuclear RNA export factor 7 isoform 2 [KO:K14284]
19384  Ran; GTP-binding nuclear protein Ran [KO:K07936]
19428  Rasl2-9; GTP-binding nuclear protein Ran, testis-specific isoform [KO:K07936]
195434  Utp14b; U3 small nucleolar RNA-associated protein 14 homolog B [KO:K14567]
19782  Rmrp; RNA component of mitochondrial RNAase P [KO:K14576]
19804  Rn5s; 5S RNA [KO:K01981]
19850  Snord3a; small nucleolar RNA, C/D box 3A [KO:K14483]
19858  Snord3b1; small nucleolar RNA, C/D box 3B1 [KO:K14483]
19859  Snord3b2; small nucleolar RNA, C/D box 3B2 [KO:K14483]
19860  Snord3b3; small nucleolar RNA, C/D box 3B3 [KO:K14483]
19861  Snord3b4; small nucleolar RNA, C/D box 3B4 [KO:K14483]
20826  Snu13; NHP2-like protein 1 [KO:K12845]
208366  Rpp40; ribonuclease P protein subunit p40 isoform 1 [KO:K14530] [EC:3.1.26.5]
213773  Tbl3; transducin beta-like protein 3 [KO:K14555]
213895  Bms1; ribosome biogenesis protein BMS1 homolog [KO:K14569]
21453  Tcof1; treacle protein isoform 2 [KO:K14562]
216987  Utp6; U3 small nucleolar RNA-associated protein 6 homolog [KO:K14557]
217109  Utp18; U3 small nucleolar RNA-associated protein 18 homolog [KO:K14553]
21771  Utp4; U3 small nucleolar RNA-associated protein 4 homolog [KO:K14548]
217995  Heatr1; HEAT repeat-containing protein 1 [KO:K14550]
224092  Lsg1; large subunit GTPase 1 homolog isoform 1 [KO:K14539] [EC:3.6.1.-]
225348  Wdr36; WD repeat-containing protein 36 isoform 1 [KO:K14554]
227522  Rpp38; ribonuclease P protein subunit p38 [KO:K14523] [EC:3.1.26.5]
230082  Nol6; nucleolar protein 6 [KO:K14544]
230737  Gnl2; nucleolar GTP-binding protein 2 [KO:K14537]
237082  Nxt2; NTF2-related export protein 2 isoform a [KO:K14285]
237107  Gnl3l; guanine nucleotide-binding protein-like 3-like protein [KO:K14538]
237730  Fbll1; rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1 [KO:K14563] [EC:2.1.1.-]
24127  Xrn1; 5'-3' exoribonuclease 1 isoform 2 [KO:K12618] [EC:3.1.13.-]
24128  Xrn2; 5'-3' exoribonuclease 2 isoform 1 [KO:K12619] [EC:3.1.13.-]
245474  Dkc1; H/ACA ribonucleoprotein complex subunit DKC1 isoform 3 [KO:K11131] [EC:5.4.99.-]
245610  Nxf3; nuclear RNA export factor 3 [KO:K14284]
269470  Wdr3; WD repeat-containing protein 3 isoform 1 [KO:K14556]
27993  Imp4; U3 small nucleolar ribonucleoprotein protein IMP4 isoform 1 [KO:K14561]
30877  Gnl3; guanine nucleotide-binding protein-like 3 [KO:K14538]
434234  Rexo5; RNA exonuclease 5 isoform 1 [KO:K14570] [EC:3.1.-.-]
52530  Nhp2; H/ACA ribonucleoprotein complex subunit 2 isoform 1 [KO:K11129]
53319  Nxf1; nuclear RNA export factor 1 isoform 1 [KO:K14284]
54364  Rpp30; ribonuclease P protein subunit p30 [KO:K03539] [EC:3.1.26.5]
55989  Nop58; nucleolar protein 58 isoform 1 [KO:K14565]
56488  Nxt1; NTF2-related export protein 1 [KO:K14285]
57815  Afg2a; ATPase family gene 2 protein homolog A isoform 1 [KO:K14575]
