KEGG   PATHWAY: mmu03420
Entry
mmu03420                    Pathway                                
Name
Nucleotide excision repair - Mus musculus (house mouse)
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
Pathway map
mmu03420  Nucleotide excision repair
mmu03420

Other DBs
GO: 0006289
Organism
Mus musculus (house mouse) [GN:mmu]
Gene
106344  Rfc4; replication factor C (activator 1) 4 [KO:K10755]
107986  Ddb2; damage specific DNA binding protein 2 [KO:K10140]
108167613  Gm6195; predicted pseudogene 6195 [KO:K10740]
12572  Cdk7; cyclin dependent kinase 7 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
13194  Ddb1; damage specific DNA binding protein 1 [KO:K10610]
13870  Ercc1; excision repair cross-complementing rodent repair deficiency, complementation group 1 [KO:K10849]
13871  Ercc2; excision repair cross-complementing rodent repair deficiency, complementation group 2 [KO:K10844] [EC:5.6.2.3]
13872  Ercc3; excision repair cross-complementing rodent repair deficiency, complementation group 3 [KO:K10843] [EC:5.6.2.4]
14884  Gtf2h1; general transcription factor II H, polypeptide 1 [KO:K03141]
14885  Gtf2h4; general transcription factor II H, polypeptide 4 [KO:K03144]
16881  Lig1; ligase I, DNA, ATP-dependent [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
17420  Mnat1; menage a trois 1 [KO:K10842]
17749  Polr2k; polymerase (RNA) II (DNA directed) polypeptide K [KO:K03009]
18538  Pcna; proliferating cell nuclear antigen [KO:K04802]
18971  Pold1; polymerase (DNA directed), delta 1, catalytic subunit [KO:K02327] [EC:2.7.7.7]
18972  Pold2; polymerase (DNA directed), delta 2, regulatory subunit [KO:K02328]
18973  Pole; polymerase (DNA directed), epsilon [KO:K02324] [EC:2.7.7.7]
18974  Pole2; polymerase (DNA directed), epsilon 2 (p59 subunit) [KO:K02325] [EC:2.7.7.7]
19358  Rad23a; RAD23 homolog A, nucleotide excision repair protein [KO:K10839]
19359  Rad23b; RAD23 homolog B, nucleotide excision repair protein [KO:K10839]
19687  Rfc1; replication factor C (activator 1) 1 [KO:K10754]
19718  Rfc2; replication factor C (activator 1) 2 [KO:K10755]
19891  Rpa2; replication protein A2 [KO:K10739]
20020  Polr2a; polymerase (RNA) II (DNA directed) polypeptide A [KO:K03006] [EC:2.7.7.6]
20021  Polr2c; polymerase (RNA) II (DNA directed) polypeptide C [KO:K03011]
20022  Polr2j; polymerase (RNA) II (DNA directed) polypeptide J [KO:K03008]
209357  Gtf2h3; general transcription factor IIH, polypeptide 3 [KO:K03143]
22590  Xpa; xeroderma pigmentosum, complementation group A [KO:K10847]
22591  Xpc; xeroderma pigmentosum, complementation group C [KO:K10838]
22592  Ercc5; excision repair cross-complementing rodent repair deficiency, complementation group 5 [KO:K10846]
231329  Polr2b; polymerase (RNA) II (DNA directed) polypeptide B [KO:K03010] [EC:2.7.7.6]
23894  Gtf2h2; general transcription factor II H, polypeptide 2 [KO:K03142]
245841  Polr2h; polymerase (RNA) II (DNA directed) polypeptide H [KO:K03016]
26370  Cetn2; centrin 2 [KO:K10840]
28015  Polr2m; polymerase (RNA) II (DNA directed) polypeptide M [KO:K21987]
319955  Ercc6; excision repair cross-complementing rodent repair deficiency, complementation group 6 [KO:K10841]
50505  Ercc4; excision repair cross-complementing rodent repair deficiency, complementation group 4 [KO:K10848] [EC:3.1.-.-]
56438  Rbx1; ring-box 1 [KO:K03868] [EC:2.3.2.32]
59001  Pole3; polymerase (DNA directed), epsilon 3 (p17 subunit) [KO:K02326] [EC:2.7.7.7]
66420  Polr2e; polymerase (RNA) II (DNA directed) polypeptide E [KO:K03013]
66467  Gtf2h5; general transcription factor IIH, polypeptide 5 [KO:K10845]
66491  Polr2l; polymerase (RNA) II (DNA directed) polypeptide L [KO:K03007]
66671  Ccnh; cyclin H [KO:K06634]
66979  Pole4; polymerase (DNA-directed), epsilon 4 (p12 subunit) [KO:K03506] [EC:2.7.7.7]
67710  Polr2g; polymerase (RNA) II (DNA directed) polypeptide G [KO:K03015]
67967  Pold3; polymerase (DNA-directed), delta 3, accessory subunit [KO:K03504]
68240  Rpa3; replication protein A3 [KO:K10740]
68275  Rpa1; replication protein A1 [KO:K07466]
69241  Polr2d; polymerase (RNA) II (DNA directed) polypeptide D [KO:K03012]
69263  Rfc3; replication factor C (activator 1) 3 [KO:K10756]
69745  Pold4; polymerase (DNA-directed), delta 4 [KO:K03505]
69833  Polr2f; polymerase (RNA) II (DNA directed) polypeptide F [KO:K03014]
69920  Polr2i; polymerase (RNA) II (DNA directed) polypeptide I [KO:K03017]
71101  Uvssa; UV stimulated scaffold protein A [KO:K23720]
71991  Ercc8; excision repaiross-complementing rodent repair deficiency, complementation group 8 [KO:K10570]
72151  Rfc5; replication factor C (activator 1) 5 [KO:K10756]
72584  Cul4b; cullin 4B [KO:K10609]
99375  Cul4a; cullin 4A [KO:K10609]
Reference
PMID:11436314
  Authors
Sugasawa K.
  Title
[Molecular mechanism of mammalian nucleotide excision repair]
  Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
PMID:11436316
  Authors
Nakatsu Y.
  Title
[Transcription-coupled repair and Cockayne syndrome]
  Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
PMID:11436323
  Authors
Nakagawa N, Masui R, Kuramitsu S.
  Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
  Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
PMID:17276014
  Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
  Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
  Journal
Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020
Reference
PMID:17884153
  Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
  Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
  Journal
Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043
Reference
PMID:16922398
  Authors
Sugasawa K.
  Title
[DNA repair pathways involving Cul4A ubiquitin ligases]
  Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
PMID:18018633
  Authors
Ito S, Ando D, Tanaka K.
  Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
  Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related
pathway
mmu03020  RNA polymerase
mmu04120  Ubiquitin mediated proteolysis
KO pathway
ko03420   

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