59028  Rcl1; RNA 3'-terminal phosphate cyclase-like protein [KO:K11108]
66161  Pop4; ribonuclease P protein subunit p29 [KO:K03538] [EC:3.1.26.5]
66181  Nop10; H/ACA ribonucleoprotein complex subunit 3 [KO:K11130]
66711  Sbds; ribosome maturation protein SBDS [KO:K14574]
66932  Rexo1; RNA exonuclease 1 homolog [KO:K14570] [EC:3.1.-.-]
67045  Riok2; serine/threonine-protein kinase RIO2 [KO:K07179] [EC:2.7.11.1]
67134  Nop56; nucleolar protein 56 [KO:K14564]
67459  Nvl; nuclear valosin-containing protein-like [KO:K14571]
67619  Nob1; RNA-binding protein NOB1 [KO:K11883]
67724  Pop1; ribonucleases P/MRP protein subunit POP1 isoform 2 [KO:K01164] [EC:3.1.26.5]
67973  Mphosph10; U3 small nucleolar ribonucleoprotein protein MPP10 [KO:K14559]
68147  Gar1; H/ACA ribonucleoprotein complex subunit 1 [KO:K11128]
68272  Rbm28; RNA-binding protein 28 [KO:K14573]
69237  Gtpbp4; GTP-binding protein 4 isoform 1 [KO:K06943]
69961  Rpp25l; ribonuclease P protein subunit p25-like protein [KO:K14525] [EC:3.1.26.5]
71340  Riok1; serine/threonine-protein kinase RIO1 [KO:K07178] [EC:2.7.11.1]
72515  Wdr43; WD repeat-containing protein 43 [KO:K14546]
72554  Utp14a; U3 small nucleolar RNA-associated protein 14 homolog A [KO:K14567]
73674  Wdr75; WD repeat-containing protein 75 [KO:K14552]
73736  Fcf1; rRNA-processing protein FCF1 homolog [KO:K14566]
74097  Pop7; ribonuclease P protein subunit p20 [KO:K14527] [EC:3.1.26.5]
74778  Rrp7a; ribosomal RNA-processing protein 7 homolog A isoform 1 [KO:K14545]
75471  1700009N14Rik; uncharacterized protein LOC75471 [KO:K07936]
83454  Nxf2; nuclear RNA export factor 5 isoform 1 [KO:K14284]
97112  Nmd3; 60S ribosomal export protein NMD3 isoform 1 [KO:K07562]
98956  Nat10; RNA cytidine acetyltransferase [KO:K14521] [EC:2.3.1.-]
Reference
PMID:20174677
  Authors
Freed EF, Bleichert F, Dutca LM, Baserga SJ
  Title
When ribosomes go bad: diseases of ribosome biogenesis.
  Journal
Mol Biosyst 6:481-93 (2010)
DOI:10.1039/b919670f
Reference
PMID:17515605
  Authors
Perez-Fernandez J, Roman A, De Las Rivas J, Bustelo XR, Dosil M
  Title
The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism.
  Journal
Mol Cell Biol 27:5414-29 (2007)
DOI:10.1128/MCB.00380-07
Reference
PMID:19850913
  Authors
Strunk BS, Karbstein K
  Title
Powering through ribosome assembly.
  Journal
RNA 15:2083-104 (2009)
DOI:10.1261/rna.1792109
Reference
PMID:15120992
  Authors
Granneman S, Baserga SJ
  Title
Ribosome biogenesis: of knobs and RNA processing.
  Journal
Exp Cell Res 296:43-50 (2004)
DOI:10.1016/j.yexcr.2004.03.016
Reference
PMID:19879902
  Authors
Kressler D, Hurt E, Bassler J
  Title
Driving ribosome assembly.
  Journal
Biochim Biophys Acta 1803:673-83 (2010)
DOI:10.1016/j.bbamcr.2009.10.009
Related
pathway
mmu03010  Ribosome
KO pathway
ko03008   

DBGET integrated database retrieval system